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1. 发明申请

WO2012054297A4 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可折叠框架的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A4
公开(公告)日：2012-09-20
申请号：PCT/US2011056167
申请日：2011-10-13
申请人： ALLERGAN INC , DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
发明人： DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了口腔肥胖治疗装置及其操作的相关方法，其占据胃内空间和/或刺激胃壁。口腔肥胖治疗装置和相关方法旨在帮助患者维持健康的体重。这些装置的特征包括经口插入并且没有侵入性手术，没有相关的患者侵入性手术风险，并且没有实质性的患者不适。这些装置的使用寿命可能与材料有关，因为这些装置在酸性胃中具有长期生存能力，但意图持续一年或更长时间。这些装置具有能够在尺寸上变化的能力，并且期望自动致动，因为它们使用内部马达或致动器改变形状和/或体积。装置的变化特征有助于防止人的胃部补偿植入物，例如有时会发生静态的胃内装置。

2. 发明申请

WO2012054297A3 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可拉框的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A3
公开(公告)日：2012-08-02
申请号：PCT/US2011056167
申请日：2011-10-13
申请人： ALLERGAN INC , DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
发明人： DOMINGUEZ ZACHARY P , BABKES MITCHELL H , SCHWAB JUSTIN J , MUDD CHRISTOPHER S , HOOVER JASON
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了跨腹部肥胖症治疗装置及其相关操作方法，其占据胃内的空间和/或刺激胃壁。经腹肥胖治疗装置和相关方法旨在帮助患者保持健康的体重。器件的特征包括经皮插入和无侵入性手术，无相关患者的侵入性手术风险，无明显的患者不适。这些装置的使用寿命可能依赖于酸性胃内的长期生存能力，但意图持续一年或更长时间。这些装置具有在尺寸上变化的能力，并且希望是自动致动，因为它们使用内部电动机或致动器改变形状和/或体积。设备的变化特性有助于防止人的胃部补偿植入物，例如有时会发生静态胃内装置。

3. 发明申请

WO2012054598A3 NON-INFLATABLE GASTRIC IMPLANTS AND SYSTEMS 审中-公开
标题翻译：非充气胃内植入物和系统
公开(公告)号：WO2012054598A3
公开(公告)日：2012-09-07
申请号：PCT/US2011056880
申请日：2011-12-02
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J , HOOVER JASON
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J , HOOVER JASON
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0089
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, or the greater and lesser curvatures in the middle of the stomach, to stimulate satiety-inducing nerves. Some devices may combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖治疗的各种被动胃内植入装置。这种被动装置不会自动改变形状，而是在胃内反应以引起饱腹感。这些装置可能会占用胃内的体积，从而减少吸收能力。另外，所述装置可以接触胃内的区域，例如围绕食管括约肌的贲门，或者胃中部的更大和更小的弯曲，以刺激引起饱腹感的神经。一些装置可以结合两种或更多种这些引起饱腹感的特征。公开了植入方法，包括压缩输送管内的装置并且经由食道经口腔推进装置以部署在胃内。反过来拆除设备。

4. 发明申请

WO2012054519A3 REACTIVE INTRAGASTRIC IMPLANT DEVICES 审中-公开
标题翻译：反应性胃内植入装置
公开(公告)号：WO2012054519A3
公开(公告)日：2012-08-02
申请号：PCT/US2011056761
申请日：2011-10-18
申请人： ALLERGAN INC , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J , BABKES MITCHELL H
发明人： DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J , BABKES MITCHELL H
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0036
摘要： Transoral three-dimensionally orthogonal intragastric spring systems, devices, methods of operation and manufacture are provided. A transoral three-dimensionally orthogonal intragastric spring system and/or device (and related methods of manufacture and operation) may reduce obesity or weight by stimulating the stomach walls of the patient. The three- dimensionally orthogonal intragastric spring device may be a purely mechanical device comprising a flexible body which in response to an input force in one direction, may deform and cause a resultant displacement in an orthogonal direction, thereby exerting a pressure on the inner stomach walls of the patient. Alternatively, a three-dimensionally orthogonal intragastric spring device may include a variable size balloon configured to occupy volume in the patient's stomach, thereby reducing the amount of space in the patient's stomach.
摘要翻译：提供经口三维正交胃内弹簧系统，装置，操作和制造方法。经口三维正交胃内弹簧系统和/或装置（以及相关的制造和操作方法）可以通过刺激患者的胃壁来减少肥胖或体重。三维正交胃内弹簧装置可以是纯粹机械的装置，其包括柔性主体，柔性主体响应于一个方向上的输入力可以变形并引起正交方向上的合成位移，由此在内部胃壁上施加压力的病人。或者，三维正交胃内弹簧装置可以包括可变尺寸气囊，该气囊构造成占据患者胃中的体积，从而减少患者胃中的空间量。

5. 发明申请

WO2012054413A2 SPACE-FILLING INTRAGASTRIC IMPLANTS WITH FLUID FLOW 审中-公开
标题翻译：带有流体流动的空间填充的胃内植入物
公开(公告)号：WO2012054413A2
公开(公告)日：2012-04-26
申请号：PCT/US2011056608
申请日：2011-10-18
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0003 , A61F5/0013 , A61F5/003 , A61F5/0036 , A61F5/0079 , A61F5/0086
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖治疗的各种被动胃内植入装置。这种被动装置不会自动改变形状，而是在胃内反应以引起饱腹感。这些装置可能会占用胃内的体积，从而减少吸收能力。另外，装置可以接触胃内的区域，例如围绕食道括约肌的贲门，以刺激引起饱腹感的神经。而且，某些装置通过阻断或阻碍通过幽门括约肌的流动来减缓胃排空。许多装置结合了两种或更多种这些引起饱腹感的特征。公开了植入方法，包括压缩输送管内的装置并且经由食道经口腔推进装置以部署在胃内。反过来拆除设备。

6. 发明申请

WO2012054413A4 SPACE-FILLING INTRAGASTRIC IMPLANTS WITH FLUID FLOW 审中-公开
标题翻译：带流体的空间填充入口植入物
公开(公告)号：WO2012054413A4
公开(公告)日：2012-08-09
申请号：PCT/US2011056608
申请日：2011-10-18
申请人： ALLERGAN INC , BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J
发明人： BABKES MITCHELL H , DOMINGUEZ ZACHARY P , SCHWAB JUSTIN J
IPC分类号： A61F5/00
CPC分类号： A61F5/0033 , A61F5/0003 , A61F5/0013 , A61F5/003 , A61F5/0036 , A61F5/0079 , A61F5/0086
摘要： A variety of passive intragastric implant devices for obesity treatment are disclosed. Such passive devices do not autonomously change shape, but instead react within the stomach to induce satiety. The devices may take up volume within the stomach, thus reducing the intake capacity. Additionally, the devices may contact areas within the stomach, such as the cardia surrounding the esophageal sphincter, to stimulate satiety-inducing nerves. Also, certain devices slow gastric emptying by blocking or otherwise impeding flow through the pyloric sphincter. A number of devices combine two or more of these satiety-inducing features. Methods of implant are disclosed including compressing the devices within a delivery tube and transorally advancing the devices through the esophagus to be deployed within the stomach. Removal of the devices occurs in the reverse.
摘要翻译：公开了用于肥胖症治疗的各种被动胃内植入装置。这种被动装置不会自主地改变形状，而是在胃内反应以引起饱腹感。这些装置可能占据胃内的体积，从而降低进气能力。此外，装置可以接触胃内的区域，例如围绕食管括约肌的贲门，以刺激饱腹引起的神经。此外，某些装置通过阻塞或阻碍通过幽门括约肌的流动来缓慢胃排空。许多装置组合了这些饱腹感特征中的两种或更多种。公开了植入物的方法，包括压缩输送管内的装置并且经由食道经过胃内部署的装置经过前进。相反的移除设备。

7. 发明申请

WO2013059419A3 IMPLANTABLE INJECTION PORT 审中-公开
标题翻译：可注射口
公开(公告)号：WO2013059419A3
公开(公告)日：2013-08-15
申请号：PCT/US2012060760
申请日：2012-10-18
申请人： ALLERGAN INC , FRANKLIN ETHAN , SCHWAB JUSTIN J , DOMINGUEZ ZACHARY P
发明人： FRANKLIN ETHAN , SCHWAB JUSTIN J , DOMINGUEZ ZACHARY P
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61M39/0208 , A61F5/0056 , A61M2039/0063 , A61M2039/0072 , Y10T156/1005
摘要： Injection ports are disclosed for use with a gastric band for the treatment of obesity. An injection port may include a septum (515) having a top surface (510), a bottom surface, and a side wall connecting the top surface to the bottom surface. The injection port may also include a housing including a first inner side wall (535) being tapered inwards such that an opening defined at a first end is larger than an opening defined at a second end, the tapering of the first inner side wall being used to secure the septum within the housing. The housing may further include a second inner side wall (540) having a first end and a second end, the first end of the second inner side wall joined to the second end of the first inner side wall, and a bottom surface joined to the second end of the second inner side wall.
摘要翻译：公开了与胃带一起用于治疗肥胖症的注射口。注入口可以包括具有顶表面（510），底表面和将顶表面连接到底表面的侧壁的隔膜（515）。注入口还可以包括壳体，其包括向内锥形的第一内侧壁（535），使得限定在第一端处的开口大于限定在第二端处的开口，使用的第一内侧壁的锥形以固定外壳内的隔膜。壳体还可以包括具有第一端和第二端的第二内侧壁（540），第二内侧壁的与第一内侧壁的第二端连接的第一端和连接到第一内侧壁的底表面第二内侧壁的第二端。

8. 发明申请

WO2012125694A3 SELF-ADJUSTING GASTRIC BAND 审中-公开
标题翻译：自调节带
公开(公告)号：WO2012125694A3
公开(公告)日：2012-11-22
申请号：PCT/US2012029025
申请日：2012-03-14
申请人： ALLERGAN INC , FRANKLIN ETHAN , SNOW SEAN , TORJESEN ERIK , SCHWAB JUSTIN J , DOMINGUEZ ZACHARY P
发明人： FRANKLIN ETHAN , SNOW SEAN , TORJESEN ERIK , SCHWAB JUSTIN J , DOMINGUEZ ZACHARY P
IPC分类号： A61F5/00 , A61B5/00
CPC分类号： A61F5/0056
摘要： Generally described herein are automatic, self-adjusting, gastric banding systems and improvements thereof, that are capable of automatically relaxing and contracting in response to a large bolus passing through the area of a patient's stomach constricted by a gastric band (1205). Alternatively, and/or in addition in one or more embodiments, the gastric banding systems described herein may also help prevent pouch dilatation and/or erosion. The apparatus and systems described herein aid in facilitating obesity control and/or treating obesity-related diseases while generally being non-invasive once implanted. Furthermore, certain embodiments of the self-adjusting gastric banding systems disclosed herein are automatically adjustable without complicated fluid control mechanisms, flow rate limiting devices, and/or valves. The automatic adjustments may also be made in response to other changes in the patient's esophageal - gastric junction, for example, in response to size, shape, and or location changes.
摘要翻译：本文通常描述的是自动，自调节，胃束带系统及其改进，其能够响应于穿过由胃束带收缩的患者胃部的区域的大量推注而自动放松和收缩（1205）。或者，和/或另外在一个或多个实施方案中，本文所述的胃束带系统还可以帮助防止囊膨胀和/或侵蚀。本文描述的装置和系统有助于促进肥胖控制和/或治疗肥胖相关疾病，同时一般植入时是非侵入性的。此外，本文公开的自调节胃束带系统的某些实施例可以在没有复杂的流体控制机构，流量限制装置和/或阀的情况下自动调节。也可以响应于患者食管 - 胃交界处的其它变化，例如响应于大小，形状和位置变化而进行自动调节。

9. 发明申请

WO2012154819A3 DIRECTIONLESS (ORIENTATION INDEPENDENT) NEEDLE INJECTION PORT 审中-公开
标题翻译：无方向性（独立方向）针头注射口
公开(公告)号：WO2012154819A3
公开(公告)日：2013-05-10
申请号：PCT/US2012037075
申请日：2012-05-09
申请人： ALLERGAN INC , SCHWAB JUSTIN J , SNOW SEAN
发明人： SCHWAB JUSTIN J , SNOW SEAN
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61F5/0056 , A61F5/0043 , A61M39/0208 , A61M2039/022 , A61M2039/0226 , A61M2039/0238
摘要： Generally described herein are certain embodiments directed to an orientation-independent injection port fluidly coupled to a gastric banding system. The injection port may be configured to simplify the port-targeting process when a medical professional attempts to penetrate the injection port with a needle during a gastric band-adjusting procedure. For example, the injection port may be orientation-independent with the entire outer shell acting as the needle access point. Alternatively, and/or in addition, the inner core of the injection port may be hard or firm, thereby allowing for easier locating (e.g., when the medical professional performs palpation). Furthermore, the hard inner core may prevent needle over-throws, and help stabilize pressure.
摘要翻译：本文通常描述的是针对流体耦合到胃束带系统的取向非依赖性注射端口的某些实施方案。注射端口可以被配置为当医疗专业人员在胃束带调整过程期间试图用针穿透注射端口时，简化端口定位过程。例如，注射口可以是取向独立的，整个外壳用作针入口点。或者，和/或另外，注射口的内芯可以是硬的或坚固的，从而允许更容易的定位（例如当医疗专业人员进行触诊时）。此外，硬内芯可以防止针头过度投掷，并有助于稳定压力。

10. 发明申请

WO2014190223A2 INJECTION DEVICE WITH STRESS PROTECTION 审中-公开
标题翻译：具有应力保护的注射装置
公开(公告)号：WO2014190223A2
公开(公告)日：2014-11-27
申请号：PCT/US2014039265
申请日：2014-05-23
申请人： ALLERGAN INC
发明人： DOMINGUEZ ZACHARY P , BERTOLOTE TIAGO , FRANKLIN ETHAN W , SCHWAB JUSTIN J , AUGARTEN MIKE , METZNER JASON S
IPC分类号： A61M5/48
CPC分类号： A61M5/31566 , A61M5/31501 , A61M5/486 , A61M5/5086 , A61M2005/3125 , A61M2005/3128 , A61M2005/31508 , A61M2005/3151 , A61M2205/3331 , A61M2205/583
摘要： Described are devices and systems for protection of injectable substances such as adipose cells from excessive stress or pressure during injection procedures. Further described are stress control mechanisms for detecting and/or controlling stress or pressure within injection devices.
摘要翻译：描述了用于在注射过程中保护可注射物质例如脂肪细胞免受过度压力或压力的装置和系统。进一步描述了用于检测和/或控制注射装置内的应力或压力的应力控制机构。

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