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1. 发明申请

WO03033655A3 ISOLATED HUMAN SECRETED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN SECRETED PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO03033655A3
公开(公告)日：2003-09-25
申请号：PCT/US0232764
申请日：2002-10-16
申请人： APPLERA CORP , YAN CHUNHUA , BRANDENBERGER RALPH , KETCHUM KAREN A , LADUNGA ISTVAN
发明人： YAN CHUNHUA , BRANDENBERGER RALPH , KETCHUM KAREN A , LADUNGA ISTVAN
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00 , C12P21/06 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.

2. 发明申请

WO03006481A3 ISOLATED HUMAN SECRETED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN SECRETED PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO03006481A3
公开(公告)日：2003-10-09
申请号：PCT/US0221574
申请日：2002-07-10
申请人： APPLERA CORP , HU SONG , KETCHUM KAREN , LADUNGA ISTVAN
发明人： HU SONG , KETCHUM KAREN , LADUNGA ISTVAN
IPC分类号： A61K38/00 , C07K14/47 , C07K17/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.

3. 发明申请

WO03006483A3 ISOLATED HUMAN SECRETED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN SECRETED PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO03006483A3
公开(公告)日：2003-05-01
申请号：PCT/US0221669
申请日：2002-07-10
申请人： APPLERA CORP , HU SONG , WEBSTER MARION , CECCARDI TONI , LADUNGA ISTVAN
发明人： HU SONG , WEBSTER MARION , CECCARDI TONI , LADUNGA ISTVAN
IPC分类号： A61K38/00 , C07K14/485 , C07K17/00
CPC分类号： C07K14/485 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.

4. 发明申请

WO03001880A3 ISOLATED HUMAN SECRETED PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN SECRETED PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO03001880A3
公开(公告)日：2003-10-09
申请号：PCT/US0220169
申请日：2002-06-25
申请人： PE CORP NY , CECCARDI TONI , ZHONG MIN , LADUNGA ISTVAN
发明人： CECCARDI TONI , ZHONG MIN , LADUNGA ISTVAN
IPC分类号： A61K38/00 , C07K14/47 , C07K14/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the secreted peptides, and methods of identifying modulators of the secreted peptides.

5. 发明申请

WO2004053769A3 A BROWSABLE DATABASE FOR BIOLOGICAL USE 审中-公开
标题翻译：用于生物用途的可浏览数据库
公开(公告)号：WO2004053769A3
公开(公告)日：2005-07-21
申请号：PCT/US0338935
申请日：2003-12-09
申请人： APPLERA CORP
发明人： THOMAS PAUL D , KEJARIWAL ANISH , CAMPBELL MICHAEL J , MI HUAIYA , DIEMER KAREN , GUO NAN , LADUNGA ISTVAN , LAZAREVA BETTY , MURUGANUJAN ANUSHYA , RABKIN STEVEN , VANDERGRIFF JODY , DOREMIEUX OLIVER
IPC分类号： G01N33/48 , G01N33/50 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/28 , G06F19/00
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22 , G06F19/24
摘要： The browsable database can allow for high-throughput analysis of protein sequences. One helpful feature may be a simplified ontology of protein function, which allows browsing of the database by biological functions. Biologist curators may have associated the ontology terms with Hidden Markov Models (HMMs), rather than individual sequences, so that they can be applied to additional sequences. To ensure accurate functional classification, HMMs may be constructed not only for families, but for curator-defined subfamilies, whenever family members have divergent functions or nomenclature. Multiple sequence alignments and phylogenetic trees, including curator-assigned information, can be available for each family. Various versions of the browsable database may include training sequences from all organisms in the GenBank non-redundant protein database, and the HMMs can be used to classify gene products across the entire genomes of human, and Drosophila melanogaster.
摘要翻译：可浏览的数据库可以允许蛋白质序列的高通量分析。一个有用的特征可以是蛋白质功能的简化本体，其允许通过生物学功能浏览数据库。生物学家策展人可能将本体术语与隐马尔可夫模型（HMM）相关联，而不是单独的序列，以便可以将其应用于其他序列。为了确保精确的功能分类，HMM可能不仅可以用于家庭，而且可以在策展人定义的亚科家庭中建立，每当家庭成员具有不同的功能或命名。可以为每个家庭提供多个序列比对和系统发育树，包括策展人分配的信息。可浏览数据库的各种版本可以包括来自GenBank非冗余蛋白质数据库中的所有生物体的训练序列，并且HMM可用于对基因产物进行整个基因组的分类，并且将其与黑腹果蝇进行分类。

6. 发明申请

WO2004053769A9 A BROWSABLE DATABASE FOR BIOLOGICAL USE 审中-公开
标题翻译：用于生物用途的可浏览数据库
公开(公告)号：WO2004053769A9
公开(公告)日：2004-08-05
申请号：PCT/US0338935
申请日：2003-12-09
申请人： APPLERA CORP
发明人： THOMAS PAUL D , KEJARIWAL ANISH , CAMPBELL MICHAEL J , MI HUAIYA , DIEMER KAREN , GUO NAN , LADUNGA ISTVAN , LAZAREVA BETTY , MURUGANUJAN ANUSHYA , RABKIN STEVEN , VANDERGRIFF JODY , DOREMIEUX OLIVER
IPC分类号： G01N33/48 , G01N33/50 , G06F19/18 , G06F19/22 , G06F19/24 , G06F19/28 , G06F19/00
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22 , G06F19/24
摘要： The browsable database can allow for high-throughput analysis of protein sequences. One helpful feature may be a simplified ontology of protein function, which allows browsing of the database by biological functions. Biologist curators may have associated the ontology terms with Hidden Markov Models (HMMs), rather than individual sequences, so that they can be applied to additional sequences. To ensure accurate functional classification, HMMs may be constructed not only for families, but for curator-defined subfamilies, whenever family members have divergent functions or nomenclature. Multiple sequence alignments and phylogenetic trees, including curator-assigned information, can be available for each family. Various versions of the browsable database may include training sequences from all organisms in the GenBank non-redundant protein database, and the HMMs can be used to classify gene products across the entire genomes of human, and Drosophila melanogaster.
摘要翻译：可浏览的数据库可以允许蛋白质序列的高通量分析。一个有用的特征可以是蛋白质功能的简化本体，其允许通过生物学功能浏览数据库。生物学家策展人可能将本体术语与隐马尔可夫模型（HMM）相关联，而不是单独的序列，以便可以将其应用于其他序列。为了确保精确的功能分类，HMM可能不仅可以用于家庭，而且可以在策展人定义的亚科家庭中建立，每当家庭成员具有不同的功能或命名。可以为每个家庭提供多个序列比对和系统发育树，包括策展人分配的信息。可浏览数据库的各种版本可以包括来自GenBank非冗余蛋白质数据库中的所有生物体的训练序列，并且HMM可用于对基因产物进行整个基因组的分类，并且将其与黑腹果蝇进行分类。

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