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1. 发明申请

WO2010045401A1 TRPV1 ANTAGONISTS 审中-公开
标题翻译： TRPV1拮抗剂
公开(公告)号：WO2010045401A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060732
申请日：2009-10-15
申请人： ABBOTT LABORATORIES , GOMTSYAN, Arthur R. , VOIGHT, Eric A. , BAYBURT, Erol K. , CHEN, Jun , DAANEN, Jerome F. , DIDOMENICO, JR., Stanley , KORT, Michael E. , KYM, Philip R. , MCDONALD, Heath A. , PERNER, Richard J. , SCHMIDT, Robert G.
发明人： GOMTSYAN, Arthur R. , VOIGHT, Eric A. , BAYBURT, Erol K. , CHEN, Jun , DAANEN, Jerome F. , DIDOMENICO, JR., Stanley , KORT, Michael E. , KYM, Philip R. , MCDONALD, Heath A. , PERNER, Richard J. , SCHMIDT, Robert G.
IPC分类号： C07D311/74 , C07D405/12 , A61K31/33 , A61P19/02
CPC分类号： C07D311/74 , C07D405/12
摘要： Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R 1 , R 2 , R 3 , R 4 , and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：本文公开了式（I）的化合物或其药学上可接受的盐，溶剂合物，前药，前药的盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

2. 发明申请

WO2010045402A1 TRPV1 ANTAGONISTS 审中-公开
标题翻译： TRPV1拮抗剂
公开(公告)号：WO2010045402A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060734
申请日：2009-10-15
申请人： ABBOTT LABORATORIES , GOMTSYAN, Arthur R. , VOIGHT, Eric A. , BAYBURT, Erol K. , CHEN, Jun , DAANEN, Jerome F. , DIDOMENICO, Stanley, Jr. , KORT, Michael E. , KYM, Philip R. , MCDONALD, Heath A. , PERNER, Richard J. , SCHMIDT, Robert G.
发明人： GOMTSYAN, Arthur R. , VOIGHT, Eric A. , BAYBURT, Erol K. , CHEN, Jun , DAANEN, Jerome F. , DIDOMENICO, Stanley, Jr. , KORT, Michael E. , KYM, Philip R. , MCDONALD, Heath A. , PERNER, Richard J. , SCHMIDT, Robert G.
IPC分类号： C07D311/74 , C07D405/12 , A61K31/33 , A61P19/02
CPC分类号： C07D405/12 , C07D311/74
摘要： Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：本文公开了式（I）化合物或其药学上可接受的盐，溶剂合物，前药，前药盐或其组合，其中R1，R2，R3，R4和m在说明书中定义。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

3. 发明申请

WO2009089082A1 TRPA1 ANTAGONISTS 审中-公开
标题翻译： TRPA1拮抗剂
公开(公告)号：WO2009089082A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030005
申请日：2009-01-02
申请人： ABBOTT LABORATORIES , PERNER, Richard, J. , KORT, Michael, E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
发明人： PERNER, Richard, J. , KORT, Michael, E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
IPC分类号： A61K31/15 , A61K45/06 , A61P19/02 , A61P29/00 , A61P13/10
CPC分类号： C07C251/40 , A61K31/15 , A61K45/06 , C07C45/004 , C07C49/235 , C07C251/00 , A61K2300/00
摘要： Compounds of formula (I), wherein R 1 , R 2 , R 3 , m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：其中R1，R2，R3，m和Y在本说明书中定义的式（I）化合物是TRPA1拮抗剂。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

4. 发明申请

WO2009089083A1 TRPA1 ANTAGONISTS 审中-公开
标题翻译： TRPA1拮抗剂
公开(公告)号：WO2009089083A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030006
申请日：2009-01-02
申请人： ABBOTT LABORATORIES , PERNER, Richard J. , KORT, Michael E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
发明人： PERNER, Richard J. , KORT, Michael E. , DIDOMENICO, Stanley, Jr. , CHEN, Jun , VASUDEVAN, Anil
IPC分类号： C07D213/53 , C07D215/12 , C07D217/14 , C07D333/20 , A61K31/4406 , A61P29/00
CPC分类号： C07D333/22 , A61K31/381 , A61K31/44 , A61K31/47 , A61K31/472 , A61K45/06 , C07D213/53 , C07D213/61 , C07D213/64 , C07D215/12 , C07D217/14 , C07D333/20
摘要： Compounds of formula (I), wherein R 1 , R 2 , R 3 , and Y are defined in the description are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译：其中R1，R2，R3和Y在说明书中定义的式（I）化合物是TRPA1拮抗剂。还公开了包含这些化合物的组合物和使用这些化合物和组合物治疗病症和病症的方法。

5. 发明申请

WO2012047284A2 NOVEL PROCESS FOR MEMS SCANNING MIRROR WITH MASS REMOVE FROM MIRROR BACKSIDE 审中-公开
标题翻译：用于MEMS扫描镜的新型工艺，从背面反射大量去除
公开(公告)号：WO2012047284A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/001704
申请日：2011-10-04
申请人： MAGIC TECHNOLOGIES, INC. , ADVANCED NUMICRO SYSTEMS, INC. , CHEN, Jun , MAO, Guomin , ZHONG, Tom , CAO, Wei , FU, Yee-Chung , TORNG, Chyu-Jiuh
发明人： CHEN, Jun , MAO, Guomin , ZHONG, Tom , CAO, Wei , FU, Yee-Chung , TORNG, Chyu-Jiuh
IPC分类号： H01L21/00
CPC分类号： B81B3/0045 , B81B2201/042 , G02B26/0841
摘要： Two methods of fabricating a MEMS scanning mirror having a tunable resonance frequency are described. The resonance frequency of the mirror is set to a particular value by mass removal from the backside of the mirror during fabrication.
摘要翻译：描述制造具有可调共振频率的MEMS扫描反射镜的两种方法。反射镜的共振频率通过在制造期间从反射镜的背面质量去除而被设定为特定的值。

6. 发明申请

WO2009088994A1 SURFACE DISPLAY-BASED YEAST TWO HYBRID SCREENING SYSTEM 审中-公开
标题翻译：基于表面显示的YEAST双混合筛选系统
公开(公告)号：WO2009088994A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/000046
申请日：2009-01-05
申请人： LOS ALAMOS NATIONAL SECURITY, LLC , CAI, Hong , CHEN, Jun
发明人： CAI, Hong , CHEN, Jun
IPC分类号： C12N1/00
CPC分类号： C12N15/1037
摘要： A surface display-based yeast two hybrid (sdY2H) system for rapid and large cDNA library scale protein interactome networking screening is provided. The sdY2H system utilizes a combination of surface display markers, highly efficient yeast mating resulting in high transformation efficiencies, and positive cell enrichment using a robust immunomagnetic affinity purification. In addition, the system of the invention can be combined with multiparameter fluorescence markers allowing further quantitative fluorescence analysis/sorting, enabling a significant reduction in the number of false positives. In some embodiments, the system uses liquid culture, rather than plate-based culture, resulting in substantially shortened cell culturing times that significantly reduce background fluorescence, allowing better discrimination of positive cells.
摘要翻译：提供了一种基于表面显示的酵母双杂交（sdY2H）系统，用于快速和大型cDNA文库规模蛋白质相互作用组合筛选。 sdY2H系统利用表面显示标记物的组合，高效酵母交配导致高转化效率，并使用强大的免疫磁性亲和纯化进行阳性细胞富集。此外，本发明的系统可以与允许进一步定量荧光分析/分选的多参数荧光标记组合，从而能够显着减少误报数量。在一些实施方案中，该系统使用液体培养而不是基于板的培养物，导致基本上缩短的细胞培养时间，显着降低背景荧光，允许更好地鉴别阳性细胞。

7. 发明申请

WO2009029055A1 P53 ISOFORM GENE TRANSGENIC NON-HUMAN ANIMAL 审中-公开
标题翻译： P53 ISOFORM基因转基因非人动物
公开(公告)号：WO2009029055A1
公开(公告)日：2009-03-05
申请号：PCT/SG2008/000322
申请日：2008-09-01
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , PENG, Jinrong , CHEN, Jun , LANE, David, P.
发明人： PENG, Jinrong , CHEN, Jun , LANE, David, P.
IPC分类号： C12N15/12 , C12N5/06 , C12Q1/68
CPC分类号： A01K67/0275 , A01K2207/05 , A01K2207/10 , A01K2217/05 , A01K2227/40 , A01K2267/0331 , A01K2267/0393 , C07K14/43595 , C07K14/4746 , C12N15/8509 , C12N2830/00
摘要： There is provided a transgenic non-human animal, wherein the transgenic non- human animal genome comprises at least one stably integrated reporter gene operably linked to regulatory elements of a p53 isoform gene, wherein the p53 isoform gene is capable of modulating the activity of p53. In particular, the transgenic non-human animal is a transgenic fish and the p53 isoform gene is Δ113p53 gene and the regulatory elements are the Δ113p53 gene's regulatory elements. There are also provided uses of the transgenic non-human animal according to the invention.
摘要翻译：提供了一种转基因非人动物，其中所述转基因非人动物基因组包含与p53同种型基因的调节元件可操作地连接的至少一个稳定整合的报告基因，其中所述p53同种型基因能够调节p53的活性。特别地，转基因非人动物是转基因鱼，p53同种型基因是〜113p53基因，调节元件是〜113p53基因的调控元件。还提供了根据本发明的转基因非人动物的用途。

8. 发明申请

WO2008036739A2 DIRECTLY COATING SOLID POLYMER COMPOSITE HAVING EDGE EXTENSIONS ON LITHIUM-ION POLYMER BATTERY ELECTRODE SURFACE 审中-公开
标题翻译：锂离子聚合物电池表面直接涂覆固体聚合物复合材料
公开(公告)号：WO2008036739A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/078891
申请日：2007-09-19
申请人： CALEB TECHNOLOGY CORPORATION , LIN, Thomas , MALINOVSKAYA, Larisa , CHEN, Jun
发明人： LIN, Thomas , MALINOVSKAYA, Larisa , CHEN, Jun
IPC分类号： H01M10/04 , B23P19/00
CPC分类号： H01M10/052 , H01M2/145 , H01M2/18 , H01M4/381 , H01M4/525 , H01M4/583 , H01M10/0404 , H01M10/0436 , H01M10/0525 , H01M10/0565 , H01M10/0585 , H01M2300/0082 , Y10T29/49115 , Y10T29/53135
摘要： A lithium-ion polymer battery, and methods and apparatus for manufacturing the same, are disclosed. The methods include placing a bottom surface of an electrode on a coating surface, such that a top surface of the electrode is exposed, forming a removable retention boundary on the coating surface and surrounding the electrode, including a space between the electrode edges and the retention boundary, depositing polymer electrolyte solution on the electrode, on the coating surface, and within the retention boundary, and allowing the polymer electrolyte solution to dry until all of the deposited polymer electrolyte solution becomes a solid polymer composite that extends beyond the electrode edges.
摘要翻译：公开了锂离子聚合物电池及其制造方法和设备。该方法包括将电极的底面放置在涂层表面上，使得电极的顶面暴露，在涂层表面上形成可除去的保留边界并围绕电极，包括电极边缘之间的空间和保持边界，将聚合物电解质溶液沉积在电极上，涂层表面上和保持边界内，并且使聚合物电解质溶液干燥，直到所有沉积的聚合物电解质溶液变成延伸超过电极边缘的固体聚合物复合材料。 / p>

9. 发明申请

WO2004067533A1 CONDUCTING POLYMERS WITH PORPHYRIN CROSS-LINKERS 审中-公开
标题翻译：导电聚合物与PORPHYRIN交联剂
公开(公告)号：WO2004067533A1
公开(公告)日：2004-08-12
申请号：PCT/AU2004/000111
申请日：2004-01-30
申请人： UNIVERSITY OF WOLLONGONG , MASSEY UNIVERSITY , ON TOO, Chee , CHEN, Jun , WALLACE, Gordon , OFFICER, David, L. , CAMPBELL, Wayne, Mason , BURRELL, Anthony, Keiran , COLLIS, Gavin, Errol
发明人： ON TOO, Chee , CHEN, Jun , WALLACE, Gordon , OFFICER, David, L. , CAMPBELL, Wayne, Mason , BURRELL, Anthony, Keiran , COLLIS, Gavin, Errol
IPC分类号： C07D487/22
CPC分类号： C08G73/0611 , C07D409/14 , C08G61/02 , C08G61/124 , C08G73/0266 , H01G9/2059 , H01L51/0006 , H01L51/0035 , H01L51/0036 , H01L51/004 , H01L51/0077 , H01L51/4206 , Y02E10/542 , Y02E10/549
摘要： The invention relates to a cross-linking monomer having the structure Q-(L) n -P-(L') m ;-Q', where Q and Q' are polymerisable units, L and L' are linkers providing direct or indirect electronic communication between Q and P and between P and Q', and P is an electrofunctional unit, and also to polymers prepared from such monomers. Q for example may be a heteroaromatic ring such as thiophene, furan and pyrrole. The electrofunctional group may be, for example, porphyrin, substituted porphyrin, phthalocyanine or substituted phthalocyanine. The invention also relates to an electrofunctional material including a base material and a cross-linked polymer such as described.
摘要翻译：本发明涉及具有结构Q-（L）nP-（L'）m; -Q'的交联单体，其中Q和Q'是可聚合单元，L和L'是提供直接或间接电子通信的接头在Q和P之间以及P和Q'之间，P是电子功能单元，以及由这些单体制备的聚合物。 Q例如可以是杂芳环，例如噻吩，呋喃和吡咯。所述官能团可以是例如卟啉，取代卟啉，酞菁或取代酞菁。本发明还涉及包括如所述的基材和交联聚合物的电功能材料。

10. 发明申请

WO2004016252A1 NON-ANIMAL PRODUCT CONTAINING VETERINARY FORMULATIONS 审中-公开
标题翻译：含动物制品的非动物产品
公开(公告)号：WO2004016252A1
公开(公告)日：2004-02-26
申请号：PCT/US2003/025448
申请日：2003-08-14
申请人： MERIAL LIMITED , CLEVERLY, Douglas , HAGENBUCH, Michelle , CHEN, Jun , AZAD, Abul , MUHITCH, James
发明人： CLEVERLY, Douglas , HAGENBUCH, Michelle , CHEN, Jun , AZAD, Abul , MUHITCH, James
IPC分类号： A61K9/28
CPC分类号： A61K9/0056 , A61K9/2013 , A61K9/2054 , A61K9/2059
摘要： This invention provides for a chewable veterinary formulation, which does not contain animal products, which comprises: -effective amount of at least one pharmaceutical agent; -at least one disintegrant; -at least one n on-animal product c ontaining flavor or flavor derived from a non-animal source; -at least one binder; -at least one humectant; -at least one granulating solvent; and -optionally, at least one antioxidant, at least one buffering agent, at least one preservative, or at least one colorant. This invention further provides for a process of producing chewable veterinary formulations as well as to a method for enhancing the patentability of oral veterinary formulations to an animal by adding a smoke hickory flavor to said formulation. This invention further provides for a tablet, which does not contain animal products.
摘要翻译：本发明提供了不含动物产品的咀嚼兽用制剂，其包括：有效量的至少一种药剂; - 至少一种崩解剂; - 至少一种动物产品c来源于非动物来源的风味或风味; - 至少一个粘合剂; - 至少一个湿润剂; - 至少一种造粒溶剂; 和至少一种抗氧化剂，至少一种缓冲剂，至少一种防腐剂或至少一种着色剂。本发明还提供了生产咀嚼型兽用制剂的方法，以及通过向所述制剂中加入烟草山核桃味，提高口服兽药制剂对动物的可专利性的方法。本发明进一步提供了不包含动物产品的片剂。

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