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    • 5. 发明申请
    • COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH
    • 用于增加头发生长的化合物和方法
    • WO2012100238A3
    • 2014-07-03
    • PCT/US2012022133
    • 2012-01-21
    • ALLERGAN INCWANG JENNY WWOODWARD DAVID F
    • WANG JENNY WWOODWARD DAVID F
    • A61Q7/00A61K8/46A61K31/5575A61K31/575A61P17/14
    • A61K31/5575A61K8/46A61K31/575A61Q7/00
    • The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7- dithiaPGEl-isopropyl ester is preferred for this treatment.
    • 本发明提供了一种用于刺激哺乳动物物种的毛发生长或将us毛或中间毛发转化为末梢毛或刺激毛囊以增加毛发生长的方法以及选自光泽,光泽,光泽,光泽的一种或多种性质 ,与毛囊相关的头发,发光或光泽的毛发,或增加睫毛或眉毛的长度,厚度,数量和密度中的一种或多种,​​其包括向患者的皮肤施用包含有效量的 EP3激动剂或EP4激动剂前药或其混合物。 用于治疗人或非人动物的皮肤或头皮的这种组合物可以包含有效量的3,7或3和7以及前列腺酸。 这种处理优选3,7-二硫键PGE1和3,7-二硫代磷酸异丙酯的混合物。
    • 6. 发明申请
    • ALTERNATIVELY SPLICED VARIANTS OF HUMAN COX1
    • 人类COX1的替代性变异
    • WO2005035713A3
    • 2009-04-16
    • PCT/US2004027105
    • 2004-08-20
    • ALLERGAN INCLIANG YANBINWOODWARD DAVID F
    • LIANG YANBINWOODWARD DAVID F
    • C12P21/06C07H21/04C07K16/40C12N20060101C12N1/20C12N9/02C12N15/70
    • C12N9/0083
    • The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 14, 16, 18, 20, 22 or 24. The invention also provides an isolated polypeptide containing a) an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 10, and b) an amino acid sequence selected from SEQ ID NOS: 14, 16, 18, 20, 22, or 24; or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, or 8. The invention also provides a method for identifying a compound that modulates a COX-1 variant by contacting an isolated COX-1 variant or a COX-1 variant over-expressed in, a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation of a COX-1 variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the COX-1 variant.
    • 本发明提供了含有SEQ ID NO:14,16,18,20,22或24的氨基酸序列的分离的多肽。本发明还提供了分离的多肽,其含有a)具有至少50%氨基酸同一性的氨基酸序列 具有SEQ ID NO:10,和b)选自SEQ ID NO:14,16,18,20,22或24的氨基酸序列; 或其保守变体。 本发明还提供了含有SEQ ID NO:2,4,6或8的氨基酸序列的分离的多肽。本发明还提供了通过使分离的COX-1接触来鉴定调节COX-1变体的化合物的方法 变体或在具有化合物的基因工程细胞中过表达的COX-1变体,并确定与COX-1变体的调节相关的指标水平,其中指示剂水平的变化与 对照水平表明该化合物是调节COX-1变体的化合物。
    • 9. 发明申请
    • HUMAN PROSTAGLANDIN FP RECEPTOR VARIANTS AND METHODS OF USING SAME
    • 人类前列腺素FP受体变体及其使用方法
    • WO2005007688A3
    • 2005-04-28
    • PCT/US2004022585
    • 2004-07-12
    • ALLERGAN INCLIANG YANBINWOODWARD DAVID F
    • LIANG YANBINWOODWARD DAVID F
    • C07K14/72G01N33/88A61K38/00C07K16/18
    • G01N33/88C07K14/72G01N2500/04
    • The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25. The invention also provides an isolated polypeptide containing an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 14 and an amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25, or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, or 12. The invention also provides a method for identifying a compound that modulates a FP receptor variant by contacting an isolated FP receptor variant or a FP receptor variant over-expressed in a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation-of a FP receptor variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the FP receptor variant.
    • 本发明提供了含有SEQ ID NO:17,18,19,20,21,22,23,24或25的氨基酸序列的分离的多肽。本发明还提供了分离的多肽,其含有氨基酸序列,该氨基酸序列至少具有 与SEQ ID NO:14具有50%的氨基酸同一性,并且具有SEQ ID NO:17,18,19,20,21,22,23,24或25的氨基酸序列或其保守变体。 本发明进一步提供了含有SEQ ID NO:2,4,6,8,10或12的氨基酸序列的分离的多肽。本发明还提供了一种鉴定调节FP受体变体的化合物的方法,其通过使分离的 FP受体变体或在受遗传工程改造的细胞中与化合物过度表达的FP受体变体,并测定与FP受体变体的调节相关的指标水平,其中指标水平与 对照水平表明该化合物是调节FP受体变体的化合物。