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    • 9. 发明申请
    • SIGNAL AMPLIFICATION IN SOLUTION-BASED PLASMONIC SPECIFIC-BINDING PARTNER ASSAYS
    • 基于解决方案的信号特定绑定合作伙伴测试中的信号放大
    • WO2017024163A1
    • 2017-02-09
    • PCT/US2016/045606
    • 2016-08-04
    • ABAXIS, INC.FRISZ, Jessica
    • FRISZ, JessicaMEHRA, Rajesh K.ARON, Kenneth P.CHIANG, Vincent
    • B82Y30/00B82Y35/00G01N21/17G01N21/55
    • G01N33/553G01N33/54373G01N2469/10Y02A50/57
    • The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.
    • 本发明涉及分析物检测装置和使用这种装置来检测样品中微量的目标分析物的方法。 特别地,本发明提供了一种检测样品中的目标分析物的方法,包括将样品与溶液中的第一检测缀合物和第二检测缀合物混合,其中第一和第二检测缀合物包含与结合配偶体偶联的金属纳米结构, 如果存在于样品中以形成第一检测缀合物,分析物和第二检测缀合物之间的复合物,则特异性结合目标分析物,其中复合物形成时光信号的变化表明靶分析物在 样品。 还描述了制备纳米结构和纳米合金以及与结合配偶体缀合的纳米结构和纳米合金的方法。