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1. 发明申请

WO2005079793A1 PROSTAGLANDIN D2 ANTAGONIST 审中-公开
公开(公告)号：WO2005079793A1
公开(公告)日：2005-09-01
申请号：PCT/US2005/004336
申请日：2005-02-07
申请人： ALLERGAN, INC. , KRAUSS, Achim, H. , WOODWARD, David , DONDE, Yariv , BURK, Robert, M.
发明人： KRAUSS, Achim, H. , WOODWARD, David , DONDE, Yariv , BURK, Robert, M.
IPC分类号： A61K31/421
CPC分类号： C07D493/08 , A61K31/422
摘要： Disclosed herein is compound (1) or a pharmaceutically acceptable salt, or a prodrug thereof. Compound (1) is useful for treating or preventing a variety of diseases or conditions. Results presented herein also demonstrate that Compound (1) is a prostaglandin D 2 antagonist, and as such is useful in the treatment or prevention of prostaglandin D 2 mediated conditions or diseases. A method comprising administering a prostaglandin D 2 antagonist to a mammal suffering from a disease or condition selected from the group consisting of the gastrointestinal tract disorders or diseases, hyperalgesia, allodynia, abdominal cramping, glaucoma, ocular hypertension, and ocular hypotension is also disclosed herein. Pharmaceutical compositions and products comprising compound (1) are also disclosed.
摘要翻译：本文公开了化合物（1）或其药学上可接受的盐或其前药。化合物（1）可用于治疗或预防各种疾病或病症。本文提供的结果还表明化合物（1）是前列腺素D2拮抗剂，因此可用于治疗或预防前列腺素D2介导的病症或疾病。还公开了向患有选自以下的疾病或病症的哺乳动物前列腺素D2拮抗剂的方法：胃肠道疾病或疾病，痛觉过敏，异常性疼痛，腹部绞痛，青光眼，眼高压和眼低血压。还公开了包含化合物（1）的药物组合物和产品。

2. 发明申请

WO2005034890A2 METHODS FOR THE TREATMENT OF GRAY HAIR USING CYCLOPENTANE(ENE) HEPTAN(EN)OIC ACID AMIDES 审中-公开
标题翻译：使用环丙烷（ENE）HEPTAN（EN）OIC酰胺治疗灰发的方法
公开(公告)号：WO2005034890A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/027547
申请日：2004-08-24
申请人： ALLERGAN, INC. , KRAUSS, Achim, H.
发明人： KRAUSS, Achim, H.
IPC分类号： A61K7/00
CPC分类号： A61K8/42 , A61K31/557 , A61Q5/065
摘要： The present invention relates to novel pharmaceutical compositions of bimatoprost and other cyclopentane(ene) heptan(en)oic acid amides and their use in preventing gray hair or promoting the conversion of gray hair to the original pigment in hair follicles.
摘要翻译：本发明涉及比马前列素和其他环戊烷（ene）庚（en）ic酸酰胺的新型药物组合物及其用于防止灰白色毛发或促进灰白色头发转移至毛囊中原始颜料的用途。

3. 发明申请

WO2005034889A2 METHOD FOR IMPARTING ARTIFICIAL TAN TO HUMAN SKIN 审中-公开
标题翻译：将人造色素注入人体皮肤的方法
公开(公告)号：WO2005034889A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/027546
申请日：2004-08-24
申请人： ALLERGAN, INC. , KRAUSS, Achim, H.
发明人： KRAUSS, Achim, H.
IPC分类号： A61K7/00
CPC分类号： A61Q19/04 , A61K8/42
摘要： The present invention relates to novel pharmaceutical compositions of bimatoprost and other cyclopentane(ene) heptan(en)oic acid amides and their use in preventing sunburn and/or providing an artificial tan to human skin.
摘要翻译：本发明涉及新比马前列素和其他环戊烷（烯）庚烷（烯）酸酰胺的药物组合物及其在防止晒斑和/或向人类皮肤提供人造黄褐斑中的用途。 p>

4. 发明申请

WO1996017608A1 USE OF GUANYLATE CYCLASE INHIBITORS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于减少心室压力的冠状胶囊抑制剂的使用
公开(公告)号：WO1996017608A1
公开(公告)日：1996-06-13
申请号：PCT/US1995015869
申请日：1995-12-05
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , KRAUSS, Achim, H.
IPC分类号： A61K31/47
CPC分类号： A61K31/5415 , A61K31/085 , A61K31/131 , A61K31/47 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more compounds having guanylate cyclase inhibition activity. Examples of guanylate cyclase inhibitors utilized in the pharmaceutical composition and method of treatment are formula (I) and pharmaceutically acceptable salts thereof.
摘要翻译：公开了药物组合物和方法，用于通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有鸟苷酸环化酶抑制活性的化合物的本发明的药物组合物来治疗哺乳动物眼中的青光眼和/或高眼压症。在药物组合物和治疗方法中使用的鸟苷酸环化酶抑制剂的实例是式（I）及其药学上可接受的盐。

5. 发明申请

WO2005026172A1 PROSTAMIDE RECEPTOR ANTAGONISTS 审中-公开
标题翻译： PROSTAMIDE受体拮抗剂
公开(公告)号：WO2005026172A1
公开(公告)日：2005-03-24
申请号：PCT/US2004/026924
申请日：2004-08-18
申请人： ALLERGAN, INC. , KRAUSS, Achim, H. , WOODWARD, David, F.
发明人： KRAUSS, Achim, H. , WOODWARD, David, F.
IPC分类号： C07D493/08
CPC分类号： C07D493/08 , G01N33/5088
摘要： The present invention provides prostamide receptor antagonist compounds that may be represented by the general formula (I) wherein A, R 1 , R 2 , R 3 , R 4 and R 6 are as defined in the specification.
摘要翻译：本发明提供可由通式（I）表示的前列腺酰胺受体拮抗剂化合物，其中A，R 1，R 2，R 3，R 4和R 6如规格。

6. 发明申请

WO1995018103A1 7-[CARBOXYALKYL OR ALKENYL]-6-[ALKYL OR ALKENYL] 3-OXO-2,4-DIOXOBICYCLO-[3.2.1] OCTANE AND DERIVATIVES THEREOF 审中-公开
标题翻译： 7- [羧甲基或烷基] -6- [烷基或亚苄基] 3-氧代-2,4-二氧代环己基 - [3.2.1]其衍生物及其衍生物
公开(公告)号：WO1995018103A1
公开(公告)日：1995-07-06
申请号：PCT/US1994014012
申请日：1994-12-05
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , BURK, Robert, M. , KRAUSS, Achim, H. , WOODWARD, David, F.
IPC分类号： C07C405/00
CPC分类号： C07D307/00 , C07D319/08 , C07D493/08
摘要： The present invention relates to 7-[carboxyalkyl or alkenyl]-6-[alkyl or alkenyl]-3-oxo-2,4-dioxobicyclo[3.2.1] octanes and derivatives thereof. In particular, hydroxyl, nitro, amino, amido, azido, oxime, thiol, ether and thiol ether derivatives of said carboxy group are contemplated. In particular, 7-[6-carboxy-2-hexenyl]-6-[3-hydroxy-1-octenyl] of 3-oxo-2,4-dioxobicyclo-[3.2.1] octane and derivatives thereof are disclosed. These compounds are useful as ocular hypotensives and as (a) thromboxane mimetics for the prevention of hemorrhaging as follows: during surgery; tooth extraction; hemorrhaging associated with gastro-intestinal diseases and conditions such as hemorrhoids, inflammatory bowel diseases and gastric and peptic ulcers; as a result of stroke; as a complication in retinal diseases resulting in impaired vision and associated with menstruation, childbirth and uterine dysfunction and (b) selective vasoconstrictors for treating systemic hypotension, e.g. in restoring normal blood pressure in hemorrhagic, anaphylactic, or septic shock victims; to provide local anti-inflammatory effects in the eye, skin and nose; to limit plasma exudation in burns, etc. and optimizing blood-born delivery of drugs and diagnostics in encapsulating vehicles.
摘要翻译：本发明涉及7- [羧基烷基或烯基] -6- [烷基或链烯基] -3-氧代-2,4-二氧代双环[3.2.1]辛烷及其衍生物。特别地，考虑到所述羧基的羟基，硝基，氨基，酰胺基，叠氮基，肟，硫醇，醚和硫醇醚衍生物。特别地，公开了3-氧代-2,4-二氧双环[3.2.1]辛烷及其衍生物的7- [6-羧基-2-己烯基] -6- [3-羟基-1-辛烯基]。这些化合物可用作眼睛低血压剂和（a）用于预防出血的凝血恶烷模拟物如下：手术期间; 拔牙; 与胃肠道疾病和痔疮，炎性肠病和胃和消化性溃疡等疾病相关的出血; 作为中风的结果; 视网膜疾病并发症，导致视力受损，并伴有月经，分娩和子宫功能障碍，以及（b）用于治疗全身性低血压的选择性血管收缩剂，例如，恢复出血性，过敏性或败血性休克患者的正常血压; 在眼睛，皮肤和鼻子中提供局部消炎作用; 限制血浆渗透等等，并优化血液输送药物和封装车辆中的诊断。

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