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1. 发明申请

WO2011146798A1 VISUALIZATION OF MEDICAL IMAGE DATA WITH LOCALIZED ENHANCEMENT 审中-公开
标题翻译：医学图像数据的可视化与本地化增强
公开(公告)号：WO2011146798A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037279
申请日：2011-05-20
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , SIEMENS AKTIENGESELLSCHAFT , ZHOU, Xiang Sean , HARDER, Martin
发明人： ZHOU, Xiang Sean , HARDER, Martin
IPC分类号： G06T7/00
CPC分类号： G06T15/08 , A61B5/4504 , A61B5/726 , A61B5/743 , G06T19/00 , G06T2219/028
摘要： Systems and methods for visualization of medical image data with localized enhancement. In one implementation, image data of a structure of interest is resampled within a predetermined plane to generate at least one background image of the structure of interest. In addition, at least one local image is reconstructed to visually enhance at least one local region of interest associated with the structure of interest. The local image and the background image are then combined to generate a composite image.
摘要翻译：用于局部增强的医学图像数据可视化的系统和方法。在一个实现中，感兴趣的结构的图像数据在预定平面内重新采样，以生成感兴趣结构的至少一个背景图像。另外，重构至少一个局部图像以视觉地增强与感兴趣的结构相关联的至少一个感兴趣的局部区域。然后组合本地图像和背景图像以生成合成图像。

2. 发明申请

WO2006029037A3 SYSTEM AND METHOD FOR TRACKING ANATOMICAL STRUCTURES IN THREE DIMENSIONAL IMAGES 审中-公开
标题翻译：用于跟踪三维图像中的解剖结构的系统和方法
公开(公告)号：WO2006029037A3
公开(公告)日：2006-08-17
申请号：PCT/US2005031444
申请日：2005-09-02
申请人： SIEMENS MEDICAL SOLUTIONS , XIAO JING , GEORGESCU BOGDAN , ZHOU XIANG SEAN , COMANICIU DORIN
发明人： XIAO JING , GEORGESCU BOGDAN , ZHOU XIANG SEAN , COMANICIU DORIN
IPC分类号： G06T7/20
CPC分类号： G06K9/3216 , A61B8/08 , A61B8/0883 , A61B8/463 , A61B8/483 , G06K2209/051 , G06T7/0016 , G06T7/12 , G06T7/149 , G06T7/246 , G06T7/277 , G06T2200/04 , G06T2200/24 , G06T2207/10136 , G06T2207/30048 , Y10S128/922
摘要： A system and method for defining and tracking a deformable shape of a candidate anatomical structure wall in a three dimensional (3D) image is disclosed. The shape of the candidate anatomical structure is represented by a plurality of labeled 3D landmark points. At least one 3D landmark point of the deformable shape in an image frame is defined. A 3D cuboid is defined around the detected 3D landmark point. For each landmark point associated with the anatomical structure, its location and location uncertainty matrix is estimated in subsequent frames relative to the reference anatomical structures. A shape model is generated to represent dynamics of the deformable shape in subsequent image frames. The shape model includes statistical information from a training data set of 3D images of representative anatomical structures. The shape model is aligned to the deformable shape of the candidate anatomical structure. The shape model is fused with the deformable shape. A current shape of the candidate anatomical strucutre is estimated.
摘要翻译：公开了一种用于定义和追踪三维（3D）图像中的候选解剖结构壁的可变形形状的系统和方法。候选解剖结构的形状由多个标记的3D地标点表示。定义了图像帧中至少一个可变形形状的3D地标点。在检测到的3D地标点周围定义3D立方体。对于与解剖结构相关联的每个界标点，在相对于参考解剖结构的后续帧中估计其位置和位置不确定性矩阵。生成形状模型以表示随后图像帧中的可变形形状的动态。形状模型包括来自代表性解剖结构的3D图像的训练数据集的统计信息。形状模型与候选解剖结构的可变形形状对齐。形状模型与可变形形状融合。估计候选解剖结构的当前形状。

3. 发明申请

WO2012061452A1 AUTOMATIC IMAGE-BASED CALCULATION OF A GEOMETRIC FEATURE 审中-公开
标题翻译：几何特征的自动图像计算
公开(公告)号：WO2012061452A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058882
申请日：2011-11-02
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , SIEMENS JAPAN K.K. , HUBER, Peter , KRISHNAN, Arun , TANIGUCHI, Takahisa , ZHOU, Xiang Sean
发明人： HUBER, Peter , KRISHNAN, Arun , TANIGUCHI, Takahisa , ZHOU, Xiang Sean
IPC分类号： G06T7/00 , G06T7/60
CPC分类号： G06T7/0012 , G06T7/68 , G06T2200/24 , G06T2207/30012 , G06T2207/30048 , G06T2207/30061
摘要： Systems and methods for automatically interpreting digital images and calculating a geometric feature based on the interpreted digital images are described herein. In accordance with one aspect of the present disclosure, a plurality of measurement elements within a digital medical image are automatically identified (306). The measurement elements are used to compute a geometric feature (308), and provided to a user for review (310). If the user modified the measurement elements (312), a final geometric feature is computed based on the user-modified measurement elements (314)
摘要翻译：本文描述了用于自动解释数字图像并基于解释的数字图像计算几何特征的系统和方法。根据本公开的一个方面，数字医学图像内的多个测量元件被自动识别（306）。测量元件用于计算几何特征（308），并提供给用户进行审查（310）。如果用户修改了测量元件（312），则基于用户修改的测量元件（314）来计算最终几何特征，

4. 发明申请

WO2008136966A2 REGISTRATION OF MEDICAL IMAGES USING LEARNED-BASED MATCHING FUNCTIONS 审中-公开
标题翻译：使用基于知识的匹配函数注册医学图像
公开(公告)号：WO2008136966A2
公开(公告)日：2008-11-13
申请号：PCT/US2008/005491
申请日：2008-04-29
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , ZHAN, Yiqiang , ZHOU, Xiang, Sean , KRISHNAN, Arun
发明人： ZHAN, Yiqiang , ZHOU, Xiang, Sean , KRISHNAN, Arun
IPC分类号： G06T7/00 , A61B5/00
CPC分类号： G06K9/32 , G06K2209/05 , G06T7/33
摘要： A method for registering a medical image includes acquiring a first medical image of a subject (S101). One or more simulated medical images are synthesized based on the acquired first medical image (S103). One or more matching functions are trained using the first medical image and the simulated medical images (S108). A second medical image of the subject is acquired. The first medical image and the second medical image are registered using the one or more trained matching functions.
摘要翻译：用于登记医用图像的方法包括获取被检体的第一医用图像（S101）。基于获取的第一医疗图像合成一个或多个模拟医学图像（S103）。使用第一医学图像和模拟医学图像训练一个或多个匹配函数（S108）。获得该受试者的第二医学图像。使用一个或多个经过训练的匹配功能来登记第一医疗图像和第二医疗图像。

5. 发明申请

WO2006044242A3 METHOD FOR DETECTING POLYPS IN A THREE DIMENSIONAL IMAGE VOLUME 审中-公开
公开(公告)号：WO2006044242A3
公开(公告)日：2006-04-27
申请号：PCT/US2005/036123
申请日：2005-10-07
申请人： SIEMENS CORPORATE RESEARCH, INC. , SIEMENS MEDICAL SOLUTIONS USA, INC. , TU, Zhuowen , ZHOU, Xiang Sean , BARBU, Adrian , BOGONI, Luca , COMANICIU, Dorin
发明人： TU, Zhuowen , ZHOU, Xiang Sean , BARBU, Adrian , BOGONI, Luca , COMANICIU, Dorin
IPC分类号： G06K9/62
摘要： A method for detecting target objects in a three dimensional (3D) image volume of an anatomical structure is disclosed. A set of candidate locations in the image volume are obtained. For each candidate location, sub-volumes of at least two different scales are cropped out. Each sub-volume comprises a plurality of voxels. For each of the sub-volumes, each sub-volume is rotated in at least two different orientations. A shape classifier is applied to each sub-volume. If the voxels in the sub-volume pass the shape classifier, a gradient direction is computed for the voxels. If the gradient direction for the voxels is one of a predefined orientation, a probability classifier is applied to the voxels. A probability measure computed by the probability classifier as a confidence measure is used for the sub-volume. If the confidence measure is above a predetermined threshold value, the sub-volume is determined to contain the target object

6. 发明申请

WO2006029037A2 SYSTEM AND METHOD FOR TRACKING ANATOMICAL STRUCTURES IN THREE DIMENSIONAL IMAGES 审中-公开
标题翻译：用于跟踪三维图像中的解剖结构的系统和方法
公开(公告)号：WO2006029037A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031444
申请日：2005-09-02
申请人： SIEMENS CORPORATE RESEARCH, INC. , XIAO, Jing , GEORGESCU, Bogdan , ZHOU, Xiang, Sean , COMANICIU, Dorin
发明人： XIAO, Jing , GEORGESCU, Bogdan , ZHOU, Xiang, Sean , COMANICIU, Dorin
IPC分类号： G06T7/20 , A61B5/00
CPC分类号： G06K9/3216 , A61B8/08 , A61B8/0883 , A61B8/463 , A61B8/483 , G06K2209/051 , G06T7/0016 , G06T7/12 , G06T7/149 , G06T7/246 , G06T7/277 , G06T2200/04 , G06T2200/24 , G06T2207/10136 , G06T2207/30048 , Y10S128/922
摘要： A system and method for defining and tracking a deformable shape of a candidate anatomical structure wall in a three dimensional (3D) image is disclosed. The shape of the candidate anatomical structure is represented by a plurality of labeled 3D landmark points. At least one 3D landmark point of the deformable shape in an image frame is defined. A 3D cuboid is defined around the detected 3D landmark point. For each landmark point associated with the anatomical structure, its location and location uncertainty matrix is estimated in subsequent frames relative to the reference anatomical structures. A shape model is generated to represent dynamics of the deformable shape in subsequent image frames. The shape model includes statistical information from a training data set of 3D images of representative anatomical structures. The shape model is aligned to the deformable shape of the candidate anatomical structure. The shape model is fused with the deformable shape. A current shape of the candidate anatomical strucutre is estimated.
摘要翻译：公开了一种在三维（3D）图像中定义和跟踪候选解剖结构壁的可变形形状的系统和方法。候选解剖结构的形状由多个标记的3D地标点表示。定义图像帧中的可变形形状的至少一个3D地标点。 3D立方体围绕检测到的3D地标点定义。对于与解剖结构相关联的每个界标点，在相对于参考解剖结构的后续帧中估计其位置和位置不确定性矩阵。生成形状模型以表示后续图像帧中的可变形形状的动态。形状模型包括来自代表性解剖结构的3D图像的训练数据集的统计信息。形状模型与候选解剖结构的可变形形状对准。形状模型与可变形的形状融合。估计候选解剖结构的当前形状。

7. 发明申请

WO2005034039A3 SYSTEM AND METHOD FOR LOCAL DEFORMABLE MOTION ANALYSIS 审中-公开
标题翻译：用于局部可变形运动分析的系统和方法
公开(公告)号：WO2005034039A3
公开(公告)日：2005-07-21
申请号：PCT/US2004032724
申请日：2004-10-04
申请人： SIEMENS CORP RES INC , GEORGESCU BOGDAN , ZHOU XIANG SEAN , COMANICIU DORIN , KRISHNAN SRIRAM
发明人： GEORGESCU BOGDAN , ZHOU XIANG SEAN , COMANICIU DORIN , KRISHNAN SRIRAM
IPC分类号： G06K9/00 , G06T7/20
CPC分类号： G06T7/20 , G06T7/0016 , G06T7/251 , G06T2207/10132 , G06T2207/30048
摘要： [0061] A system and method for local deformable motion analysis and for accurately tracking motion of an object isolating local motion of an object from global motion of an object is disclosed. The object is viewed in an image sequence and image regions are sampled to identify object image regions and background image regions. The motion of at least one of the identified background image regions is estimated to identify those background image regions affected by global motion. Motion from multiple background image regions are combined to measure the global motion in that image frame. The measured global motion in the object image regions are compensated to measure local motion of the object and the local motion of the object is tracked. A system and method for accurately measuring the local deformable motion of an object as the relative motion between two control point sets is disclosed. The point sets are defined as the inner contour and the outer contour of an object. The motion of the control point sets is estimated and the relative motion is used to characterize the local deformation and local motion of the object
摘要翻译：公开了一种用于局部可变形运动分析和准确跟踪物体的运动的系统和方法，该物体隔离物体的局部运动与物体的全局运动。该对象在图像序列中被查看并且图像区域被采样以识别对象图像区域和背景图像区域。估计所识别的背景图像区域中的至少一个的运动以识别受全局运动影响的那些背景图像区域。来自多个背景图像区域的运动被组合以测量该图像帧中的全局运动。对物体图像区域中的测量的全局运动进行补偿以测量物体的局部运动，并跟踪物体的局部运动。公开了一种用于精确测量物体的局部可变形运动的系统和方法，作为两个控制点集之间的相对运动。点集被定义为对象的内部轮廓和外部轮廓。估计控制点集的运动，并使用相对运动来表征物体的局部变形和局部运动

8. 发明申请

WO2005034039A2 SYSTEM AND METHOD FOR LOCAL DEFORMABLE MOTION ANALYSIS 审中-公开
标题翻译：用于局部可变运动分析的系统和方法
公开(公告)号：WO2005034039A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032724
申请日：2004-10-04
申请人： SIEMENS CORPORATE RESEARCH, INC. , GEORGESCU, Bogdan , ZHOU, Xiang Sean , COMANICIU, Dorin , KRISHNAN, Sriram
发明人： GEORGESCU, Bogdan , ZHOU, Xiang Sean , COMANICIU, Dorin , KRISHNAN, Sriram
IPC分类号： G06T7/20
CPC分类号： G06T7/20 , G06T7/0016 , G06T7/251 , G06T2207/10132 , G06T2207/30048
摘要： [0061] A system and method for local deformable motion analysis and for accurately tracking motion of an object isolating local motion of an object from global motion of an object is disclosed. The object is viewed in an image sequence and image regions are sampled to identify object image regions and background image regions. The motion of at least one of the identified background image regions is estimated to identify those background image regions affected by global motion. Motion from multiple background image regions are combined to measure the global motion in that image frame. The measured global motion in the object image regions are compensated to measure local motion of the object and the local motion of the object is tracked. A system and method for accurately measuring the local deformable motion of an object as the relative motion between two control point sets is disclosed. The point sets are defined as the inner contour and the outer contour of an object. The motion of the control point sets is estimated and the relative motion is used to characterize the local deformation and local motion of the object
摘要翻译：公开了一种用于局部可变形运动分析和用于精确跟踪物体的局部运动与对象的全局运动隔离的物体的运动的系统和方法。以图像序列查看对象，并对图像区域进行采样以识别对象图像区域和背景图像区域。估计所识别的背景图像区域中的至少一个的运动以识别受全局运动影响的那些背景图像区域。来自多个背景图像区域的运动被组合以测量该图像帧中的全局运动。在对象图像区域中测量的全局运动被补偿以测量对象的局部运动，并跟踪对象的局部运动。公开了一种用于精确测量物体的局部可变形运动作为两个控制点组之间的相对运动的系统和方法。点集被定义为对象的内轮廓和外轮廓。估计控制点集的运动，并使用相对运动来表征对象的局部变形和局部运动

9. 发明申请

WO2008136966A3 REGISTRATION OF MEDICAL IMAGES USING LEARNED-BASED MATCHING FUNCTIONS 审中-公开
标题翻译：使用基于知识的匹配函数注册医学图像
公开(公告)号：WO2008136966A3
公开(公告)日：2009-04-30
申请号：PCT/US2008005491
申请日：2008-04-29
申请人： SIEMENS MEDICAL SOLUTIONS , ZHAN YIQIANG , ZHOU XIANG SEAN , KRISHNAN ARUN
发明人： ZHAN YIQIANG , ZHOU XIANG SEAN , KRISHNAN ARUN
IPC分类号： G06T7/00
CPC分类号： G06K9/32 , G06K2209/05 , G06T7/33
摘要： A method for registering a medical image includes acquiring a first medical image of a subject (S101). One or more simulated medical images are synthesized based on the acquired first medical image (S103). One or more matching functions are trained using the first medical image and the simulated medical images (S108). A second medical image of the subject is acquired. The first medical image and the second medical image are registered using the one or more trained matching functions.
摘要翻译：用于登记医用图像的方法包括获取被检体的第一医用图像（S101）。基于获取的第一医学图像合成一个或多个模拟医学图像（S103）。使用第一医学图像和模拟医学图像训练一个或多个匹配函数（S108）。获取受试者的第二个医学图像。第一医用图像和第二医用图像使用一个或多个经过训练的匹配功能进行登记。

10. 发明申请

WO2007019504A3 SYSTEM AND METHOD FOR INTEGRATING HETEROGENEOUS BIOMEDICAL INFORMATION 审中-公开
公开(公告)号：WO2007019504A3
公开(公告)日：2007-02-15
申请号：PCT/US2006/030893
申请日：2006-08-07
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , ZHOU, Xiang Sean , COMANICIU, Dorin , GUPTA, Alok , TU, Zhuowen , FASULO, Daniel , WANG, Lu-Yong , LIU, Peiya , MUKHERJEE, Saikat , CHAKRABORTY, Amit
发明人： ZHOU, Xiang Sean , COMANICIU, Dorin , GUPTA, Alok , TU, Zhuowen , FASULO, Daniel , WANG, Lu-Yong , LIU, Peiya , MUKHERJEE, Saikat , CHAKRABORTY, Amit
IPC分类号： G06F19/00
摘要： A system and method for using heterogeneous data from multiple healthcare information sources in a medical decision support system is disclosed. Each healthcare information system stores medical data using a different local schema. The medical decision support system provides responses to user queries. A query is received from a user that is generated in a standardized global schema. The query includes information from medical ontologies. Database queries are generated from the user queries that use the medical ontologies to generate constraints in the queries. The medical ontologies are also used to infer database queries. The generated query is translated into multiple queries for the multiple healthcare systems wherein each query is in the local schema of the healthcare information system that is being queried. Each database query is transmitted to one of the healthcare information systems based on the local schema of the particular query. Data is collected from each of the queried healthcare information system and analyzed. A query response is formulated for the user

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