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1. 发明申请

WO2005010151A2 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗体指导表皮生长因子受体的缺失突变及其应用
公开(公告)号：WO2005010151A2
公开(公告)日：2005-02-03
申请号：PCT/US2004020295
申请日：2004-06-25
申请人： ABGENIX INC , WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
发明人： WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53 , C12N
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
摘要翻译：本发明涉及新型抗体，特别是针对表皮生长因子受体缺失突变体的抗体，特别是涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体缺失突变体特别是EGFRvIII的人单克隆抗体。还提供了此类抗体的诊断和治疗制剂及其免疫缀合物。

2. 发明申请

WO2005012479A3 ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 审中-公开
标题翻译：抗体生长因子受体的遗传突变体的抗体及其用途
公开(公告)号：WO2005012479A3
公开(公告)日：2006-10-12
申请号：PCT/US2004020564
申请日：2004-06-25
申请人： ABGENIX INC , WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
发明人： WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
IPC分类号： C07K16/28 , A61K39/395 , A61K39/44 , A61K47/48 , C07H21/04 , C07K14/71 , C07K16/22 , C07K16/42 , C07K17/00 , C12N20060101 , C12N5/06 , C12N5/12 , C12P21/08 , G01N33/53 , G01N33/552 , G01N33/577
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
摘要翻译：本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

3. 发明申请

WO2004050683A8 ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF 审中-公开
标题翻译：针对肿瘤坏死因子的抗体及其用途
公开(公告)号：WO2004050683A8
公开(公告)日：2005-07-28
申请号：PCT/US0338281
申请日：2003-12-02
申请人： ABGENIX INC , BABCOOK JOHN S , KANG JASPAL S , FOORD ORIT , GREEN LARRY , FENG XIAO , KLAKAMP SCOTT , HAAK-FRENDSCHO MARY , RATHANASWAMI PALANISWAMI , PIGOTT CRAIG , LIANG MEINA L , LEE ROZANNE , MANCHULENCHO KATHY , FAGGIONI RAFFAELLA , SENALDI GIORGIO , SU QIAOJUAN JANE
发明人： BABCOOK JOHN S , KANG JASPAL S , FOORD ORIT , GREEN LARRY , FENG XIAO , KLAKAMP SCOTT , HAAK-FRENDSCHO MARY , RATHANASWAMI PALANISWAMI , PIGOTT CRAIG , LIANG MEINA L , LEE ROZANNE , MANCHULENCHO KATHY , FAGGIONI RAFFAELLA , SENALDI GIORGIO , SU QIAOJUAN JANE
IPC分类号： C07K16/24 , C07K16/00 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译：针对抗原TNFa的抗体和这种抗体的用途。特别是针对抗原TNFa的完全人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

4. 发明申请

WO2004050683A3 ANTIBODIES DIRECTED TO TUMOR NECROSIS FACTOR AND USES THEREOF 审中-公开
标题翻译：抗体指向肿瘤坏死因子及其用途
公开(公告)号：WO2004050683A3
公开(公告)日：2005-04-14
申请号：PCT/US0338281
申请日：2003-12-02
申请人： ABGENIX INC , BABCOOK JOHN S , KANG JASPAL S , FOORD ORIT , GREEN LARRY , FENG XIAO , KLAKAMP SCOTT , HAAK-FRENDSCHO MARY , RATHANASWAMI PALANISWAMI , PIGOTT CRAIG , LIANG MEINA L , LEE ROZANNE , MANCHULENCHO KATHY , FAGGIONI RAFFAELLA , SENALDI GIORGIO , SU QIAOJUAN JANE
发明人： BABCOOK JOHN S , KANG JASPAL S , FOORD ORIT , GREEN LARRY , FENG XIAO , KLAKAMP SCOTT , HAAK-FRENDSCHO MARY , RATHANASWAMI PALANISWAMI , PIGOTT CRAIG , LIANG MEINA L , LEE ROZANNE , MANCHULENCHO KATHY , FAGGIONI RAFFAELLA , SENALDI GIORGIO , SU QIAOJUAN JANE
IPC分类号： C07K16/24 , C07K16/00 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译：针对抗原TNFα的抗体和这些抗体的用途。特别是针对抗原TNFα的完全人类单克隆抗体。编码核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR's）的连续重链和轻链序列的序列，特别是FR1至FR4或CDR1至CDR3 。表达此类免疫球蛋白分子和单克隆抗体的杂交瘤或其他细胞系。

5. 发明申请

WO2006081139A3 ANTIBODIES AGAINST INTERLEUKIN-1 BETA 审中-公开
标题翻译：抗白细胞介素-1抗体
公开(公告)号：WO2006081139A3
公开(公告)日：2007-02-15
申请号：PCT/US2006002011
申请日：2006-01-19
申请人： ABGENIX INC , GREEN LARRY , FAGGIONI RAFFAELLA , FOORD ORIT , KLAKAMP SCOTT L , SENALDI GIORGIO , SCHNEIDER AMY K
发明人： GREEN LARRY , FAGGIONI RAFFAELLA , FOORD ORIT , KLAKAMP SCOTT L , SENALDI GIORGIO , SCHNEIDER AMY K
IPC分类号： C07K16/00 , A61K39/00 , A61K39/395
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y10S424/801 , Y10S530/867
摘要： Antibodies directed to the antigen IL-1ß and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1ß are discussed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are described.
摘要翻译：描述了针对抗原IL-1β的抗体和这种抗体的用途。特别地，讨论了针对抗原IL-1β的完全人单克隆抗体。编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。描述了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

6. 发明申请

WO2005047307A3 IL-18 BINDING PROTEINS 审中-公开
标题翻译： IL-18结合蛋白
公开(公告)号：WO2005047307A3
公开(公告)日：2006-08-31
申请号：PCT/US2004037971
申请日：2004-11-12
申请人： ABBOTT LAB , GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
发明人： GHAYUR TARIQ , LABKOVSKY BORIS , VOSS JEFFREY W , GREEN LARRY , BABCOOK JOHN , JIA XIAO-CHI , WIELER JAMES , KANG JASPAL SINGH , HEDBERG BRAD
IPC分类号： C07K16/00 , A61K39/395 , C07H21/04 , C07K16/24 , C12N15/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6869 , A61K2039/505 , C07K16/244 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译：本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。具体地，本发明涉及完全是人抗体的抗体。优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。本发明的抗体可以是全长抗体或其抗原结合部分。还提供了制备方法和使用本发明抗体的方法。本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。

7. 发明申请

WO2006116269A3 ANTIBODIES TO MYOSTATIN 审中-公开
标题翻译：肌肉蛋白抗体
公开(公告)号：WO2006116269A3
公开(公告)日：2007-03-01
申请号：PCT/US2006015407
申请日：2006-04-24
申请人： PFIZER , AMGEN FREMONT INC , CHIN EVA ROSE , IBEBUNJO CHIKWENDU , KRASNEY PHILIP ALBERT , YIE JUNMING , ZACHWIEJA JOSEPH , GREEN LARRY
发明人： CHIN EVA ROSE , IBEBUNJO CHIKWENDU , KRASNEY PHILIP ALBERT , YIE JUNMING , ZACHWIEJA JOSEPH , GREEN LARRY
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to myostatin, and that function to inhibit myostatin. The invention also relates to human anti-myostatin antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-myostatin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-myostatin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-myostatin antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及结合肌生成抑制素的抗体，包括人抗体及其抗原结合部分，并且其功能是抑制肌生成抑制素。本发明还涉及人抗肌生成抑制素抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗肌生成抑制素抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗肌生成抑制素抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗肌生成抑制素抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

8. 发明申请

WO2011123708A3 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES 审中-公开
标题翻译：非人类动物遗传工程生产半抗体
公开(公告)号：WO2011123708A3
公开(公告)日：2012-01-19
申请号：PCT/US2011030823
申请日：2011-03-31
申请人： ABLEXIS LLC , GREEN LARRY , SHIZUYA HIROAKI
发明人： GREEN LARRY , SHIZUYA HIROAKI
IPC分类号： C12N15/13 , A01K67/027 , C07K16/46 , C12N5/10 , C12N15/62
CPC分类号： C07K16/461 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/64 , C12N15/8509 , C12N2510/02
摘要： The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
摘要翻译：本发明提供具有编码嵌合抗体的基因组的非人类细胞和哺乳动物以及产生转基因细胞和哺乳动物的方法。本发明的某些方面包括嵌合抗体，人源化抗体，药物组合物和试剂盒。本发明的某些方面还涉及使用本发明的抗体的诊断和治疗方法。

9. 发明申请

WO2010039900A2 NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES 审中-公开
标题翻译：用于生产抗体的非人类哺乳动物
公开(公告)号：WO2010039900A2
公开(公告)日：2010-04-08
申请号：PCT/US2009059131
申请日：2009-09-30
申请人： ALIVA BIOPHARMACEUTICALS INC , GREEN LARRY , SHIZUYA HIROAKI
发明人： GREEN LARRY , SHIZUYA HIROAKI
IPC分类号： C12N15/13 , A01K67/027 , A61K39/395 , C07K16/18
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/462 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/8509
摘要： The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
摘要翻译：本发明提供了敲入非人细胞和哺乳动物，其具有编码嵌合抗体的基因组和产生敲入细胞和哺乳动物的方法。本发明的某些方面包括嵌合抗体，人源化抗体，药物组合物和试剂盒。本发明的某些方面还涉及使用本发明的抗体的诊断和治疗方法。

10. 发明申请

WO2009143472A3 METHOD OF GENERATING SINGLE VL DOMAIN ANTIBODIES IN TRANSGENIC ANIMALS 审中-公开
标题翻译：在转基因动物中产生单个VL域抗体的方法
公开(公告)号：WO2009143472A3
公开(公告)日：2010-03-11
申请号：PCT/US2009045052
申请日：2009-05-22
申请人： ALIVA BIOPHARMACEUTICALS INC , SHIZUYA HIROAKI , GREEN LARRY
发明人： SHIZUYA HIROAKI , GREEN LARRY
IPC分类号： C07K16/46 , A01K67/027 , A61K39/395 , C07K16/18 , C12N5/10 , C12N15/13
CPC分类号： A01K67/0275 , A01K2217/00 , A01K2267/01 , C07K16/00 , C07K2317/24 , C07K2317/52 , C07K2317/569 , C07K2319/00 , C12N15/8509
摘要： The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin ? or ? light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain.
摘要翻译：本发明描述了产生单一VL结构域抗体的方法，包括包含人免疫球蛋白β的可变区的嵌合单链抗体要么？轻链和非人类恒定区。非人恒定区缺少第一恒定结构域CH1，并且可变区缺失重链可变结构域。

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