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1. 发明申请

WO2004043300A1 PROSTHESIS WITH MULTIPLE DRUGS IN DISCRETE UNMIXED DROPLETS 审中-公开
标题翻译：与多种药物在不同程度的药物中进行预防
公开(公告)号：WO2004043300A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035627
申请日：2003-11-07
申请人： ABBOTT LABORATORIES , VERLEE, Donald , CROMACK, Keith , TARCHA, Peter , TONER, John , HUI, Ho-Wa
发明人： VERLEE, Donald , CROMACK, Keith , TARCHA, Peter , TONER, John , HUI, Ho-Wa
IPC分类号： A61F2/06
CPC分类号： B05C13/025 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/067 , A61F2002/825 , A61F2002/826 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , B05C5/0216 , G11B7/00
摘要： An interventional device for delivery of multiple beneficial agents. The device includes a prosthesis having a surface loaded with a plurality of discrete droplets of first and second beneficial agents. The discrete droplets of beneficial agent are loaded along a first controlled trajectory and the second beneficial agent is loaded along a second controlled trajectory. The first controlled trajectory and the second controlled trajectory can be aligned to allow mixing of the first and second beneficial agents prior to being loaded onto the surface of the prosthesis.
摘要翻译：用于递送多种有益药剂的介入装置。该装置包括具有装载有第一和第二有益试剂的多个离散液滴的表面的假体。沿着第一受控轨迹加载有益试剂的离散液滴，并且沿第二受控轨迹加载第二有益试剂。第一受控轨迹和第二受控轨迹可以被对准以允许在被加载到假体的表面之前混合第一和第二有益试剂。

2. 发明申请

WO2004043298A1 PROSTHESIS HAVING VARIED CONCENTRATION OF BENEFICIAL AGENT 审中-公开
标题翻译：具有不同浓度浓度的有益药剂
公开(公告)号：WO2004043298A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035563
申请日：2003-11-07
申请人： ABBOTT LABORATORIES , VERLEE, Donald , CROMACK, Keith , TARCHA, Peter , TONER, John , BURKE, Sandra , CLIFFORD, Anton , FISHER, Charles
发明人： VERLEE, Donald , CROMACK, Keith , TARCHA, Peter , TONER, John , BURKE, Sandra , CLIFFORD, Anton , FISHER, Charles
IPC分类号： A61F2/06
CPC分类号： B05C13/025 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/067 , A61F2002/825 , A61F2002/826 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , B05C5/0216 , G11B7/00
摘要： An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.
摘要翻译：用于将有益剂递送到管腔的介入装置及其装载和制造方法，其包括装载有益剂的假体，以向受管腔提供受控剂量浓度的有益剂。有益剂通过流体分配器装载到假体上，流体分配器具有能够以离散液滴分配有益剂的分配元件，每个液滴具有受控的轨迹。介入装置具有受控的局部面积密度，用于全身输送或输送到腔壁的有益药剂。有益药剂的局部面积密度可以沿着假体变化。介入装置包括具有受控面积密度的有效试剂的重叠或分叉支架。

3. 发明申请

WO2004043299A1 METHOD OF LOADING BENEFICIAL AGENT TO A PROSTHESIS BY FLUID-JET APPLICATION 审中-公开
标题翻译：通过流体喷射应用装载优点的方法
公开(公告)号：WO2004043299A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/035624
申请日：2003-11-07
申请人： ABBOTT LABORATORIES , VERLEE, Donald , TARCHA, Peter , CROMACK, Keith , QUINT, Richard
发明人： VERLEE, Donald , TARCHA, Peter , CROMACK, Keith , QUINT, Richard
IPC分类号： A61F2/06
CPC分类号： B05C13/025 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/067 , A61F2002/825 , A61F2002/826 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2250/0067 , A61F2250/0068 , A61F2250/0098 , B05C5/0216 , G11B7/00
摘要： An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.
摘要翻译：用于将有益剂递送到管腔的介入装置及其装载和制造方法，其包括装载有益剂的假体，以向受管腔提供受控剂量浓度的有益剂。有益剂通过流体分配器装载到假体上，流体分配器具有能够以离散液滴分配有益剂的分配元件，每个液滴具有受控的轨迹。加载有益试剂的方法包括沿着分配路径以光栅格式和/或离轴格式分配有益试剂。

4. 发明申请

WO2007137294A2 COMPOSITIONS AND METHODS FOR ADMINISTERING DEXAMETHASONE WHICH PROMOTE HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION 审中-公开
标题翻译：用于治疗人类冠状动脉内皮细胞迁移的DEXAMETHASONE的组合物和方法
公开(公告)号：WO2007137294A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/069576
申请日：2007-05-23
申请人： ABBOTT LABORATORIES , MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
发明人： MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
IPC分类号： A61L31/16 , A61K31/573
CPC分类号： A61L31/16 , A61L2300/43 , A61L2300/606
摘要： A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of dexamethasone is disposed thereon. The therapeutically effective amount of dexamethasone allows for the drug to elute from the supporting structure so as to obtain a concentration of dexamethasone that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of dexamethasone is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion. Additionally, the therapeutically effective amount of dexamethasone induces cell migration such that migrating cells promote healing of the lesion.
摘要翻译：药物洗脱内用假体被配置用于抑制再狭窄和血栓形成，并且用于促进受试者体内的病变愈合。这种内用假体至少包括支撑结构，治疗有效量的地塞米松位于其上。地塞米松的治疗有效量允许药物从支持结构中洗脱，以获得足以抑制再狭窄和/或抑制血栓形成的地塞米松浓度。此外，地塞米松的治疗有效量基本上没有抑制细胞迁移，使得迁移的细胞促进损伤的愈合。此外，治疗有效量的地塞米松诱导细胞迁移，使得迁移的细胞促进损伤的愈合。

5. 发明申请

WO2007137298A2 SYSTEMS AND METHODS FOR DELIVERING A RAPAMYCIN ANALOG THAT DO NOT INHIBIT HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION 审中-公开
标题翻译：用于递送不阻止人冠状动脉内皮细胞迁移的雷帕霉素类似物的系统和方法
公开(公告)号：WO2007137298A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/069583
申请日：2007-05-23
申请人： ABBOTT LABORATORIES , MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
发明人： MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
IPC分类号： A61L27/50 , A61L27/54 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L27/50 , A61L27/54 , A61L31/14 , A61L2300/416 , A61L2300/606
摘要： A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of the rapamycin analog is disposed thereon. The therapeutically effective amount of the rapamycin analog allows for the rapamycin analog to elute from the supporting structure so as to obtain a concentration of the rapamycin analog that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of rapamycin analog is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion.
摘要翻译：药物洗脱内置假体被配置用于抑制再狭窄和血栓形成，并且用于促进受试者身体中的损伤的愈合。这种内置假体包括至少一个支撑结构，并在其上布置治疗有效量的雷帕霉素类似物。雷帕霉素类似物的治疗有效量允许雷帕霉素类似物从支持结构洗脱，以获得足以抑制再狭窄和/或抑制血栓形成的雷帕霉素类似物浓度。而且，雷帕霉素类似物的治疗有效量基本上没有抑制细胞迁移，从而迁移细胞促进病变的愈合。

6. 发明申请

WO2007137296A2 SYSTEMS AND METHODS FOR DELIVERING A RAPAMYCIN ANALOG THAT DO NOT INHIBIT HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION 审中-公开
标题翻译：用于递送RAPAMYCIN模拟物的系统和方法，其不会抑制人类冠状动脉内皮细胞迁移
公开(公告)号：WO2007137296A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/069579
申请日：2007-05-23
申请人： ABBOTT LABORATORIES , MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
发明人： MACK, Matthew , BURKE, Sandra , TONER, John , CROMACK, Keith
IPC分类号： A61L27/50 , A61L27/54 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L27/50 , A61L27/54 , A61L31/14 , A61L2300/416 , A61L2300/606
摘要： A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of the rapamycin analog is disposed thereon. The therapeutically effective amount of the rapamycin analog allows for the rapamycin analog to elute from the supporting structure so as to obtain a concentration of the rapamycin analog that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of rapamycin analog is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion.
摘要翻译：药物洗脱内用假体被配置用于抑制再狭窄和血栓形成，并且用于促进受试者体内的病变愈合。这样的内用假体至少包括支撑结构，并且治疗有效量的雷帕霉素类似物置于其上。雷帕霉素类似物的治疗有效量允许雷帕霉素类似物从支持结构洗脱，以获得足以抑制再狭窄和/或抑制血栓形成的雷帕霉素类似物的浓度。此外，雷帕霉素类似物的治疗有效量基本上没有抑制细胞迁移，使得迁移的细胞促进损伤的愈合。

7. 发明申请

WO2004010971A1 IMPLANTABLE MEMS MEDICINE DELIVERY SYSTEM 审中-公开
标题翻译：可植入MEMS药物输送系统
公开(公告)号：WO2004010971A1
公开(公告)日：2004-02-05
申请号：PCT/US2003/023612
申请日：2003-07-29
申请人： ABBOTT LABORATORIES
发明人： CHO, Steven, T. , CROMACK, Keith , JARA-ALMONTE, James , VERLEE, Don, J.
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61M5/14276 , A61M31/002 , A61M2205/0244
摘要： A medicine delivery system (10) implantable into a human or animal body includes a medicine delivery unit (14) and a control unit (12). A membrane (26) seals the delivery opening (22) of a medicine compartment (18) and is pre-stressed by an amount less than the predetermined elastic deformation and rupture point limits of the membrane (26). A release element (28) associated with compartment (18) causes the membrane (26) to be stressed beyond the deformation and rupture point limits in response to a control signal (78). Release element (28) ruptures the membrane (26) along a predetermined rupture pattern to permit a first membrane portion (35), forming a hinged lid, to separate from a second membrane portion (37) along the predetermined rupture pattern while remaining attached to the second membrane portion at a hinge (39).
摘要翻译：植入人体或动物体内的药物输送系统（10）包括药物输送单元（14）和控制单元（12）。膜（26）密封药物隔室（18）的输送口（22），并且预压力小于膜（26）的预定弹性变形和破裂点极限的量。与隔室（18）相关联的释放元件（28）响应于控制信号（78）使膜（26）被应力超过变形和破裂点限制。释放元件（28）沿着预定的破裂图案破裂膜（26），以允许形成铰接盖的第一膜部分（35）沿着预定的破裂图案与第二膜部分（37）分离，同时保持附着于铰链（39）处的第二膜部分。

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