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1. 发明申请

WO2010006201A2 METHODS OF REDUCING NON-SPECIFIC INTERACTION IN METAL NANOPARTICLE ASSAYS 审中-公开
标题翻译：减少金属纳米颗粒测定中的非特异性相互作用的方法
公开(公告)号：WO2010006201A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050159
申请日：2009-07-09
申请人： ABAXIS, INC. , MEHRA, Rajesh, K. , CHIANG, Vincent , ARON, Kenneth, P.
发明人： MEHRA, Rajesh, K. , CHIANG, Vincent , ARON, Kenneth, P.
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/5306 , G01N33/54393 , Y02A50/57
摘要： The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity of these assays. In particular, the methods entail neutralizing the chemical reactivity of functional groups present in interfering species by addition of a neutralizing agent, such as an alkylating agent or heavy metal ion. The methods are especially useful in assays for the detection of analytes in biological samples. Reagent kits and assay mixtures for the practice of the described methods are also disclosed.
摘要翻译：本发明公开了在基于金属纳米粒子的测定中减少样品中存在的干扰物质的非特异性相互作用的方法，由此增加这些测定的灵敏度。具体而言，所述方法需要通过添加中和剂如烷化剂或重金属离子来中和存在于干扰物质中的官能团的化学反应性。该方法在检测生物样品中分析物的分析中特别有用。还公开了用于实施所述方法的试剂盒和测定混合物。

2. 发明申请

WO2018140953A1 SOLUTION-BASED PLASMON SPECIFIC-BINDING PARTNER ASSAYS AND METALLIC NANOSTRUCTURES 审中-公开
公开(公告)号：WO2018140953A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/015981
申请日：2018-01-30
申请人： ABAXIS, INC. , CHIANG, Vincent , UNSER, Sarah Ann
发明人： CHIANG, Vincent , UNSER, Sarah Ann , MEHRA, Rajesh K. , ARON, Kenneth P.
IPC分类号： G01N21/62 , G01N33/53 , G01N33/532
摘要： The present invention relates to nanostructure-binding partner conjugates, as well as reaction mixtures, analyte detection devices, and methods of making and using the conjugates. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample.

3. 发明申请

WO2009117510A3 MULTI-WAVELENGTH ANALYSES OF SOL-PARTICLE SPECIFIC BINDING ASSAYS 审中-公开
公开(公告)号：WO2009117510A3
公开(公告)日：2009-09-24
申请号：PCT/US2009/037553
申请日：2009-03-18
申请人： ABAXIS, INC. , CHIANG, Vincent , MEHRA, Rajesh
发明人： CHIANG, Vincent , MEHRA, Rajesh
IPC分类号： G01N33/52 , G01N21/77 , G01N33/569 , G06F19/00
摘要： The present invention discloses methods for detecting the presence of a complex between a first reagent and a second reagent in solution. In particular, the invention provides methods for qualitative or quantitative detection of an analyte or its specific binding partner in complex biological samples. The invention further discloses algorithms using summary rate changes at selected wavelengths in the absorbance spectra of colloidal metal-labeled analytes or specific binding partners to identify intermolecular interactions between the analyte and its binding partner.

4. 发明申请

WO2017024163A1 SIGNAL AMPLIFICATION IN SOLUTION-BASED PLASMONIC SPECIFIC-BINDING PARTNER ASSAYS 审中-公开
标题翻译：基于解决方案的信号特定绑定合作伙伴测试中的信号放大
公开(公告)号：WO2017024163A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045606
申请日：2016-08-04
申请人： ABAXIS, INC. , FRISZ, Jessica
发明人： FRISZ, Jessica , MEHRA, Rajesh K. , ARON, Kenneth P. , CHIANG, Vincent
IPC分类号： B82Y30/00 , B82Y35/00 , G01N21/17 , G01N21/55
CPC分类号： G01N33/553 , G01N33/54373 , G01N2469/10 , Y02A50/57
摘要： The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.
摘要翻译：本发明涉及分析物检测装置和使用这种装置来检测样品中微量的目标分析物的方法。特别地，本发明提供了一种检测样品中的目标分析物的方法，包括将样品与溶液中的第一检测缀合物和第二检测缀合物混合，其中第一和第二检测缀合物包含与结合配偶体偶联的金属纳米结构，如果存在于样品中以形成第一检测缀合物，分析物和第二检测缀合物之间的复合物，则特异性结合目标分析物，其中复合物形成时光信号的变化表明靶分析物在样品。还描述了制备纳米结构和纳米合金以及与结合配偶体缀合的纳米结构和纳米合金的方法。

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