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1. 发明申请

WO2008104386A3 METHOD FOR THE TREATMENT OF AMYLOIDOSES 审中-公开
标题翻译：用于治疗淀粉样变性的方法
公开(公告)号：WO2008104386A3
公开(公告)日：2009-02-12
申请号：PCT/EP2008001549
申请日：2008-02-27
申请人： ABBOTT GMBH & CO KG , NIMMRICH VOLKER , BARGHORN STEFAN , EBERT ULRICH , HILLEN HEINZ , GROSS GERHARD , DRAGUHN ANDREAS , BRUEHL CLAUS , GRIMM CHRISTIANE , KRANTZ CARSTEN
发明人： NIMMRICH VOLKER , BARGHORN STEFAN , EBERT ULRICH , HILLEN HEINZ , GROSS GERHARD , DRAGUHN ANDREAS , BRUEHL CLAUS , GRIMM CHRISTIANE , KRANTZ CARSTEN
IPC分类号： A61K31/519 , A61K31/015 , A61K31/05 , A61P25/28
CPC分类号： A61K31/015 , A61K31/05 , A61K31/519 , A61K39/3955
摘要： The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an agonist of the P/Q type voltage-gated presynaptic calcium channel to said subject.
摘要翻译：本发明涉及在有需要的受试者中治疗淀粉样变性如阿尔茨海默氏病的方法，其特征在于其包括向所述受试者施用P / Q型电压门控突触前钙通道的激动剂。

2. 发明申请

WO2008104385A8 METHOD FOR THE TREATMENT OF AMYLOIDOSES 审中-公开
标题翻译：用于治疗淀粉样变性的方法
公开(公告)号：WO2008104385A8
公开(公告)日：2009-10-08
申请号：PCT/EP2008001548
申请日：2008-02-27
申请人： ABBOTT GMBH & CO KG , NIMMRICH VOLKER , BARGHORN STEFAN , EBERT ULRICH , HILLEN HEINZ , GROSS GERHARD , DRAGUHN ANDREAS , BRUEHL CLAUS , GRIMM CHRISTIANE , KRANTZ CARSTEN
发明人： NIMMRICH VOLKER , BARGHORN STEFAN , EBERT ULRICH , HILLEN HEINZ , GROSS GERHARD , DRAGUHN ANDREAS , BRUEHL CLAUS , GRIMM CHRISTIANE , KRANTZ CARSTEN
IPC分类号： A61K39/395 , A61P25/28 , C07K16/28
CPC分类号： C07K16/28 , A61K31/7076 , A61K2039/505 , C07K2317/76 , G01N33/6872 , G01N33/6896 , G01N2333/4709 , G01N2333/705 , G01N2500/02 , G01N2500/10 , G01N2800/2821
摘要： The present invention relates to a method for the treatment of an amyloidosis such as Alzheimer's disease in a subject in need thereof, characterized in that it comprises administering an inhibitor of the interaction between Aß globulomer and the P/Q type voltage-gated presynaptic calcium channel to said subject.
摘要翻译：本发明涉及在有需要的受试者中治疗淀粉样变性如阿尔茨海默病的方法，其特征在于其包括施用A球蛋白与P / Q型电压门控突触前钙通道之间相互作用的抑制剂对所述主题。

3. 发明申请

WO2006136391A2 METHOD OF TREATING A SOLID TUMOR DISEASE COMPRISING ADMINISTERING A COMBINATION COMPRISING IMATINIB AND AN INHIBITOR OF AN EFFLUX PUMP ACTIVE AT THE BLOOD BRAIN BARRIER OR DEMETHYL IMATINIB 审中-公开
标题翻译：治疗包括包含IMATINIB的组合和在血脑屏障或DEMETHYL IMATINIB上活化的血液泵的抑制剂的固体肿瘤疾病的方法
公开(公告)号：WO2006136391A2
公开(公告)日：2006-12-28
申请号：PCT/EP2006005960
申请日：2006-06-21
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BIHOREL SEBASTIEN , GROSS GERHARD , LEMAIRE MICHEL , CAMENISCH GIAN P
发明人： BIHOREL SEBASTIEN , GROSS GERHARD , LEMAIRE MICHEL , CAMENISCH GIAN P
IPC分类号： F16H7/20 , F16C1/00
CPC分类号： A61K45/06 , A61K31/506 , A61K2300/00
摘要： The invention relates to a method of treating a warm-blooded animal having a solid tumor disease comprising administering a combination which comprises: a) a N-phenyl-2- pyrimidine-amine derivative, especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]- 2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, b) at least one compound inhibiting the efflux pump active at the blood brain barrier selected from MDR1 and MRP2, c) optionally an antineoplastic agent, especially as defined herein, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease. In a further aspect, the present invention pertains to a combination which comprises: a) optionally a N-phenyl-2-pyrimidine-amine derivative, especially N-{5-[4-(4- methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine (STI571 ), b) N-{5-[4-(piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine (CGP74588), c) optionally an antineoplastic agent, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease.
摘要翻译：本发明涉及一种治疗具有实体肿瘤疾病的温血动物的方法，包括施用组合，其包含：a）N-苯基-2-嘧啶胺衍生物，特别是N- {5- [4-（4 - 甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺，b）至少一种抑制血液屏障的外排泵活性的化合物，其选自MDR1和 MRP2，c）任选的抗肿瘤剂，特别是如本文定义的d）任选的烷化剂和e）任选的羟基脲; 涉及使用这种组合来制备用于治疗实体瘤疾病的药物; 以及包含这种组合的商业包装或产品以及治疗实体瘤疾病的说明书。在另一方面，本发明涉及一种组合，其包括：a）任选地N-苯基-2-嘧啶胺衍生物，特别是N- {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基 ] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺（STI571），b）N- {5- [4-（哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4- （3-吡啶基）-2-嘧啶胺（CGP74588），c）任选的抗肿瘤剂，d）任选的烷化剂和e）任选的羟基脲; 涉及使用这种组合来制备用于治疗实体瘤疾病的药物; 以及包含这种组合的商业包装或产品以及治疗实体瘤疾病的说明书。

4. 发明申请

WO9853908A3 APPARATUS AND METHOD FOR CONDUCTING REACTIONS IN FLUIDIZED PARTICLE LAYERS 审中-公开
标题翻译：在流化颗粒层中引起反应的装置和方法
公开(公告)号：WO9853908A3
公开(公告)日：1999-03-04
申请号：PCT/EP9803114
申请日：1998-05-27
申请人： MESSER GRIESHEIM GMBH , BAYER AG , KERR MCGEE PIGMENTS GMBH & CO , GROSS GERHARD , LAILACH GUENTER , WUELBECK DIETER
发明人： GROSS GERHARD , LAILACH GUENTER , WUELBECK DIETER
IPC分类号： B01J8/00 , B01J8/24
CPC分类号： B01J8/1872 , B01J8/1827 , Y10T137/0318
摘要： The invention relates to an apparatus for conducting reactions in a fluidized particle layer located above a bottom through which the fluidization gas flows. One or several supersonic nozzles, through which one or several reactants are fed, are arranged in the wall of the apparatus above said bottom. The invention also relates to a method for conducting reactions in a fluidized particle layer, whereby the reactants are introduced into said fluidized particle layer by supersonic transversal injection.

5. 发明申请

WO2004087862A3 TAK1-MEDIATED INHIBITION OF OSTEOGENESIS 审中-公开
标题翻译： TAK1介导的OSTEOGENESIS抑制
公开(公告)号：WO2004087862A3
公开(公告)日：2005-09-09
申请号：PCT/IL2004000286
申请日：2004-03-29
申请人： YISSUM RES DEV CO , BIOTECHNOLOG FORSCHUNG GMBH , FLANDERS INTERUNIVERSITY FOR B , LEUVEN K U RES & DEV , GAZIT DAN , PELLED GADI , TURGEMAN GADI , HOFFMANN ANDREA , GROSS GERHARD , WODARCZYK CLAAS , VERSCHUEREN KRISTIN
发明人： GAZIT DAN , PELLED GADI , TURGEMAN GADI , HOFFMANN ANDREA , GROSS GERHARD , WODARCZYK CLAAS , VERSCHUEREN KRISTIN
IPC分类号： A61K31/38 , A61K48/00 , C12N20060101 , C12N9/12 , C12N15/11 , C12N15/85 , C12N15/86
CPC分类号： C12N9/1205 , A61K31/38
摘要： This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.
摘要翻译：本发明涉及TAK1介导的SMAD活性调节中的方法，核酸和组合物。促进与SMAD中MH2结构域的TAK1相互作用负调控SMAD生物活性。 BMP介导的SMAD活性受TAK1作用。

6. 发明申请

WO9927977A3 BONE MATRIX, THE UTILIZATION THEREOF, THERAPEUTIC PREPARATION AND KIT 审中-公开
标题翻译：骨基质及其用途，治疗制剂和试剂盒
公开(公告)号：WO9927977A3
公开(公告)日：1999-09-10
申请号：PCT/EP9807708
申请日：1998-11-30
申请人： BIOTECHNOLOG FORSCHUNG GMBH , MAYER HUBERT , GROSS GERHARD , ROHDE MANFRED , JAEGER VOLKER , SCHLIEPHAKE HENNING , BARTHOLD MARC
发明人： MAYER HUBERT , GROSS GERHARD , ROHDE MANFRED , JAEGER VOLKER , SCHLIEPHAKE HENNING , BARTHOLD MARC
IPC分类号： A61K35/12 , A61L27/38 , C12N5/077 , A61L27/00 , C12N5/06
CPC分类号： A61L27/3821 , A61K35/12 , A61L27/3608 , A61L27/3683 , A61L2430/02 , C12N5/0654 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/37
摘要： The invention relates to a bone matrix which can be obtained by: (a) starting out from an explantation and obtaining osteogenic precursor cells or starting out from an osteogenic cell line; (b) optionally expanding the obtained osteogenic precursor cells or the osteogenic cell line in-vitro; (c) permitting the osteogenic precursor cells to propagate, said cells being obtained according to (a) or expanded according to (b), or permitting the cell line to propagate, said cell line being inserted according to (a) or expanded according to (b), and optionally obtaining osteogenic cells; (d) separate from step (c), permitting the osteogenic cells to synthesize in-vitro in an extracellular matrix, said cells being obtained according to (a) or expanded according to (b), or permitting the cell line to synthesize in-vitro in an extracellular matrix, said cell line being introduced according to (a) or expanded according to (b); (e) optionally liberating the synthesized matrix from cells and optionally obtaining a cell-free bone matrix; (f) populating the obtained cell-free bone matrix once more with osteogenic cells which have been obtained according to (c) and optionally obtaining a populated bone matrix by using osteogenic cells.
摘要翻译：本发明涉及一种骨基质，这是在该得到的原料（a）一种外植体，和成骨祖细胞的获得或从成骨细胞系开始，（b）任选扩大衍生的成骨前体细胞或体外成骨细胞系，（c）中根据（a）或根据（b）中展开的成骨前体细胞或根据（a）中，根据（a）中回收的用过的或根据（b）中可以多重扩增的细胞系和任选地，成骨细胞获胜，（d）中分别从测量（c）中得到可以合成或根据（b）中展开的成骨细胞或根据（a）中使用，或根据（b）中的体外细胞外基质扩增的细胞系，（e）中合成的基质，在适当情况下，释放的细胞和任选的无细胞的骨基质的胜，（f）中，将回收的再次根据（c）中已产生结算与骨原细胞的无细胞的骨基质，并gegebenenf 承滴盘由骨细胞的骨基质胜填充。

7. 发明申请

WO2004045493A3 METHODS OF INDUCING OR ENHANCING CARTILAGE REPAIR 审中-公开
标题翻译：诱导或增强消化系统修复的方法
公开(公告)号：WO2004045493A3
公开(公告)日：2004-11-04
申请号：PCT/IL0300976
申请日：2003-11-18
申请人： YISSUM RES DEV CO , GBF GES FUR BIOTECHNOLOGISHE F , GAZIT DAN , ZILBERMAN YORAM , TURGEMAN GADI , PELLED GADI , GROSS GERHARD , HOFFMANN ANDREA
发明人： GAZIT DAN , ZILBERMAN YORAM , TURGEMAN GADI , PELLED GADI , GROSS GERHARD , HOFFMANN ANDREA
IPC分类号： A61K35/12 , C12N5/077 , A01N63/00 , A61K48/00
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00
摘要： The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.

8. 发明申请

WO0067847A3 USE OF DOPAMINE D3 RECEPTOR LIGANDS FOR PRODUCING MEDICAMENTS FOR TREATING KIDNEY DISORDERS 审中-公开
标题翻译：作者多巴胺D3受体配体的药品生产用于肾功能不全的治疗
公开(公告)号：WO0067847A3
公开(公告)日：2001-08-02
申请号：PCT/EP0003865
申请日：2000-04-28
申请人： BASF AG , MUEHLBAUER BERND , GROSS GERHARD , STARCK DOROTHEA , TREIBER HANS JOERG
发明人： MUEHLBAUER BERND , GROSS GERHARD , STARCK DOROTHEA , TREIBER HANS-JOERG
IPC分类号： C07D241/04 , A61K31/00 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5513 , A61K45/00 , A61P1/00 , A61P13/12 , C07D401/12 , C07D403/12
CPC分类号： A61K31/517 , A61K31/00 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/506
摘要： The invention relates to the use of dopamine D3 receptor ligands for producing medicaments for treating kidney disorders.
摘要翻译：本发明涉及使用多巴胺D 3受体配体用于制备药物的用于肾功能不全的治疗。

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