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1. 发明申请

WO2007116336A9 METHOD AND APPARATUS FOR MONITORING ALTERATION OF FLOW CHARACTERISTICS IN A LIQUID SAMPLE 审中-公开
标题翻译：用于监测液体样品中流动特性变化的方法和装置
公开(公告)号：WO2007116336A9
公开(公告)日：2008-11-27
申请号：PCT/IB2007051129
申请日：2007-03-29
申请人： AGAMATRIX INC , HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
发明人： HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
IPC分类号： G01N33/49
CPC分类号： G01N27/26 , G01N33/4905 , G01N33/86
摘要： A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.
摘要翻译：用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。本发明的装置与连接到第一和第二电极的装置结合使用，用于测量第一和第二电极之间的电流。观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

2. 发明申请

WO2005022143A3 METHOD AND APPARATUS FOR ASSAY OF ELECTROCHEMICAL PROPERTIES 审中-公开
标题翻译：电化学性质测定方法及装置
公开(公告)号：WO2005022143A3
公开(公告)日：2005-05-12
申请号：PCT/US2004027441
申请日：2004-08-23
申请人： AGAMATRIX INC , IYENGAR SRIDHAR G , HARDING IAN
发明人： IYENGAR SRIDHAR G , HARDING IAN
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/416 , G01N33/487 , G01N27/48
CPC分类号： G01N27/26 , A61B5/14532 , A61B5/1486 , A61B5/1495 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3274 , G01N27/4168
摘要： The presence of a select analyte in the sample is evaluated in an an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.
摘要翻译：在使用导电细胞型装置的电化学系统中评价样品中选择的分析物的存在。在电池的两个电极之间产生电势或电流，足以使分析物或分析物检测氧化还原系统中的介质发生氧化或还原，由此形成两个电极之间的分析物或介体的化学势梯度梯度建立后，中止施加的电位或电流，并从化学势梯度的弛豫中获得与分析物无关的信号。分析物独立信号用于校正在施加电位或电流期间获得的分析物依赖信号。这种校正允许改进分析物浓度的测量，因为它校正了器件特异性和测试特定因素，例如分析物和/或介体的传输（迁移率），有效电极面积和电极间距（以及结果，样品体积），不需要单独的校准值。可以使用手持式仪表中的一次性测试条进行分析，例如进行葡萄糖测试。

3. 发明申请

WO2008007277A3 DETECTION OF ANALYTES IN A DUAL-MEDIATOR ELECTROCHEMICAL TEST STRIP 审中-公开
标题翻译：双介质电化学测试条中分析物的检测
公开(公告)号：WO2008007277A3
公开(公告)日：2008-05-15
申请号：PCT/IB2007052474
申请日：2007-06-26
申请人： AGAMATRIX INC , HARDING IAN , IYENGAR SRIDHAR G
发明人： HARDING IAN , IYENGAR SRIDHAR G
IPC分类号： C12Q1/26
CPC分类号： C12Q1/004 , C12Q1/006 , G01N27/3271
摘要： Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer electrons between the enzyme and the electrodes. The first electron transfer agent is a mediator that interacts with the enzyme after it has acted on the analyte to regenerate enzyme in its active form. The second electron transfer agent is a shuttle that interacts with the electrodes and optionally the mediator. The oxidation and reduction of the shuttle serves as the major source of current that is measured as an indication of analyte.
摘要翻译：使用多种电子转移试剂例如两种电子转移试剂来完成样品中诸如葡萄糖的分析物的确定，所述电子转移试剂一起工作以在酶和电极之间转移电子。第一种电子转移剂是一种介体，它在酶作用于分析物后以其活性形式再生酶时与酶相互作用。第二种电子转移剂是与电极和任选的介体相互作用的梭。梭子的氧化和还原作为测量电流的主要来源，作为分析物的指示。

4. 发明申请

WO2005119234B1 MEASURING DEVICE AND METHODS FOR USE THEREWITH 审中-公开
标题翻译：测量装置及其使用方法
公开(公告)号：WO2005119234B1
公开(公告)日：2006-10-19
申请号：PCT/IB2005051641
申请日：2005-05-20
申请人： AGAMATRIX INC , FLAHERTY JOSEPH , HARDING IAN , HUANG EILEEN , IYENGAR SRIDHAR G , VU SONNY , WEI BAOGUO , DIAMOND STEVEN , FOREST MARTIN
发明人： FLAHERTY JOSEPH , HARDING IAN , HUANG EILEEN , IYENGAR SRIDHAR G , VU SONNY , WEI BAOGUO , DIAMOND STEVEN , FOREST MARTIN
IPC分类号： G01N33/487 , G01N27/00 , G01N27/28 , G11C7/00
CPC分类号： G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要： The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood. In further embodiments the apparatus comprises a housing (70) and an elongated test strip electrode (90), which may take the firm of an optical waveguide. An LED (91) provides illumination and the results of the test are displayed in bar graph form on LCD Display (71).
摘要翻译：在电流测量和电位测量之间切换的能力在执行未知数的分析方面提供了极大的灵活性。装置和方法可以提供这种切换以从电化学电池收集数据。细胞可以含有用于测量人血液中的葡萄糖的试剂。在另外的实施例中，该装置包括壳体（70）和细长的测试条电极（90），其可以占据光波导的固定。 LED（91）提供照明，测试结果以液晶显示器（71）的条形图形式显示。

5. 发明申请

WO2005022143B1 METHOD AND APPARATUS FOR ASSAY OF ELECTROCHEMICAL PROPERTIES 审中-公开
标题翻译：电化学性质测定方法及装置
公开(公告)号：WO2005022143B1
公开(公告)日：2005-11-10
申请号：PCT/US2004027441
申请日：2004-08-23
申请人： AGAMATRIX INC , IYENGAR SRIDHAR G , HARDING IAN
发明人： IYENGAR SRIDHAR G , HARDING IAN
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/416 , G01N33/487 , G01N27/48
CPC分类号： G01N27/26 , A61B5/14532 , A61B5/1486 , A61B5/1495 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3274 , G01N27/4168
摘要： The presence of a select analyte in the sample is evaluated in an electrochemical system using a conduction cell-type apparatus. A potential or current is generated between the two electrodes of the cell sufficient to bring about oxidation or reduction of the analyte or of a mediator in an analyte-detection redox system, thereby forming a chemical potential gradient of the analyte or mediator between the two electrodes. After the gradient is established, the applied potential or current is discontinued and an analyte-independent signal is obtained from the relaxation of the chemical potential gradient. The analyte-independent signal is used to correct the analyte-dependent signal obtained during application of the potential or current. This correction allows an improved measurement of analyte concentration because it corrects for device-specific and test specific factors such as transport (mobility) of analyte and/or mediator, effective electrode area, and electrode spacing (and as a result, sample volume), without need for separate calibration values. The analysis can be performed using disposable test strips in a hand held meter, for example for glucose testing.
摘要翻译：在使用导电细胞型装置的电化学系统中评估样品中选择分析物的存在。在电池的两个电极之间产生电势或电流，足以使分析物或分析物检测氧化还原系统中的介质发生氧化或还原，由此形成两个电极之间的分析物或介体的化学势梯度。梯度建立后，中止施加的电位或电流，并从化学势梯度的弛豫中获得与分析物无关的信号。分析物独立信号用于校正在施加电位或电流期间获得的分析物依赖信号。这种校正允许改进分析物浓度的测量，因为它校正了器件特异性和测试特定因素，例如分析物和/或介体的传输（迁移率），有效电极面积和电极间距（以及结果，样品体积），不需要单独的校准值。可以使用手持式仪表中的一次性测试条进行分析，例如进行葡萄糖测试。

6. 发明申请

WO2007116336A2 METHOD AND APPARATUS FOR MONITORING ALTERATION OF FLOW CHARACTERISTICS IN A LIQUID SAMPLE 审中-公开
标题翻译：用于监测液体样品中流动特性改变的方法和设备
公开(公告)号：WO2007116336A2
公开(公告)日：2007-10-18
申请号：PCT/IB2007051129
申请日：2007-03-29
申请人： AGAMATRIX INC , HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
发明人： HARDING IAN , IYENGAR SRIDHAR G , NGUYEN HA , WILLIAMS RICHARD
IPC分类号： G01N33/49
CPC分类号： G01N27/26 , G01N33/4905 , G01N33/86
摘要： A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.
摘要翻译：用于测量凝血时间的装置由第一基底形成; 第二衬底; 设置在所述第一和第二基板之间的间隔层，所述间隔层具有形成在其中的开口，所述开口限定样品接收室，排气式吸收室和形成用于在所述样品接收室和所述吸收室之间的液体移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在第二基板上的第二电极，所述第二电极通过间隔层中的第二开口暴露在储存部分中。本发明的装置与连接到第一和第二电极的设备结合使用，用于测量第一和第二电极之间的电流。观察到的电流的变化指示通过装置的流动，并且停止流动指示凝结。

7. 发明申请

WO2005119234A2 MEASURING DEVICE AND METHODS FOR USE THEREWITH 审中-公开
标题翻译：测量装置及其使用方法
公开(公告)号：WO2005119234A2
公开(公告)日：2005-12-15
申请号：PCT/IB2005051641
申请日：2005-05-20
申请人： AGAMATRIX INC , FLAHERTY JOSEPH , HARDING IAN , HUANG EILEEN , IYENGAR SRIDHAR G , VU SONNY , WEI BAOGUO , DIAMOND STEVEN , FOREST MARTIN
发明人： FLAHERTY JOSEPH , HARDING IAN , HUANG EILEEN , IYENGAR SRIDHAR G , VU SONNY , WEI BAOGUO , DIAMOND STEVEN , FOREST MARTIN
IPC分类号： G01N27/00 , G01N33/487 , G11C7/00
CPC分类号： G01N27/28 , G01N27/3271 , G01N27/3272 , G01N27/3273 , G01N27/403 , G01N33/50
摘要： The ability to switch at will between amperometric measurements and potentiometric measurements provides great flexibility in performing analyses of unknowns. Apparatus and methods can provide such switching to collect data from an electrochemical cell. The cell may contain a reagent disposed to measure glucose in human blood.
摘要翻译：在电流测量和电位测量之间切换的能力在执行未知数的分析方面提供了极大的灵活性。装置和方法可以提供这种切换以从电化学电池收集数据。细胞可以含有用于测量人血液中的葡萄糖的试剂。

8. 发明申请

WO03060154A2 METHOD AND APPARATUS FOR PROCESSING ELECTROCHEMICAL SIGNALS 审中-公开
标题翻译：用于处理电化学信号的方法和装置
公开(公告)号：WO03060154A2
公开(公告)日：2003-07-24
申请号：PCT/US0301113
申请日：2003-01-15
申请人： AGAMATRIX INC , IYENGAR SRIDHAR G , HAAS DANIEL , BOLON CRAIG
发明人： IYENGAR SRIDHAR G , HAAS DANIEL , BOLON CRAIG
IPC分类号： G01N27/26 , G01N27/416 , G01N27/48 , G01N27/49 , C12Q1/00
CPC分类号： G01N27/3274
摘要： Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.
摘要翻译：本文提供的系统和方法用于通过数字信号处理技术提高传感器的选择性和生产率。根据一个说明性实施例，在用于监测具有干扰分析物的混合样品中的选择分析物的电化学方法中，提供了一种改进，其包括向样品施加大幅度电位刺激波形以产生非线性电流信号; 以及通过矢量投影方法解析来自所生成的信号中的选择分析物的信号贡献，所述分析物向量包括用于选择分析物的参考电流信号的一个或多个频率的一个或多个傅立叶系数的多个实部和虚部。

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