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1. 发明申请

WO2012135095A9 S1P ANTAGONISTS AS ADJUNCT OCULAR HYPOTENSIVES 审中-公开
标题翻译： S1P ANTAGONISTS作为ADJUNCT OCULAR HYPTENSIVES
公开(公告)号：WO2012135095A9
公开(公告)日：2013-03-07
申请号：PCT/US2012030523
申请日：2012-03-26
申请人： ALLERGAN INC , WOODWARD DAVID F , HEIDELBAUGH TODD M , STAMER W DANIEL
发明人： WOODWARD DAVID F , HEIDELBAUGH TODD M , STAMER W DANIEL
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/4178 , A61K31/5575 , A61K38/177
摘要： The invention provides compositions and methods for further reducing IOP in a subject who has already achieved maximal IOP reduction using known IOP lowering agents. The activity of an ocular hypotensive treatment regimen may be increased by adding an S1P antagonist to prevent S1P mediated reversal as a result of decreased aqueous humor outflow.
摘要翻译：本发明提供了使用已知的IOP降低剂已经达到最大IOP降低的受试者中进一步减少IOP的组合物和方法。通过添加S1P拮抗剂可以增加眼部降血压治疗方案的活性，以防止由于房水流出降低导致的S1P介导的逆转。

2. 发明申请

WO2012135095A3 S1P ANTAGONISTS AS ADJUNCT OCULAR HYPOTENSIVES 审中-公开
标题翻译： S1P拮抗剂作为佐剂性眼压过低
公开(公告)号：WO2012135095A3
公开(公告)日：2013-01-17
申请号：PCT/US2012030523
申请日：2012-03-26
申请人： ALLERGAN INC , WOODWARD DAVID F , HEIDELBAUGH TODD M , STAMER W DANIEL
发明人： WOODWARD DAVID F , HEIDELBAUGH TODD M , STAMER W DANIEL
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/4178 , A61K31/5575 , A61K38/177
摘要： The invention provides compositions and methods for further reducing IOP in a subject who has already achieved maximal IOP reduction using known IOP lowering agents. The activity of an ocular hypotensive treatment regimen may be increased by adding an S1P antagonist to prevent S1P mediated reversal as a result of decreased aqueous humor outflow.
摘要翻译：本发明提供了使用已知的IOP降低剂已经实现最大IOP降低的受试者中进一步降低IOP的组合物和方法。降眼压治疗方案的活性可以通过加入S1P拮抗剂来增加，以防止S1P介导的逆转，这是由于房水外流减少的结果。

3. 发明申请

WO2013096496A3 COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE 审中-公开
标题翻译：在多种PROSTAGLANDIN受体上起作用的化合物产生一般的抗炎反应
公开(公告)号：WO2013096496A3
公开(公告)日：2013-08-15
申请号：PCT/US2012070701
申请日：2012-12-19
申请人： ALLERGAN INC , CARLING WILLIAM R , MARTOS JOSE L , KANGASMETSA JUSSI J , WANG JENNY W , WOODWARD DAVID F
发明人： CARLING WILLIAM R , MARTOS JOSE L , KANGASMETSA JUSSI J , WANG JENNY W , WOODWARD DAVID F
IPC分类号： C07D209/08 , A61K31/404 , A61K31/416 , A61P29/00 , C07D231/56 , C07D235/08 , C07D401/06 , C07D471/04
CPC分类号： C07D471/04 , C07D209/08 , C07D231/56 , C07D235/06 , C07D235/08 , C07D401/06
摘要： The present invention provides a compound, that is a 1-({halo-2-[(2-hydrocarbyl or substituted hydrocarbyl)oxy]phenyl}methyl)-(fused bicyclic nitrogen heteroaryl) carboxylic acid or an ester or sulfonamide thereof. The compound may be represented by the following formula I, Wherein R1, R2, R3, R4 A, X, W, Z and Y are as defined in the specification. The compounds may be administered to treat DP, FP, EP1, TP and/or EP4 receptor-mediated diseases or conditions.
摘要翻译：本发明提供了化合物，即1 - （{卤代-2 - [（2-烃基或取代的烃基）氧基]苯基}甲基） - （稠合双环氮杂芳基）羧酸或其酯或磺酰胺。化合物可以由下式I表示，其中R1，R2，R3，R4A，X，W，Z和Y如说明书中所定义。可以施用化合物以治疗DP，FP，EP1，TP和/或EP4受体介导的疾病或病症。

4. 发明申请

WO2012100238A3 COMPOUNDS AND METHODS FOR ENHANCING HAIR GROWTH 审中-公开
标题翻译：用于增加头发生长的化合物和方法
公开(公告)号：WO2012100238A3
公开(公告)日：2014-07-03
申请号：PCT/US2012022133
申请日：2012-01-21
申请人： ALLERGAN INC , WANG JENNY W , WOODWARD DAVID F
发明人： WANG JENNY W , WOODWARD DAVID F
IPC分类号： A61Q7/00 , A61K8/46 , A61K31/5575 , A61K31/575 , A61P17/14
CPC分类号： A61K31/5575 , A61K8/46 , A61K31/575 , A61Q7/00
摘要： The present invention provides a method for stimulating hair growth in a mammalian species or converting vellus hair or intermediate hair to terminal hair or stimulating hair follicles to increase hair growth and one or more properties selected from the group consisting of luster, sheen, brilliance, gloss, glow, shine or patina of hair associated with the follicles or increasing one or more of: length, thickness, number, and density, of eyelash hair or eyebrow hair comprising applying to the skin of a patient a composition comprising an effective amount of an EP3 agonist or an EP4 agonist prodrug or a mixture thereof. Such compositions which are used in treating the skin or scalp of a human or non-human animal may comprise an effective amount of 3, 7 or 3 and 7 thia prostanoic acid. A mixture of 3,7-dithia PGE1 and 3,7- dithiaPGEl-isopropyl ester is preferred for this treatment.
摘要翻译：本发明提供了一种用于刺激哺乳动物物种的毛发生长或将us毛或中间毛发转化为末梢毛或刺激毛囊以增加毛发生长的方法以及选自光泽，光泽，光泽，光泽的一种或多种性质，与毛囊相关的头发，发光或光泽的毛发，或增加睫毛或眉毛的长度，厚度，数量和密度中的一种或多种，其包括向患者的皮肤施用包含有效量的 EP3激动剂或EP4激动剂前药或其混合物。用于治疗人或非人动物的皮肤或头皮的这种组合物可以包含有效量的3,7或3和7以及前列腺酸。这种处理优选3,7-二硫键PGE1和3,7-二硫代磷酸异丙酯的混合物。

5. 发明申请

WO2005035713A3 ALTERNATIVELY SPLICED VARIANTS OF HUMAN COX1 审中-公开
标题翻译：人类COX1的替代性变异
公开(公告)号：WO2005035713A3
公开(公告)日：2009-04-16
申请号：PCT/US2004027105
申请日：2004-08-20
申请人： ALLERGAN INC , LIANG YANBIN , WOODWARD DAVID F
发明人： LIANG YANBIN , WOODWARD DAVID F
IPC分类号： C12P21/06 , C07H21/04 , C07K16/40 , C12N20060101 , C12N1/20 , C12N9/02 , C12N15/70
CPC分类号： C12N9/0083
摘要： The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 14, 16, 18, 20, 22 or 24. The invention also provides an isolated polypeptide containing a) an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 10, and b) an amino acid sequence selected from SEQ ID NOS: 14, 16, 18, 20, 22, or 24; or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, or 8. The invention also provides a method for identifying a compound that modulates a COX-1 variant by contacting an isolated COX-1 variant or a COX-1 variant over-expressed in, a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation of a COX-1 variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the COX-1 variant.
摘要翻译：本发明提供了含有SEQ ID NO：14,16,18,20,22或24的氨基酸序列的分离的多肽。本发明还提供了分离的多肽，其含有a）具有至少50％氨基酸同一性的氨基酸序列具有SEQ ID NO：10，和b）选自SEQ ID NO：14,16,18,20,22或24的氨基酸序列; 或其保守变体。本发明还提供了含有SEQ ID NO：2,4,6或8的氨基酸序列的分离的多肽。本发明还提供了通过使分离的COX-1接触来鉴定调节COX-1变体的化合物的方法变体或在具有化合物的基因工程细胞中过表达的COX-1变体，并确定与COX-1变体的调节相关的指标水平，其中指示剂水平的变化与对照水平表明该化合物是调节COX-1变体的化合物。

6. 发明申请

WO2012106249A3 METHOD OF ENHANCING HAIR GROWTH 审中-公开
标题翻译：增加头发生长的方法
公开(公告)号：WO2012106249A3
公开(公告)日：2014-02-27
申请号：PCT/US2012023148
申请日：2012-01-30
申请人： ALLERGAN INC , WOODWARD DAVID F , WANG JENNY W
发明人： WOODWARD DAVID F , WANG JENNY W
IPC分类号： A61K8/42 , A61K8/49 , A61Q7/00
CPC分类号： A61K8/4953 , A61K8/42 , A61K31/215 , A61K31/505 , A61K2800/592 , A61Q5/00 , A61Q7/00 , Y10S514/88
摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include bimatoprost and minoxidil in a vehicle for topical application to the skin of a mammal, e.g. a human, whereby the combination of bimatoprost and minoxidil produces a faster onset of hair growth in humans or other mammals and wherein said composition brings about a synergestic result of faster onset of hair growth as compared to compositions comprising bimatoprost and minoxidil, alone.
摘要翻译：公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括用于局部施用于哺乳动物皮肤的载体中的比马前列素和米诺地尔。由此，比马前列素和米诺地尔的组合在人或其它哺乳动物中产生更快的头发生长发生，并且与单独包含比马前列素和米诺地尔的组合物相比，所述组合物产生更快发生头发生长的协同作用。

7. 发明申请

WO2005040341A3 HUMAN PROSTAGLANDIN EP4 RECEPTOR VARIANTS AND METHODS OF USING SAME 审中-公开
标题翻译：人类PROSTAGLANDIN EP4受体变异体及其使用方法
公开(公告)号：WO2005040341A3
公开(公告)日：2005-11-03
申请号：PCT/US2004027840
申请日：2004-08-27
申请人： ALLERGAN INC , LIANG YANBIN , WOODWARD DAVID F
发明人： LIANG YANBIN , WOODWARD DAVID F
IPC分类号： C07H21/04 , C07K14/72 , G01N33/53 , C07K1/00 , C07K14/00 , C07K17/00 , C12N1/20 , C12N5/00 , C12N5/02 , C12N15/00 , C12N15/74 , C12P21/06 , G01N33/567
CPC分类号： C07K14/72 , C07H21/04
摘要： The present invention provides alternatively spliced EP4 receptor variants, as well as related nucleic acid molecules and screening methods.
摘要翻译：本发明提供了选择性剪接的EP4受体变体，以及相关的核酸分子和筛选方法。

8. 发明申请

WO2005007688A3 HUMAN PROSTAGLANDIN FP RECEPTOR VARIANTS AND METHODS OF USING SAME 审中-公开
标题翻译：人类前列腺素FP受体变体及其使用方法
公开(公告)号：WO2005007688A3
公开(公告)日：2005-04-28
申请号：PCT/US2004022585
申请日：2004-07-12
申请人： ALLERGAN INC , LIANG YANBIN , WOODWARD DAVID F
发明人： LIANG YANBIN , WOODWARD DAVID F
IPC分类号： C07K14/72 , G01N33/88 , A61K38/00 , C07K16/18
CPC分类号： G01N33/88 , C07K14/72 , G01N2500/04
摘要： The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25. The invention also provides an isolated polypeptide containing an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 14 and an amino acid sequence of SEQ ID NO: 17, 18, 19, 20, 21, 22, 23, 24, or 25, or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, 10, or 12. The invention also provides a method for identifying a compound that modulates a FP receptor variant by contacting an isolated FP receptor variant or a FP receptor variant over-expressed in a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation-of a FP receptor variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the FP receptor variant.
摘要翻译：本发明提供了含有SEQ ID NO：17,18,19,20,21,22,23,24或25的氨基酸序列的分离的多肽。本发明还提供了分离的多肽，其含有氨基酸序列，该氨基酸序列至少具有与SEQ ID NO：14具有50％的氨基酸同一性，并且具有SEQ ID NO：17,18,19,20,21,22,23,24或25的氨基酸序列或其保守变体。本发明进一步提供了含有SEQ ID NO：2,4,6,8,10或12的氨基酸序列的分离的多肽。本发明还提供了一种鉴定调节FP受体变体的化合物的方法，其通过使分离的 FP受体变体或在受遗传工程改造的细胞中与化合物过度表达的FP受体变体，并测定与FP受体变体的调节相关的指标水平，其中指标水平与对照水平表明该化合物是调节FP受体变体的化合物。

9. 发明申请

WO02096432A3 HYPOTENSIVE LIPID (PROSTAGLANDIN DERIVATIVES) AND TIMOLOL COMPOSITIONS AND METHODS OF USING SAME 审中-公开
标题翻译： HYPOTENSIVE LIPID（PROSTAGLANDIN DERIVATIVES）and TIMOLOL COMPOSITIONS AND METHODS OF USAMEAME
公开(公告)号：WO02096432A3
公开(公告)日：2003-05-08
申请号：PCT/US0217291
申请日：2002-05-30
申请人： ALLERGAN INC , CHEN JUNE , WOODWARD DAVID F , KHARLAMB ALEXANDER B
发明人： CHEN JUNE , WOODWARD DAVID F , KHARLAMB ALEXANDER B
IPC分类号： A61K31/05 , A61K31/222 , A61K31/535 , A61K31/557 , A61K31/5575 , A61K45/06 , A61P27/02 , A61P27/06
CPC分类号： A61K31/5575 , A61K9/0048 , A61K31/165 , A61K31/535 , A61K31/5377 , A61K31/557 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , Y10S514/913 , A61K2300/00
摘要： New compositions for and methods of treating ocular hypertension provide for effective treatment of ocular hypertension often using reduced concentrations of active components. Such compositions include a timolol component and a hypotensive lipid component. The present compositions and methods are relatively straightforward, can be easily produced, for example, using conventional manufacturing techniques, and can be easily and conveniently practiced, for example, using application or administration techniques or methodologies which are substantially similar to those employed with prior compositions used to treat ocular hypertension.
摘要翻译：治疗高眼压症的新组合物和方法提供有效治疗高眼压症，通常使用降低浓度的活性成分。此类组合物包括噻吗洛尔组分和降血脂组分。本发明的组合物和方法相对简单，可以容易地制备，例如使用常规制造技术，并且可以容易地和方便地实施，例如使用与现有组合物使用的那些基本相似的应用或施用技术或方法用于治疗眼高血压。

10. 发明申请

WO2012145737A8 FATTY ACID AMIDE HYDROLASE INHIBITORS FOR TREATING PAIN 审中-公开
标题翻译：脂肪酸酰胺水解酶抑制剂治疗疼痛
公开(公告)号：WO2012145737A8
公开(公告)日：2014-01-03
申请号：PCT/US2012034626
申请日：2012-04-23
申请人： ALLERGAN INC , WOODWARD DAVID F , MARTOS JOSE L , CARLING WILLIAM R , POLOSO NEIL J , WANG JENNY W
发明人： WOODWARD DAVID F , MARTOS JOSE L , CARLING WILLIAM R , POLOSO NEIL J , WANG JENNY W
IPC分类号： C07D413/04 , A61K31/422 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14
摘要： Compounds of Formula 1 are described herein. These compounds may be administered to a patient for treatment of suffering from pain or other FAAH mediated conditions.
摘要翻译：式1的化合物在本文中描述。这些化合物可以施用于患者以治疗患有疼痛或其它FAAH介导的病症。

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