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1. 发明申请

WO2022155729A1 METHOD FOR PRODUCING BLOOD PLASMA PRODUCT USEFUL IN THE TREATMENT OF VIRAL INFECTIONS CHARACTERIZED BY AN UNCONTROLLED RELEASE OF PROINFLAMMATORY CYTOKINES 审中-公开
公开(公告)号：WO2022155729A1
公开(公告)日：2022-07-28
申请号：PCT/CA2022/050059
申请日：2022-01-17
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K35/16 , A61K38/19 , A61P31/12 , A61P31/14 , C07K16/08 , C12N5/078 , G01N33/569
摘要： A method of producing blood plasma useful in the treatment of a virus causing a viral infection characterized by an uncontrolled release of proinflammatory cytokines in a human affected by the viral infection comprises the following steps: adding a quantity of sodium citrate to a tube; delivering a blood collected from a human donor having antibodies to the virus to the tube; incubating the blood at a temperature of about 37°C for about 6 hours to about 24 hours; centrifuging the blood to separate the blood into a plasma component and a cellular fraction; and collecting the plasma component. The plasma component can be administered to patient infected with a virus causing a viral infection characterized by an uncontrolled release of proinflammatory cytokines.

2. 发明申请

WO2021184116A1 METHOD FOR PRODUCING ENHANCED ANTI-INFLAMMATORY/ ANTI-CATABOLIC AGENTS FROM AUTOLOGOUS PHYSIOLOGICAL FLUID 审中-公开
公开(公告)号：WO2021184116A1
公开(公告)日：2021-09-23
申请号：PCT/CA2021/050351
申请日：2021-03-16
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K35/14 , A61P17/00 , A61P19/04 , A61P29/00 , C12N5/078
摘要： A method of producing an autologous anti-inflammatory/anti-catabolic autologous compositionuseful in the treatment of a mammal suffering from damaged and/or injured connective tissues,chronic tendinosis, chronic muscle tears, chronic degenerative joint conditions, and/or skininflammatory disorders is provided. The method comprising the following steps: delivering ablood collected from the mammal to a tube; storing the blood in presence of sodium citrate at atemperature of from about 20°C to about 40°C for at least about 3.5 hours; centrifuging the bloodto separate the blood into a supernatant component and a cellular fraction; and collecting thesupernatant component.

3. 发明申请

WO2020243807A1 METHOD AND COMPOSITION FOR PRODUCING ENHANCED ANTI-INFLAMMATORY/ANTI-CATABOLIC AND REGENERATIVE AGENTS FROM AUTOLOGOUS PHYSIOLOGICAL FLUID 审中-公开
公开(公告)号：WO2020243807A1
公开(公告)日：2020-12-10
申请号：PCT/CA2019/000082
申请日：2019-06-05
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K35/14 , A01N1/00 , A61K35/19 , A61K38/20 , A61K38/57 , A61P19/04
摘要： Described are methods of producing an autologous composition useful for treatment of damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal. The method comprises preparing an anti-inflammatory/ anti-catabolic component of the autologous composition comprising IL-1ra and TIMPs. An anti-inflammatory/ anti-catabolic component is prepared comprising: collecting blood from the mammal; delivering the blood to a tube; incubating the blood at a temperature of from about 37°C to about 39°C for about 24 hours preferably in the presence of sodium citrate; centrifuging the blood to separate the blood into a supernatant component and a cellular fraction; collecting the supernatant component. The method further comprises the step of preparing a regenerative component of the autologous composition comprising: collecting blood from the mammal; delivering the blood to a tube in the presence of about 4% citric acid; centrifuging the blood to separate a platelet rich plasma component from a whole blood; collecting the platelet rich plasma component. The anti- inflammatory/ anti-catabolic component and PRP component are frozen for up to at least 18 months and thawed prior to being combined and administered.

4. 发明申请

WO2020243808A1 METHOD FOR THE PREPARATION AND PROLONGED STORAGE OF GROWTH FACTORS AND CYTOKINES OBTAINED FROM PLATELET RICH PLASMA 审中-公开
公开(公告)号：WO2020243808A1
公开(公告)日：2020-12-10
申请号：PCT/CA2019/000083
申请日：2019-06-05
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K35/19 , A01N1/00 , A61K38/18 , A61K38/19 , A61P19/04
摘要： Described is a method of producing an autologous composition comprising regenerative growth factors and cytokines obtained from platelets. The method comprises the steps of collecting or providing blood from a mammal; delivering the blood to a receptacle; centrifuging the blood to separate a platelet rich plasma component from the blood; collecting the platelet rich plasma component; freezing and storing the platelet rich plasma component; thawing the platelet rich plasma component and passing the platelet rich plasma component through a small pore filter to provide the activated autologous composition. The storage stable autologous composition retains regenerative biological activity for up to at least eighteen months after storage of the platelet rich plasma component in a frozen state. Also described is a storage stable autologous composition comprising regenerative growth factors and cytokines obtained from platelets produced by the method as described.

5. 发明申请

WO2018102909A1 METHOD FOR THE PREPARATION AND PROLONGED STORAGE OF GROWTH FACTORS AND CYTOKINES OBTAINED FROM PLATELET RICH PLASMA 审中-公开
公开(公告)号：WO2018102909A1
公开(公告)日：2018-06-14
申请号：PCT/CA2017/000262
申请日：2017-12-06
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K38/19 , A61K35/16 , A61K38/18 , A61K38/20
摘要： Described is a method of producing a storage stable autologous composition comprising regenerative growth factors and cytokines obtained from platelets. The method comprises the steps of collecting or providing blood from a mammal; delivering the blood to a receptacle; centrifuging the blood to separate a platelet rich plasma component from the blood; collecting the platelet rich plasma component; passing the platelet rich plasma component through a small pore filter to produce the storage stable autologous composition comprising regenerative growth factors and cytokines derived from platelets; and collecting the storage stable autologous composition. The storage stable autologous composition retains regenerative biological activity for up to at least nine months when stored in a frozen state. Also described is a storage stable autologous composition comprising regenerative growth factors and cytokines obtained from platelets produced by the method as described.

6. 发明申请

WO2016049746A1 METHOD AND COMPOSITION FOR PRODUCING ENHANCED ANTI-INFLAMMATORY/ ANTI-CATABOLIC AND REGENERATIVE AGENTS FROM AUTOLOGOUS PHYSIOLOGICAL FLUID 审中-公开
标题翻译：用于生产来自自动生理流体的增强抗炎/抗反转录病毒和再生剂的方法和组合物
公开(公告)号：WO2016049746A1
公开(公告)日：2016-04-07
申请号：PCT/CA2015/000521
申请日：2015-09-30
申请人： ANTNOR LIMITED
发明人： GALEA, Anthony , BROKHMAN, Irina
IPC分类号： A61K38/48 , A61K35/14 , A61K38/19 , A61P19/00 , A61P21/00 , C07K1/14 , C07K14/54 , C12N9/64
CPC分类号： A61K35/14 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/2006 , C07K1/14 , C12N9/64 , A61K2300/00
摘要： Described are methods of producing an autologous composition useful for treatment of damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal. The method comprises preparing an anti-inflammatory/ anti-catabolic component of the autologous composition comprising IL-1ra and TIMPs. An anti-inflammatory/ anti-catabolic component is prepared comprising: collecting blood from the mammal; delivering the blood to a tube; incubating the blood at a temperature of from about 37°C to about 39°C for about 24 hours preferably in the presence of sodium citrate; centrifuging the blood to separate the blood into a supernatant component and a cellular fraction; collecting the supernatant component. The method further comprises the step of preparing a regenerative component of the autologous composition comprising: collecting blood from the mammal; delivering the blood to a tube in the presence of about 4% citric acid; centrifuging the blood to separate a platelet rich plasma component from a whole blood; collecting the platelet rich plasma component; and mixing the supernatant component with the platelet rich plasma component to provide the autologous composition. Also provided is a method of treating damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a subject with the autologous composition, an autologous composition for treating damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal and the use of the autologous composition for the treatment of damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal.
摘要翻译：描述了生产用于治疗哺乳动物的损伤和/或损伤的结缔组织，慢性腱炎，慢性肌肉撕裂和/或慢性退行性关节病症和皮肤炎症性疾病的自体组合物的方法。该方法包括制备包含IL-1ra和TIMP的自体组合物的抗炎/抗分解代谢成分。制备抗炎/抗分解代谢成分，其包括：从哺乳动物收集血液; 将血液输送到管中; 在约37℃至约39℃的温度下孵育血液约24小时，优选在柠檬酸钠存在下进行; 离心血液将血液分离成上清液组分和细胞级分; 收集上清组分。该方法还包括制备自体组合物的再生组分的步骤，包括：从哺乳动物收集血液; 在约4％柠檬酸存在下将血液输送到管中; 离心血液以分离富含血小板的血浆成分与全血; 收集富含血小板的血浆成分; 并将上清液组分与富含血小板的血浆组分混合以提供自体组合物。还提供了一种用自体组合物治疗受试者的损伤和/或损伤的结缔组织，慢性腱炎，慢性肌肉撕裂和/或慢性退行性关节病症和皮肤炎症性疾病的方法，用于治疗损伤和/或受伤的自体组合物结缔组织，慢性腱炎，慢性肌肉撕裂和/或慢性退行性关节病症和皮肤炎症性疾病，以及使用自体组合物治疗受损和/或损伤的结缔组织，慢性腱炎，慢性肌肉撕裂和/ 或慢性退行性关节病症和皮肤炎症性疾病。

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