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    • 2. 发明申请
    • PH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER
    • PH传感器集成到一次性生物反应器/混合器
    • WO2012082974A1
    • 2012-06-21
    • PCT/US2011065033
    • 2011-12-15
    • ROSEMOUNT ANALYTICAL INCFENG CHANG-DONGBENTON BARRY WANDERSON DAVEYANG FONG SWOOD WAYNE B
    • FENG CHANG-DONGBENTON BARRY WANDERSON DAVEYANG FONG SWOOD WAYNE B
    • C12M1/34
    • C12M23/14C12M41/26C12M41/32C12M41/34
    • A pH sensing bioreaction system is provided. The system includes a bioreaction container (51) having a plastic wall (50) and a pH sensor (40, 60, 80, 100, 120) attached to the plastic wall (50). The pH sensor (40, 60, 80, 100, 120) includes a sensor body (82) having a flange (76) that is sealingly attached to the plastic wall (50). The sensor body (82) has a reference electrolyte (142) therein and a first sensing element (152) disposed in the reference electrolyte (142). The first sensing element (152) is configured to contact both the reference electrolyte (142) and a sample solution (52) inside the bioreaction container. A second sensing element (62, 92, 148) is positionable into an interior of the bioreaction container (51). The pH sensor (40, 60, 80, 100, 120) has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container (51), and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container (51).
    • 提供pH感测生物反应系统。 该系统包括具有塑料壁(50)和连接到塑料壁(50)的pH传感器(40,60,80,100,120)的生物反应容器(51)。 pH传感器(40,60,80,100,120)包括具有密封地附接到塑料壁(50)的凸缘(76)的传感器主体(82)。 传感器主体(82)中具有参考电解质(142)和设置在参考电解质(142)中的第一传感元件(152)。 第一传感元件(152)被配置为接触参考电解质(142)和生物反应容器内的样品溶液(52)两者。 第二传感元件(62,92,148)可定位在生物反应容器(51)的内部。 pH传感器(40,60,80,100,120)具有多种构造,其中至少一个传感元件与生物反应容器(51)的内部隔离的引导构型和其中服务构造 该至少一个感测元件流体耦合到生物反应容器(51)的内部。