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1. 发明申请

WO2011084668A1 NESTORONE®/ESTRADIOL TRANSDERMAL GEL 审中-公开
标题翻译： NESTORONE®/ ESTRADIOL TRANSDERMAL GEL
公开(公告)号：WO2011084668A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060941
申请日：2010-12-17
申请人： THE POPULATION COUNCIL, INC. , ANTARES PHARMA IPL AG , SITRUK-WARE, Regine , CARRARA, Dario Norberto, Ramon , GRENIER, Arnaud
发明人： SITRUK-WARE, Regine , CARRARA, Dario Norberto, Ramon , GRENIER, Arnaud
IPC分类号： A61K31/565 , A61K31/57 , A61K9/00 , A61P15/18
CPC分类号： A61K31/565 , A61K9/0014 , A61K31/57 , A61K2300/00
摘要： The invention discloses compositions and methods for ensuring in both women of fertile age where it ensures also a contraception with additional health benefits and in postmenopausal women where it offers a hormonal therapy with additional medical benefits such as the potential for lower risk of thrombosis. The aforementioned compositions comprising NES as a potent progestational and antiovulatory agent with no androgenic nor estrogenic nor glucocorticoid effect, and combined with estradiol formulated for non-oral transdermal administration as specific daily doses.
摘要翻译：本发明公开了用于确保两性生育年龄的妇女的组合物和方法，其确保具有额外的健康益处的避孕措施以及绝经后妇女，其中提供具有额外医疗益处的激素疗法，例如血栓形成风险降低的潜力。上述组合物包含NES作为无雄激素和雌激素而不是糖皮质激素作用的有效的孕激素和抗iov药，并与配制用于非口服透皮给药的雌二醇组合作为特定的日剂量。

2. 发明申请

WO2008067991A2 SKIN-FRIENDLY DRUG COMPLEXES FOR TRANSDERMAL ADMINISTRATION 审中-公开
标题翻译：用于经皮给药的皮肤友好药物配合物
公开(公告)号：WO2008067991A2
公开(公告)日：2008-06-12
申请号：PCT/EP2007010522
申请日：2007-12-04
申请人： ANTARES PHARMA IPL AG , GRENIER ARNAUD , CARRARA DARIO NORBERTO RAMON , ROGUE CHRISTELLE
发明人： GRENIER ARNAUD , CARRARA DARIO NORBERTO RAMON , ROGUE CHRISTELLE
CPC分类号： A61K9/0014 , A61K31/167 , A61K31/40 , A61K31/428 , A61K47/10 , A61K47/58
摘要： The present invention generally relates to pharmaceutical compositions for the treatment of various diseases and disorders, in particular the use of novel complexes of amine drugs with polyacrylic acid carbomer polymers. The compositions of the present invention can be administered transdermally or transmucosally to patients in need thereof for a systemic or for a local therapeutic effect. The compositions of the present invention present the additional benefits of being free or substantially free of excipients which may potentially be responsible for skin local reactions and unpleasant smell.
摘要翻译：本发明总体上涉及用于治疗各种疾病和病症的药物组合物，特别是使用胺药物与聚丙烯酸卡波姆聚合物的新型复合物。本发明的组合物可以透皮或透粘膜给药至有需要的患者，用于全身性或局部治疗效果。本发明的组合物具有不含或基本上不含可能造成皮肤局部反应和不愉快气味的赋形剂的附加益处。

3. 发明申请

WO2007022924A3 PHARMACEUTICAL COMPOSITIONS WITH MELTING POINT DEPRESSANT AGENTS AND METHOD OF MAKING SAME 审中-公开
标题翻译：含有熔点抑制剂的药物组合物及其制备方法
公开(公告)号：WO2007022924A3
公开(公告)日：2007-08-09
申请号：PCT/EP2006008170
申请日：2006-08-18
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
发明人： CARRARA DARIO NORBERTO , GRENIER ARNAUD , ALBERTI INGO , ROGUE CHRISTELLE , BESSE CELINE , LAETITIA HENRY
IPC分类号： A61K9/00 , A61K9/06 , A61K31/00 , A61K47/14 , A61K47/32 , A61K47/34
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/00 , A61K47/10 , A61K47/24 , A61K47/32 , A61K47/44
摘要： The invention relates to the use of chemical fragrance ingredient to lower the melting point of active agents, thereby changing crystalline active agents into an amorphous state. The invention also relates to methods of enhancing the transdermal or transmucosal skin permeation or skin penetration of pharmacologically active agents to patients in need thereof. The compositions of the present invention present the additional benefits of being substantially alcohol-free and having a pleasant olfactory profile.
摘要翻译：本发明涉及使用化学香料成分来降低活性剂的熔点，从而将结晶活性剂变为无定形状态。本发明还涉及增强药理活性剂对需要其的患者的透皮或透粘膜皮肤渗透或皮肤渗透的方法。本发明的组合物具有基本不含酒精并具有令人愉快的嗅觉特征的额外益处。

4. 发明申请

WO2005105059B1 PERMEATION ENHANCER COMPRISING GENUS CURCUMA OR GERMACRONE FOR TRANSDERMAL AND TOPICAL ADMINISTRATION OF ACTIVE AGENTS 审中-公开
标题翻译：渗透性增强剂包括基因曲霉或灭活剂用于活性代谢物的超导和局部给药
公开(公告)号：WO2005105059B1
公开(公告)日：2006-02-02
申请号：PCT/EP2005004594
申请日：2005-04-28
申请人： ANTARES PHARMA IPL AG , CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , ALBERTI INGO , HENRY LAETITIA
发明人： CARRARA DARIO NORBERTO R , GRENIER ARNAUD , BESSE CELINE , ALBERTI INGO , HENRY LAETITIA
IPC分类号： A61K9/00 , A61K9/70 , A61K31/121 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/46
CPC分类号： A61K9/0014 , A61K31/121 , A61K36/9066 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/46 , A61K2300/00
摘要： A formulation, method and system for the topical, transdermal or transmucosal administration of a therapeutically effective active agent. Particularly, the invention provides a formulation, system and method for enhancing the permeation or penetration of active agents across the dermal or mucosal surfaces of a mammalian subject. The formulation includes a plant extract of the genus
摘要翻译：用于局部，透皮或经粘膜给药治疗有效活性剂的制剂，方法和系统。特别地，本发明提供了用于增强活性剂穿过哺乳动物受试者的皮肤或粘膜表面的渗透或渗透的制剂，系统和方法。所述制剂包括所述植物提取物

5. 发明申请

WO2005107812A1 PERMEATION ENHANCING COMPOSITIONS FOR ANTICHOLINERGIC AGENTS 审中-公开
标题翻译：渗透剂增强抗化学药剂组合物
公开(公告)号：WO2005107812A1
公开(公告)日：2005-11-17
申请号：PCT/EP2005/004799
申请日：2005-05-03
申请人： ANTARES PHARMA IPL AG , GRENIER, Arnaud , CARRARA, Dario, Norberto, R. , BESSE, Celine
发明人： GRENIER, Arnaud , CARRARA, Dario, Norberto, R. , BESSE, Celine
IPC分类号： A61K47/18
CPC分类号： A61K47/18 , A61K9/0014 , A61K9/06 , A61K9/7023 , A61K31/17 , A61K31/195 , A61K47/10 , Y10S514/818 , Y10S514/821 , A61K2300/00
摘要： A transdermal or topical composition including anticholinergic agents, such as oxybutynin, a urea-containing compound and a carrier system. A method is disclosed for treating a subject for urinary incontinence while reducing the incidences of peak concentrations of drug and undesirable side effects.
摘要翻译：一种透皮或局部组合物，包括抗胆碱剂，例如奥昔布宁，含尿素化合物和载体系统。公开了一种用于治疗受试者尿失禁同时减少药物峰值浓度和不良副作用的发生率的方法。

6. 发明申请

WO2005039531A1 TRANSDERMAL PHARMACEUTICAL FORMULATION FOR MINIMIZING SKIN RESIDUES 审中-公开
标题翻译：用于最小化皮肤残留物的透皮药物制剂
公开(公告)号：WO2005039531A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011175
申请日：2004-10-06
申请人： ANTARES PHARMA IPL AG , R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
发明人： R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
IPC分类号： A61K9/06
CPC分类号： A61K9/7007 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/025 , A61K31/435 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/38 , Y10S514/946 , Y10S514/947
摘要： This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically active ingredient, and a solvent system having a monoalkylether of diethylene gycol and a gycol present in specified ratios, and a mixture of water and alcohol. The invention also relates to a method for inhibiting or delaying crystallization of an active agent in a pharmaceutical formulation.
摘要翻译：本发明涉及新型透皮或透粘膜药物制剂，其减少其他个体的污染的发生以及对使用者衣服的转移。该新型制剂包含至少一种药理学活性成分，以及具有二乙二醇和一定比例存在的gycol的单烷基醚和水与醇的混合物的溶剂体系。本发明还涉及抑制或延迟药物制剂中活性剂结晶的方法。

7. 发明申请

WO2008001204A3 TRANSDERMAL COMPOSITIONS OF PRAMIPEXOLE HAVING ENHANCED PERMEATION PROPERTIES 审中-公开
标题翻译：具有增强渗透特性的普拉克索透皮组合物
公开(公告)号：WO2008001204A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007001760
申请日：2007-06-27
申请人： ANTARES PHARMA IPL AG , GRENIER ARNAUD , CARRARA DARIO NORBERTO
发明人： GRENIER ARNAUD , CARRARA DARIO NORBERTO
IPC分类号： A61K9/70 , A61K31/428 , A61K47/18
CPC分类号： A61K31/428 , A61K9/0014
摘要： A pharmaceutical composition for transdermal or transmucosal delivery of an active agent to treat a movement disorder such as Parkinson's disease. The composition provides enhanced transdermal or transmucosal delivery of the active agent by including an alkanolamine as a permeation enhancer with a carrier of water and at least one short-chain alcohol and with the composition having a neutral pH. The composition provides controlled and sustained release of the active agent suitable for daily administration.
摘要翻译：用于透皮或透粘膜递送活性剂以治疗运动障碍如帕金森病的药物组合物。该组合物通过包含链烷醇胺作为渗透促进剂和水和至少一种短链醇的载体并且该组合物具有中性pH来提供增强的透皮或透粘膜递送活性剂。该组合物提供适合于日常施用的活性剂的受控和持续释放。

8. 发明申请

WO2008012071A2 PHARMACEUTICAL COMPOSITIONS OF NICOTINE AND METHODS OF USE THEREOF 审中-公开
标题翻译：烟碱的药物组合物及其使用方法
公开(公告)号：WO2008012071A2
公开(公告)日：2008-01-31
申请号：PCT/EP2007/006579
申请日：2007-07-24
申请人： ANTARES PHARMA IPL AG , R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
发明人： R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
IPC分类号： A61K9/06 , A61P25/34
CPC分类号： A61K9/0014 , A61K9/7015 , A61K47/10
摘要： The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between about pH 5.5 and about pH 6.5. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.
摘要翻译：本发明包括用于透皮递送尼古丁的非闭合性组合物，更特别是其药学上可接受的盐及其制备方法。例如，该组合物可以是适用于透皮或透粘膜应用的凝胶。本发明的组合物通常包含水和醇的混合物以及具有以特定比例和特定量存在的二甘醇和二醇的单烷基醚的溶剂体系，其中凝胶的pH通常在约pH 5.5和约pH 6.5。组合物可以包含其他组分，例如，水醇载体可以进一步包含另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂。本发明还涉及持续输送尼古丁药学上可接受的盐以治疗多种病症和病症的方法。

9. 发明申请

WO2007124250A3 METHODS OF TREATING HOT FLASHES WITH FORMULATIONS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION 审中-公开
标题翻译：用烫伤或转移应用制剂处理烫伤的方法
公开(公告)号：WO2007124250A3
公开(公告)日：2007-12-21
申请号：PCT/US2007065950
申请日：2007-04-04
申请人： ANTARES PHARMA IPL AG , SIMES STEPHEN M , LEHMAN LEAH M
发明人： SIMES STEPHEN M , LEHMAN LEAH M
IPC分类号： A61K9/06 , A61K31/565
CPC分类号： A61K9/06 , A61K31/565 , A61K47/08 , A61K47/10
摘要： The present invention relates to transdermal or transmucosal formulations, methods of use for preparing medicaments for treating hot flashes and methods for treatment thereof by administering such formulations for transdermal or transmucosal administration of estrogen. The formulations are effective at surprisingly low daily doses, preferably the lowest effective dose of estrogen to treat hot flashes, namely about 0.45 to about 0.6 mg of estrogen per day in a delivery vehicle that includes a C 2 to C 4 alkanol, a polyalcohol, and a permeation enhancer of monoalkyl ether of diethylene glycol. The amount of estrogen which is administered produces an estimated nominal daily estrogen dose in a subject undergoing treatment of from about 10 to about 15 micrograms, and a serum estradiol level of between about 25 pg/ml to about 50 pg/ml.
摘要翻译：本发明涉及透皮或透粘膜制剂，用于制备治疗潮热的药物的方法及其治疗方法，其通过施用这种用于经皮或经粘膜施用雌激素的制剂。制剂在令人惊讶的低日剂量下是有效的，优选地是雌激素治疗潮热的最低有效剂量，即包括C 2〜N 2的递送载体中每天约0.45至约0.6mg的雌激素 C 4链烷醇，多元醇和二甘醇单烷基醚的渗透促进剂。施用的雌激素的量在经历约10至约15微克的治疗的受试者中产生估计的标称日间雌激素剂量，血清雌二醇水平为约25pg / ml至约50pg / ml。

10. 发明申请

WO2006125642A1 METHODS AND APPARATUS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION OF TESTOSTERONE 审中-公开
标题翻译： TERMOSTERONE的超导或转移应用的方法和装置
公开(公告)号：WO2006125642A1
公开(公告)日：2006-11-30
申请号：PCT/EP2006/004993
申请日：2006-05-24
申请人： ANTARES PHARMA IPL AG , LEHMAN, Leah, M. , SIMES, Stephen, M.
发明人： LEHMAN, Leah, M. , SIMES, Stephen, M.
IPC分类号： A61K31/565 , A61K9/06 , A61P5/26
CPC分类号： A61K31/565 , A61K9/0014 , A61K9/0034 , A61K9/06 , A61K47/10
摘要： Methods, formulations, and devices for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods treat symptoms of hormonal disorders including hypogonadism, female sexual desire disorder, female menopausal disorder, and adrenal insufficiency.
摘要翻译：用于向有需要的受试者提供透皮或经粘膜递送活性剂的方法，制剂和装置。制剂和方法治疗激素失调症状，包括性腺机能减退，女性性欲障碍，女性绝经障碍和肾上腺功能不全。

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