专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005007601A2 SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：用作病毒复制抑制剂的取代的芳香硫脲衍生物
公开(公告)号：WO2005007601A2
公开(公告)日：2005-01-27
申请号：PCT/US2004/022599
申请日：2004-07-08
申请人： ACHILLION PHARMACEUTICALS, INC. , PHADKE, Avinash , QUINN, Jesse , OHKANDA, Junko , THURKAUF, Andrew , SHEN, Yiping , LIU, Cuixian , CHEN, Dawei , LI, Shouming
发明人： PHADKE, Avinash , QUINN, Jesse , OHKANDA, Junko , THURKAUF, Andrew , SHEN, Yiping , LIU, Cuixian , CHEN, Dawei , LI, Shouming
IPC分类号： C07C15/00
CPC分类号： C07D211/64 , C07C335/12 , C07C335/14 , C07C335/16 , C07C335/18 , C07C335/20 , C07C335/22 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/44 , C07D211/14 , C07D211/62 , C07D215/06 , C07D217/04 , C07D295/135 , C07D317/66
摘要： Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein.
摘要翻译：本文提供了式I的取代的芳基硫脲化合物和可用作抗病毒剂的此类化合物的药学上可接受的盐。本文公开的某些取代的芳基硫脲是病毒复制的有效和/或选择性抑制剂，特别是丙型肝炎病毒复制。本文提供了含有一种或多种取代的芳基硫脲化合物和一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。这种药物组合物可以含有取代的芳基硫脲作为唯一的活性剂，或者可以含有取代的芳基硫脲衍生物和一种或多种其它药物活性剂的组合。本文还提供了治疗哺乳动物的丙型肝炎病毒感染的方法。

2. 发明申请

WO2006083271A3 SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION 审中-公开
公开(公告)号：WO2006083271A3
公开(公告)日：2006-08-10
申请号：PCT/US2005/017308
申请日：2005-05-17
申请人： ACHILLION PHARMACEUTICALS, INC. , PHADKE, Avinash , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , LI, Shouming , OHKANDA, Junko
发明人： PHADKE, Avinash , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , LI, Shouming , OHKANDA, Junko
IPC分类号： C07C335/26 , A61K31/17 , A61P31/12 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/78 , C07D213/56 , C07D213/82 , C07D215/54 , C07D231/14 , C07D233/54 , C07D233/90 , C07D237/24
摘要： The invention provides certain acylthiourea derivatives and pharmaceutically acceptable salts thereof. These compounds possess potent antiviral activity. The invention particularly provides compounds that are potent and/or selective inhibitors of hepatitis C virus replication. The invention also provides pharmaceutical compositions containing a compound of the invention and at least one pharmaceutically acceptable excipient and packaged pharmaceutical compositions comprising such a pharmaceutical composition in a container together with instructions for using the composition to treat a viral infection. The invention further comprises a method of inhibiting hepatitis C virus replication by contacting a compound of the invention with a cell that is infected by hepatitis C virus and a method of treating or preventing hepatitis C viral infection by administering an amount of a compound of the invention to a subject in need thereof.

3. 发明申请

WO2004046095A1 SUBSTITUTED ARYL THIOUREAS AND RELEATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION 审中-公开
标题翻译：取代的芳香化合物和相关化合物; VIRAL REPLICATION的抑制剂
公开(公告)号：WO2004046095A1
公开(公告)日：2004-06-03
申请号：PCT/US2003/036809
申请日：2003-11-18
申请人： ACHILLION PHARMACEUTICALS, INC. , CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , PHADKE, Avinash , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , OHKANDA, Junko , LI, Shouming
发明人： CHEN, Dawei , DESHPANDE, Milind , THURKAUF, Andrew , PHADKE, Avinash , WANG, Xiangzhu , SHEN, Yiping , LIU, Cuixian , QUINN, Jesse , OHKANDA, Junko , LI, Shouming
IPC分类号： C07C335/26
CPC分类号： C07D209/48 , C07C335/26 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/12 , C07D207/16 , C07D207/34 , C07D207/416 , C07D209/42 , C07D211/14 , C07D211/62 , C07D211/70 , C07D211/86 , C07D213/64 , C07D213/65 , C07D213/81 , C07D215/06 , C07D215/48 , C07D217/04 , C07D231/14 , C07D233/42 , C07D233/90 , C07D239/26 , C07D241/24 , C07D241/44 , C07D249/06 , C07D257/04 , C07D261/18 , C07D263/34 , C07D263/57 , C07D271/08 , C07D271/12 , C07D277/56 , C07D277/66 , C07D277/68 , C07D285/06 , C07D295/135 , C07D295/15 , C07D307/52 , C07D307/68 , C07D307/85 , C07D311/24 , C07D311/66 , C07D317/66 , C07D319/20 , C07D333/20 , C07D333/34 , C07D333/38 , C07D333/70 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/04 , C07D495/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula I that are potent and/ or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式I的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。某些本文所述的具有强抗病毒活性的式I化合物。本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式I化合物。本发明还提供含有一种或多种式I化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括给予式I化合物作为单一活性剂或将一种式I化合物与一种或多种其它治疗剂组合施用。

4. 发明申请

WO2003006012A1 COMPOUNDS AND METHODS FOR THE INHIBITION OF TRYPANOSOMA CRUZI 审中-公开
标题翻译：化合物和方法抑制TRYPANOSOMA CRUZ I
公开(公告)号：WO2003006012A1
公开(公告)日：2003-01-23
申请号：PCT/US2002/022195
申请日：2002-07-11
申请人： YALE UNIVERSITY , UNIVERSITY OF WASHINGTON , HAMILTON, Andrew, D. , VAN VOORHIS, Wesley, C. , YOKOYAMA, Kohei , BUCKNER, Frederick, S. , OHKANDA, Junko , GELB, Michael
发明人： HAMILTON, Andrew, D. , VAN VOORHIS, Wesley, C. , YOKOYAMA, Kohei , BUCKNER, Frederick, S. , OHKANDA, Junko , GELB, Michael
IPC分类号： A61K31/4178
CPC分类号： C07D233/64 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds according to the formula (I): Where R A is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): R B is a C 1 -C 10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are each independently selected from H, C 1 -C 10 (preferably a C 1 -C 4 )alkyl or alkenyl group, CF 3 , F, Cl, Br, I, CN, NO 2 , NH 2 , NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO 2 R (carboxylic acid or ester group ), or COSR (thioester group) where R is H or a C 1 -C 10 (preferably a C 1 -C 4 )alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R 3 is H, a C 1 -C 10 (preferably a C 1 -C 4 ) alkyl, alkenyl, ether or a thioether group; and R 11 and R 12 are independently selected from H or a C 1 -C 3 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof and methods for treating infections caused by protozoal, fungal and/or bacterial agents such as Trypanosoma cruzi, Mycobacterium spp., Leishmania spp., Cryptococcus spp., Aspergillus spp., Histoplasma spp., Candida spp. especially Candida albicans, Pneumocystis carinii, Trichophyton spp., Microsporum spp., Malassezia spp., Rhizopus spp., Pseudallescheria spp., Blastomyces dermatitidis and Coccidiodes spp. , among others.
摘要翻译：本发明涉及式（I）的化合物：其中R AA为C1-C10取代或未取代的直链，支链或环状烷基或链烯基或根据式（II）的苯基： R B是C 1 -C 10取代或未取代的直链，支链或环状烷基或链烯基或式（III）的苯基：R 1，R 2，R 3，R R 5，R 6，R 7，R 8，R 9和R 10各自独立地选自H，C 1 -C 10（优选C 1 -C 4）烷基或烯基，CF 3，F，Cl，Br，I，CN，NO 2，NH 2，NHR，NRR，COR（酰基），OR（羟基或醚基），CO 2 R（羧酸或酯基）（硫酯基），其中R是H或C1-C10（优选C1-C4）烷基或烯基，未取代或取代的芳基（优选苯基）或杂环基或（IV）基，其中R3是H ，C1-C10（优选C1-C4）烷基，烯基，醚或硫醚基; R 11和R 12独立地选自H或C 1 -C 3烷基或链烯基，或其药学上可接受的盐，以及用于治疗由原生动物，真菌和/或细菌药物如克氏锥虫（Trypanosoma cruzi）引起的感染的方法，分枝杆菌属（Mycobacterium spp。），利什曼原虫属（Leishmania spp。），隐球菌属（Cryptococcus spp。），曲霉属（Aspergillus spp。），组织胞浆菌（Histoplasma spp。），假丝酵母属（Candida spp。特别是白色念珠菌，卡氏肺孢子虫，毛癣菌属，微孢子虫属，马拉色氏菌属，根霉属，假花链球菌属，皮球菌属和球孢子菌属等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式