基本信息:
- 专利标题： CHEMOKINE RECEPTOR BINDING POLYPEPTIDES
- 专利标题（中）：化合物受体结合多肽
- 申请号：PCT/IB2013/053711 申请日：2013-05-08
- 公开(公告)号：WO2013168108A2 公开(公告)日：2013-11-14
- 发明人： BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
- 申请人： NOVARTIS AG , BROWN, Zarin , BRADLEY, Michelle , CHARLTON, Steven John , VAN HEEKE, Gino Anselmus , CROMIE, Karen , DOMBRECHT, Bruno , STEFFENSEN, Soren , BAUMEISTER, Judith , BOUCHE, Marie-Paule , BOUTTON, Carlo , BUYSE, Marie-Ange , SNOECK, Veerle , STAELENS, Stephanie
- 申请人地址： Lichtstrasse 35 CH-4056 Basel CH
- 专利权人： NOVARTIS AG,BROWN, Zarin,BRADLEY, Michelle,CHARLTON, Steven John,VAN HEEKE, Gino Anselmus,CROMIE, Karen,DOMBRECHT, Bruno,STEFFENSEN, Soren,BAUMEISTER, Judith,BOUCHE, Marie-Paule,BOUTTON, Carlo,BUYSE, Marie-Ange,SNOECK, Veerle,STAELENS, Stephanie
- 当前专利权人： NOVARTIS AG,BROWN, Zarin,BRADLEY, Michelle,CHARLTON, Steven John,VAN HEEKE, Gino Anselmus,CROMIE, Karen,DOMBRECHT, Bruno,STEFFENSEN, Soren,BAUMEISTER, Judith,BOUCHE, Marie-Paule,BOUTTON, Carlo,BUYSE, Marie-Ange,SNOECK, Veerle,STAELENS, Stephanie
- 当前专利权人地址： Lichtstrasse 35 CH-4056 Basel CH
- 优先权： US61/644,582 20120509
摘要：
The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.
摘要（中）：
本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。