专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012061227A2 BIOLOGICAL STERILIZATION INDICATOR 审中-公开
标题翻译：生物灭菌指标
公开(公告)号：WO2012061227A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/058257
申请日：2011-10-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , SMITH, Jeffrey D. , DUDA, RuthAnn R. , ENGEL, Brian J.
发明人： CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , SMITH, Jeffrey D. , DUDA, RuthAnn R. , ENGEL, Brian J.
IPC分类号： C12Q1/22
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
摘要翻译：生物灭菌指示器（BI）。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体并且容器的至少一部分可以是易碎的。 BI还可以包括第一腔室和第二腔室。第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一腔室和第二腔室之间的壳体中的基板。衬底可以定位成与第一室和第二室流体连通，并且衬底可以进一步定位成使得衬底不直接与生物活性源接触。

2. 发明申请

WO2012061212A1 METHOD OF DETECTING A BIOLOGICAL ACTIVITY 审中-公开
标题翻译：检测生物活性的方法
公开(公告)号：WO2012061212A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058210
申请日：2011-10-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , ENGEL, Brian J.
发明人： CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , ENGEL, Brian J.
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , C12Q1/04
摘要： A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and concentrates a biological derivative of the indicator reagent. The method further includes observing a portion of the substrate to detect the biological derivative. The method can be used to detect the presence or absence of a target cell.
摘要翻译：提供了检测生物活性的方法。该方法包括接触; 在选择用于促进预定生物活性的液体介质中; 样品，指示剂试剂和接收并浓缩指示剂试剂的生物衍生物的底物。该方法还包括观察基底的一部分以检测生物衍生物。该方法可用于检测靶细胞的存在或不存在。

3. 发明申请

WO2013122852A1 BIOLOGICAL STERILIZATION INDICATOR DEVICES AND METHODS OF USE 审中-公开
标题翻译：生物灭菌指示剂装置及其使用方法
公开(公告)号：WO2013122852A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025500
申请日：2013-02-11
申请人： 3M INNOVATIVE PROPERTIES COMPANY , AHIMOU, Francois , CHANDRAPATI, Sailaja , HALVERSON, Kurt J. , WEBB, Heather M. , WILLIAMS, Michael G.
发明人： AHIMOU, Francois , CHANDRAPATI, Sailaja , HALVERSON, Kurt J. , WEBB, Heather M. , WILLIAMS, Michael G.
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , G01N21/6428 , G01N2201/061
摘要： A biological sterilization indicator device is provided. The device comprises a body, a plurality of test microorganisms, and an oxygen-modulated first fluorescent sensor. The body comprises a first layer attached to a second layer, forming at least one isolatable microchamber and at least one primary passageway that provides fluidic communication between ambience and the at least one microchamber. The microchamber has an isolated volume of about 0.5 microliters to about 9.5 microliters. The plurality of test microorganisms and the oxygen-modulated first fluorescent sensor are disposed in the microchamber. A method of using the device to determine the effectiveness of a sterilization process is also provided.
摘要翻译：提供生物灭菌指示装置。该装置包括主体，多个测试微生物和氧调制的第一荧光传感器。主体包括附接到第二层的第一层，形成至少一个可隔离的微室和至少一个主要通道，其提供环境与至少一个微室之间的流体连通。微室具有约0.5微升至约9.5微升的隔离体积。多个测试微生物和氧调制的第一荧光传感器设置在微室中。还提供了使用该装置来确定灭菌过程的有效性的方法。

4. 发明申请

WO2010045433A1 STERILITY INDICATING BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS 审中-公开
标题翻译：表明生物组成的无效性，文章和方法
公开(公告)号：WO2010045433A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060805
申请日：2009-10-15
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather, M. , WEI, Ai-Ping
发明人： CHANDRAPATI, Sailaja , WEBB, Heather, M. , WEI, Ai-Ping
IPC分类号： A61L2/28 , C12Q1/18 , C12M1/40
CPC分类号： C12Q1/37 , A61L2/28 , C12Q1/22
摘要： A sterility indicating composition comprising a plurality of sterilization process resistant spores which contain an active protease during germination and initial outgrowth of the spores; and a germination medium comprising at least one labeled protease substrate and at least one nutrient for germination of the spores; wherein the medium is essentially free of a) any active protease other than the active protease contained by the plurality of spores and b) any protease substrate other than the at least one labeled protease substrate, other than any protease substrate originating from the plurality of spores, and other than any protease substrate which does not compete with the labeled protease substrate for the active protease; and wherein the at least one labeled protease substrate comprises a peptide which can be cleaved by the active protease and which is labeled with one or more dye groups, at least one of which undergoes a detectable change when the peptide is cleaved by the active protease, and wherein the labeled protease substrate is stable at least at a temperature for incubating the spores, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.
摘要翻译：一种不育指示组合物，其包含多个灭菌过程抗性孢子，其在萌发期间含有活性蛋白酶和孢子的初始产生; 以及包含至少一种标记的蛋白酶底物和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述培养基基本上不含a）除所述多个孢子所含的活性蛋白酶以外的任何活性蛋白酶，和b）除所述至少一个标记的蛋白酶底物之外的任何蛋白酶底物，而不是源于所述多个孢子的任何蛋白酶底物，而不是与活性蛋白酶的标记的蛋白酶底物竞争的任何蛋白酶底物以外的其它蛋白酶底物; 并且其中所述至少一个标记的蛋白酶底物包含可被活性蛋白酶切割并且被一个或多个染料基团标记的肽，当肽被活性蛋白酶切割时，其中的至少一种经历可检测的变化，并且其中标记的蛋白酶底物至少在培养孢子的温度下是稳定的，包括该组合物的灭菌过程指示剂以及使用该组合物和指示剂确定灭菌过程的有效性的方法。

5. 发明申请

WO2011011189A1 BIOLOGICAL STERILIZATION INDICATOR AND METHOD OF USING SAME 审中-公开
标题翻译：生物灭菌指示剂及其使用方法
公开(公告)号：WO2011011189A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/041010
申请日：2010-07-06
申请人： 3M INNOVATIVE PROPERTIES COMPANY , SMITH, Jeffrey D. , PEDERSON, Jeffrey C. , CHANDRAPATI, Sailaja
发明人： SMITH, Jeffrey D. , PEDERSON, Jeffrey C. , CHANDRAPATI, Sailaja
IPC分类号： C12Q1/22 , A61L2/28
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion (104), and a second portion (106), which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container (120) comprising a liquid. The BI can further include a spore reservoir (114) and a projection (158) positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
摘要翻译：生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括壳体，其可以包括第一部分（104）和第二部分（106），第二部分可以在第一和第二位置之间相对于第一部分移动。 BI还可以包括包含液体的易碎容器（120）。 BI还可包括孢子储存器（114）和定位在壳体中的突起（158）。突起可以被构造成当壳体的第二部分从第一位置移动到第二位置时破裂容器。该方法可以包括当壳体的第二部分处于第一位置时保持容器周围的空间的最小横截面面积，并且响应于在第一和第二位置之间移动第二部分而破裂容器。

6. 发明申请

WO2012061229A1 BIOLOGICAL STERILIZATION INDICATOR SYSTEM AND METHOD 审中-公开
标题翻译：生物灭菌指标体系及方法
公开(公告)号：WO2012061229A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058262
申请日：2011-10-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , PEDERSON, Jeffrey, C. , CHANDRAPATI, Sailaja , BEHUN, Bryan S. , ROBOLE, Barry W. , LONGWORTH, Leroy J. , CHEN, Kaileen
发明人： PEDERSON, Jeffrey, C. , CHANDRAPATI, Sailaja , BEHUN, Bryan S. , ROBOLE, Barry W. , LONGWORTH, Leroy J. , CHEN, Kaileen
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28
摘要： A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first "unactivated" position and a second "activated" position. The reading apparatus can detect at least one of (i) when the well is empty; (ii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the first position, and (iii) when the biological sterilization indicator is positioned in the well with the second portion of the housing in the second position. The method can include detecting at least one of the above conditions, which can be used to detect an activation status of the biological sterilization indicator.
摘要翻译：一种生物灭菌指示剂（BI）系统和方法。该系统可以包括BI和包括井的读取装置。 BI可以包括可以包括第一部分的壳体和可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。读取装置可以检测以下中的至少一个：（i）当井为空时; （ii）当所述生物灭菌指示器位于所述井中时，所述壳体的第二部分位于所述第一位置，并且（iii）当所述生物灭菌指示器位于所述井中时，所述壳体的所述第二部分处于所述第二位置。该方法可以包括检测可用于检测生物灭菌指示剂的活化状态的上述条件中的至少一个。

7. 发明申请

WO2012061226A1 BIOLOGICAL STERILIZATION INDICATOR AND METHOD OF USING SAME 审中-公开
标题翻译：生物灭菌指示剂及其使用方法
公开(公告)号：WO2012061226A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058256
申请日：2011-10-28
申请人： 3M INNOVATIVE PROPERTIES COMPANY , SMITH, Jeffrey D. , PEDERSON, Jeffrey C. , CHANDRAPATI, Sailaja , DUDA, RuthAnn R.
发明人： SMITH, Jeffrey D. , PEDERSON, Jeffrey C. , CHANDRAPATI, Sailaja , DUDA, RuthAnn R.
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22
摘要： A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
摘要翻译：生物灭菌指示剂（BI）及其使用方法。 BI可以包括壳体和位于壳体中的容器。容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。第二室可以包括至少一种生物活性来源。 BI还可以包括定位成流体耦合第一室和第二室的第一流体路径，以及定位成允许排出的气体移出第二室的第二流体路径。该方法可以包括当消毒剂经由第一流体路径移动到第二室中时和/或当液体经由第一流体路径移动到第二室中时，通过第二流体路径将移动的气体移出第二室。

8. 发明申请

WO2010045517A1 BIOLOGICAL COMPOSITIONS, ARTICLES AND METHODS FOR MONITORING STERILIZATION PROCESSES 审中-公开
标题翻译：生物组合物，用于监测灭菌过程的文章和方法
公开(公告)号：WO2010045517A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060936
申请日：2009-10-16
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather M. , HALVERSON, Kurt J.
发明人： CHANDRAPATI, Sailaja , WEBB, Heather M. , HALVERSON, Kurt J.
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22
摘要： A sterility indicating composition comprising a plurality of sterilization process resistant spores; a germination medium comprising a sub-lethal amount of at least one cell-permeant nucleic acid-interacting fluorescent dye and at least one nutrient for germination of the spores; wherein the at least one cell-permeant fluorescent dye can interact with nucleic acids present in and produced by the plurality of spores during germination or during germination and outgrowth of the spores to produce an increase in fluorescence intensity, indicating that viable spores are present, and wherein the cell-permeant fluorescent dye is sufficiently stable at least at a temperature for incubating the spores to produce the increase in fluorescence intensity, a sterilization process indicator comprising the composition, and a method of determining the effectiveness of a sterilization process using the composition and indicator are disclosed.
摘要翻译：一种无菌指示组合物，其包含多个耐灭菌过程的孢子; 包含亚致死量的至少一种细胞渗透性核酸相互作用荧光染料和至少一种用于孢子发芽的营养物的发芽培养基; 其中所述至少一种细胞透过性荧光染料可以在发芽过程中或在芽孢的发芽和生长期间与存在于和由多个孢子产生的核酸相互作用以产生荧光强度的增加，从而表明存在可行的孢子，以及其中所述细胞透过性荧光染料至少在用于培养孢子以产生荧光强度增加的温度下是足够稳定的，包含该组合物的灭菌过程指示剂以及使用该组合物确定灭菌过程的有效性的方法，以及指标。

9. 发明申请

WO2013188102A1 METHODS AND KITS FOR DETECTING A XEROPHILIC MICROORGANISM OR AN OSMOPHILIC MICROORGANISM 审中-公开
标题翻译：检测XEROPHILIC MICROORGANISM或OSMOPHILIC MICROORGANISM的方法和试剂盒
公开(公告)号：WO2013188102A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/042996
申请日：2013-05-29
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , NORDBY, Tera, M.
发明人： CHANDRAPATI, Sailaja , NORDBY, Tera, M.
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/44 , G01N2333/37 , G01N2333/39
摘要： A method for detecting a xerophilic microorganism is provided. The method comprises providing a sample to be tested, an aqueous diluent comprising about 1.0 to about 10.2 weight percent glycerol, and a thin film culture device comprising a cold water-reconstitutable medium to facilitate the growth of a microorganism. The method further comprises mixing the sample with the aqueous diluent to form an inoculum, contacting a predefined amount of the inoculum with the reconstitutable medium to form an inoculated thin film culture device, incubating the inoculated thin film culture device for a period of time, and detecting a presence or an absence of colony of a microorganism. Kits for detecting a xerophilic microorganism according to the method are also provided.
摘要翻译：提供了一种用于检测嗜性微生物的方法。该方法包括提供待测样品，包含约1.0至约10.2重量％甘油的含水稀释剂和包含有助于微生物生长的冷水可重构培养基的薄膜培养装置。该方法还包括将样品与水性稀释剂混合以形成接种物，将预定量的接种物与可重构培养基接触以形成接种的薄膜培养装置，将接种的薄膜培养装置孵育一段时间，以及检测微生物存在或不存在菌落。还提供了用于根据该方法检测嗜性微生物的试剂盒。

10. 发明申请

WO2009067503A1 SAMPLE PREPARATION FOR ENVIRONMENTAL SAMPLING 审中-公开
标题翻译：环境采样样品制备
公开(公告)号：WO2009067503A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/084015
申请日：2008-11-19
申请人： 3M INNOVATIVE PROPERTIES COMPANY , HALVERSON, Kurt J. , JOSEPH, Stephen C. P. , RAJAGOPAL, Raj , REIER, Matthew D. , VELASQUEZ, David J. , ZOOK, Cynthia D. , CHANDRAPATI, Sailaja
发明人： HALVERSON, Kurt J. , JOSEPH, Stephen C. P. , RAJAGOPAL, Raj , REIER, Matthew D. , VELASQUEZ, David J. , ZOOK, Cynthia D. , CHANDRAPATI, Sailaja
IPC分类号： B01L3/00 , G01N1/38
CPC分类号： G01N1/38 , B01L3/5029
摘要： A system and method for preparing samples to test an environmental surface for an analyte of interest. The system can include a deformable self-supporting receptacle comprising a reservoir, and a loaded substrate positioned in the reservoir of the deformable self-supporting receptacle. The loaded substrate can include a substrate and a source collected from the surface. The method can include combining the loaded substrate and a diluent in the reservoir, and agitating the loaded substrate and the diluent to form a liquid composition comprising the source and the diluent.
摘要翻译：用于制备样品以测试感兴趣分析物的环境表面的系统和方法。该系统可以包括可变形的自支撑容器，其包括储存器和位于可变形自支撑容器的储存器中的加载基板。装载的衬底可以包括衬底和从表面收集的源。该方法可以包括将加载的基底和稀释剂组合在储存器中，并且搅拌加载的基底和稀释剂以形成包含源和稀释剂的液体组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式