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1. 发明申请

WO2011103509A1 HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：杂环化合物和作为反应剂的用途
公开(公告)号：WO2011103509A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025550
申请日：2011-02-18
申请人： ACEA BIOSCIENCES INC. , MAO, Long , WANG, Xiaobo , XU, Xiao , ZHAO, Li , LIU, Jia
发明人： MAO, Long , WANG, Xiaobo , XU, Xiao , ZHAO, Li , LIU, Jia
IPC分类号： C07D471/04 , C07D513/04 , A61K31/437 , A61K31/4188 , A61P35/00
CPC分类号： C07D471/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic hetero aromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo , and to reduce the size of tumors in vivo . Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被噻唑环取代的稠合双环杂芳族环系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

2. 发明申请

WO2012097196A1 PYRAZOLOPYRIMIDINE DERIVATIVES AND USES AS ANTICANCER AGENTS 审中-公开
标题翻译：吡唑并嘧啶衍生物和作为抗原剂的用途
公开(公告)号：WO2012097196A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/021144
申请日：2012-01-12
申请人： ACEA BIOSCIENCES INC. , MAO, Long , ZHAO, Li , LIU, Jia , WANG, Xiaobo , XU, Xiao
发明人： MAO, Long , ZHAO, Li , LIU, Jia , WANG, Xiaobo , XU, Xiao
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Novel compounds having a fused pyrazolopyrimidine derivatives and related fused ring systems are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Pharmaceutical compositions, and methods of using these compounds and compositions to treat cancer and other diseases related to the dysregulation of kinase (such as Aurora A, Aurora B, Aurora C, cMet, JAK2, ROS1, but not limited to) pathways are disclosed. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有稠合吡唑并嘧啶衍生物和相关稠环体系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。公开了药物组合物和使用这些化合物和组合物治疗与激酶失调相关的癌症和其它疾病（如Aurora A，Aurora B，Aurora C，cMet，JAK2，ROS1但不限于）途径的方法。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

3. 发明申请

WO2017059702A1 PHARMACEUTICAL SALTS, PHYSICAL FORMS, AND COMPOSITIONS OF PYRROLOPYRIMIDINE KINASE INHIBITORS, AND METHODS OF MAKING SAME 审中-公开
标题翻译：药用盐，物理形态和吡咯烷基激酶抑制剂的组合物及其制备方法
公开(公告)号：WO2017059702A1
公开(公告)日：2017-04-13
申请号：PCT/CN2016/087857
申请日：2016-06-30
申请人： ACEA BIOSCIENCES, INC , ACEA PHARMACEUTICAL RESEARCH CO., LTD.
发明人： MAO, Long , LIU, Jia , CHEN, Yile , HUA, Yuning , DAI, Kongen , BAO, Yimei , WENG, Bojie , MO, Xiaopeng , WU, Jian , XU, Xiao , XU, Wanhong , WANG, Xiaobo
IPC分类号： A61K31/52 , C07D487/04 , A61P35/00
CPC分类号： A61K31/52 , C07D487/04
摘要： Provided are methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.
摘要翻译：提供制备某些吡咯并嘧啶衍生物的方法，其可用于治疗与激酶失调相关的增殖障碍和其它疾病（例如但不限于EGFR（包括HER），Alk，PDGFR，BLK，BMX / ETK，BTK，FLT3（D835Y），ITK，JAK1，JAK2，JAK3，TEC和TXK）和/或所述化合物的相应途径，盐，多晶型物和无定形形式，用于制备所述化合物的合成中间体和包含所述化合物和制备这种组合物的方法。

4. 发明申请

WO2014075293A1 TRANSMISSION OF MOTION DATA 审中-公开
标题翻译：传送动作数据
公开(公告)号：WO2014075293A1
公开(公告)日：2014-05-22
申请号：PCT/CN2012/084746
申请日：2012-11-16
申请人： NOKIA CORPORATION , CHEN, Canfeng , LIU, Jia
发明人： CHEN, Canfeng , LIU, Jia
IPC分类号： G06F3/00 , G01C19/00
CPC分类号： H04W4/006 , G06F1/1694 , G06F3/0346 , G06F3/038 , G06F2203/0384 , H04W4/38
摘要： An apparatus comprises at least one processor and at least one non-transitory memory medium having computer-readable code stored thereon, the computer-readable code together with the at least one processor causing the apparatus: to include motion data based on at least one signal generated by at least one motion sensor in a message portion, the message portion comprising a first field and a second field, the motion data being included in the second field of the message portion; to include signalling data in the first field of the message portion, the signalling data being for indicating a type of the motion data included in the second field; and to cause the message portion to be transmitted wirelessly to a recipient device.
摘要翻译：一种装置包括至少一个处理器和至少一个其上存储有计算机可读代码的非暂时性存储介质，所述计算机可读代码与所述至少一个处理器一起使得所述装置：基于至少一个信号包括运动数据由消息部分中的至少一个运动传感器产生，所述消息部分包括第一场和第二场，所述运动数据包括在所述消息部分的第二场中; 将信令数据包括在消息部分的第一字段中，信令数据用于指示包括在第二字段中的运动数据的类型; 并且使消息部分被无线地发送到接收方设备。

5. 发明申请

WO2014008658A1 HANDLING PACKET DATA UNITS 审中-公开
标题翻译：处理数据包数据单元
公开(公告)号：WO2014008658A1
公开(公告)日：2014-01-16
申请号：PCT/CN2012/078599
申请日：2012-07-13
申请人： NOKIA CORPORATION , CHEN, Canfeng , LIU, Jia , KERAI, Kanji
发明人： CHEN, Canfeng , LIU, Jia , KERAI, Kanji
IPC分类号： H04B5/00
CPC分类号： H04W4/008 , H04M1/575 , H04M1/7253 , H04M3/02 , H04M3/42042 , H04M3/436 , H04M3/4878 , H04M2203/354 , H04M2203/558 , H04W4/20 , H04W4/70 , H04W4/80
摘要： Apparatus has at least one processor and at least one memory having computer- readable code stored thereon which when executed controls the at least one processor: to extract telephone number data from a received advertisement packet data unit [PDU]; to compare the telephone number data with telephone numbers present in a contacts database; and in the event of the comparison providing a match, to cause presentation of information from the contacts database relating to a contact with which a match was found.
摘要翻译：装置具有至少一个处理器和至少一个具有存储在其上的计算机可读代码的存储器，当被执行时控制所述至少一个处理器：从接收到的广告包数据单元[PDU]中提取电话号码数据; 将电话号码数据与联系人数据库中存在的电话号码进行比较; 并且在比较的情况下提供匹配，以引起来自与找到匹配的联系人有关的联系人数据库中的信息的呈现。

6. 发明申请

WO2011090993A2 HIGH-CAPACITANCE AND LOW-OXYGEN POROUS CARBON FOR EDLCS 审中-公开
标题翻译：用于EDLCS的高电容和低氧多孔碳
公开(公告)号：WO2011090993A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021661
申请日：2011-01-19
申请人： CORNING INCORPORATED , GADKAREE, Kishor P. , LIU, Jia
发明人： GADKAREE, Kishor P. , LIU, Jia
CPC分类号： H01G11/34 , C01B32/30 , C01B32/342 , H01G11/44 , H01M4/625 , H01M4/8673 , Y02E60/13
摘要： A method for producing a low oxygen content activated carbon material includes heating a natural, non-lignocellulosic carbon precursor in an inert or reducing atmosphere to form a first carbon material, mixing the first carbon material with an inorganic compound to form an aqueous mixture, heating the aqueous mixture in an inert or reducing atmosphere to incorporate the inorganic compound into the first carbon material, removing the inorganic compound from the first carbon material to produce a second carbon material, and heating the second carbon material in an inert or reducing atmosphere to form the low oxygen content activated carbon material. The activated carbon material is suitable to form improved carbon-based electrodes for use in high energy density devices.
摘要翻译：一种生产低氧含量活性炭材料的方法包括在惰性或还原性气氛中加热天然的非木质纤维素碳前体以形成第一碳材料，将第一碳材料与无机化合物混合以形成含水混合物，加热所述含水混合物在惰性或还原气氛中将所述无机化合物并入所述第一碳材料中，从所述第一碳材料中除去所述无机化合物以产生第二碳材料，并在惰性或还原性气氛中加热所述第二碳材料以形成低氧含量的活性炭材料。活性炭材料适用于形成用于高能量密度装置的改进的碳基电极。

7. 发明申请

WO2009120344A2 METHODS FOR COATING A SUBSTRATE 审中-公开
标题翻译：涂覆基材的方法
公开(公告)号：WO2009120344A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/001880
申请日：2009-03-25
申请人： CORNING INCORPORATED , KOHNKE, Glenn, E , LIU, Jia
发明人： KOHNKE, Glenn, E , LIU, Jia
IPC分类号： B05D1/18
CPC分类号： H01L31/02168 , H01L31/02366 , Y02E10/50 , Y10T428/24372
摘要： Coated substrates and methods for coating substrates, for example, a self-assembly method, disclosed herein are useful for, for example, photovoltaic cells.
摘要翻译：涂覆的基底和用于涂覆基底的方法，例如本文公开的自组装方法可用于例如光伏电池。

8. 发明申请

WO2009086683A1 AUTOMATIC DETECTION, LABELING AND TRACKING OF TEAM MEMBERS IN A VIDEO 审中-公开
标题翻译：视频中团队成员的自动检测，标签和跟踪
公开(公告)号：WO2009086683A1
公开(公告)日：2009-07-16
申请号：PCT/CN2007/003986
申请日：2007-12-29
申请人： INTEL CORPORATION , TONG, Xiaofeng , LIU, Jia , ZHANG, Yimin
发明人： TONG, Xiaofeng , LIU, Jia , ZHANG, Yimin
IPC分类号： H04N7/18
CPC分类号： G06K9/00624 , G06K9/00362
摘要： In some embodiments, an automatic detection, labeling and tracking of team members in a video is presented. In this regard, a method is introduced to receive a frame from a sports video, to identify a playing surface in the frame, to identify player regions on the playing surface, to transform pixels from the player regions into player models, to aggregate the player models from a plurality of frames, and to determine a team model to represent a first team and a second team based on clustering of player models. Other embodiments are also provided.
摘要翻译：在一些实施例中，呈现视频中的团队成员的自动检测，标记和跟踪。在这方面，引入一种方法来从运动视频接收帧，识别帧中的播放表面，以识别播放表面上的播放器区域，以将来自玩家区域的像素转换为播放器模型，以将播放器聚合来自多个框架的模型，并且基于玩家模型的聚类来确定团队模型来表示第一团队和第二团队。还提供了其他实施例。

9. 发明申请

WO2007139948A2 IMIDAZOAZEPINONE COMPOUNDS 审中-公开
标题翻译：咪咪唑酮化合物
公开(公告)号：WO2007139948A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012516
申请日：2007-05-25
申请人： EISAI R & D MANAGEMENT CO., LTD , SPYVEE, Mark , SELETSKY, Boris, M. , SCHILLER, Shawn , SHAFFER, Christina, J. , LIU, Jia , LI, Xiang-Yi , CHEN, Qian , BOIVIN, Roch
发明人： SPYVEE, Mark , SELETSKY, Boris, M. , SCHILLER, Shawn , SHAFFER, Christina, J. , LIU, Jia , LI, Xiang-Yi , CHEN, Qian , BOIVIN, Roch
IPC分类号： A61K31/435 , A61K31/55 , A61P37/00 , A61P37/06 , A61P17/06 , A61P3/10 , A61P9/10
CPC分类号： A61K31/55 , A61K31/435
摘要： The present invention provides an enantiomerically pure compound of formula I: along with pharmaceutical formulations containing the same and methods of use thereof the treatment of autoimmune disease.
摘要翻译：本发明提供了对映异构体纯的式I化合物以及含有其的药物制剂及其使用方法治疗自身免疫性疾病。

10. 发明申请

WO2006033007A2 POLYMORPHIC AND AMORPHOUS FORMS OF THE PHOSPHATE SALT OF 8-FLUORO-2-{4-[(METHYLAMINO)METHYL]PHENYL}-1,3,4,5-TETRAHYDRO-6H-AZEPINO[5,4,3-CD]INDOL-6-ONE 审中-公开
标题翻译： 8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-2H-吡喃并[5,4,3-CD]吲哚的磷酸盐的多晶型和非晶形式 -6-ONE
公开(公告)号：WO2006033007A2
公开(公告)日：2006-03-30
申请号：PCT/IB2005/002941
申请日：2005-09-12
申请人： PFIZER INC. , CANCER RESEARCH TECHNOLOGY LTD. , LIU, Jia , NAYYAR, Naresh , GUO, Ming , WU, Zhen-Ping , BORER, Bennett, Chaplin , SRIRANGAM, Aparna, Nadig , MITCHELL, Mark, Bryan , LI, Yi , CHU, Jan-Jon
发明人： LIU, Jia , NAYYAR, Naresh , GUO, Ming , WU, Zhen-Ping , BORER, Bennett, Chaplin , SRIRANGAM, Aparna, Nadig , MITCHELL, Mark, Bryan , LI, Yi , CHU, Jan-Jon
IPC分类号： C07D487/06 , A61K31/55 , A61P35/00 , A61P25/00
CPC分类号： C07D487/06 , C07D487/04
摘要： The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.
摘要翻译：本发明涉及8-氟-2- {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-氮杂基[5,4]的磷酸盐的新型多晶型和无定形形式，3-cd]吲哚-6-酮，以及其制备方法。这样的多晶型物可以是药物组合物的组分，并且可以用于治疗由聚（ADP-核糖）聚合酶活性介导的哺乳动物疾病状况，包括疾病状况如癌症。

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