专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996017608A1 USE OF GUANYLATE CYCLASE INHIBITORS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于减少心室压力的冠状胶囊抑制剂的使用
公开(公告)号：WO1996017608A1
公开(公告)日：1996-06-13
申请号：PCT/US1995015869
申请日：1995-12-05
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , KRAUSS, Achim, H.
IPC分类号： A61K31/47
CPC分类号： A61K31/5415 , A61K31/085 , A61K31/131 , A61K31/47 , Y10S514/912 , Y10S514/913
摘要： Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more compounds having guanylate cyclase inhibition activity. Examples of guanylate cyclase inhibitors utilized in the pharmaceutical composition and method of treatment are formula (I) and pharmaceutically acceptable salts thereof.
摘要翻译：公开了药物组合物和方法，用于通过向哺乳动物眼睛施用含有作为活性成分的一种或多种具有鸟苷酸环化酶抑制活性的化合物的本发明的药物组合物来治疗哺乳动物眼中的青光眼和/或高眼压症。在药物组合物和治疗方法中使用的鸟苷酸环化酶抑制剂的实例是式（I）及其药学上可接受的盐。

2. 发明申请

WO1996016780A2 CAST MOLDING OF INTRAOCULAR LENSES 审中-公开
标题翻译：内镜镜片的铸造
公开(公告)号：WO1996016780A2
公开(公告)日：1996-06-06
申请号：PCT/US1995015024
申请日：1995-11-21
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , GLICK, Robert, E. , DEACON, Jim , KENT, Bruce, W.
IPC分类号： B29C33/36
CPC分类号： B29D11/00057 , A61F2/16 , B29C33/0038 , B29C33/303 , B29D11/023 , B29L2011/0016 , Y10S425/808
摘要： The invention provides a disposable plastic mold assembly (10) for an intraocular lens or the optic body thereof, which is inexpensive, less labor intensive than prior art intraocular lens molding techniques, and produces an intraocular lens having smooth, polished edges which require little or no post-mold finishing work. Numerous innovative features of the invention include an edge design which assures a seal between the male (12) and female (14) molds to thereby minimize flash during the cast molding operation, and the provision of a means for pre-aligning the male and female molds during assembly, consisting of an interference fitting relationship between the male and female molds. An additional feature is a means for maintaining contact between the male and female molds during casting, which particularly involves the provision of a negative draft angle on the inner surface of the female mold's outer wall, or, alternatively, texturing which is applied to that inner surface so that it engages the outer edge at the top of the male mold during assembly. Yet another important feature of the invention is a means for achieving axial and rotational orientation to produce lens edge geometries without unwanted steps on the lens edge. The alignment is achieved with interlocking steps (34, 36, 38) on the male and female molds. The interlocking elements may be pins or annular elements.
摘要翻译：本发明提供了一种用于眼内透镜或其光学本体的一次性塑料模具组件（10），其廉价，比现有技术的眼内透镜模制技术更少的劳动密集度，并且产生具有光滑抛光边缘的眼内透镜，其需要很少或无后模整理工作。本发明的许多创新特征包括边缘设计，其确保在阳模（12）和阴模（14）之间的密封，从而在浇铸模制操作期间最小化闪光，并且提供用于预对准男性和女性组装过程中的模具由阳模和阴模之间的干涉配合关系组成。额外的特征是用于在铸造期间保持阳模和阴模之间的接触的手段，其特别地涉及在阴模的外壁的内表面上提供负牵伸角，或者替代地，施加到内模表面，使得其在组装期间与阳模的顶部处的外边缘接合。本发明的另一个重要特征是用于实现轴向和旋转取向以产生透镜边缘几何形状而在镜片边缘上没有不必要的步骤的手段。在阳模和阴模上具有互锁台阶（34,36,38）来实现对准。互锁元件可以是销或环形元件。

3. 发明申请

WO1996011649A1 APPARATUS AND METHODS FOR CONTROLLED INSERTION OF INTRAOCULAR LENSES 审中-公开
标题翻译：用于控制内镜镜片的装置和方法
公开(公告)号：WO1996011649A1
公开(公告)日：1996-04-25
申请号：PCT/US1995012735
申请日：1995-10-14
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , BRADY, Daniel, G. , MC NICHOLAS, Thomas, M.
IPC分类号： A61F02/16
CPC分类号： A61F2/1664
摘要： Apparatus and methods for inserting foldable IOL's into the eye are disclosed. The present apparatus includes a load chamber and an injection tube. A hand piece may be included which is structured to reinforce the injection tube, in particular the proximal end portion of the injection tube. The open distal end of the injection tube may be beveled, preferably so that the open distal end faces generally toward the right, so that the IOL can be inserted into the eye through a smaller incision in a controlled manner, for example, to reduce the need for post-surgical manipulation of the IOL in the eye. Methods for inserting IOL's into eyes of patients, particularly using the present apparatus, are also disclosed.
摘要翻译：公开了将折叠式IOL插入到眼睛中的装置和方法。本装置包括负载室和注入管。可以包括手部件，其被构造成加强注射管，特别是注射管的近端部分。注射管的敞开的远端可以是倾斜的，优选地使得开放的远端大致朝向右侧面，使得IOL可以以受控的方式通过较小的切口插入到眼睛中，例如以减少需要对眼内的IOL进行手术后手术。还公开了将IOL插入患者眼睛的方法，特别是使用本发明的装置。

4. 发明申请

WO1996010971A1 LIQUID CONTACT LENS 审中-公开
标题翻译：液体接触镜
公开(公告)号：WO1996010971A1
公开(公告)日：1996-04-18
申请号：PCT/US1995013844
申请日：1995-10-10
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , OBRAZTSOV, Nickolay
IPC分类号： A61F09/00
CPC分类号： G02C7/04 , A61F9/00 , G02B5/32
摘要： Compositions useful to at least partially correct an effect of ametropia in a mammalian eye are disclosed. Such compositions comprise a plurality of particles sized and adapted to be placed in proximity to the outer surface of the cornea of a mammalian eye to at least partially correct an effect of ametropia in the mammalian eye. Each of the plurality of particles carries a complete hologram, preferably a complete hologram which holds all the information needed to at least partially correct the effect of ametropia in the mammalian eye. A particularly useful method of administering the plurality of particles to a mammalian eye is to use an additional component in an amount effective to act as a carrier for the plurality of particles. In one embodiment, this carrier component is an ophthalmically acceptable, aqueous-based liquid. Methods for using such compositions to at least partially correct an effect of ametropia in the mammalian eye, and methods for producing such compositions are also disclosed.
摘要翻译：公开了可用于至少部分校正哺乳动物眼中屈光不正的作用的组合物。这样的组合物包括多个尺寸并适于放置在哺乳动物眼睛的角膜的外表面附近以至少部分地校正哺乳动物眼睛中屈光不正的作用的多个颗粒。多个颗粒中的每一个携带完整的全息图，优选完整的全息图，其保存了至少部分地校正哺乳动物眼睛中屈光不正的作用所需的全部信息。向哺乳动物眼睛施用多个颗粒的特别有用的方法是使用有效作为多个颗粒的载体的量的附加组分。在一个实施方案中，该载体组分是眼科可接受的基于水的液体。还公开了使用这些组合物至少部分矫正哺乳动物眼睛中屈光不正的作用的方法，以及制备这些组合物的方法。

5. 发明申请

WO1996000179A1 TABLET DISPENSING SYSTEM 审中-公开
标题翻译：片剂分配系统
公开(公告)号：WO1996000179A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007510
申请日：1995-06-13
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , HOLMES, Alix, A.
IPC分类号： B65D83/04
CPC分类号： B65D83/0463 , B65D81/3205
摘要： A tablet dispensing system (10) includes a container in arcuate housing means (12) for containing a supply of tablets (14, 16). The arcuate housing is configured for being removably attached around a generally cylindrical container (22) and has sufficient length to extend around a majority of the perimeter of the container. The arcuate housing may be shipped in a single circular piece with a perforation (43) therein for separating the arcuate housing and in order to removably dispose same on the cylindrical container. An open end (40) of the arcuate housing is provided for dispensing the tablets therefrom, and a resilient outer wall (58) of the arcuate housing enables one-by-one dispensing of tablets in a carrier therefrom without dispensing of tablets sequentially held in the carrier.
摘要翻译：片剂分配系统（10）包括用于容纳片剂（14,16）的弓形壳体装置（12）的容器。弓形壳体构造成可移除地附接在大致圆柱形的容器（22）周围，并且具有足够的长度以围绕容器的大部分周边延伸。弓形壳体可以在其中具有用于分离弓形壳体的穿孔（43）的单个圆形件中运输，并且为了可拆卸地将其布置在圆柱形容器上。提供弓形壳体的开口端（40）用于从中分配片剂，并且弧形壳体的弹性外壁（58）能够在载体中一次一片地分配片剂，而不分散片剂，其顺次保持在承运人

6. 发明申请

WO1995033489A1 STABLE GEL FORMULATION FOR TOPICAL TREATMENT OF SKIN CONDITIONS 审中-公开
标题翻译：稳定的凝胶配方用于皮肤条件的局部治疗
公开(公告)号：WO1995033489A1
公开(公告)日：1995-12-14
申请号：PCT/US1995007338
申请日：1995-06-07
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , CHARU, Prakash, M.
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K8/042 , A61K8/49 , A61K8/671 , A61K9/0014 , A61K31/4436 , A61K31/455 , A61K47/10 , A61K47/26 , A61Q19/00 , Y10S514/859 , Y10S514/863 , Y10S514/886 , Y10S514/887 , Y10S514/944 , Y10S514/964
摘要： The present invention provides a stable gel formulation for topical treatment of skin conditions in humans. The stable gel formulation includes an active agent, having activity for treatment of acne and psoriasis, which is insoluble in water and a plurality of nonaqueous vehicles for both solubilizing said active agent and forming a gel therewith enabling topical application of the gel to a skin condition. The plurality of vehicles are each present in amounts, and in combination, to control release of the active agent from the gel to the skin condition.
摘要翻译：本发明提供用于局部治疗人类皮肤状况的稳定凝胶制剂。稳定的凝胶制剂包括具有治疗痤疮和牛皮癣活性的活性剂，其不溶于水和多种非水性载体，用于增溶所述活性剂并形成凝胶，从而使凝胶局部施用于皮肤状态。多种载体各自以量和组合的形式存在以控制活性剂从凝胶释放到皮肤状态。

7. 发明申请

WO1995027515A1 PHOSPHOLIPID PRESERVATION OF HYDROGEN PEROXIDE-CONTAINING COMPOSITIONS 审中-公开
标题翻译：含氢过氧化物组合物的磷脂保护
公开(公告)号：WO1995027515A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004095
申请日：1995-04-03
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , NAKAJI, Martin, K.
IPC分类号： A61L02/18
CPC分类号： A61L12/124 , A01N57/12 , A01N59/00 , A01N2300/00
摘要： Compositions and methods for disinfecting contact lenses are disclosed. In one embodiment, the present compositions include water, hydrogen peroxide in an amount effective to disinfect a contact lens contacted with the composition, and a phosphate quaternary component in an amount effective in preserving the composition after the hydrogen peroxide is destroyed.
摘要翻译：公开了消毒隐形眼镜的组合物和方法。在一个实施方案中，本发明的组合物包括水，有效消毒与组合物接触的隐形眼镜的量的过氧化氢和在过氧化氢被破坏后有效保护组合物的量的磷酸盐季铵组分。

8. 发明申请

WO1995018803A1 ACETYLENES DISUBSTITUTED WITH A PHENYL OR HETEROARYL GROUP AND A 2-OXOCHROMANYL, 2-OXOTHIOCHROMANYL OR 2-OXO-1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY 审中-公开
标题翻译：用苯基或杂芳基取代的乙酰基和具有类似反应活性的2-氧杂环戊二烯或2-氧代-1,2,3,4-四氢喹啉醇基
公开(公告)号：WO1995018803A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000268
申请日：1995-01-09
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , CHANDRARATNA, Roshantha, A.
IPC分类号： C07D405/06
CPC分类号： C07D215/227 , C07D311/20 , C07D311/58 , C07D335/06 , C07D401/06 , C07D405/06 , C07D409/06 , C07F7/0812
摘要： Compounds of formula (1) where R1 and R2 are hydrogen, lower alkyl of 1-6 carbons, or halogen; R3 is hydrogen, lower alkyl of 1-6 carbons, halogen, OR11, SR11, OCOR11, SCOR11, NH2, NHR11, N(R11)2, NHCOR11 or NR11COR11; X is O, S or NR' where R' is hydrogen or lower alkyl of 1-6 carbons; Y is phenyl or a heteroaryl group selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH2)n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds; alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, or CR7OR13O, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, have retinoid-like biological activity.
摘要翻译：其中R1和R2是氢，1-6个碳的低级烷基或卤素的式（1）化合物; R3是氢，1-6个碳的低级烷基，卤素，OR11，SR11，OCOR11，SCOR11，NH2，NHR11，N（R11）2，NHCOR11或NR11COR11; X是O，S或NR'，其中R'是氢或1-6个碳的低级烷基; Y是苯基或选自吡啶基，噻吩基，呋喃基，哒嗪基，嘧啶基，吡嗪基，噻唑基和恶唑基的杂芳基; A是（CH 2）n，其中n是0-5，具有3-6个碳的低级支链烷基，具有3-6个碳的环烷基，具有2-6个碳原子的链烯基和1或2个双键; 具有2-6个碳原子和1或2个三键的炔基; B是氢，COOH或其药学上可接受的盐，COOR8，CONR9R10，-CH2OH，CH2OR11，CH2OCOR11，CHO，CH（OR12）2，CHOR13O，-COR7，CR7（OR12）2或CR7OR13O，其中R7是烷基，碳原子数为1〜5的环烷基或链烯基，R8为碳原子数为1〜10的烷基或碳原子数为5〜10的环烷基，或R8为苯基或低级烷基苯基，R9和R10分别为氢，烷基 1〜10个碳原子的环烷基或5-10个碳原子的环烷基，或苯基或低级烷基苯基，R11为低级烷基，苯基或低级烷基苯基，R12为低级烷基，R13为2-5个碳原子的二价烷基，具有类视黄醇样生物活性。

9. 发明申请

WO1995016017A1 SUGAR-BASED CLEANSING COMPOSITION FOR CONTACT LENSES 审中-公开
标题翻译：用于接触眼镜的基于糖的清洁组合物
公开(公告)号：WO1995016017A1
公开(公告)日：1995-06-15
申请号：PCT/US1994014040
申请日：1994-12-02
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , CHEN, Jie
IPC分类号： C11D03/00
CPC分类号： A61L12/082 , C11D3/0078 , C11D3/221 , C11D3/38609 , C11D17/0073
摘要： A composition for cleaning contact lenses includes a protease and a sugar in an amount effective to maintain substantially neutral pH in a borate buffer upon dissolution of the composition therein.
摘要翻译：用于清洁隐形眼镜的组合物包括蛋白酶和糖，其量有效地在组合物溶解时在硼酸盐缓冲液中保持基本上中性的pH。

10. 发明申请

WO1995011682A3 CYCLOPENTANE HEPTANOIC OR HEPTENOIC ACID, 2-ARYLALKYL OR ARYLALKENYL AND DERIVATIVES AS THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO1995011682A3
公开(公告)日：1995-05-04
申请号：PCT/US1994012017
申请日：1994-10-20
申请人： ALLERGAN, INC.
发明人： ALLERGAN, INC. , ANDREWS, Steven, W.
IPC分类号： A61K31/557

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式