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1. 发明申请

WO2008020452A1 IMPROVED PROCESS FOR THE PREPARATION OF RIVASTIGMINE 审中-公开
标题翻译：改进RIVASTIGMINE的改进方法
公开(公告)号：WO2008020452A1
公开(公告)日：2008-02-21
申请号：PCT/IN2006/000404
申请日：2006-10-06
申请人： ALEMBIC LIMITED , DESHPANDE, Pandurang, Balwant , KHEMANI, Kishore , BODA, Bharat, Becharbhai , SHAH, Tushar, Rajnikant , ACHARYA, Hitarth, Harshendu , LUTHRA, Parven, Kumar
发明人： DESHPANDE, Pandurang, Balwant , KHEMANI, Kishore , BODA, Bharat, Becharbhai , SHAH, Tushar, Rajnikant , ACHARYA, Hitarth, Harshendu , LUTHRA, Parven, Kumar
IPC分类号： C07C215/50 , C07C271/44 , C07C269/04
CPC分类号： C07C213/08 , C07C269/00 , C07C217/50 , C07C271/44
摘要： The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R 1 = R 2 = H or R 1 = H and R 2 = CH 3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
摘要翻译：本发明涉及一种制备式（I）的利凡斯坦或其药学上可接受的盐的改进方法，其包括式（III）化合物的N-甲基化步骤，其中R 1 = H 2或H 2 R 2 = CH 3或其酸加成盐，使用多聚甲醛在阮内镍和氢气存在下，在合适的溶剂中，得到式（II）化合物。

2. 发明申请

WO2007110880A2 A PROCESS FOR THE PURIFICATION OF ROPINIROLE HYDROCHLORIDE 审中-公开
标题翻译： ROPINIROLE HYDROCHLORIDE的纯化方法
公开(公告)号：WO2007110880A2
公开(公告)日：2007-10-04
申请号：PCT/IN2007/000117
申请日：2007-03-21
申请人： ALEMBIC LIMITED , DESHPANDE, Pandurang, Balwant , LUTHRA, Parven, Kumar , ACHARYA, Hitarth, Harshendu
发明人： DESHPANDE, Pandurang, Balwant , LUTHRA, Parven, Kumar , ACHARYA, Hitarth, Harshendu
IPC分类号： C07D209/34
CPC分类号： C07D209/34
摘要： The present invention provides an improved process for the purification of Ropinirole hydrochloride of formula (Ia) comprising steps of: (i) treating Ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating Ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.
摘要翻译：本发明提供了一种用于纯化式（Ia）的盐酸罗匹尼罗的改进方法，包括以下步骤：（i）用合适的醇溶剂中的二硫酸钠和木炭处理盐酸罗匹尼罗; （ii）用乙醇研磨步骤（i）中获得的罗匹尼罗盐酸盐; （iii）将研磨的固体与碱在水不混溶的溶剂中反应并分离游离碱; （iv）用乙醇HCl处理步骤（iii）中获得的游离碱，得到盐酸罗匹尼罗。

3. 发明申请

WO2007110879A2 A PROCESS FOR THE PURIFICATION OF ROPINIROLE HYDROCHLORIDE 审中-公开
标题翻译： ROPINIROLE HYDROCHLORIDE的纯化方法
公开(公告)号：WO2007110879A2
公开(公告)日：2007-10-04
申请号：PCT/IN2007/000116
申请日：2007-03-21
申请人： ALEMBIC LIMITED , DESHPANDE, Pandurang, Balwant , SHANISHCHARA, Ashok, Prataprai , SHAH, Trushar, Rajanikant , ACHARYA, Hitarth, Harshendu , LUTHRA, Parven, Kumar
发明人： DESHPANDE, Pandurang, Balwant , SHANISHCHARA, Ashok, Prataprai , SHAH, Trushar, Rajanikant , ACHARYA, Hitarth, Harshendu , LUTHRA, Parven, Kumar
CPC分类号： C07D209/34
摘要： The present invention provides an improved process for the purification of Ropinirole hydrochloride of formula (Ia) comprising steps of: (i) dissolving Ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; (iv) treating the free base obtained in step (iii) with ethanolic HCl to give Ropinirole hydrochloride.
摘要翻译：本发明提供了一种用于纯化式（Ia）的盐酸罗匹尼罗的改进方法，包括以下步骤：（i）将盐酸罗匹尼罗溶解在水中; （ii）用二硫酸钠和木炭处理步骤（i）中得到的溶液; （iii）用与水不混溶的溶剂和碱处理在步骤（ii）中获得的滤液并分离游离碱; （iv）用乙醇HCl处理步骤（iii）中获得的游离碱，得到盐酸罗匹尼罗。

4. 发明申请

WO2006123356A1 PROCESS FOR THE PREPARATION OF INDOLONE DERIVATIVE 审中-公开
标题翻译：制备吲哚酚衍生物的方法
公开(公告)号：WO2006123356A1
公开(公告)日：2006-11-23
申请号：PCT/IN2006/000052
申请日：2006-02-15
申请人： ALEMBIC LIMITED , SONI, Rohit, Ravikant , ACHARYA, Hitarth, Harshendu , SHAH, Hetal, Rameshchandra , SHAH, Trushar, Rajnikant , REDDY, Buchi, Reguri
发明人： SONI, Rohit, Ravikant , ACHARYA, Hitarth, Harshendu , SHAH, Hetal, Rameshchandra , SHAH, Trushar, Rajnikant , REDDY, Buchi, Reguri
IPC分类号： C07D207/26
CPC分类号： C07D207/26
摘要： A process for the preparation of 4-[2-(Di-n-propylamino) ethyl]-2,3-dihydro-1 H-indol-2-one of formula (I) and its pharmaceutically acceptable salts, solvates Formaula I involving new intermediates of compound of formula (A) and (B) wherein R represents (i) a halogen atom selected from fluorine, chlorine atom, bromine atom and iodine atom; (ii) lower alkanesulfonyloxy group selected from methanesulfonyloxy, ethanesulfonyloxy, isopropanesulfonyloxy, propanesulfonyloxy, butanesulfonyloxy, tert-butanesulfonyloxy, pentanesulfonyloxy, hexanesulfonyloxy; (iii) substituted or unsubstantiated arylsulfonyloxy group selected from phenylsulfonyloxy, 4-methylphenylsulfonyloxy, 2-methylphenylsulfonyloxy, 4- nitrophenylsulfonyloxy, 4- methoxyphenylsulfonyloxy, 3-chlorophenylsulfonyloxy; (iv) arylalkylsulfonyloxy group selected from benzylsulfonyloxy, 2- phenylethylsulfonyloxy, 4-phenylbutylsulfonyloxy, 4- methylbenzylsulfonyloxy, 2- methylbenzylsulfonyloxy, 4- nitrobenzylsulfonyloxy, 4-methoxybenzylsulfonyloxy, 3- chlorobenzylsulfonyloxy.
摘要翻译：制备式（I）的4- [2-（二正丙基氨基）乙基] -2,3-二氢-1H-吲哚-2-酮及其药学上可接受的盐，溶剂合物的方法涉及式（A）和（B）化合物的新中间体，其中R表示（i）选自氟，氯原子，溴原子和碘原子的卤素原子; （ii）选自甲磺酰氧基，乙磺酰氧基，异丙磺酰氧基，丙磺酰氧基，丁磺酰氧基，叔丁磺酰氧基，戊磺酰氧基，己磺酰氧基等低级烷磺酰氧基。（iii）选自苯基磺酰氧基，4-甲基苯基磺酰氧基，2-甲基苯基磺酰氧基，4-硝基苯基磺酰氧基，4-甲氧基苯基磺酰氧基，3-氯苯基磺酰氧基等的取代或未经取代的芳基磺酰氧基; （iv）选自苄基磺酰氧基，2-苯基乙基磺酰氧基，4-苯基丁基磺酰氧基，4-甲基苄基磺酰氧基，2-甲基苄基磺酰氧基，4-硝基苄基磺酰氧基，4-甲氧基苄基磺酰氧基，3-氯苄基磺酰氧基的芳烷基磺酰氧基。

5. 发明申请

WO2010103443A1 A PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE 审中-公开
标题翻译：一种制备DOROXETINE氢氯化物的方法
公开(公告)号：WO2010103443A1
公开(公告)日：2010-09-16
申请号：PCT/IB2010/050957
申请日：2010-03-05
申请人： ALEMBIC LIMITED , PONNAIAH, Ravi , PRASAD, Ashok , PATEL, Killol , ACHARYA, Hitarth, Harshendu
发明人： PONNAIAH, Ravi , PRASAD, Ashok , PATEL, Killol , ACHARYA, Hitarth, Harshendu
IPC分类号： C07D333/20
CPC分类号： C07D333/20
摘要： The present invention relates to a process for the preparation of Duloxetine hydrochloride of formula (I).
摘要翻译：本发明涉及制备式（I）的盐酸度洛西汀的方法。

6. 发明申请

WO2011004298A1 MONTELUKAST HEXAMETHYLENEDIAMINE SALT AND ITS USE FOR THE PREPARATION OF MONTELUKAST SODIUM 审中-公开
标题翻译： MONTELUKAST十六烷基磺酸盐及其制备MONTELUKAST SODIUM的用途
公开(公告)号：WO2011004298A1
公开(公告)日：2011-01-13
申请号：PCT/IB2010/053041
申请日：2010-07-02
申请人： ALEMBIC LIMITED , PONNAIAH, Ravi , PRASAD, Ashok , TALUKDAR, Sanjay , PATEL, Killol , ACHARYA, Hitarth, Harshendu , PARMAR, Jitendra
发明人： PONNAIAH, Ravi , PRASAD, Ashok , TALUKDAR, Sanjay , PATEL, Killol , ACHARYA, Hitarth, Harshendu , PARMAR, Jitendra
IPC分类号： C07D215/18
CPC分类号： C07D215/18
摘要： The present invention relates to a montelukast hexamethylenediamine, Formule (I). It also relates to a process for the preparation of montelukast hexamethylenediamine and its use for the preparation of Montelukast Sodium.
摘要翻译：本发明涉及孟鲁司特六亚甲基二胺（Formule（I））。它还涉及制备孟鲁司特六亚甲基二胺的方法及其制备孟鲁司特钠的用途。

7. 发明申请

WO2013020672A1 PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE 审中-公开
标题翻译：制备阿维哌唑的方法
公开(公告)号：WO2013020672A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/003284
申请日：2012-08-02
申请人： PHARMATHEN S.A. , KOFTIS, Theocharis, V. , SONI, Rohit, Ravikant , ACHARYA, Hitarth, Harshendu , PATEL, Kandarpkumar, Hasmukhbhai , AHIRRAO, Manoh, Devidas
发明人： KOFTIS, Theocharis, V. , SONI, Rohit, Ravikant , ACHARYA, Hitarth, Harshendu , PATEL, Kandarpkumar, Hasmukhbhai , AHIRRAO, Manoh, Devidas
IPC分类号： C07D215/227
CPC分类号： C07D215/227
摘要： The present invention relates to an improved process for the preparation of high pure crystalline Aripiprazole of formula (I) having low residue ethanol content. The process comprises slurrying Aripiprazole obtained from the reaction mixture with water.
摘要翻译：本发明涉及制备具有低残留乙醇含量的式（I）的高纯度结晶阿立哌唑的改进方法。该方法包括将得自反应混合物的阿立哌唑与水混合。

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