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1. 发明申请

WO2012175740A1 IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS DIRECTED AGAINST IGE 审中-公开
标题翻译： IMMUNOGLOBULIN针对IGE的单向可变域
公开(公告)号：WO2012175740A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/062250
申请日：2012-06-25
申请人： ABLYNX NV , MEERTS, Peter , CORNELIS, Sigrid, , HERMANS, Guy , VERCAMMEN, Jo , VERDONCK, Frank Kamiel Delphina , STAELENS, Stephanie
发明人： MEERTS, Peter , CORNELIS, Sigrid, , HERMANS, Guy , VERCAMMEN, Jo , VERDONCK, Frank Kamiel Delphina , STAELENS, Stephanie
IPC分类号： C07K16/18 , C07K16/42 , A61P37/08
CPC分类号： C07K16/4291 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： Polypeptides and protein constructs are provided that are directed against IgE. In a particular aspect, Nanobodies against IgE are described linked to a serum albumin binding peptide. Further described are nucleic acids that encode such polypeptides and protein constructs; compositions, and in particular pharmaceutical compositions, that comprise such polypeptides and protein constructs; and uses of such polypeptides, protein constructs and compositions.
摘要翻译：提供针对IgE的多肽和蛋白质构建体。在特定方面，描述了抗IgE的纳米抗体与血清白蛋白结合肽相连。进一步描述的是编码这种多肽和蛋白质构建体的核酸; 组合物，特别是药物组合物，其包含这种多肽和蛋白质构建体; 以及这些多肽，蛋白质构建体和组合物的用途。

2. 发明申请

WO2012175741A2 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
标题翻译：涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术
公开(公告)号：WO2012175741A2
公开(公告)日：2012-12-27
申请号：PCT/EP2012/062251
申请日：2012-06-25
申请人： ABLYNX NV , BAUMEISTER, Judith , BOUCHE, Marie-Paule, Lucienne, Armanda , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
发明人： BAUMEISTER, Judith , BOUCHE, Marie-Paule, Lucienne, Armanda , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/00 , C07K16/2875 , C07K16/42 , C07K16/4283 , C07K2317/22 , C07K2317/31 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5306 , G01N33/6854
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
摘要翻译：本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法测定（例如在ADA免疫测定中）。这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; - 修改和/或改进ISV以消除或减少其引起这种蛋白质干扰或这种信号的趋势的方法; - 可以引入到ISV中的修饰，其去除或减少引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的引起这种蛋白质干扰或这种信号的倾向; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。

3. 发明申请

WO2011073180A1 SINGLE VARIABLE DOMAIN ANTIBODIES AGAINST OX40L, CONSTRUCTS AND THERAPEUTIC USE 审中-公开
标题翻译：针对OX40L，构造和治疗用途的单个可变区域抗体
公开(公告)号：WO2011073180A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/069606
申请日：2010-12-14
申请人： ABLYNX N.V. , VERDONCK, Frank , CORNELIS, Sigrid , STAELENS, Stephanie
发明人： VERDONCK, Frank , CORNELIS, Sigrid , STAELENS, Stephanie
IPC分类号： C07K16/28 , A61P11/06
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/2875 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/31 , G01N33/6845 , G01N33/6854 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to immunoglobulin single variable domain sequences that are directed against (as defined herein) OX40L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such immunoglobulin single variable domain sequences. In particular these immunoglobulin single variable domain sequences can block binding of OX40L to OX40. The immunoglobulin single variable domains, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of inflammatory disease and/or disorder such as e.g. asthma, allergic asthma, chronic colitis, Crohn's disease, inflammatory bowel disease, and/or arthrosclerosis.
摘要翻译：本发明涉及针对（如本文所定义）OX40L的免疫球蛋白单可变结构域序列，以及包含或基本上由一个或多个这样的免疫球蛋白单可变结构域组成的化合物或构建体，特别是蛋白质和多肽，序列。特别地，这些免疫球蛋白单可变结构域序列可以阻断OX40L与OX40的结合。免疫球蛋白单可变结构域，化合物和构建体可用于预防，治疗或诊断目的，例如用于治疗炎性疾病和/或病症，例如，哮喘，过敏性哮喘，慢性结肠炎，克罗恩病，炎性肠病和/或关节病。

4. 发明申请

WO2010139808A3 MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS 审中-公开
公开(公告)号：WO2010139808A3
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057921
申请日：2010-06-07
申请人： ABLYNX NV , DEPLA, Erik , STORTELERS, Catelijne , STAELENS, Stephanie
发明人： DEPLA, Erik , STORTELERS, Catelijne , STAELENS, Stephanie
IPC分类号： C07K16/10
摘要： Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.

5. 发明申请

WO2011042398A1 IMMUNOGLOBULIN SINGLE VARIABLE DOMAIN DIRECTED AGAINST HUMAN CXCR4 AND OTHER CELL ASSOCIATED PROTEINS AND METHODS TO GENERATE THEM 审中-公开
标题翻译：免疫球蛋白针对人CXCR4和其他细胞相关蛋白的单一变异域及其生成方法
公开(公告)号：WO2011042398A1
公开(公告)日：2011-04-14
申请号：PCT/EP2010/064766
申请日：2010-10-04
申请人： ABLYNX NV , BESTE, Gerald , STAELENS, Stephanie , VANLANDSCHOOT, Peter , PAJUELO, Maria Gonzalez , REVETS, Hilde Adi Pierrette , SCHOTTE, Peter , STALS, Hilde , BRIGE, Ann , DEWILDE, Maarten , STORTELERS, Catelijne
发明人： BESTE, Gerald , STAELENS, Stephanie , VANLANDSCHOOT, Peter , PAJUELO, Maria Gonzalez , REVETS, Hilde Adi Pierrette , SCHOTTE, Peter , STALS, Hilde , BRIGE, Ann , DEWILDE, Maarten , STORTELERS, Catelijne
IPC分类号： C07K16/28 , C07K16/00
CPC分类号： C07K16/2866 , C07K16/00 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to immunoglobulin single variable domains directed against specific human CXCR4 epitopes (herein also referred to interchangeably as "compounds of the invention ", "amino acid sequences of the invention ", or "building blocks of the invention ") and polypeptides comprising them (herein also referred to as "polypeptides of the invention ", ''"'compounds of the invention ", or "constructs of the invention "). Furthermore, the present invention relates to nucleic acids encoding the compounds of the invention (also referred to herein as "nucleic acids of the invention" or '"nucleotide sequences of the invention")-, to methods for preparing the compounds of the invention; to host cells expressing or capable of expressing the compounds of the invention; to compositions, and in particular to pharmaceutical compositions, that comprise the compounds of the invention; and to uses of the compounds of the invention and the aforementioned nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein. The invention also relates to methods for generating immunoglobulin single variable domains against a target such as a cell-associated protein and constructs comprising said immunoglobulin single variable domains. The invention also provides immunoglobulin single variable domains obtainable by the methods of the invention. Specifically, the present invention relates to the generation of immunoglobulin single variable domains and constructs thereof by use of epitope walking with multimer libraries. More specifically, the present invention relates to the generation of immunoglobulin single variable domains derived from camelids directed against a particular epitope of a target, in particular against a target with multiple transmembrane spanning domains, including GPCRs and ion channels, by epitope walking with multimer libraries.
摘要翻译：本发明涉及针对特异性CXCR4表位的免疫球蛋白单可变结构域（本文还可以互换地称为“本发明的化合物”，“本发明的氨基酸序列”或“本发明的构建模块”）和包含它们的多肽（本文还称为“本发明的多肽”，“本发明的化合物”或“本发明的构建体”）。此外，本发明涉及编码本发明化合物的核酸（本文中也称为“本发明的核酸”或“本发明的核苷酸序列”） - 制备本发明化合物的方法; 宿主表达或能够表达本发明化合物的细胞; 包括本发明化合物的组合物，特别是药物组合物; 以及本发明化合物和上述核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的，例如本文提及的预防，治疗或诊断目的。本发明还涉及用于产生针对靶的免疫球蛋白单可变结构域的方法，例如细胞相关蛋白和包含所述免疫球蛋白单可变结构域的构建体。本发明还提供可通过本发明的方法获得的免疫球蛋白单可变结构域。具体而言，本发明涉及通过使用多聚体文库进行表位走路来产生免疫球蛋白单可变结构域及其构建体。更具体地说，本发明涉及通过用多聚体文库进行抗原表位的步骤来产生源自靶的特定表位的骆驼的免疫球蛋白单可变结构域，特别是针对具有多个跨膜跨越结构域（包括GPCR和离子通道）的靶。

6. 发明申请

WO2008068280A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS 审中-公开
标题翻译：能够与血清蛋白结合的肽
公开(公告)号：WO2008068280A1
公开(公告)日：2008-06-12
申请号：PCT/EP2007/063348
申请日：2007-12-05
申请人： ABLYNX N.V. , REVETS, Hilde Adi Pierrette , KOLKMAN, Joost Alexander , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , VERHEESEN, Peter , STAELENS, Stephanie
发明人： REVETS, Hilde Adi Pierrette , KOLKMAN, Joost Alexander , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , VERHEESEN, Peter , STAELENS, Stephanie
IPC分类号： C07K16/18 , C07K14/435
CPC分类号： C07K16/18 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2319/31 , G01N33/5047 , G01N33/6857
摘要： The present invention relates to amino acid sequences that are capable of binding to serum proteins; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合血清蛋白质的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

7. 发明申请

WO2013168108A2 CHEMOKINE RECEPTOR BINDING POLYPEPTIDES 审中-公开
标题翻译：化合物受体结合多肽
公开(公告)号：WO2013168108A2
公开(公告)日：2013-11-14
申请号：PCT/IB2013/053711
申请日：2013-05-08
申请人： NOVARTIS AG , BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
发明人： BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/468 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/31
摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要翻译：本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

8. 发明申请

WO2009127691A1 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME 审中-公开
标题翻译：能够与血清蛋白和化合物结合的蛋白质，构建物和包含其的多肽
公开(公告)号：WO2009127691A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054533
申请日：2009-04-16
申请人： ABLYNX N.V. , REVETS, Hilde Adi Pierrette , BOUTTON, Carlo , STAELENS, Stephanie , VERHEESEN, Peter
发明人： REVETS, Hilde Adi Pierrette , BOUTTON, Carlo , STAELENS, Stephanie , VERHEESEN, Peter
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K14/765 , C07K16/36 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/31
摘要： The present invention relates to amino acid sequences that are capable of binding to human serum albumin; to compounds, proteins, polypeptides, fusion proteins or constructs comprising or essentially consisting of such amino acid sequences; to nucleic acids that encode such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; to compositions, and in particular pharmaceutical compositions, that comprise such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs; and to uses of such amino acid sequences, compounds, proteins, polypeptides, fusion proteins or constructs.
摘要翻译：本发明涉及能够结合人血清白蛋白的氨基酸序列; 化合物，蛋白质，多肽，融合蛋白或包含或基本上由此类氨基酸序列组成的构建体; 编码这种氨基酸序列的核酸，化合物，蛋白质，多肽，融合蛋白或构建体; 包括这样的氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的组合物，特别是药物组合物; 以及这些氨基酸序列，化合物，蛋白质，多肽，融合蛋白或构建体的使用。

9. 发明申请

WO2022129637A1 T CELL RECRUITING POLYPEPTIDES BASED ON TCR ALPHA/BETA REACTIVITY 审中-公开
公开(公告)号：WO2022129637A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/086843
申请日：2021-12-20
申请人： ABLYNX NV , SANOFI
发明人： NEYT, Katrijn , ROOBROUCK, Annelies , STAELENS, Stephanie , VAN BELLE, Tom , VERHELST, Judith , DULLAERS, Melissa
IPC分类号： C07K16/28 , C07K16/32 , C07K16/30 , A61P35/00 , A61P37/00
摘要： The present technology provides T cell recruiting polypeptides that specifically bind to the constant domain of a human and of a non-human primate TCR. The present technology also provides nucleic acids, vectors, and compositions. The polypeptides can be used in methods for treatment of cancer.

10. 发明申请

WO2018104444A1 IMPROVED SERUM ALBUMIN BINDING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
公开(公告)号：WO2018104444A1
公开(公告)日：2018-06-14
申请号：PCT/EP2017/081818
申请日：2017-12-07
申请人： ABLYNX NV
发明人： STAELENS, Stephanie , STEFFENSEN, Soren , MORIZZO, Erika , PONSAERT, Raf , OTTEVAERE, Ingrid , CERDOBBEL, An
IPC分类号： C07K16/18 , A61K39/00
摘要： The present invention relates to amino acid sequences that can bind to serum albumin. In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin. The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.

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