专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006094187A3 PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2006094187A3
公开(公告)日：2006-09-08
申请号：PCT/US2006/007583
申请日：2006-03-03
申请人： AMGEN INC
发明人： TASKER, Andrew , ZHANG, Dawei , CAO, Guo-Qiang , CHAKRABARTI, Partha, Pratim , FALSEY, James, Richard , HERBERICH, Bradley, J. , HUNGATE, Randall, W. , PETTUS, Liping, H. , REED, Anthony , RZASA, Robert, M. , SHAM, Kelvin, K.C. , THAMAN, Maya, C. , XU, Shimin
IPC分类号： C07D237/32 , C07D237/34 , C07D237/30 , C07D413/12 , C07D417/12 , C07D498/04 , C07D487/04 , C07D417/04 , C07D491/10 , C07D409/04 , C07D401/04 , C07D403/04 , A61K31/502 , A61P29/00
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula (I), wherein A 1 , A 2 , B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I. The compounds have effect on the levels of TNF-X and various Interleukins.

2. 发明申请

WO2008030466A1 PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：苯丙氨酸，亚氨基和二氮杂苯并咪唑化合物及其使用方法
公开(公告)号：WO2008030466A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019350
申请日：2007-09-04
申请人： AMGEN INC. , TASKER, Andrew , ZHANG, Dawei , PETTUS, Liping, H. , RZASA, Robert, M. , SHAM, Kelvin, K.C. , XU, Shimin , CHAKRABARTI, Partha, Pratim
发明人： TASKER, Andrew , ZHANG, Dawei , PETTUS, Liping, H. , RZASA, Robert, M. , SHAM, Kelvin, K.C. , XU, Shimin , CHAKRABARTI, Partha, Pratim
IPC分类号： C07D237/30 , C07D237/34 , C07D403/10 , C07D403/12 , C07D413/12 , C07D417/10 , C07D471/04 , A61K31/501 , A61P29/00
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A 1 , A 2 , B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

3. 发明申请

WO2014138484A1 PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE 审中-公开
标题翻译：作为β-分泌酶抑制剂的全氟化环丙氯联-1,3-氧化物-2-胺化合物及其使用方法
公开(公告)号：WO2014138484A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/021412
申请日：2014-03-06
申请人： AMGEN INC.
发明人： MINATTI, Ana Elena , LOW, Jonathan, D. , ALLEN, Jennifer, R. , AMEGADZIE, Albert , BROWN, James , FROHN, Michael, J. , GUZMAN-PEREZ, Angel , HARRINGTON, Paul, E. , LOPEZ, Patricia , MA, Vu Van , NISHIMURA, Nobuko , QIAN, Wenyuan , RUMFELT, Shannon , RZASA, Robert, M. , SHAM, Kelvin , SMITH, Adrian, L. , WHITE, Ryan , XUE, Qiufen
IPC分类号： C07D413/14 , C07D413/10 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D265/12 , C07D491/048 , A61P25/00 , A61K31/536
CPC分类号： C07D413/12 , C07D265/12 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048
摘要： PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: {INSERT STRUCTURE HERE} I wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.
摘要翻译：作为β-分泌酶抑制剂的全氟化环丙氯联-1,3-氧化物-2-胺化合物及其使用方法本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。该化合物具有通式I：其中式I中的各个R a，R b，R 1，R 2，R 3和R 7各自独立地定义的变量A4，A5，A6，A8的定义如下。本发明还提供包含该化合物的药物组合物，以及该化合物和组合物用于治疗由BACE的生物学活性产生的与A-β斑块形成和沉积有关的病症和/或病症的用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II和III的化合物及其分子式实施方案，用于制备本发明化合物的中间体和方法。

4. 发明申请

WO2006037117A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：WO2006037117A1
公开(公告)日：2006-04-06
申请号：PCT/US2005/035134
申请日：2005-09-27
申请人： AMGEN INC.
发明人： ANDERSEN, Denise, Lyn , CHANG, Catherine, M. , FALSEY, James, R. , FROHN, Michael, J. , HONG, Fang-Tsao , LIAO, Hongyu , LIU, Longbin , LOPEZ, Patricia , RETZ, Daniel, Martin , RISHTON, Gilbert, M. , RZASA, Robert, M. , SIEGMUND, Aaron, C. , TADESSE, Seifu , TAMAYO, Nuria , TEGLEY, Christopher, M.
IPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to pyridines, pyrimidines and derivatives thereof, (I) or a pharmaceutically acceptable salts thereof, wherein X 1 is N or CR 3 ; X 2 is N or CR 4 ; or -X 1 =X 2 - is -C(=O)-N(R a )- or -N(R a )-C(=O)-; X 3 is N or CR 4 ; X 4 is N or CR 4 ; X 5 is N or CR 6 ; X 6 is N or CR 6 ; wherein only 1, 2 or 3 of X 1 , X 2 , X 3 and X 4 are N; R 1 is a saturated partially saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring is substituted by 0, 1, 2 or 3 substituents. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
摘要翻译：本发明涉及吡啶，嘧啶及其衍生物，（I）或其药学上可接受的盐，其中X 1是N或CR 3; X 2是N或CR 4; 或-X 1 = X 2 - 是-C（= O）-N（R a） - 或-N（R 0） >一） - C（= O） - ; X 3是N或CR 4; X 4是N或CR 4; X 5是N或CR 6; X 6是N或CR 6; 其中X 1，X 2，X 3和X 4中仅有1,2或3是N; R 1是饱和的部分饱和或不饱和的含有0,1,2或3个选自N，O和S的原子的5-，6-或7-元环，其中环被 0,1,2或3个取代基。还包括治疗炎症，类风湿性关节炎，佩吉特病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征（ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病，中风，心肌梗塞，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒），流感病毒，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的如上所述的化合物。

5. 发明申请

WO2009137404A1 UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS 审中-公开
标题翻译：尿素化合物作为GAMMA秘密调节剂
公开(公告)号：WO2009137404A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/042711
申请日：2009-05-04
申请人： AMGEN INC. , BISWAS, Kaustav , CHEN, Jian, J. , FALSEY, James, Richard , GORE, Vijay, Keshav , LIU, Qingyian , MA, Vu, Van , MERCEDE, Stephanie, J. , RZASA, Robert, M. , TEGLEY, Christopher, M. , ZHU, Jiawang
发明人： BISWAS, Kaustav , CHEN, Jian, J. , FALSEY, James, Richard , GORE, Vijay, Keshav , LIU, Qingyian , MA, Vu, Van , MERCEDE, Stephanie, J. , RZASA, Robert, M. , TEGLEY, Christopher, M. , ZHU, Jiawang
IPC分类号： C07D213/40 , C07D213/61 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4709 , A61P25/28
CPC分类号： C07D213/40 , C07D213/61 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译：本发明提供了作为γ-分泌酶调节剂的式（I）化合物，因此可用于治疗通过调节γ-分泌酶如阿尔茨海默病可治疗的疾病。还提供含有这些化合物的药物组合物和制备这些化合物的方法。

6. 发明申请

WO2008045393A2 IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF 审中-公开
标题翻译：咪唑并 - 三唑并吡啶化合物及其使用方法
公开(公告)号：WO2008045393A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/021505
申请日：2007-10-05
申请人： AMGEN INC. , ZHANG, Dawei , TASKER, Andrew , SHAM, Kelvin, K.C. , CHAKRABARTI, Partha, Pratim , FALSEY, Richard, James , HERBERICH, Bradley, J. , PETTUS, Liping, H. , RZASA, Robert, M.
发明人： ZHANG, Dawei , TASKER, Andrew , SHAM, Kelvin, K.C. , CHAKRABARTI, Partha, Pratim , FALSEY, Richard, James , HERBERICH, Bradley, J. , PETTUS, Liping, H. , RZASA, Robert, M.
CPC分类号： C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have general Formula (I), wherein A, B, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula (I).
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式（I），其中A，B，R 1，R 2，R 3和R 4， / SUP>。本发明还包括包含一种或多种式（I）化合物的药物组合物，这些化合物和组合物用于治疗P38地图激酶介导的疾病（包括类风湿性关节炎，牛皮癣和其他炎症疾病）的用途，以及可用于式（I）化合物的制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式