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1. 发明申请

WO2007095601A3 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
标题翻译：新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：WO2007095601A3
公开(公告)日：2007-10-04
申请号：PCT/US2007062179
申请日：2007-02-15
申请人： ABBOTT LAB , KEYES ROBERT F , GU YU GUI , SHAM HING L
发明人： KEYES ROBERT F , GU YU GUI , SHAM HING L
IPC分类号： C07D277/68 , A61K31/428 , A61P3/10 , C07D417/12
CPC分类号： C07D277/68 , C07D277/82 , C07D417/12
摘要： The present invention relates to compounds of Formula (I) which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及抑制乙酰辅酶A羧化酶（ACC）的式（I）化合物，可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。

2. 发明申请

WO0128996A3 PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES 审中-公开
标题翻译：吡咯啉衍生物，其制备及其作为神经酰胺酶抑制剂的用途
公开(公告)号：WO0128996A3
公开(公告)日：2001-11-29
申请号：PCT/US0027910
申请日：2000-10-10
申请人： ABBOTT LAB , MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L
发明人： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , HANESSIAN STEPHEN , WANG GARY T , KRUEGER ALLAN C , CHEN HUI-JU , CHEN YUANWEI , DEGOEY DAVID A , FLOSI WILLIAM J , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , KLEIN LARRY L , LIN ZHEN , MADIGAN DAROLD L
IPC分类号： C07D401/12 , A61K31/357 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/66 , A61K31/662 , A61P31/00 , A61P31/12 , A61P31/16 , A61P43/00 , C07D20060101 , C07D207/00 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/32 , C07D207/327 , C07D207/38 , C07D207/46 , C07D303/16 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D407/06 , C07D407/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D521/00 , C07F9/40 , C07F9/572
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof, which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.

3. 发明申请

WO2007095603A3 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
标题翻译：新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：WO2007095603A3
公开(公告)日：2008-03-13
申请号：PCT/US2007062181
申请日：2007-02-15
申请人： ABBOTT LAB , GU YU GUI , XU XIANGDONG , WEITZBERG MOSHE , SHAM HING
发明人： GU YU GUI , XU XIANGDONG , WEITZBERG MOSHE , SHAM HING
IPC分类号： C07D277/34 , A61K31/426 , A61K31/427 , C07D417/04
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention is directed to compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or combination thereof, wherein Y is selected from the group consisting of-CR x R y -, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein each of R x and R y is independently selected from the group consisting of hydrogen. alkyl, hydroxyalkyl, and haloalkyl; or R x and R y together with the carbon to which they are attached form a monocyclic cycloalkyl or heterocycle ring, Ar 1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl, Ar 3 is phenyl or monocyclic heteroaryl, wherein Ar 3 is substituted with 1, 2, 3 or 4 substituents Ar 2 is a group of formula (a), (b), (c), (d), or (e); wherein R is hydrogen, cycloalkyj, alkyl or haloalkyl, Z 1 , Z 2 , Z 3 and Z 4 are C(R 101 ), or one or two of Z 1 , Z 2 , Z 3 and Z 4 is N and the others are C(R 101 ); Z 5 , Z 6 and Z 7 are C( 102 ). or one or two of Z 5 , Z 6 and Z 7 are N, and the others are C(R 102 ), Z is selected from the group consisting of -OR 5 , -alkylenyl-OR 5 , -N(R 6 )(R 7 ) and -alkylenyI-N(R 6 )(R 7 ), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中Y选自-CR 1 x R -C（O） - ， - O - ， - N（H） - ， - N（烷基） - 和-S-; 其中R x和R y y各自独立地选自氢。烷基，羟基烷基和卤代烷基; 或R x和R y与它们所连接的碳一起形成单环环烷基或杂环，Ar 1选自由苯基和单环五元或六元杂芳基组成的基团是苯基或单环杂芳基，其中Ar 3 3被1,2,3或4个取代取代基Ar 2是式（a），（b），（c），（d）或（e）的基团。其中R是氢，环烷基，烷基或卤代烷基，Z 1，Z 2，Z 3和Z 4。是C（R 101），或Z 1，Z 2，Z 3和Z 1中的一个或两个 4是N，其余是C（R 101）; Z 5，Z 6和Z 7是C（C 102）。或Z 5，Z 6和Z 7中的一个或多个为N，其余为C（R 102） Z）选自-OR 5， - 亚烷基-OR 5，-N（R 6）（R 6） R 7）和 - 亚烷基-N（R 6 S）（R 7），其抑制乙酰辅酶A羧化酶（ACC）并且是有用的用于预防或治疗人类的代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。

4. 发明申请

WO2008079610A3 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
标题翻译：新型乙酰-CoA羧化酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：WO2008079610A3
公开(公告)日：2008-08-14
申请号：PCT/US2007086440
申请日：2007-12-05
申请人： ABBOTT LAB , GU YU GUI , CLARK RICHARD F , LI QUN , WEITZBERG MOSHE , SHAM HING
发明人： GU YU GUI , CLARK RICHARD F , LI QUN , WEITZBERG MOSHE , SHAM HING
IPC分类号： C07D277/34 , A61K31/09 , A61K31/426 , A61P3/10 , C07C43/275
CPC分类号： C07D277/34 , C07C233/18 , C07C233/22
摘要： The present invention relates to compounds of formula (I); Pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic diseases or conditions are also provided.
摘要翻译：本发明涉及式（I）的化合物; 还提供了可用于治疗或预防代谢疾病或病症的药物组合物和方法。

5. 发明申请

WO2007095602A3 NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 审中-公开
标题翻译：新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用
公开(公告)号：WO2007095602A3
公开(公告)日：2007-11-08
申请号：PCT/US2007062180
申请日：2007-02-15
申请人： ABBOTT LAB , GU YU GUI , WEITZBERG MOSHE , XU XIANGDONG , CLARK RICHARD F , ZHANG TIANYUAN , LI QUN , HANSEN TODD M , SHAM HING , BEUTEL BRUCE A , CAMP HEIDI S , WANG XIAOJUN
发明人： GU YU GUI , WEITZBERG MOSHE , XU XIANGDONG , CLARK RICHARD F , ZHANG TIANYUAN , LI QUN , HANSEN TODD M , SHAM HING , BEUTEL BRUCE A , CAMP HEIDI S , WANG XIAOJUN
IPC分类号： C07D277/34 , A61K31/427 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), wherein R 1 is selected from the group consisting of hydrogen, cycloalkyl, alkyl and haloalkyl; Y is selected from the group consisting of -(CR 4a R- 4b ) m -, -C(O)-, -O-, -N(H)-, -N(alkyl)- and -S-; wherein m is 1, 2 or 3; Ar 3 is phenyl or monocyclic heteroaryl; wherein Ar 3 is substituted with 1, 2 or 3 or 4 substituents. Ar 1 is selected from the group consisting of phenyl and a monocyclic, five or six- membered heteroaryl; Ar 2 is a monocyclic five membered heteroaryl, wherein each Ar 2 is independently unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of alkyl, alkenyl, halogen, -CN, -NO 2 , hydroxy, alkoxy, -NH 2 , -N(H)(alkyl), -N(alkyl) 2 . -C(O)OH, -C(O)Oalkyl, -C(O)H, -C(O)alkyl, and haloalkyl; Z is selected from the group consisting of -OR 9a , -alkylenyl-OR 9a , -NR 6 R9 9b ; and -alkylenyl-NR 6 R 9b ; which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type U diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译：本发明涉及式（I）化合物，其中R 1选自氢，环烷基，烷基和卤代烷基; Y选自 - （CR 4a），-S（O） - ， - C（O） - ， - ，-N（H） - ， - N（烷基） - 和-S-; 其中m为1,2或3; Ar 3是苯基或单环杂芳基; 其中Ar 3 3被1,2或3或4个取代基取代。 Ar 1选自苯基和单环，五或六元杂芳基; Ar 2是单环五元杂芳基，其中每个Ar 2 2独立地是未取代的或被1或2个选自烷基，烯基，卤素， CN，-NO 2，羟基，烷氧基，-NH 2，-N（H）（烷基）， - N（烷基）。 -C（O）OH，-C（O）O烷基，-C（O）H，-C（O）烷基和卤代烷基; Z选自-OR 9a， - 亚烷基-OR 9a，-NR 6 R 9 9b，/ N >; 和 - 亚烷基-NR 6 R 9b; 其抑制乙酰辅酶A羧化酶（ACC），并且可用于预防或治疗人类的代谢综合征，U型糖尿病，肥胖症，动脉粥样硬化和心血管疾病。

6. 发明申请

WO0128979A3 INHIBITORS OF NEURAMINIDASES 审中-公开
标题翻译：神经酰胺酶抑制剂
公开(公告)号：WO0128979A3
公开(公告)日：2001-12-27
申请号：PCT/US0027938
申请日：2000-10-10
申请人： ABBOTT LAB
发明人： MARING CLARENCE J , GIRANDA VINCENT L , KEMPF DALE J , STOLL VINCENT S , SUN MINGHUA , ZHAO CHEN , GU YU GUI , WANG GARY T , KRUEGER ALLAN C , CHEN YUANWEI , DEGOEY DAVID A , GRAMPOVNIK DAVID J , KATI WARREN M , KENNEDY APRIL L , LIN ZHEN , MADIGAN DONALD L , MUCHMORE STEVEN W , SHAM HING L , STEWART KENT D , WANG SHELDON , YEUNG MING C
IPC分类号： A61K31/195 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07D233/54 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04 , A61K31/325 , A61K31/34 , A61K31/415 , A61K31/42 , A61P31/00
CPC分类号： C07D233/64 , C07B2200/07 , C07B2200/09 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07C2601/08 , C07C2601/10 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04
摘要： Disclosed are compounds of formula (I), (II) or (III) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译：公开了可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶的式（I），（II）或（III）的化合物。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

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