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1. 发明申请

WO2007100464A3 BONE MARROW ASPIRATION DEVICE 审中-公开
标题翻译：骨髓吸引装置
公开(公告)号：WO2007100464A3
公开(公告)日：2008-02-21
申请号：PCT/US2007003465
申请日：2007-02-09
申请人： ADVANCED CARDIOVASCULAR SYSTEM , COX DANIEL L , MICHAL EUGENE T , AINSWORTH ROBERT D , CHAN GREGORY W , LEE JEONG S , CHIN ALBERT K , WILLIS GEOFF , YIP PHILIP S
发明人： COX DANIEL L , MICHAL EUGENE T , AINSWORTH ROBERT D , CHAN GREGORY W , LEE JEONG S , CHIN ALBERT K , WILLIS GEOFF , YIP PHILIP S
IPC分类号： A61B10/02
CPC分类号： A61B10/025 , A61B10/0283 , A61B34/20 , A61B2010/0208 , A61B2010/0258
摘要： A bone marrow aspiration device is described. In one embodiment, the bone marrow aspiration device includes a central body portion having a proximal end and a distal end, and an outer shaft portion coupled to the distal end of the central body portion. The outer shaft portion also has a distal opening. A first lumen is formed by the central body portion and the outer shaft portion, and the first lumen extends from the proximal end to the distal opening. An aspiration needle is disposed within the first lumen. The aspiration needle has a substantially linear configuration when positioned within the first lumen, and a substantially curved configuration when extended from die distal opening. The aspiration needle is adapted to aspirate liquid bone marrow from a first region of a bone cavity.
摘要翻译：描述骨髓抽吸装置。在一个实施例中，骨髓抽吸装置包括具有近端和远端的中心主体部分，以及联接到中心主体部分的远端的外轴部分。外轴部分还具有远端开口。第一管腔由中心主体部分和外轴部分形成，并且第一内腔从近端延伸到远端开口。抽吸针设置在第一管腔内。当定位在第一内腔内时，抽吸针具有基本上线性的构型，并且当从模具远端开口延伸时具有基本弯曲的构造。抽吸针适于从骨腔的第一区域吸出液体骨髓。

2. 发明申请

WO2007111908A2 METHOD AND APPARATUS FOR TREATING VULNERABLE PLAQUE 审中-公开
标题翻译：用于处理易损碎屑的方法和装置
公开(公告)号：WO2007111908A2
公开(公告)日：2007-10-04
申请号：PCT/US2007007040
申请日：2007-03-20
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MANDRUSOV EVGENIA , MICHAL EUGENE T , CHOW MINA , HOSSAINY SYED FAIYEZ AHMED , KILPATRICK DEBORAH , SIMHAMBHATLA MURTHY , CHIU JESSICA G , CLAUDE CHARLES D , WEBLER WILLIAM E
发明人： MANDRUSOV EVGENIA , MICHAL EUGENE T , CHOW MINA , HOSSAINY SYED FAIYEZ AHMED , KILPATRICK DEBORAH , SIMHAMBHATLA MURTHY , CHIU JESSICA G , CLAUDE CHARLES D , WEBLER WILLIAM E
IPC分类号： A61B17/22 , A61F2/82 , A61F2/86 , A61M29/02
CPC分类号： A61F2/07 , A61B5/02007 , A61B2017/22077 , A61F2/82 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/077 , A61F2220/0058 , A61F2250/0067 , A61M1/3613 , A61M25/104 , A61M2025/105 , A61M2025/1056 , A61M2025/107 , A61M2025/1086 , A61M2025/1095
摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.
摘要翻译：描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

3. 发明申请

WO2006076121A3 TISSUE REGENERATION 审中-公开
标题翻译：组织再生
公开(公告)号：WO2006076121A3
公开(公告)日：2007-01-11
申请号：PCT/US2005045627
申请日：2005-12-16
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MANDRUSOV EVGENIA , CLAUDE CHARLES , MICHAL EUGENE T
发明人： MANDRUSOV EVGENIA , CLAUDE CHARLES , MICHAL EUGENE T
IPC分类号： A61L27/38 , A61L27/54
CPC分类号： A61L27/3873 , A61L27/54 , A61L2300/414 , A61L2300/602 , A61L2300/622
摘要： A method including positioning a delivery device at a location in a vessel within a mammalian body, introducing a first treatment agent including a cellular component through the delivery device, and introducing a different second treatment agent disposed in a carrier through the delivery device. A method including identifying an infarct region within myocardial tissue and a border region of perfused tissue adjacent the infarct region, introducing a treatment agent including a cellular component to the border region, and introducing a plurality of microparticles to the infarct region. A kit including a treatment agent including a cellular component in a form suitable for percutaneous delivery, and a separate amount of a plurality of microparticles in a form suitable for percutaneous delivery.
摘要翻译：一种方法，包括将输送装置定位在哺乳动物体内的血管中的位置，通过输送装置引入包括细胞组分的第一处理剂，以及通过输送装置引入设置在载体中的不同的第二处理剂。一种方法，包括鉴定心肌组织内的梗死区域和与梗塞区域相邻的灌注组织的边界区域，将包括细胞组分的治疗剂引入边界区域，以及将多个微粒引入梗塞区域。一种试剂盒，其包括包含适于经皮递送形式的细胞成分的处理剂，以及适合于经皮递送形式的分开量的多个微粒。

4. 发明申请

WO2005011770A3 BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES 审中-公开
标题翻译：用于可植入设备的生物吸收性涂料
公开(公告)号：WO2005011770A3
公开(公告)日：2005-08-18
申请号：PCT/US2004022018
申请日：2004-07-08
申请人： ADVANCED CARDIOVASCULAR SYSTEM , HOSSAINY SYED F A , MICHAL EUGENE T , TANG YIWEN
发明人： HOSSAINY SYED F A , MICHAL EUGENE T , TANG YIWEN
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。生物活性剂可以与嵌段共聚物缀合。

5. 发明申请

WO2007112048A3 METHODS AND APPARATUSES FOR COATING A LESION 审中-公开
标题翻译：用于涂层的方法和装置
公开(公告)号：WO2007112048A3
公开(公告)日：2008-08-14
申请号：PCT/US2007007343
申请日：2007-03-22
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MICHAL EUGENE T , TROLLSAS MIKAEL , TANG EVELEEN , GLAUSER THIERRY , HOSSAINY SYED FAIYEZ AHMED
发明人： MICHAL EUGENE T , TROLLSAS MIKAEL , TANG EVELEEN , GLAUSER THIERRY , HOSSAINY SYED FAIYEZ AHMED
IPC分类号： A61L31/12 , A61L27/44 , A61L27/50 , A61L31/14 , C07K14/78
CPC分类号： A61L31/043 , A61L2430/36
摘要： A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
摘要翻译：描述了一种处理容器区域的方法和装置。将蛋白质弹性蛋白基聚合物从装置中释放出来，作为主要疗法或辅助治疗来涂覆血管衬里，随着具有或不具有药物涂层的支架的递送和展开。基于蛋白质弹性蛋白的聚合物可以包括具有弹性蛋白五肽作为侧翼嵌段的三嵌段结构和作为中间嵌段的五肽的亲水性变体。可以改变侧面和中间嵌段以改变聚合物的结构和化学性质。特别地，基于蛋白质弹性蛋白的聚合物适于执行控制治疗剂释放，刺激内皮细胞生长和稳定易损斑块中的至少一种，以防止脆弱斑块的破裂。

6. 发明申请

WO2007100475A2 HYDROGEL BIOSCAFFOLDINGS AND BIOMEDICAL DEVICE COATINGS 审中-公开
标题翻译： HYDROGEL生物医药和生物医疗器械涂料
公开(公告)号：WO2007100475A2
公开(公告)日：2007-09-07
申请号：PCT/US2007003614
申请日：2007-02-09
申请人： ADVANCED CARDIOVASCULAR SYSTEM , MICHAL EUGENE T
发明人： MICHAL EUGENE T
IPC分类号： A61L27/38 , A61L27/26 , A61L27/52 , A61L27/54
CPC分类号： A61L27/52 , A61L27/20 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/3826 , A61L27/383 , A61L27/3834 , A61L27/3873 , C08L89/06 , C08L5/04
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1-lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1-lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PRl 1, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.
摘要翻译：描述了由水凝胶形成的生物支架，其通过迈克尔加成反应或通过氧化过程形成的二硫键在心脏（心肌）的梗死区域原位交联。所描述的每个生物支架包括透明质酸作为水凝胶组分之一，另一组分选自胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸和纤维蛋白。生物支架还可包括藻酸盐组分。生物支架可具有诸如血管生成因子和结合于胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸或纤维蛋白原水凝胶组分的干细胞归巢因子的生物功能组。特别地，生物功能基团可以是PR11，PR39，VEGF，bFGF，聚精氨酸/ DNA质粒复合物或DNA /聚乙烯亚胺（PEI）复合物。此外，水凝胶组分可以与含有干细胞归巢因子的干细胞和微球一起注入梗塞区域。生物支架可以形成在支架或心脏医疗装置上。

7. 发明申请

WO2010030995A2 LOCAL DELIVERY OF WATER-SOLUBLE OR WATER-INSOLUBLE THERAPEUTIC AGENTS TO THE SURFACE BODY LUMENS 审中-公开
标题翻译：将水溶性或水不溶性治疗剂局部输送到表面体液
公开(公告)号：WO2010030995A2
公开(公告)日：2010-03-18
申请号：PCT/US2009056842
申请日：2009-09-14
申请人： CV INGENUITY , MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
发明人： MICHAL EUGENE T , LERNER DANIEL J , POLLMAN MATTHEW J
IPC分类号： A61K47/02 , A61F2/958 , A61K31/337 , A61K31/4353 , A61K31/436 , A61L31/08 , A61L31/16
CPC分类号： A61L29/106 , A61K47/02 , A61L29/10 , A61L29/16 , A61L2300/114 , A61L2300/216 , A61L2300/41 , A61L2300/416
摘要： A method and device for local delivery of water-soluble or water-insoluble therapeutic agents to the surface of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with an amphiphilic polymer coating comprising a therapeutic agent and an amphiphilic polymer or co-polymer. The medical disposable device is inserted into a body lumen, and expanded to contact the amphiphilic polymer coating against the body lumen. The total solubility of the polymer or co-polymer in vivo prevents any embolic hazard associated with the amphiphilic polymer coating.
摘要翻译：公开了一种将水溶性或水不溶性治疗剂局部递送到正常或患病体腔表面的方法和装置。医疗一次性装置（例如球囊导管的球囊）的可膨胀结构用包含治疗剂和两亲性聚合物或共聚物的两亲性聚合物涂层涂覆。将医疗一次性装置插入体腔中，并膨胀以使两亲性聚合物涂层抵靠体腔接触。聚合物或共聚物在体内的总溶解度可防止与两亲性聚合物涂层相关的任何栓塞危险。

8. 发明申请

WO2008008139A2 METHODS AND DEVICES FOR FORMING TREATMENT AGENT CARRIERS 审中-公开
标题翻译：用于形成处理剂载体的方法和设备
公开(公告)号：WO2008008139A2
公开(公告)日：2008-01-17
申请号：PCT/US2007013315
申请日：2007-06-05
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , BASU SHUBHAYU , MICHAL EUGENE T
发明人： BASU SHUBHAYU , MICHAL EUGENE T
IPC分类号： A61K9/14
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有生物可降解聚合物，溶剂和处理剂的溶液通过电动喷嘴以形成包封处理剂的颗粒。从电动喷嘴喷出的颗粒可能暴露在与喷嘴相反的电荷下。颗粒可以沉积在包含液相的收集组件中。另一种方法包括将生物可降解聚合物，溶剂和处理剂混合以形成溶液，将溶液电沉积成颗粒形式，其中颗粒将处理剂包封在包含液相的收集组件中，并将颗粒与生物可蚀性材料描述了能够形成凝胶的能力。还公开了具有电动喷嘴，具有与喷嘴的电荷相反的电荷的接地电极和包含液相的收集组件的设备。

9. 发明申请

WO2008089452A3 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
标题翻译：改善心肌梗塞扩张的方法
公开(公告)号：WO2008089452A3
公开(公告)日：2009-08-06
申请号：PCT/US2008051505
申请日：2008-01-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
发明人： MICHAL EUGENE T , BASU SHUBHAYU , SHEEHY ALEXANDER J , SPINALE FRANCIS G , MUKHERJEE RUPAK
IPC分类号： A61L26/00
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
摘要翻译：可以在足以引起心肌梗死扩张速率衰减的后心肌梗死区域中形成生物支架。在心肌梗死后区域可进一步形成生物支架以引起左后壁厚度的增加。凝胶或生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分）的至少两种不同的双组分凝胶化体系以形成第二混合物。

10. 发明申请

WO2008013743A3 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A3
公开(公告)日：2008-07-03
申请号：PCT/US2007016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
发明人： MICHAL EUGENE T , CALLAS PETER L , LUDWIG FLORIAN N
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，该方法包括将导管组件引入血管内腔的阻塞区域并用导管组件重新阻塞阻塞区域。在再通之前或再通过期间，可以通过导管组件将治疗剂递送至受阻区域下游的脉管区域。治疗剂可能具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且利用医疗装置对阻塞区域进行再通。处理剂可被输送至受阻区域下游的容器区域。治疗剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其他方法中，可将输送套管引入闭塞血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤性质的治疗剂可通过输送套管输送至未灌注区域。在递送治疗剂之后，可以通过将血管成形术装置推进到闭塞的血管中来使闭塞的血管再通。

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