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1. 发明申请

WO2010056043A9 CELL-PENETRATING, SEQUENCE-SPECIFIC AND NUCLEIC ACID-HYDROLYZING ANTIBODY, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2010056043A9
公开(公告)日：2010-05-20
申请号：PCT/KR2009/006628
申请日：2009-11-11
申请人： AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KIM, Yong Sung , KWON, Myung Hee , LEE, Woo Ram
发明人： KIM, Yong Sung , KWON, Myung Hee , LEE, Woo Ram
IPC分类号： C07K16/00 , C07K16/28
摘要： Disclosed are a cell-penetrating, base sequence-specific, nucleic acid-hydrolyzing antibody, a method of preparing the same, and a pharmaceutical composition comprising the same. The antibody can be prepared by modifying a particular site of a cell-penetrating, nucleic acid-hydrolyzing antibody which lacks substrate specificity to impart sequence specificity thereto without alteration in nucleic acid-hydrolyzing ability. The antibody, when penetrating into cells by itself or ectopically expressed within cells, binds specifically to single- or double-stranded nucleic acid targets and hydrolyzes them, thus downregulating the expression of the targeted genes.

2. 发明申请

WO2010024629A3 QUANTUM DOT PHOTOVOLTAIC DEVICE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：量子光伏器件及其制造方法
公开(公告)号：WO2010024629A3
公开(公告)日：2010-04-29
申请号：PCT/KR2009004852
申请日：2009-08-28
申请人： KOREA RES INST OF STANDARDS , KIM KYUNG JOONG , LEE WOO , KIM YONG SUNG , KIM YOUNG HEON , HONG SEUNG HUI , YUN WAN SOO , KANG SANG WOO
发明人： KIM KYUNG JOONG , LEE WOO , KIM YONG SUNG , KIM YOUNG HEON , HONG SEUNG HUI , YUN WAN SOO , KANG SANG WOO
IPC分类号： H01L31/042
CPC分类号： H01L31/035218 , H01L31/18
摘要： The present invention provides a semiconductor based photovoltaic device and a manufacturing method thereof. The semiconductor based photovoltaic device is able to absorb light with a wide band wavelength, and has high photoelectric conversion efficiency since it has high electron-hole pair separation efficiency. More specifically, the method for manufacturing the photovoltaic device comprises the steps of: a) forming a thin semiconductor quantum dot film on a p or n-type semiconductor substrate, wherein the thin semiconductor quantum dot film includes semiconductor quantum dots inside a medium at which the same type of impurities as the semiconductor substrate are doped; b) forming a pore array through partial etching, wherein the pore array penetrates the thin semiconductor quantum dot film; c) depositing a semiconductor in which complementary impurities to the semiconductor substrate are doped on the thin semiconductor quantum dot film at which the pore array is formed; and d) forming sequentially a transparent conductive film and an upper electrode on the semiconductor in which the complementary impurities are doped and forming a lower electrode at a lower portion of the semiconductor substrate.
摘要翻译：本发明提供一种基于半导体的光电器件及其制造方法。基于半导体的光电器件能够吸收宽带波长的光，并且由于具有高的电子 - 空穴对分离效率，因此光电转换效率高。更具体地说，制造光伏器件的方法包括以下步骤：a）在p型或n型半导体衬底上形成薄的半导体量子点膜，其中薄的半导体量子点膜包括介质内的半导体量子点，与半导体衬底掺杂相同类型的杂质; b）通过部分蚀刻形成孔阵列，其中孔阵列穿透薄的半导体量子点膜; c）在其上形成有孔阵列的薄半导体量子点膜上沉积半导体衬底掺杂杂质的半导体; 以及d）在所述半导体上顺序形成透明导电膜和上电极，其中所述互补杂质被掺杂并在所述半导体衬底的下部形成下电极。

3. 发明申请

WO2009034481A2 METHYLATION BIOMARKER FOR EARLY DETECTION OF GASTRIC CANCER 审中-公开
标题翻译：甲状腺生物标志物早期检测胃癌
公开(公告)号：WO2009034481A2
公开(公告)日：2009-03-19
申请号：PCT/IB2008/003482
申请日：2008-04-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Yong Sung
发明人： KIM, Yong Sung , NOH, Seung Moo , YOO, Hyang Sook , KIM, Jeong Hwan , KIM, Mi Rang , JANG, Hay Ran , SONG, Kyu Sang , JEONG, Hyun Yong , CHO, June Sik , KIM, Seon-Young
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present application describes a method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene such as POPDC3, FLJ25393, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, BC036441, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9, NCAM2, AMPD3, NOG, SP6, AK124779, or CSS3, or a combination thereof.
摘要翻译：本申请描述了一种诊断受试者胃癌或癌症进展阶段的方法，包括测定标记基因如POPDC3，FLJ25393，LRRC3B，PRKD1，CYP1B1，LIMS2，DCBLD2，BC036441， ADCY8，BACH2，ALOX5，TCF4，CXXC4，CAMK2N2，EMX1，KCNK9，NCAM2，AMPD3，NOG，SP6，AK124779或CSS3，或其组合。

4. 发明申请

WO2009014323A1 SYSTEM AND METHOD OF SAVING DIGITAL CONTENT CLASSIFIED BY PERSON-BASED CLUSTERING 审中-公开
标题翻译：基于人群聚类分类数字内容的系统和方法
公开(公告)号：WO2009014323A1
公开(公告)日：2009-01-29
申请号：PCT/KR2008/003690
申请日：2008-06-26
申请人： SAMSUNG ELECTRONICS CO., LTD. , KIM, Yong-Sung , KIM, Duck-Hoon , PARK, Hee-Seon , LEE, Hye-Soo
发明人： KIM, Yong-Sung , KIM, Duck-Hoon , PARK, Hee-Seon , LEE, Hye-Soo
IPC分类号： G06F17/40
CPC分类号： G06F17/30247 , G06F17/30601 , G06K9/00288 , G06K9/00664
摘要： A system and method of saving digital content classified by person-based clustering. The system for saving digital content classified by person-based clustering, includes a database to save a plurality of digital content classified by person-based clustering; a data structure generation unit to generate a data structure composed of a plurality of nodes using the plurality of digital content; a face recognition unit to extract a face descriptor of new digital content to be saved in the database; a cluster classification unit to classify the new digital content and the plurality of digital content by the person-based clustering using the extracted face descriptor, and a data structure update unit to update the data structure according to the classification.
摘要翻译：一种基于人群聚类分类的数字内容保存系统和方法。用于保存按人群聚类分类的数字内容的系统包括：数据库，用于保存按人群聚类分类的多个数字内容; 数据结构生成单元，使用所述多个数字内容生成由多个节点构成的数据结构; 面部识别单元，用于提取要保存在数据库中的新数字内容的面部描述符; 集群分类单元，使用所提取的面部描述符通过基于人的聚类对新的数字内容和多个数字内容进行分类，以及数据结构更新单元，根据分类来更新数据结构。

5. 发明申请

WO2005001126A1 DETECTION KIT FOR GASTRIC CANCER AND METASTATIC GASTRIC CANCER 审中-公开
标题翻译：胃癌和胃癌胃癌检测工具
公开(公告)号：WO2005001126A1
公开(公告)日：2005-01-06
申请号：PCT/KR2004/000677
申请日：2004-03-25
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KIM, Nam-Soon , KIM, Yong Sung , LEE, Ju-Yeon , OH, Jung-Hwa , PARK, Hong-Seog , AHN, Hee-Young , YOON, Sun-Young , HAN, Yoonsoo , KIM, Sangsoo , KIM, Jeong-Min , BYUN, Sang-Soon , NOH, Seung-Moo , SONG, Kyu-Sang , YOO, Hyang Sook
发明人： KIM, Nam-Soon , KIM, Yong Sung , LEE, Ju-Yeon , OH, Jung-Hwa , PARK, Hong-Seog , AHN, Hee-Young , YOON, Sun-Young , HAN, Yoonsoo , KIM, Sangsoo , KIM, Jeong-Min , BYUN, Sang-Soon , NOH, Seung-Moo , SONG, Kyu-Sang , YOO, Hyang Sook
IPC分类号： C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N2500/00
摘要： Disclosed is a kit for diagnosing gastric cancer and metastatic gastric cancer, more particularly to the diagnostic kit for detecting gastric cancer, which has been designed developed for detecting the expression levels of the up-regulated and the down-regulated gene in gastric cancer to determine whether tested gastric sample is a gastric cancer or not; and to the diagnostic kit for detecting the metastatic gastric cancer, designed and developed for detecting the expression levels of the up-regulated and down-regulated gene in metastatic gastric cancer to diagnose whether tested gastric cancer sample is metastatic cancer or not.
摘要翻译：公开了用于诊断胃癌和转移性胃癌的试剂盒，更具体地，涉及用于检测胃癌的诊断试剂盒，其被设计用于检测胃癌中上调基因和下调基因的表达水平以确定是否测试胃样本是胃癌吗？以及用于检测转移性胃癌的诊断试剂盒，其设计和开发用于检测转移性胃癌中的上调和下调基因的表达水平，以诊断测试的胃癌样品是否为转移性癌症。

6. 发明申请

WO2011078495A3 CHEMO-SENSITIVE PREDICTION METHOD FOR SNP 审中-公开
标题翻译：用于SNP的CHEMO-SENSITIVE PREDICTION METHOD
公开(公告)号：WO2011078495A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008640
申请日：2010-12-03
申请人： ASAN FOUNDATION , KIM JIN CHEON , CHO DONG HYUNG , KIM YONG SUNG , KIM SEON YOUNG
发明人： KIM JIN CHEON , CHO DONG HYUNG , KIM YONG SUNG , KIM SEON YOUNG
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/15
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/106 , C12Q2600/172
摘要： The present invention relates to a chemosensitive screening method for predicting Single Nucleotide Polymorphism (SNP) using single nucleotide polymorphic markers, and predicting susceptibility to cancer using such SNP markers. The method also provides a means to select the best treatment course and the most suitable anti-cancer medication even in cases of drug resistance after patients have been selectively identified according to the present invention.
摘要翻译：本发明涉及使用单核苷酸多态性标记预测单核苷酸多态性（SNP）的化学敏感性筛选方法，并且使用这种SNP标记预测对癌症的易感性。该方法还提供了选择最佳治疗过程和最合适的抗癌药物的方法，即使在根据本发明选择性鉴定患者之后，耐药性的情况也是如此。

7. 发明申请

WO2009134027A3 ANTI-NUCLEIC ACID ANTIBODY INDUCING CELL DEATH OF CANCER CELLS AND COMPOSITION FOR PREVENTING OR TREATING CANCERS COMPRISING THE SAME 审中-公开
标题翻译：抗核酸抗体诱导癌细胞细胞死亡和组合物，用于预防或治疗包括其的癌症
公开(公告)号：WO2009134027A3
公开(公告)日：2010-01-21
申请号：PCT/KR2009001973
申请日：2009-04-16
申请人： AJOU UNIV IND ACAD COOP FOUND , KWON MYUNG-HEE , KIM YONG-SUNG , JANG JI-YOUNG
发明人： KWON MYUNG-HEE , KIM YONG-SUNG , JANG JI-YOUNG
IPC分类号： A61K39/395 , A61K36/48 , C12N9/12 , C12P21/04
CPC分类号： C07K16/44 , A61K2039/505 , C07K16/30 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/82 , C12N9/0002 , C12N9/22
摘要： There are provided an anti-nucleic acid antibody inducing cell death of cancer cells by invading normal cells; and a composition for preventing or treating cancers comprising the anti-nucleic acid antibody, which shows anticancer effect of an anti-nucleic acid antibody that shows cytotoxicity by damaging nucleic acid strands, that is, genetic information of a cancer cell when the anti-nucleic acid antibody, which has binding activity and degrading activity to the nucleic acid strands in cells at the same time, is overexpressed in the cancer cell, or flows in the cancer cell. Therefore, the composition for treating cancers may be useful to induce the selective cell death in cancer cells than in normal cells since the anti-nucleic acid antibody very easily permeates into the cancer cells due to the excellent selectivity, compared to the normal cells.
摘要翻译：提供通过侵入正常细胞诱导癌细胞的细胞死亡的抗核酸抗体; 以及用于预防或治疗包含抗核酸抗体的癌症的组合物，其显示通过损伤核酸链显示细胞毒性的抗核酸抗体的抗癌作用，即抗核酸抗体的抗核酸抗体，即抗核酸抗体的遗传信息同时对细胞中的核酸链具有结合活性和降解活性的酸抗体在癌细胞中过表达，或在癌细胞中流动。因此，与正常细胞相比，用于治疗癌症的组合物可以用于诱导癌细胞中的选择性细胞死亡，因为与正常细胞相比，抗核酸抗体由于优异的选择性而非常容易地渗入癌细胞。

8. 发明申请

WO2012012409A2 INTEGRATED POLARIZED LIGHT EMITTING DIODE WITH A BUILT-IN ROTATOR 审中-公开
标题翻译：集成偏振光发射二极管与内置旋转器
公开(公告)号：WO2012012409A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044512
申请日：2011-07-19
申请人： RENSSELAER POLYTECHNIC INSTITUTE , LIN, Shawn-Yu , KIM, Yong Sung , HSIEH, Mei-Li
发明人： LIN, Shawn-Yu , KIM, Yong Sung , HSIEH, Mei-Li
IPC分类号： H01L33/58
CPC分类号： H01L33/46 , G02B5/18 , G02B5/30 , G02B5/3008 , G02B5/3058 , G02B5/3083 , G02B5/32 , H01L33/58 , H01L2933/0083
摘要： The invention is directed to an integrated polarized light emitting diode device that has a light emitting diode, a metal grating, an oxide layer, and a built-in photonic crystal rotator. Additional teachings include a method for making the integrated polarized light emitting diode, a method for improving the polarization selectivity and energy efficiency of a light emitting diode, and a method for rotating polarization of a light emitting diode.
摘要翻译：本发明涉及一种具有发光二极管，金属光栅，氧化物层和内置光子晶体旋转器的集成偏振发光二极管器件。附加的教导包括制造集成偏振发光二极管的方法，改善发光二极管的极化选择性和能量效率的方法，以及用于旋转发光二极管的偏振的方法。

9. 发明申请

WO2010056043A3 CELL-PENETRATING, SEQUENCE-SPECIFIC AND NUCLEIC ACID-HYDROLYZING ANTIBODY, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：细胞穿刺，序列特异性和核酸抗氢化抗体，其制备方法和包含其的药物组合物
公开(公告)号：WO2010056043A3
公开(公告)日：2010-10-07
申请号：PCT/KR2009006628
申请日：2009-11-11
申请人： AJOU UNIV IND ACAD COOP FOUND , KIM YONG SUNG , KWON MYUNG HEE , LEE WOO RAM
发明人： KIM YONG SUNG , KWON MYUNG HEE , LEE WOO RAM
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/44 , C07K16/32 , C07K2317/34 , C07K2317/569 , C07K2317/73 , C07K2317/77 , C07K2317/82 , C07K2317/92 , C12N9/0002
摘要： Disclosed are a cell-penetrating, base sequence-specific, nucleic acid-hydrolyzing antibody, a method of preparing the same, and a pharmaceutical composition comprising the same. The antibody can be prepared by modifying a particular site of a cell-penetrating, nucleic acid-hydrolyzing antibody which lacks substrate specificity to impart sequence specificity thereto without alteration in nucleic acid-hydrolyzing ability. The antibody, when penetrating into cells by itself or ectopically expressed within cells, binds specifically to single- or double-stranded nucleic acid targets and hydrolyzes them, thus downregulating the expression of the targeted genes.
摘要翻译：披露了细胞穿透性，碱基序列特异性核酸水解抗体，其制备方法和包含其的药物组合物。抗体可以通过修饰缺乏底物特异性的细胞穿透性核酸水解抗体的特定位点来赋予其序列特异性而不改变核酸水解能力来制备。当抗体本身穿透细胞或在细胞内外表达时，该抗体特异性结合于单链或双链核酸靶，并将其水解，从而下调靶基因的表达。

10. 发明申请

WO2010047509A9 ANTI-DR5 ANTIBODY WITH IMPROVED AFFINITY AND STABILITY, AND COMPOSITION FOR CANCER PREVENTION OR TREATMENT INCLUDING SAME 审中-公开
标题翻译：具有改善的亲和力和稳定性的抗DR5抗体，以及用于癌症预防或治疗的组合物，包括相同的
公开(公告)号：WO2010047509A9
公开(公告)日：2010-09-02
申请号：PCT/KR2009006036
申请日：2009-10-20
申请人： AJOU UNIV IND ACAD COOP FOUND , KIM YONG SUNG , KWON MYUNG HEE , LEE SEUNG HYUN , PARK KYUNG JIN
发明人： KIM YONG SUNG , KWON MYUNG HEE , LEE SEUNG HYUN , PARK KYUNG JIN
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N15/13
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to an anti-DR5 antibody with improved affinity and stability that specifically binds to the death receptor 5 (DR5) to destroy cancer cells effectively and the composition for cancer prevention or treatment including the same. The anti-DR5 antibody of the present invention causes mutageneses on the amino acid residues of VH-CDR2 and VH-CDR3 within the heavy chain variable region and the amino acid residue of VL-CDR3 within the light chain variable region of HW1 which is the known anti-DR5 antibody, and replaces the framework within the heavy chain variable region from a VH6 subtype to a VH3 subtype and replaces the framework within the light chain variable region with the framework part of Vk1 or Vk3 so that affinity and stability are improved over the known anti-DR5 antibody, HW1. In addition, the anti-DR5 antibody of the present invention effectively induces cell death with respect to TRAIL-sensitive cancer cells that express DR5 and TRAIL-resistant cancer cells that express DR5 by autophagy so that it may be usefully employed in preventing or treating cancers caused by DR5 expression.
摘要翻译：本发明涉及特异性结合死亡受体5（DR5）以有效破坏癌细胞的具有改善的亲和力和稳定性的抗DR5抗体，并且涉及用于癌症预防或治疗的组合物以及包含其的组合物。本发明的抗DR5抗体对重链可变区内的VH-CDR2和VH-CDR3的氨基酸残基和HW1的轻链可变区内的VL -CDR3的氨基酸残基进行诱变，并将重链可变区内的框架从VH6亚型替换为VH3亚型并用Vk1或Vk3的框架部分置换轻链可变区内的框架，从而改善了亲和性和稳定性已知的抗DR5抗体HW1。此外，本发明的抗DR5抗体相对于表达DR5和TRAIL抗性癌细胞的TRAIL敏感性癌细胞，通过自噬来有效地诱导细胞死亡，从而其可有效用于预防或治疗癌症由DR5表达引起。

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