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1. 发明申请

WO2014093780A2 STENT WITH REINFORCED JOINTS 审中-公开
标题翻译：具有加强连接的STENT
公开(公告)号：WO2014093780A2
公开(公告)日：2014-06-19
申请号：PCT/US2013/074933
申请日：2013-12-13
申请人： 480 BIOMEDICAL, INC. , CONCAGH, Danny , PALASIS, Maria , NAIMARK, Wendy , HO, Kicherl , WEBBER, Stephanie , KUANG, Yina
发明人： CONCAGH, Danny , PALASIS, Maria , NAIMARK, Wendy , HO, Kicherl , WEBBER, Stephanie , KUANG, Yina
IPC分类号： A61F2/90
CPC分类号： A61F2/90 , A61F2210/0004 , A61F2210/0023 , A61F2220/0041 , A61F2220/0075 , A61F2220/0091 , A61F2250/0042
摘要： Stents for insertion into bodily lumens are disclosed. The stents comprise at least one strand that form self-expanding tubular structures. The strand or strands form a plurality of intersections at which a first portion of a strand is in proximity to another portion of the same or different strand. The stents further include a plurality of reinforcement members, each of which are located at one of the intersections.
摘要翻译：公开了用于插入体液的支架。支架包括形成自膨胀管状结构的至少一条股线。股线或股线形成多个交叉点，在该交叉处，股线的第一部分在相邻或不同股线的另一部分附近。支架还包括多个加强构件，每个加强构件位于一个交叉点处。

2. 发明申请

WO2015035387A1 DRUG DELIVERY SYSTEMS AND RELATED METHODS 审中-公开
标题翻译：药物输送系统及相关方法
公开(公告)号：WO2015035387A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054792
申请日：2014-09-09
申请人： ARSENAL MEDICAL, INC. , PALASIS, Maria , CONCAGH, Danny , CORE, Lee , WEBBER, Stephanie , KUANG, Yina , NAIMARK, Wendy , KNOX, Raymond
发明人： PALASIS, Maria , CONCAGH, Danny , CORE, Lee , WEBBER, Stephanie , KUANG, Yina , NAIMARK, Wendy , KNOX, Raymond
IPC分类号： A61B17/12
CPC分类号： A61M25/10 , A61F2/90 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , A61M2025/105 , A61M2025/1075 , C08L67/04
摘要： The present invention provides systems and methods for the targeted delivery of a therapeutic agent using expandable devices that are temporarily or permanently placed within the body. Such therapeutic agents may be delivered as a coating on the outer surface of the expandable device. Once positioned at a desired location within the body, the device is expanded such that its drug-coated outer surface establishes direct contact with a target tissue. The expanded device remains in contact with the target tissue for a pre-determined amount of time prior to being withdrawn from the body. Delivery of the therapeutic agent using the expandable device may be followed, or preceded, by delivery of a second expandable device to the same location within the body.
摘要翻译：本发明提供了使用临时或永久地放置在体内的可扩展装置来靶向递送治疗剂的系统和方法。这样的治疗剂可以作为涂层递送到可扩张装置的外表面上。一旦定位在身体内的期望位置，则该装置被扩张，使得其药物涂覆的外表面与靶组织直接接触。膨胀的装置在从身体取出之前保持与目标组织接触预定量的时间。可以通过将第二可扩张装置递送到身体内的相同位置，或之前进行使用可扩张装置的治疗剂的递送。

3. 发明申请

WO2014126957A1 MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒
公开(公告)号：WO2014126957A1
公开(公告)日：2014-08-21
申请号：PCT/US2014/015931
申请日：2014-02-12
申请人： 480 BIOMEDICAL, INC. , PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Gregory, T.
发明人： PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Gregory, T.
IPC分类号： A61L31/06 , A61L31/14 , A61L31/10
CPC分类号： A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04 , C08L75/06
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高回收性和所需的机械性能。

4. 发明申请

WO2014172319A1 DRUG ELUTING MEDICAL IMPLANT 审中-公开
标题翻译：药物植入物
公开(公告)号：WO2014172319A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034095
申请日：2014-04-15
申请人： 480 BIOMEDICAL, INC. , PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kirchel , SHARMA, Upma , ZUGATES, Gregory, T.
发明人： PALASIS, Maria , YOU, Changcheng , CONCAGH, Danny , CORE, Lee , HO, Kirchel , SHARMA, Upma , ZUGATES, Gregory, T.
IPC分类号： A61L31/10 , A61L27/34 , A61L31/16 , A61L27/54
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高回收性和所需的机械性能。

5. 发明申请

WO2013158619A2 DRUG ELUTING MEDICAL IMPLANT 审中-公开
标题翻译：药物植入物
公开(公告)号：WO2013158619A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/036743
申请日：2013-04-16
申请人： 480 BIOMEDICAL, INC. , PALASIS, Maria , YOU, Changcheng , CONCAGH, Daniel , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Greg
发明人： PALASIS, Maria , YOU, Changcheng , CONCAGH, Daniel , CORE, Lee , HO, Kicherl , SHARMA, Upma , ZUGATES, Greg
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2/86 , A61F2250/003 , A61L31/16 , A61L2300/416 , A61L2420/08 , D04C1/06 , D10B2509/06 , C08L67/04
摘要： Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
摘要翻译：公开了用于放置在患者的内腔内的自扩张医用植入物。植入物包括具有基本上管状构造的织造或非织造结构，并且被设计为低轮廓，使得它们可以用小直径导管递送。植入物具有高可回收性和所需的机械性能。

6. 发明申请

WO2006107408A1 ROTATABLE MULTI-PORT THERAPEUTIC DELIVERY DEVICE 审中-公开
标题翻译：可旋转的多端口治疗设备
公开(公告)号：WO2006107408A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/005009
申请日：2006-02-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , SHAW, William, J.
发明人： NAIMARK, Wendy , PALASIS, Maria , FREYMAN, Toby , SHAW, William, J.
IPC分类号： A61M25/00
CPC分类号： A61M25/0069
摘要： The present invention relates to the delivery of therapeutic to a target area. More particularly, the present invention relates to therapeutic delivery devices, with, one or more therapeutic delivery bodies that have new and unique degrees of freedom of motion. A therapeutic delivery device (100, 300, 700, 900, 1200, 1300, 1800) according to the invention comprises a steerable elongated member (310, 710, 910, 1210, 1310, 1810) sized for insertion into a body of a patient; and a rotatable therapeutic delivery body (320, 720, 920, 1220, 1320, 1815) rotatably supported by the elongated member; the delivery body free to rotate about at least one axis of rotation, the delivery body having one or more therapeutic delivery ports, the rotatable therapeutic delivery body sized for insertion into a body of a patient.
摘要翻译：本发明涉及将治疗剂递送至目标区域。更具体地，本发明涉及具有一种或多种具有新的和独特的运动自由度的治疗递送体的治疗递送装置。根据本发明的治疗性输送装置（100,300,700,900,1200,1300,1800）包括尺寸适于插入患者体内的可操纵细长构件（310,710,910,1210,1310,1810） ; 以及由所述细长构件可旋转地支撑的可旋转治疗递送体（320,720,920,1220,1320,1815）所述递送体自由地围绕至少一个旋转轴线旋转，所述递送体具有一个或多个治疗递送口，所述可转动的治疗递送体的尺寸设置成插入到患者体内。

7. 发明申请

WO2007089976A2 LOCAL CONTROL OF INFLAMMATION 审中-公开
标题翻译：炎症的局部控制
公开(公告)号：WO2007089976A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/060581
申请日：2007-01-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61F2/06
CPC分类号： A61F2/02 , A61F2/0077 , A61F2/07 , A61F2230/008 , A61F2250/0039 , A61F2250/0067
摘要： A medical device includes a carrier and an agent. The agent is formulated to control inflammation of biological tissue, such as heart tissue, and is releasably coupled to the carrier. The carrier is configured to be disposed in operative proximity to the biological tissue to be treated by the agent. In one embodiment, the carrier is configured to release the agent or otherwise deliver the agent to the biological tissue, thus controlling inflammation of the tissue. Also, a method to improve healing of biological tissue includes placing a medical device proximate to the heart of a patient, where the medical device has a carrier and an agent configured to control inflammation, the agent is releasably coupled to the carrier. In one embodiment, the method includes causing the agent to be released from the carrier.
摘要翻译：医疗器械包括载体和药剂。制剂用于控制诸如心脏组织的生物组织的炎症，并且可释放地联接到载体上。载体被配置为设置在操作中接近要由药剂处理的生物组织。在一个实施方案中，载体被配置为释放试剂或以其它方式将试剂递送到生物组织，从而控制组织的炎症。而且，改善生物组织愈合的方法包括将医疗装置放置在患者的心脏附近，其中医疗装置具有载体和构造成控制炎症的药剂，药剂可释放地联接到载体上。在一个实施例中，该方法包括使得试剂从载体释放。

8. 发明申请

WO2007037850A2 ENHANCED DELIVERY OF CELLS 审中-公开
标题翻译：增强细胞的传递
公开(公告)号：WO2007037850A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/032767
申请日：2006-08-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy
发明人： FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy
IPC分类号： A61K35/28
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.
摘要翻译：本发明提供了一种方法，其包括通过血管输注施用细胞并施用血管扩张剂，血管增强剂或两者。根据一个实施方案，通过在细胞治疗之前或期间通过施用一种或多种血管扩张剂和/或血管通透性增强剂来改善通过冠状动脉内输注将干细胞递送至心肌。

9. 发明申请

WO2009089110A2 METHODS FOR REPAIR AND REGENERATION OF BONE MARROW 审中-公开
标题翻译：骨质疏松修复和再生方法
公开(公告)号：WO2009089110A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030046
申请日：2009-01-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61K49/00 , A61K35/12
CPC分类号： A61L27/3847 , A61L27/3633 , A61L27/3834
摘要： The invention is directed to a method for treating a tissue or organ in a subject by directly administering an effective amount of an exogenous, decellularized extracellular matrix or a mixture of extracellular matrix and mesenchymal stem cells into the intended site of activity, such as bone marrow cavity. In one embodiment, the invention provides methods of treating bone marrow to increase the number of circulating progenitor and stem cells. In some other embodiments of the invention, the decellularized extracellular matrix to be directly administered is configured to be a time released therapeutic.
摘要翻译：本发明涉及一种通过将有效量的外源性脱细胞细胞外基质或细胞外基质和间充质干细胞的混合物直接施用于预期的活性位点（例如骨髓）来治疗受试者的组织或器官的方法腔。在一个实施方案中，本发明提供了治疗骨髓以增加循环祖细胞和干细胞数量的方法。在本发明的一些其它实施方案中，待直接施用的脱细胞细胞外基质配置为时间释放治疗剂。

10. 发明申请

WO2008042466A2 APPARATUSES AND METHODS TO TREAT ATHEROSCLEROTIC PLAQUES 审中-公开
标题翻译：用于治疗动脉粥样硬化斑块的装置和方法
公开(公告)号：WO2008042466A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/068354
申请日：2007-05-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , HERRMANN, Robert , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , HERRMANN, Robert , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/148 , A61L2300/604
摘要： This invention comprises an apparatus for treating an atherosclerotic plaque in a coronary artery of a mammal by placing at or proximate to an entrance to the coronary artery and upstream of the vulnerable plaque, and an effective amount of a therapeutic agent for the treatment of the plaque. This invention comprises delivering a deposition of a therapeutic drug high in the coronary arterial tree for treatment of downstream vulnerable plaques. The invention also comprises slow release formulation and delivery of an apparatus that is totally degradable or removed and/or replaced.
摘要翻译：本发明包括一种用于通过放置在冠状动脉的入口处或在冠状动脉的入口附近和易损斑块的上游来治疗哺乳动物冠状动脉中的动脉粥样硬化斑块的设备，以及有效量的用于治疗斑块的治疗剂。本发明包括递送在冠状动脉树中高度治疗药物的沉积以治疗下游易损斑块。本发明还包括缓释制剂和递送完全可降解或移除和/或替换的装置。

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