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1. 发明申请

WO2006019105A1 蛍光ラベル化剤审中-公开
标题翻译：荧光标签代理
公开(公告)号：WO2006019105A1
公开(公告)日：2006-02-23
申请号：PCT/JP2005/014983
申请日：2005-08-17
申请人：第一化学薬品株式会社 , 長野哲雄 , 浦野泰照 , 峯野知子 , 上野匡
发明人：長野哲雄 , 浦野泰照 , 峯野知子 , 上野匡
IPC分类号： C09B11/28 , G01N33/532
CPC分类号： C09B11/08 , G01N33/533 , G01N33/582
摘要： Fluorescent labeling agents represented by the general formula (I): (I) wherein R 1 to R 4 are each independently hydrogen or a monovalent substituent, with the proviso that at least one of R 1 to R 4 is a reactive functional group capable of binding to a substance to be labeled through a covalent bond; R 5 is hydrogen or a monovalent group exclusive of carboxy and sulfo; R 6 and R 7 are each independently hydrogen or halogeno; and R 8 is hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, with the proviso that R 1 to R 5 must be a combination which can give the benzene ring to which they are bonded such a low reduction potential that the compound represented by the general formula (I) can exhibit substantially high fluorescence in a state bound to the substrate to be labeled through a covalent bond.
摘要翻译：由通式（I）表示的荧光标记物：其中R 1至R 4各自独立地为氢或一价取代基，条件是至少 R 1至R 4之一是通过共价键与待标记的物质结合的反应性官能团; R 5是氢或不包括羧基和磺基的一价基团; R 6和R 7各自独立地为氢或卤素; R 8是氢，烷基羰基或烷基羰氧基甲基，条件是R 1至R 5必须是可以产生苯的组合它们所键合的这种低还原电位使得由通式（I）表示的化合物在结合到待通过共价键标记的底物的状态下显示出显着高的荧光。

2. 发明申请

WO2007055364A1 パーオキシナイトライト蛍光プローブ审中-公开
标题翻译：过氧化物荧光探针
公开(公告)号：WO2007055364A1
公开(公告)日：2007-05-18
申请号：PCT/JP2006/322599
申请日：2006-11-14
申请人：国立大学法人東京大学 , 長野哲雄 , 浦野泰照 , 上野匡
发明人：長野哲雄 , 浦野泰照 , 上野匡
IPC分类号： C07F5/02 , G01N31/00
CPC分类号： C07F5/022 , C07F5/003 , G01N31/228
摘要： A compound represented by the following general formula (I): (I) (A) {wherein R 1 , R 3 , R 6 , and R 8 each represents methyl, etc.; R 2 and R 7 each represents cyano, etc.; R 4 and R 5 each represents fluorine, etc.; and X represents a group represented by the formula (A) [wherein R 11 is monocarboxylated C 1-8 alkoxy, etc.; R 12 , R 14 , and R 15 each is hydrogen, etc.; and R 13 is hydroxy, etc.], provided that these substituents are present in such a combination that the compound represented by the formula (I) is substantially nonfluorescent before reaction with a peroxynitrite and the compound represented by the formula (I) becomes, through reaction with a peroxynitrite, a compound which has the group represented by the formula (A) in a nitrated form and is substantially highly fluorescent} or a salt of the compound. The compound and salt are useful as a fluorescent probe for peroxynitrite detection.
摘要翻译：由下列通式（I）表示的化合物：（I）（A）{其中R 1，R 3，R 6，和R 8各自代表甲基等; R 2和R 7各自表示氰基等; R 4和R 5各自表示氟等; 并且X表示由式（A）表示的基团[其中R 11是单羧基C 1-8烷氧基等; R 12，R 14和R 15各自为氢等; 并且R 13是羟基等]，条件是这些取代基以这样的组合形式存在，使得式（I）表示的化合物在与过氧亚硝酸盐反应之前基本上不发荧光，并且由式（I）通过与过氧亚硝酸盐反应，变成具有硝酸化形式的具有式（A）表示的基团并且基本上高度荧光的化合物或化合物的盐。化合物和盐可用作过氧亚硝酸盐检测的荧光探针。

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