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    • 10. 发明申请
    • SUBSTRATES AND COMPOUNDS BONDED THERETO BY TETHERING COMPOUNDS COMPRISING PHOSPHONITRILIC GROUPS
    • 通过包含磷酸盐基团的化合物与其结合的基底和化合物
    • WO2005066634A1
    • 2005-07-21
    • PCT/US2004/042489
    • 2004-12-17
    • 3M INNOVATIVE PROPERTIES COMPANY
    • LAKSHMI, Brinda, B.
    • G01N33/543
    • G01N33/54353Y10T428/249953Y10T428/28Y10T428/2804Y10T428/2852
    • Articles and methods for the use of such articles are described for use in immobilizing nucleophile-containing materials. In one aspect, the invention provides an article comprising: a substrate having a first surface and a second surface; and a phosphonitrilic tethering group affixed to the first surface of the substrate, the phosphonitrilic tethering group comprising a reaction product of a complementary functional group on the first surface of the substrate with a phosphonitrilic tethering compound. A method of immobilizing a nucleophile-containing material to a substrate is also described, the method comprising: providing a phosphonitrilic tethering compound; providing a substrate having a complementary functional group capable of reacting with phosphonitrilic tethering compound; preparing a substrate-attached phosphonitrilic tethering group by reacting the phosphonitrilic tethering compound with the complementary functional group on the substrate resulting in an ionic bond, covalent bond, or combinations thereof; and reacting the substrate-attached phosphonitrilic tethering group with a nucleophile-containing material to immobilize the nucleophile-containing material.
    • 描述了使用这些制品的制品和方法用于固定含亲核试剂的材料。 一方面,本发明提供了一种制品,其包括:具有第一表面和第二表面的基底; 以及固定在基材的第一表面上的膦酸性束缚基团,所述膦酸性束缚基包含在底物的第一表面上的互补官能团的反应产物和磷酸三苯酯系链化合物。 还描述了将含亲核试剂的材料固定到基底的方法,所述方法包括:提供磷酸三苯酯键合化合物; 提供具有能够与膦腈键合化合物反应的互补官能团的底物; 通过使磷腈络合的化合物与底物上的互补官能团反应制备与底物连接的膦酸基束合基团,得到离子键,共价键或其组合; 并使与底物连接的磷酸盐系链基团与含有亲核试剂的材料反应以固定含有亲核试剂的材料。