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    • 3. 发明申请
    • MULTILAYERED CHROMONIC STRUCTURES
    • 多层色谱结构
    • WO2007075252A1
    • 2007-07-05
    • PCT/US2006/045589
    • 2006-11-29
    • 3M INNOVATIVE PROPERTIES COMPANY
    • MOHANTY, SanatSAHOUANI, HassanMORAN, Cristin, E.
    • A61K9/22A01N47/36
    • A61K9/0019A61K47/22Y10T428/2989Y10T428/2991Y10T428/31504
    • A method of making a multilayered chromonic structure comprises (a) preparing a first aqueous mixture comprising (i) a first continuous water-soluble polymer phase and (ii) a first discontinuous chromonic phase comprising a chromonic material, to form chromonic nanoparticles;(b) non-covalently crosslinking the resulting chromonic nanoparticles with a multivalent cation salt; (c) dispersing the resulting crosslinked chromonic nanoparticles in a composition comprising a chromonic material to form a chromonic nanoparticle dispersion; and (d) preparing a second aqueous mixture comprising (i) a second discontinuous chromonic phase comprising the chromonic nanoparticle dispersion and (ii) a second continuous water-soluble polymer phase, to encapsulate the chromonic nanoparticles; wherein at least one of the first discontinuous chromonic phase and the second discontinuous chromonic phase further comprises a guest compound.
    • 制备多层发色结构的方法包括(a)制备第一含水混合物,其包含(i)第一连续水溶性聚合物相和(ii)包含发色材料的第一不连续发色相以形成发色纳米颗粒;(b )用多价阳离子盐非共价交联得到的发色纳米颗粒; (c)将得到的交联发色纳米颗粒分散在包含发色材料的组合物中以形成发色纳米粒子分散体; 和(d)制备第二含水混合物,其包含(i)包含发色纳米颗粒分散体的第二不连续发色相和(ii)第二连续水溶性聚合物相,以包封发色纳米颗粒; 其中所述第一不连续发色相和所述第二不连续发色相中的至少一个还包含客体化合物。