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1. 发明申请

WO2003016332A3 ENHANCING SOLUBILITY OF IRON AMINO ACID CHELATES AND IRON PROTEINATES 审中-公开
公开(公告)号：WO2003016332A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/026118
申请日：2002-08-15
申请人： ALBION INTERNATIONAL, INC.
发明人： ERICSON, Clayton , ASHMEAD, H., DeWayne
IPC分类号： A23L1/304
摘要： A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into existing iron amino acid chelates or iron proteinates. The iron amino acid chelates and iron proteinates may have a ligand to metal molar ratio from about 1:1 to 4:1, preferably 2:1 to 3:1.

2. 发明申请

WO1993014638A1 IMPROVING FOOD ENERGY UTILIZATION FROM CARBOHYDRATES IN ANIMALS 审中-公开
标题翻译：改善动物中碳氢化合物的食物能量利用
公开(公告)号：WO1993014638A1
公开(公告)日：1993-08-05
申请号：PCT/US1992009589
申请日：1992-11-05
申请人： ALBION INTERNATIONAL, INC.
发明人： ALBION INTERNATIONAL, INC. , ASHMEAD, H., DeWayne
IPC分类号： A01N59/16
CPC分类号： A23K50/30 , A23K20/30
摘要： A method for facilitating digestion of carbohydrates into simple sugars in warm-blooded animals by maintaining and enhancing the natural disaccharidase enzymatic activity in the mucosal cells of the small intestines. Iron is an essential mineral and other minerals selected from the group consisting of copper, zinc, manganese and cobalt are provided in the form of amino acid chelates having a ligand to mineral molar ratio of at least 1:1, a molecular weight of no more than 1500 daltons and a stability constant of between about 10 and 10 and administered orally. Additionally, magnesium and chromium, as amino acid chelates, may be added to improve disaccharidase activity as may potassium in inorganic salt form or as a 1:1 ligand to potassium amino acid complex. The minerals are taken into the mucosal cells lining the small intestine where they are utilized to facilitate the production and activity of disaccharidase enzymes such as maltases, sucrase and lactase. These enzymes promote the hydrolysis of disaccharides resulting from degradation of more complex carbohydrates or of sucrose and lactose into simple sugars or monosaccharides for absorption from the intestinal tract.
摘要翻译：通过维持和增强小肠粘膜细胞中的天然二糖酶酶活性，促进在温血动物中将碳水化合物消化成简单糖的方法。铁是一种重要的矿物质，其中选自铜，锌，锰和钴的其他矿物以氨基酸螯合物的形式提供，其配体与矿物摩尔比至少为1:1，分子量不超过超过1500道尔顿和约10 6至10 16之间的稳定常数，并口服给药。另外，作为氨基酸螯合物可以加入镁和铬，以改善二糖苷酶的活性，如无机盐形式的钾或作为配体与钾氨基酸复合物的1:1配体。将矿物质摄入到小肠内的粘膜细胞中，在其中它们用于促进二糖酶如麦芽糖酶，蔗糖酶和乳糖酶的产生和活性。这些酶促进由更复杂的碳水化合物或蔗糖和乳糖降解成单糖或单糖以从肠道吸收而引起的二糖水解。

3. 发明申请

WO1993010777A1 COMPOSITION AND METHOD FOR REDUCING FREE RADICAL CELLULAR OXIDATIVE STRESS IN WARM-BLOODED ANIMALS 审中-公开
标题翻译：用于降低温血动物中的自由放射性细胞氧化应激的组合物和方法
公开(公告)号：WO1993010777A1
公开(公告)日：1993-06-10
申请号：PCT/US1992009587
申请日：1992-11-05
申请人： ALBION INTERNATIONAL, INC.
发明人： ALBION INTERNATIONAL, INC. , ASHMEAD, H., DeWayne , ASHMEAD, Harvey, H. , JEPPSON, Robert, B.
IPC分类号： A61K31/28
CPC分类号： A61K31/315 , A61K31/28 , A61K31/295 , A61K31/30 , A61K33/04 , A61K2300/00
摘要： A method for reducing free radical cellular oxidative stress in warm-blooded animals showing symptoms of free radical toxicity is disclosed. The method comprises the steps of confirming the presence of a free radical cellular oxidative stress in the animal; determining which trace minerals selected from the group consisting of copper, zinc, iron and manganese, with or without optional amounts of selenium are needed to strengthen and maintain the functioning of enzymes which relate to oxidative bursts in neutrophils and macrophages in the animal; providing a composition containing effective amounts of at least one of the minerals copper, zinc, iron and manganese in the form of an amino acid chelate having a ligand to mineral ratio of at least 1:1, a molecular weight of no more than 1500 daltons and a stability constant of between about 10 and 10 , with or without optional amounts of selenium which may be present either in amino acid chelated form or as inorganic selenium, and administering the composition to the animal, preferably in oral form. The presence of free radical cellular oxidative stress is preferably confirmed by direct assay of the activity of oxidative enzymes selected from the group consisting of CuZnSOD, glutathione peroxidase and catalase.
摘要翻译：公开了一种降低自由基毒性症状的温血动物中自由基细胞氧化应激的方法。该方法包括确认动物中存在自由基细胞氧化应激的步骤; 需要选择含有或不含有任选量的硒的铜，锌，铁和锰组成的微量矿物质以加强和维持与动物嗜中性粒细胞和巨噬细胞中的氧化性爆发相关的酶的功能; 提供含有有效量的至少一种矿物铜，锌，铁和锰中的至少一种形式的氨基酸螯合物，其配体的矿物质比例至少为1:1，分子量不超过1500道尔顿和约10 6至10 16的稳定常数，有或没有任选量的可以以氨基酸螯合形式存在或作为无机硒存在的硒，并将组合物施用于动物，优选口服形成。自由基细胞氧化应激的存在优选通过直接测定选自CuZnSOD，谷胱甘肽过氧化物酶和过氧化氢酶的氧化酶的活性来证实。

4. 发明申请

WO2003016332A2 ENHANCING SOLUBILITY OF IRON AMINO ACID CHELATES AND IRON PROTEINATES 审中-公开
标题翻译：提高铁胺酸钙和铁蛋白的溶解度
公开(公告)号：WO2003016332A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/026118
申请日：2002-08-15
申请人： ALBION INTERNATIONAL, INC.
发明人： ERICSON, Clayton , ASHMEAD, H., DeWayne
IPC分类号： C07K
CPC分类号： C07C227/44 , C07C229/76
摘要： A method of enhancing the solubility of iron amino acid chelates and iron proteinates is disclosed. This is accomplished by mixing an effective amount of an organic acid solubilizing agent into existing iron amino acid chelates or iron proteinates. The iron amino acid chelates and iron proteinates may have a ligand to metal molar ratio from about 1:1 to 4:1, preferably 2:1 to 3:1.
摘要翻译：公开了提高铁氨基酸螯合物和铁蛋白质的溶解度的方法。这通过将有效量的有机酸增溶剂混合到现有的铁氨基酸螯合物或铁蛋白质中来实现。铁氨基酸螯合物和铁蛋白质可以具有约1:1至4:1，优选为2:1至3:1的配体与金属的摩尔比。

5. 发明申请

WO1996006101A1 AMINO ACID CHELATES HAVING IMPROVED PALATABILITY 审中-公开
标题翻译：具有改进的可食性的氨基酸螯合物
公开(公告)号：WO1996006101A1
公开(公告)日：1996-02-29
申请号：PCT/US1995010568
申请日：1995-08-21
申请人： ALBION INTERNATIONAL, INC.
发明人： ALBION INTERNATIONAL, INC. , PEDERSEN, Mark , ASHMEAD, H., DeWayne
IPC分类号： C07F13/00
CPC分类号： C07F15/065 , C07C229/76 , C07F1/005 , C07F3/003 , C07F11/005 , C07F13/005 , C07F15/025
摘要： A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the central metal ion while, at the same time, maintaining charge balance in the chelate molecule. There must be at least one ligand of the polydentate type which must be an alpha -amino acid with the further proviso that any unidentate or polydentate ligand(s) must be charge balanced organic ligands. Charge balancing may be accomplished by means of an organic acid and dicarboxylic, hydroxycarboxylic, hydroxydicarboxylic or hydroxytricarboxylic acids in particular, which maintains the chelate molecule as an optimum pH for purposes of stability and palatability.
摘要翻译：公开了一种用于给予人和其他温血动物的可口的金属氨基酸螯合物，其中存在足够的配体以提供等于中心金属离子的配位数的离子和配位共价键，同时保持电荷平衡在螯合分子中。必须有至少一种多齿类型的配体，其必须是α-氨基酸，进一步的条件是任何单齿或多齿配体必须是电荷平衡的有机配体。电荷平衡可以通过有机酸和二羧酸，羟基羧酸，羟基二羧酸或羟基三羧酸来实现，其特征在于，为了稳定性和适口性，将螯合分子保持为最佳pH。

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