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1. 发明申请

WO2012054297A2 INTRAGASTRIC IMPLANTS WITH COLLAPSIBLE FRAMES 审中-公开
标题翻译：具有可折叠框架的INTRAGASTRIC植入物
公开(公告)号：WO2012054297A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056167
申请日：2011-10-13
申请人： ALLERGAN, INC. , DOMINGUEZ, Zachary P. , BABKES, Mitchell H. , SCHWAB, Justin J. , MUDD, Christopher S. , HOOVER, Jason
发明人： DOMINGUEZ, Zachary P. , BABKES, Mitchell H. , SCHWAB, Justin J. , MUDD, Christopher S. , HOOVER, Jason
IPC分类号： A61F5/00
CPC分类号： A61F5/0036 , A61F5/0033 , A61F5/0079 , A61F5/0086 , A61F5/0089
摘要： Transoral obesity treatment devices and related methods for operation thereof are described which occupy space within a stomach and/or stimulate the stomach wall. The transoral obesity treatment devices and related methods are intended to assist a patient in maintaining a healthy body weight. Features of the devices include insertion transorally and without invasive surgery, without associated patient risks of invasive surgery, and without substantial patient discomfort. The life span of these devices may be material-dependent upon long-term survivability within an acidic stomach, but is intended to last one year or longer. The devices have the capacity to vary in size and are desirably self-actuating in that they change shape and/or volume using internal motors or actuators. The changing character of the devices helps prevent the person's stomach from compensating for the implant, such as sometimes happens with static intragastric devices.
摘要翻译：描述了口腔肥胖治疗装置及其操作的相关方法，其占据胃内空间和/或刺激胃壁。口腔肥胖治疗装置和相关方法旨在帮助患者维持健康的体重。这些装置的特征包括经口插入并且没有侵入性手术，没有相关的患者侵入性手术风险，并且没有实质性的患者不适。这些装置的使用寿命可能与材料有关，因为这些装置在酸性胃中具有长期生存能力，但意图持续一年或更长时间。这些装置具有能够在尺寸上变化的能力，并且期望自动致动，因为它们使用内部马达或致动器改变形状和/或体积。装置的变化特征有助于防止人的胃部对种植体进行补偿，例如有时会发生静态的胃内装置。

2. 发明申请

WO2012054522A2 ANCHORED NON-PIERCING DUODENAL SLEEVE AND DELIVERY SYSTEMS 审中-公开
标题翻译：锚定式非连接套管和输送系统
公开(公告)号：WO2012054522A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056765
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0079 , A61F5/0076
摘要： An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing/compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.
摘要翻译：公开了一种用于肥胖症治疗的胃内植入物。该装置通过提供十二指肠套管来延缓消化，并且还可以通过限制通过幽门括约肌的流动来减缓胃排空。植入物包括细长的可轴向压缩的十二指肠套管，其具有在近端上的非组织刺穿锚固件，其大小设置在十二指肠球囊内。锚固件可以具有相反方向的锚固凸缘以抵抗两个方向的迁移。套筒还可以具有倒钩肋，以抵抗近端移动回到胃中。一种植入物的方法包括塌缩/压缩装置，并将其经过食道通过其前端部署在十二指肠内。可溶解的护套可以限制植入物用于递送，并且在植入时自然地溶解。相反，可能会发生植入物的移除。

3. 发明申请

WO2012054410A3 INTRAGASTRIC IMPLANTS WITH MULTIPLE FLUID CHAMBERS 审中-公开
公开(公告)号：WO2012054410A3
公开(公告)日：2012-04-26
申请号：PCT/US2011/056605
申请日：2011-10-18
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , OLROYD, Craig , D'AUGUSTA, Jonathan M.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , OLROYD, Craig , D'AUGUSTA, Jonathan M.
IPC分类号： A61F5/00 , A61B10/00
摘要： An intragastric obesity treatment implant promotes a feeling of satiety in the patient by contacting the insides of the stomach wall, reducing the space in the stomach, or otherwise reducing the amount of food consumed. One intragastric obesity treatment implant two inflatable balloons coupled via a flow restrictor through which fluid may flow in response to peristaltic motions of a patient's stomach. Additionally, one implant comprises a pumping chamber coupled to a reservoir, where the pumping chamber moves stomach fluids into the reservoir in response to peristaltic motions of the patient's stomach.

4. 发明申请

WO2012051108A2 RE-SHAPING INTRAGASTRIC IMPLANTS 审中-公开
标题翻译：重新形成的INTRAGASTRIC植入
公开(公告)号：WO2012051108A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/055598
申请日：2011-10-10
申请人： ALLERGAN, INC. , BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , RAVEN, Joseph S.
发明人： BABKES, Mitchell H. , DOMINGUEZ, Zachary P. , MUDD, Christopher S. , RAVEN, Joseph S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0036
摘要： The present application provides implantable intragastric devices for the treatment of obesity. The intragastric devices advantageously act as a volume-occupying device, and is able to survive implantation in a patient's stomach for a year or longer. In addition, the intragastric devices may be configured to stimulate an inner stomach wall and/or temporarily block the pylorus to slow gastric emptying and/or be rotationally variant, thereby encouraging different stimulation points on the inner wall of the stomach and limiting the stomach's ability to adapt over long term implantation. The intragastric devices may reshape the stomach cavity, such as by pushing on opposite sides so as to "planarize" the stomach. For instance, the device may be an inflated disk, or an implantable loop or a springy coil that may be straightened for delivery/extraction yet assume the loop or coil shape upon implant.
摘要翻译：本申请提供了用于治疗肥胖症的可植入胃内装置。胃内装置有利地用作体积占用装置，并且能够在患者的胃中植入一年或更长时间。此外，胃内装置可构造成刺激胃内壁和/或暂时阻塞幽门以减缓胃排空和/或旋转变化，从而促进胃内壁上的不同刺激点并限制胃的能力以适应长期植入。胃内装置可以重塑胃腔，例如通过推动相对侧以便“平面化” 胃。例如，该装置可以是充气盘，或者可植入环或弹性线圈，其可以被拉直以用于递送/提取，但是在植入时呈现环或线圈形状。

5. 发明申请

WO2012106420A1 IMPLANTABLE BOTTOM EXIT PORT 审中-公开
标题翻译：可伸缩底部出口口
公开(公告)号：WO2012106420A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023471
申请日：2012-02-01
申请人： ALLERGAN, INC. , HONARYAR, Babak , BORRELL, Marcos , MUDD, Christopher S. , RAVEN, Joseph S. , ALLEN, Jeff , SNOW, Sean , VINCENT, Vernon L.
发明人： HONARYAR, Babak , BORRELL, Marcos , MUDD, Christopher S. , RAVEN, Joseph S. , ALLEN, Jeff , SNOW, Sean , VINCENT, Vernon L.
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61M39/0208 , A61F5/0056 , A61M2039/0223 , A61M2039/0226 , A61M2039/0229
摘要： The present invention provides a system for attaching a fluid access port to a patient. The system generally comprises an implantable access port (10, 210) with a bottom exit port (16, 216) and method for attaching an access port to a patient. In addition, a tube guard (30), flexible tube exit port (16, 216), tissue guard, and porous coupling member (20, 220) are disclosed.
摘要翻译：本发明提供了一种用于将流体进入口附接到患者的系统。该系统通常包括具有底部出口（16,216）的可植入进入口（10,210）和用于将进入端口附接到患者的方法。此外，公开了一种管保护件（30），柔性管出口（16,216），组织护罩和多孔连接件（20,220）。

6. 发明申请

WO2011071654A1 SLOTTED SYRINGE 审中-公开
标题翻译：缝制的SYRINGE
公开(公告)号：WO2011071654A1
公开(公告)日：2011-06-16
申请号：PCT/US2010/056304
申请日：2010-11-11
申请人： ALLERGAN, INC. , MUDD, Christopher S.
发明人： MUDD, Christopher S.
IPC分类号： A61M5/178 , A61M5/31
CPC分类号： A61M5/3137 , A61M5/3129 , A61M5/3135 , A61M5/31511 , A61M5/3158 , A61M2005/3139 , A61M2005/31518 , A61M2005/5006 , A61M2202/06
摘要： A syringe is disclosed. The syringe may include a syringe body (101) with a fluid chamber, the syringe body having a proximal end and a distal end, with an extrusion opening at the proximal end; a first slot (102) formed in the syringe body, starting near the proximal end of the syringe body and ending near the distal end of the syringe body; a first sleeve covering the first slot; a thumb grip, the thumb grip including a first slot guide disposed in the first slot, the thumb grip shaped to slide from a first position near the distal end of the syringe body toward a second position near the proximal end of the syringe body; and a plunger disposed in the fluid chamber of the syringe body, the plunger configured to move towards the proximal end of the syringe body in response to pressure applied by a user to the thumb grip, the plunger including a first plunger slot guide disposed in the first slot.
摘要翻译：公开了一种注射器。注射器可以包括具有流体室的注射器主体（101），注射器主体具有近端和远端，在近端具有挤出开口; 形成在注射器主体中的第一槽（102），从注射器主体的近端开始并在注射器主体的远端附近结束; 覆盖所述第一槽的第一套筒; 拇指手柄，包括设置在第一槽中的第一槽导向件，该拇指夹被成形为从注射器主体的远端附近的第一位置朝向靠近注射器本体的近端的第二位置滑动; 以及设置在所述注射器主体的流体室中的柱塞，所述柱塞构造成响应于由使用者施加到所述拇指把手的压力而朝向所述注射器本体的近端移动，所述柱塞包括设置在所述注射器主体中的第一柱塞狭槽引导件第一个插槽

7. 发明申请

WO2011059909A1 POLYSACCHARIDE GEL FORMULATION HAVING MULTI-STAGE BIOACTIVE AGENT DELIVERY 审中-公开
标题翻译：具有多阶段生物交换剂的多糖凝胶配方
公开(公告)号：WO2011059909A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055801
申请日：2010-11-08
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
IPC分类号： A61K8/60 , A61K8/73 , A61K8/04 , A61K8/34 , A61K9/10 , A61K47/36 , A61K47/10 , A61K47/26 , A61K31/728 , A61K31/738
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

8. 发明申请

WO2012051434A2 IMPLANTABLE COUPLING DEVICE 审中-公开
标题翻译：可植入耦合器件
公开(公告)号：WO2012051434A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/056181
申请日：2011-10-13
申请人： ALLERGAN, INC. , HONARYAR, Babak , BORRELL, Marcos , MUDD, Christopher S. , RAVEN, Joseph S. , SNOW, Sean , VINCENT, Vernon L.
发明人： HONARYAR, Babak , BORRELL, Marcos , MUDD, Christopher S. , RAVEN, Joseph S. , SNOW, Sean , VINCENT, Vernon L.
IPC分类号： A61M39/02 , A61F5/00
CPC分类号： A61M39/0208 , A61B17/064 , A61F5/0056 , A61M39/04 , A61M2039/0223 , A61M2210/1053
摘要： The present invention provides a system for attaching a fluid access port to a patient. The system generally comprises an implantable access port and method for attaching an access port to a patient. In addition, a tube guard, tube shroud, tissue guard, porous coupling member and a prefabricated mesh member may be attached to the access port. For example, the prefabricated mesh may be coupled to the access port to facilitate securing the access port to the tissue of the patient.
摘要翻译：本发明提供了一种用于将流体进入口附接到患者的系统。该系统通常包括用于将访问端口附接到患者的可植入访问端口和方法。此外，管保护件，管罩，组织护罩，多孔连接构件和预制网状构件可以附接到进入端口。例如，预制网可以联接到接入端口以便于将接入端口固定到患者的组织。

9. 发明申请

WO2011146713A1 MODULAR INJECTION DEVICE 审中-公开
标题翻译：模块化注射装置
公开(公告)号：WO2011146713A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037147
申请日：2011-05-19
申请人： ALLERGAN, INC. , MUDD, Christopher S. , TEZEL, Ahmet , QIU, Shaohui , POWERS, Lee F.
发明人： MUDD, Christopher S. , TEZEL, Ahmet , QIU, Shaohui , POWERS, Lee F.
IPC分类号： A61M5/142 , A61M5/145 , A61M5/20
CPC分类号： A61M5/20 , A61M5/1413 , A61M5/14244 , A61M5/14546 , A61M5/14566 , A61M5/3129 , A61M2005/2407 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2205/14 , A61M2205/3334 , A61M2205/586 , A61M2205/8206 , A61M2205/8268 , A61M2209/086 , A61M2209/088
摘要： A modular injection device for administration of dermal filler compositions is provided. The injection device may include a handheld injector unit including a drive unit, the drive unit configured to apply an extrusion force to a fluid; a control unit remote from the injector unit, the control unit configured to control the drive unit; and a cable configured to connect the control unit to the injector unit.
摘要翻译：提供了用于施用皮肤填充剂组合物的模块化注射装置。注射装置可以包括手动注射器单元，其包括驱动单元，该驱动单元被配置为向流体施加挤压力; 远离所述喷射器单元的控制单元，所述控制单元被配置为控制所述驱动单元; 以及配置成将控制单元连接到喷射器单元的电缆。

10. 发明申请

WO2013074364A1 MODULAR INJECTION SYSTEM AND METHOD FOR DILUTING AN INJECTABLE FLUID 审中-公开
标题翻译：模块化注射系统和用于稀释注射液的方法
公开(公告)号：WO2013074364A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/064106
申请日：2012-11-08
申请人： ALLERGAN, INC.
发明人： MUDD, Christopher S. , DOMINGUEZ, Zachary P. , JOSENHANS, Corey L. , TEZEL, Ahmet , BABKES, Mitchell H. , PRICHARD, Michael J. , LLEWELLYN, Martha E. , QIU, Shaohui , POWERS, Lee F. , JOHNSON, Brett R.
IPC分类号： A61M5/14 , A61M5/142 , A61M5/145 , A61M5/19 , A61C5/06 , A61M5/24
CPC分类号： A61M5/1408 , A61M5/14244 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/172 , A61M5/19 , A61M2209/088
摘要： A modular injection system enables a user to control the dilution ratio of mixed injectable fluid. In one embodiment, modular injection system includes a handheld injection device operatively connected to a separate control device. In one embodiment, the control device includes a drive unit configured to apply extrusion forces to fluids. In another embodiment, the handheld injection device includes the drive unit. In one embodiment, the modular injection system produces the mixed injectable fluid based on a selected dilution ratio. In one embodiment, the modular injection system produces the mixed injectable fluid based on selected injection rates.
摘要翻译：模块化注射系统使得用户能够控制混合可注射流体的稀释比。在一个实施例中，模块化注射系统包括可操作地连接到单独的控制装置的手持式注射装置。在一个实施例中，控制装置包括构造成将挤压力施加到流体的驱动单元。在另一个实施例中，手持式注射装置包括驱动单元。在一个实施例中，模块化注射系统基于所选择的稀释比产生混合的可注射流体。在一个实施例中，模块化注射系统基于所选择的注射速率产生混合的可注射流体。

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