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1. 发明申请

WO2007093305A2 LOW-FRIABILITY, PATIENT-FRIENDLY ORALLY DISINTEGRATING FORMULATIONS 审中-公开
标题翻译：低适应性，患者友好的ORALLY DISINC制剂
公开(公告)号：WO2007093305A2
公开(公告)日：2007-08-23
申请号：PCT/EP2007/001011
申请日：2007-02-06
申请人： ANTARES PHARMA IPL AG , GRENIER, Arnaud , DECAUDIN, Celine , CARRARA, Dario, Norberto , CONTE, Ubaldo , MAGGI, Lauretta
发明人： GRENIER, Arnaud , DECAUDIN, Celine , CARRARA, Dario, Norberto , CONTE, Ubaldo , MAGGI, Lauretta
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2095 , A61K31/78
摘要： The present invention relates to a rapidly disintegrating orally administratable solid dosage formulation that includes at least one active ingredient, at least one first disintegration agent that is at least one type-C methacrylic acid copolymer according to the U.S. Pharmacopoeia National Formulary US/NF, a second disintegration agent of crospovidone or a cross-linked povidone polymer derivative thereof, and a non-cariogenic diluent that does not increase glucose blood levels. The at least one first disintegration agent does not function as an enteric coating, insulation coating intended to protect active ingredient(s), or coating intended to mask taste or smell. The solid dosage form has a mass of about 50 to about 1000 mg, and the at least one first disintegration agent is present in the dosage form in an amount not exceeding 15%, with respect to the total weight of the dosage form. The second disintegration agent is present in the dosage form in an amount not exceeding 15% with respect to the total weight of the dosage form. The first and the second disintegration agent are present in total amounts that provide a weight ratio of about 1 : 1 to about 1:3, wherein the dosage form provides at least one of the in vitro or in vivo disintegration time that is less than 30 seconds, and has a friability of 1% or less according to the U.S. Pharmacopoeia test.
摘要翻译：本发明涉及快速崩解的可口服给药的固体剂型制剂，其包含至少一种活性成分，至少一种第一崩解剂，其是根据US Pharmacopoeia National Formulary US / NF至少一种C型甲基丙烯酸共聚物，交联聚维酮的第二崩解剂或其交联聚维酮聚合物衍生物和不增加葡萄糖血液水平的非致龋剂稀释剂。至少一种第一崩解剂不用作肠溶衣，旨在保护活性成分的绝缘涂层或旨在掩盖味道或气味的涂层。相对于剂型的总重量，固体剂型具有约50至约1000mg的质量，并且至少一种第一崩解剂以不超过15％的量存在于剂型中。相对于剂型的总重量，第二崩解剂以不超过15％的量存在于剂型中。第一和第二崩解剂以提供重量比为约1:1至约1:3的总量存在，其中该剂型提供至少一种体外或体内崩解时间小于30 秒，根据美国药典测试，其脆度为1％以下。

2. 发明申请

WO2003075897A1 THERAPEUTIC SYSTEM FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENTS 审中-公开
标题翻译：用于控制释放活性成分的治疗系统
公开(公告)号：WO2003075897A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002536
申请日：2003-03-12
申请人： JAGOTEC AG , MAGGI, Lauretta , CONTE, Ubaldo
发明人： MAGGI, Lauretta , CONTE, Ubaldo
IPC分类号： A61K9/28
CPC分类号： A61K9/209 , A61K9/2072 , A61K9/2886
摘要： A system designed to release one or more active substances in different, previously programmable modes, is described. The system is constituted by a tablet in three layers, two of which (the outer layers) vehicularise the active ingredient(s), whilst the third (the central layer) is constituted of a polymeric barrier which does not contain active substance and has the appropriate characteristics of erodibility or gelation. The tablet is completely coated with a film of polymeric material insoluble in water and/or in aqueous fluids, on which one or more incisions delimiting an area of exactly calculated geometric shape and size, have been made through the use of a laser beam of appropriate power and intensity. The removal of the film inside the incision(s) allows the release of the active ingredient(s) into aqueous fluid in predetermined amounts and times. The procedure for the production of the aforementioned pharmaceutical form is also described.
摘要翻译：描述了设计用于释放不同的先前可编程模式中的一种或多种活性物质的系统。该系统由三层的片剂构成，其中两层（外层）是活性成分，而第三层（中心层）由不含活性物质的聚合物屏障构成，并具有适当的可蚀性或凝胶化特性。片剂完全涂覆有不溶于水和/或水性流体的聚合物材料薄膜，其中通过使用适当的激光束制成限定精确计算的几何形状和尺寸的区域的一个或多个切口功率和强度。在切口内去除膜允许以预定量和次数将活性成分释放到水性流体中。还描述了用于生产上述药物形式的方法。

3. 发明申请

WO2003075894A1 A SYSTEM FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENTS 审中-公开
标题翻译：用于控制性释放活性成分的系统
公开(公告)号：WO2003075894A1
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002537
申请日：2003-03-12
申请人： JAGOTEC AG , CONTE, Ubaldo , MAGGI, Lauretta
发明人： CONTE, Ubaldo , MAGGI, Lauretta
IPC分类号： A61K9/22
CPC分类号： A61K9/2072 , A61K9/2886
摘要： A new release system is disclosed for releasing one or more active substances vehicularised in it, at a predetermined rate and duration. The system is constituted by a pharmaceutical tablet, coated with a film of polymeric material impermeable and insoluble in aqueous fluids; on the coating film, one or more apertures of geometrically precise size and shape are made, through the use of a laser beam of appropriate power and intensity, in a way such that the active ingredient contained in the therapeutic system is released only from the non coated portion of the tablet surface at the desired rate and time. The technology for manufacturing such system is also described.
摘要翻译：公开了一种新的释放系统，用于以预定的速率和持续时间释放其中车辆的一种或多种活性物质。该系统由药片形成，涂覆有不透水且不溶于涂膜上的水性流体的聚合物材料的膜，通过使用适当功率的激光束制成几何精确尺寸和形状的一个或多个孔和强度，使得包含在治疗系统中的活性成分仅以片剂表面的未涂覆部分以期望的速率和时间释放。还描述了用于制造这种系统的技术。

4. 发明申请

WO2005123034A3 MICROPARTICULATE SYSTEMS FOR THE ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
公开(公告)号：WO2005123034A3
公开(公告)日：2005-12-29
申请号：PCT/IT2005/000353
申请日：2005-06-20
申请人： UNIVERSITA'DEGLI STUDI DI MILANO , UNIVERSITA'DEGLI STUDI DI PAVIA , VIGO, Daniele , RUSSO, Vincenzo , FAUSTINI, Massimo , PACE, Mario, Francesco , MUNARI, Eleonora , TORRE, Maria, Luisa , CONTE, Ubaldo
发明人： VIGO, Daniele , RUSSO, Vincenzo , FAUSTINI, Massimo , PACE, Mario, Francesco , MUNARI, Eleonora , TORRE, Maria, Luisa , CONTE, Ubaldo
IPC分类号： A61K9/16
摘要： The present invention relates to microparticulate systems consisting of a gastroresistant, biocompatible and biodegradable polymer matrix, comprising a gastroresistant and enterosoluble polymer, a cryoprotector or lyoprotector, a divalent or trivalent metal salt of i biocompatible and biodegradable polymer having acid groups, and biologically active substances. Such gastroresistant microparticulate systems are used for the administration, preferably oral, of biologically active substances to animal species. The special composition of such microparticulate systems allows the protection of said biologically active substances from degradation by proteases and gastric acid, allowing their release into the intestine, where they may perform their activities.

5. 发明申请

WO2005041942A2 PREPARATION OF THREE-DIMENSIONAL MAMMALIAN OVARIAN FOLLICULAR CELL AND OVARIAN FOLLICLE CULTURE SYSTEMS IN A BIOCOMPATIBLE MATRIX 审中-公开
标题翻译：生物相容性基质制备三维哺乳动物卵巢卵泡和卵巢卵囊培养系统
公开(公告)号：WO2005041942A2
公开(公告)日：2005-05-12
申请号：PCT/EP2004/012384
申请日：2004-11-02
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , UNIVERSITA' DEGLI STUDI DI PAVIA , UNIVERSITA' DEGLI STUDI DI BOLOGNA , VIGO, Daniele , RUSSO, Vincenzo , FAUSTINI, Massimo , STACCHEZZINI, Simona , CONTE, Ubaldo , TORRE, Maria, Luisa , ACCORSI, Pier, Attilio , GALEATI, Giovanna , SPINACI, Marcella
发明人： VIGO, Daniele , RUSSO, Vincenzo , FAUSTINI, Massimo , STACCHEZZINI, Simona , CONTE, Ubaldo , TORRE, Maria, Luisa , ACCORSI, Pier, Attilio , GALEATI, Giovanna , SPINACI, Marcella
IPC分类号： A61K9/50
CPC分类号： C12N5/0609 , A61K9/5036 , A61K35/48 , C12N5/0012 , C12N2502/243 , C12N2533/74
摘要： A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro , and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules are constituted by: a nucleus containing stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos and/or a biocompatible and/or biodegradable polymer; a semi-permeable membrane constituted by a divalent or trivalent metal ion salt of alginic acid, optionally cross-linked on the inner and/or outer surface and/or on both surfaces, optionally vehicularising a second or more cellular species. The cells and follicles prepared and cultivated using this methodology are used for the in vitro and/or in vivo production of peptides, proteins, antibodies, hormones and hormone precursors, metabolites and catabolites typical of these cellular structures, plasma membranes, nuclear membranes, cytoplasmic organelles, somatic cell nuclei or gametes and embryos.
摘要翻译：一种用于封装和固定哺乳动物干细胞，卵巢滤泡细胞，配子，卵巢滤泡或哺乳动物胚胎的方法，其能够在体外自动组织成三维结构体并且以与在生物体内观察到的相似的方式表达生物功能。胶囊由含有干细胞的细胞核，卵巢滤泡细胞，配子，卵巢滤泡或哺乳动物胚胎和/或生物相容和/或生物可降解聚合物构成; 由藻酸的二价或三价金属离子盐构成的半透膜，任选在内表面和/或外表面和/或两个表面上交联，任选地使第二种或更多种细胞物种交联。使用该方法制备和培养的细胞和滤泡用于体外和/或体内生产肽，蛋白质，抗体，激素和激素前体，代谢物和典型的这些细胞结构的分解代谢物，质膜，核膜，细胞质细胞器，体细胞核或配子和胚胎。

6. 发明申请

WO2006106400A2 CAPSULES CONTAINING SEMINAL MATERIAL FOR ARTIFICIAL INSEMINATION 审中-公开
标题翻译：包含用于人工清除的研究材料的胶囊
公开(公告)号：WO2006106400A2
公开(公告)日：2006-10-12
申请号：PCT/IB2006/000768
申请日：2006-04-03
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , UNIVERSITA' DEGLI STUDI DI PAVIA , VIGO, Daniele , TORRE, Maria, Luisa , FAUSTINI, Massimo , MUNARI, Eleonora , RUSSO, Vincenzo , CONTE, Ubaldo
发明人： VIGO, Daniele , TORRE, Maria, Luisa , FAUSTINI, Massimo , MUNARI, Eleonora , RUSSO, Vincenzo , CONTE, Ubaldo
IPC分类号： A61K9/48
CPC分类号： A61K35/52 , A61D19/022 , A61K9/501 , A61K9/5036 , A61K9/5089
摘要： Capsules or microcapsules comprising: a) a nucleus containing seminal material or the spermatozoa of animal species chosen from the group consisting of equids, buffalo, ovicaprids, canids, felids, lagomorphs, laboratory animal species chosen from mice and rats, and possibly man, b) a membrane of a bivalent or trivalent metal alginate.
摘要翻译：胶囊或微胶囊包含：a）含有选自下组的精液或精子的细胞核，其选自马匹，水牛，卵磷脂，犬科动物，蛙科动物，拉姆霉素，选自小鼠和大鼠的实验室动物，以及可能的人，b ）二价或三价金属藻酸盐的膜。

7. 发明申请

WO2007072535A2 MICROPARTICULATE SYSTEMS FOR THE ORAL ADMINISTRATION OF BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：用于生物活性物质的口服管理的微生物系统
公开(公告)号：WO2007072535A2
公开(公告)日：2007-06-28
申请号：PCT/IT2006/000874
申请日：2006-12-22
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , UNIVERSITA' DEGLI STUDI DI PAVIA , UNIVERSITA' DEGLI STUDI DI SALERNO , VIGO, Daniele , FAUSTINI, Massimo , SCOCCA, Sarah , MUNARI, Eleonora , TORRE, Maria Luisa , CONTE, Ubaldo , DE SIMONE, Francesco , AQUINO, Rita Patrizia , LAURO, Maria Rosaria
发明人： VIGO, Daniele , FAUSTINI, Massimo , SCOCCA, Sarah , MUNARI, Eleonora , TORRE, Maria Luisa , CONTE, Ubaldo , DE SIMONE, Francesco , AQUINO, Rita Patrizia , LAURO, Maria Rosaria
IPC分类号： A61K9/16
CPC分类号： A61K9/1635 , A23K10/18 , A23K10/37 , A23K20/147 , A23K20/163 , A23K20/174 , A23K20/30 , A23K50/00 , A61K9/1617 , A61K9/1652 , Y02P60/877
摘要： The present invention relates to gastroresistant and enterosoluble microparticulate systems for the encapsulation of biologically active substances selected from: flavonoids, vitamins, antioxidants, immunostimulants, starchy and non-starchy polysaccharides, probiotics, prebiotics, intestinal trophism regulators, oligoelements, enzymes and bioactive peptides. Such microparticulate systems allow the administration of the aforementioned nutraceutic substances to animals such as porcines, bovines, caprines, ovines, equids, canids, felines, camelids, lagomorphs, rodents, fowl, and other mammals, including humans, fish and crustaceans, increasing the bioavailability.
摘要翻译：本发明涉及用于包封选自以下的生物活性物质的抗胃肠道和肠溶性微粒体系：黄酮类，维生素，抗氧化剂，免疫增强剂，淀粉和非淀粉多糖，益生菌，益生元，肠营养调节剂，寡聚物，酶和生物活性肽。这样的微粒体系允许将前述的营养药物施用于动物，例如猪，牛，狗，羊，马齿苋，犬科动物，猫科动物，骆驼科动物，骆驼科动物，啮齿动物，家禽和其他哺乳动物，包括人，鱼和甲壳类动物，生物利用度。

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