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1. 发明申请

WO2009117664A2 METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 审中-公开
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置
公开(公告)号：WO2009117664A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037815
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V. , HILL, Jeremy, R.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V. , HILL, Jeremy, R.
IPC分类号： G01N33/49
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

2. 发明申请

WO2009126800A1 METHOD FOR MEASURING THE AREA OF A SAMPLE DISPOSED WITHIN AN ANALYSIS CHAMBER 审中-公开
标题翻译：用于测量在分析室中处理的样品的区域的方法
公开(公告)号：WO2009126800A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/040057
申请日：2009-04-09
申请人： ABBOTT POINT OF CARE, INC. , LALPURIA, Niten, V. , WARDLAW, Stephen, C.
发明人： LALPURIA, Niten, V. , WARDLAW, Stephen, C.
IPC分类号： G01N15/14 , G06T7/00 , G06T7/60
CPC分类号： G01N21/17 , G01N15/05 , G01N2015/055 , G06T7/0012 , G06T7/62 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , Y10T436/11
摘要： A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent. The method includes the steps of: a) illuminating the sample residing within the analysis chamber at one or more wavelengths operable to highlight interfaces between the sample and air, and to highlight a constituent within the sample; b) imaging the sample along the one or more wavelengths, and producing image signals representative of the interaction of the one or more wavelengths with the sample; c) determining a location of at least one interface between the sample and air, using the image signals; d) determining a location of one or more constituents within the sample relative to the at least one sample-air interface using the image signals; and e) determining an area of the chamber containing the sample, using the location of the one or more constituents and the at least one sample-air interface.
摘要翻译：提供了一种用于确定由静止在腔室内的生物流体样品覆盖的分析室的面积的方法。该室具有带内表面的第一面板和具有内表面的第二面板，两个面板都是透明的。该方法包括以下步骤：a）以可操作以突出样品和空气之间的界面的一个或多个波长照亮驻留在分析室内的样品，并突出显示样品内的成分; b）沿着一个或多个波长对样本进行成像，并产生表示一个或多个波长与样本的相互作用的图像信号; c）使用图像信号确定样品和空气之间的至少一个界面的位置; d）使用所述图像信号，相对于所述至少一个采样空气接口确定所述样本内的一个或多个成分的位置; 以及e）使用所述一个或多个成分和所述至少一个样品 - 空气界面的位置来确定包含所述样品的所述室的面积。

3. 发明申请

WO2009117652A1 METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 审中-公开
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的HEMATOCRIT的方法和装置
公开(公告)号：WO2009117652A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037796
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , LEVINE, Robert, A. , WARDLAW, Stephen, C. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V.
发明人： LEVINE, Robert, A. , WARDLAW, Stephen, C. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V.
IPC分类号： G01N33/49
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of : 1) depositing the sample into an analysis chamber (10) adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces (14, 18) of first and second panels (12, 16) and a height (20) extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells (22) within the sample contact both interior surfaces of the panels and one or more lacunae (24) within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静止保持样品进行分析的分析室（10）中，所述室由所述内表面（14,18））和第一和第二面板（12,16）之间的高度（20），其中两个面板是透明的，并且高度使得样品内的至少一些红细胞（22）与内部所述面板的表面和所述静止样品内的一个或多个空隙（24）在所述内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对准的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

4. 发明申请

WO2009117678A1 METHOD AND APPARATUS FOR DETERMINING A FOCAL POSITION OF AN IMAGING DEVICE ADAPTED TO IMAGE A BIOLOGIC SAMPLE 审中-公开
标题翻译：用于确定适用于图像生物样品的成像装置的焦点位置的方法和装置
公开(公告)号：WO2009117678A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037839
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
发明人： WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
IPC分类号： G02B21/24 , H04N5/232
CPC分类号： G02B21/241
摘要： A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect of the disclosure includes the steps of: 1) disposing lenslets within a field of a biologic sample, which lenslets have a height, and have a refractive index and which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; 2) imaging at least a portion of the sample including a plurality of lenslets using transmittance at one or more predetermined wavelengths; 3) determining an average light transmittance intensity of the sample at the wavelengths; 4) determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and 5) determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets.
摘要翻译：提供了用于聚焦用于对生物样品进行成像的装置的方法和装置。本公开的方法方面包括以下步骤：1）在生物样品的场内设置小透镜，哪些小透镜具有高度，并且具有折射率并且折射率不同于样品的折射率，其中一个或两个成像装置和样品相对定位，使得成像装置的焦点位置可以沿着小透镜的高度移动; 2）使用一个或多个预定波长的透射率对包含多个小透镜的样品的至少一部分进行成像; 3）确定样品在波长处的平均光透射强度; 4）确定每个小透镜在该波长处的区域的平均透光强度; 以及5）使用样品的平均光透射强度和小透镜区域的平均光透射强度来确定成像装置的焦点位置。

5. 发明申请

WO2009117683A2 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 审中-公开
标题翻译：用于分析使用荧光淬火和/或漂白的个体细胞或颗粒的方法和设备
公开(公告)号：WO2009117683A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037845
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE , LEVINE, Robert, A. , WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
发明人： LEVINE, Robert, A. , WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
IPC分类号： G01N21/64 , G01N15/14 , G01N33/50
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: a) providing a blood sample having one or more first constituents and one or more second constituents, which second constituents are different from the first constituents; b) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; c) admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce upon exposure to predetermined first wavelengths of light, and which colorant is operative to absorb light at one or more predetermined second wavelengths of light; d) illuminating at least a portion of the sample containing the first constituents and the second constituents at the first wavelengths and at the second wavelengths; e) imaging the at least a portion of the sample, including producing image signals indicative of fluorescent emissions from the first constituents and the second constituents and the optical density of the first constituents and the second constituents; f) determining a fluorescence value for each the first constituents and second constituents using the image signals; g) determining an optical density value for each of the first constituents and second constituents, which optical density is a function of the colorant absorbed by the constituents, using the image signals; and h) identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：a）提供具有一个或多个第一成分和一个或多个第二成分的血液样本，该第二成分不同于第一成分成分; b）将样品沉积到分析室中，该分析室适于静止地保持样品用于分析，该室由第一面板和第二面板限定，这两个面板都是透明的; c）将着色剂与样品混合，该着色剂可操作以在暴露于预定的第一波长的光时使第一组分和第二组分发荧光，并且该着色剂可操作以吸收一种或多种预定的第二波长的光; d）以第一波长和第二波长照射包含第一组分和第二组分的至少一部分样品; e）对样本的至少一部分进行成像，包括产生指示来自第一成分和第二成分的荧光发射以及第一成分和第二成分的光密度的图像信号; f）使用图像信号确定每个第一成分和第二成分的荧光值; g）使用所述图像信号确定所述第一成分和第二成分中的每一个的光密度值，所述光密度是由所述成分吸收的所述着色剂的函数; 和h）使用所确定的荧光和光密度值来识别第一组分和第二组分。

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