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1. 发明申请

WO1994002163A1 NEUROMEDIN B RECEPTOR ANTAGONISTS 审中-公开
标题翻译：神经母细胞B受体拮抗剂
公开(公告)号：WO1994002163A1
公开(公告)日：1994-02-03
申请号：PCT/US1993007036
申请日：1993-07-27
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BIOMEASURE, INC.
发明人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BIOMEASURE, INC. , COY, David, H. , TAYLOR, John, E.
IPC分类号： A61K37/00
CPC分类号： C07K14/6555 , A61K38/31
摘要： A method of selectively inhibiting biochemical activity of cells induced by neuromedin B. The method includes the step of contacting cells which contain neuromedin B receptor with a cyclic octapeptide, D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2, or an analog thereof.
摘要翻译：一种选择性抑制由神经介肽B诱导的细胞的生化活性的方法。该方法包括使含有神经介肽B受体的细胞与环状八肽D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys- Nal-NH 2或其类似物。

2. 发明申请

WO1989004666A1 TREATMENT OF CANCER WITH SOMATOSTATIN AND ANALOGS THEREOF 审中-公开
标题翻译：用SOMATOSTATIN治疗癌症及其类似物
公开(公告)号：WO1989004666A1
公开(公告)日：1989-06-01
申请号：PCT/US1988004126
申请日：1988-11-18
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
发明人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , TAYLOR, John, E. , BOGDEN, Arthur, E. , MOREAU, Jacques-Pierre , COY, David, H.
IPC分类号： A61K37/24
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 mug/kg/day.

3. 发明申请

WO1994011018A1 OPIOID PEPTIDES 审中-公开
公开(公告)号：WO1994011018A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010711
申请日：1993-11-04
申请人： BIOMEASURE, INC.
发明人： BIOMEASURE, INC. , KIM, Sun, Hyuk , MOREAU, Jacques-Pierre , TAYLOR, John, E.
IPC分类号： A61K37/02
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/0812 , C07K5/1016 , Y02A50/475
摘要： Opioid peptides including those of formula (I), in which A1 is the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, azatyrosine, and 2,6-dimethyltyrosine; A2 is the identifying group of an amino acid selected from D-Ala and D-Arg; A3 is H, or the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine and 3,4-dimethoxyphenylalanine, A4 is H, cyclohexylmethyl, the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, Phe, and substituted Phe with its benzene ring substituted by halogen, NO2, OH, or CH3; A5 is the identifying group of a D- or L-amino acid selected from Leu, Nle, Lys, Met and Met(O), or is deleted together with R4-CH attached thereto; each R1 and R2 is -H, -C(NH2) = NH, or C1-12 alkyl; R3 is -(a) or (b); R4 is (c); (d), or (e); and R5 is -(CH2)n+1OH, (f), or (g); wherein m is 0-6, n is 0-6, and X is H, C1-12 alkyl, C6-12 aryl, C7-18 aralkyl, C7-18 alkaryl, C7-18 alkaryl, C6-17 pyridylalkyl, or C6-17 alkylpyridyl; provided that when one of R1 and R2 is -C(NH2) = NH, the other must be H; or a pharmaceutically acceptable salt thereof.
摘要翻译：阿片肽包括式（I）的那些，其中A1是选自3,4-二羟基苯丙氨酸，3,4-二甲氧基苯丙氨酸，氨甲酰酪氨酸和2,6-二甲基酪氨酸的氨基酸的鉴定基团; A2是选自D-Ala和D-Arg的氨基酸的鉴定基团; A3是H，或选自3,4-二羟基苯丙氨酸和3,4-二甲氧基苯丙氨酸的氨基酸的鉴定基团，A4是H，环己基甲基，选自3,4-二羟基苯丙氨酸，3,4 二甲氧基苯丙氨酸，Phe和取代的Phe，其苯环被卤素，NO 2，OH或CH 3取代; A5是选自Leu，Nle，Lys，Met和Met（O）的D-或L-氨基酸的鉴定基团，或与其连接的R4-CH一起缺失; 每个R 1和R 2是-H，-C（NH 2）= NH或C 1-12烷基; R3为 - （a）或（b）; R4是（c）; （d）或（e）; 并且R 5是 - （CH 2）n + 1OH，（f）或（g）; 其中m为0-6，n为0-6，X为H，C1-12烷基，C6-12芳基，C7-18芳烷基，C7-18烷芳基，C7-18烷芳基，C6-17吡啶基烷基或C6 -17烷基吡啶基; 条件是当R 1和R 2中的一个是-C（NH 2）= NH时，另一个必须是H; 或其药学上可接受的盐。

4. 发明申请

WO1995004752A1 THERAPEUTIC PEPTIDE DERIVATIVES 审中-公开
标题翻译：治疗肽衍生物
公开(公告)号：WO1995004752A1
公开(公告)日：1995-02-16
申请号：PCT/US1994008875
申请日：1994-08-08
申请人： BIOMEASURE, INC.
发明人： BIOMEASURE, INC. , KIM, Sun, Hyuk , DONG, Zhengxin , TAYLOR, John, E. , MOREAU, Sylviane , KEYES, Susan, Riley
IPC分类号： C07K05/04
CPC分类号： C07K7/086 , A61K38/00 , C07K14/6555
摘要： Peptide derivatives containing one or more substituents separately linked by an amide, amino or sulfonamide bond to an amino group on either the N-terminal end or side chain of a biologically active peptide moiety. The peptide derivatives have relatively enhanced biological activity when compared to the corresponding peptide alone.
摘要翻译：含有一个或多个取代基的肽衍生物通过酰胺，氨基或磺酰胺键与生物活性肽部分的N-末端或侧链上的氨基分别连接。当与单独的相应肽相比时，肽衍生物具有相对增强的生物活性。

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