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1. 发明申请

WO2007137255A3 BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF 审中-公开
公开(公告)号：WO2007137255A3
公开(公告)日：2007-11-29
申请号：PCT/US2007/069455
申请日：2007-05-22
申请人： THIOREDOXIN SYSTEMS AB , THYOGEN PHARMACEUTICALS, INC. , HOLMGREN, Arne , LU, Jun , VLAMIS-GARDIKAS, Alexios , ZHAO, Rong , KANDASAMY, K. , ENGMAN, Lars , ENGSTRAND, Lars , HOFFNER, Sven
发明人： HOLMGREN, Arne , LU, Jun , VLAMIS-GARDIKAS, Alexios , ZHAO, Rong , KANDASAMY, K. , ENGMAN, Lars , ENGSTRAND, Lars , HOFFNER, Sven
IPC分类号： A61K31/555 , A61K31/385 , A61K31/38
摘要： The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E.coli TrxR with K i of 0.14 µM and 0.46 µM, respectively. E.coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.

2. 发明申请

WO2007137255A2 BACTERIAL THIOREDOXIN REDUCTASE INHIBITORS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：细菌三氧化二氮还原酶抑制剂及其使用方法
公开(公告)号：WO2007137255A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069455
申请日：2007-05-22
申请人： THIOREDOXIN SYSTEMS AB , THYOGEN PHARMACEUTICALS INC , HOLMGREN ARNE , LU JUN , VLAMIS-GARDIKAS ALEXIOS , ZHAO RONG , KANDASAMY K , ENGMAN LARS , ENGSTRAND LARS , HOFFNER SVEN
发明人： HOLMGREN ARNE , LU JUN , VLAMIS-GARDIKAS ALEXIOS , ZHAO RONG , KANDASAMY K , ENGMAN LARS , ENGSTRAND LARS , HOFFNER SVEN
IPC分类号： A61K31/41
CPC分类号： C07D421/04 , A61K31/381 , A61K31/41 , C07D293/12
摘要： The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E.coli TrxR with K i of 0.14 µM and 0.46 µM, respectively. E.coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter
摘要翻译： Ebselen的作用机制区分细菌和哺乳动物硫氧还蛋白还原酶（TrxR）。它显示哺乳动物Trx的快速氧化，并且通过NADPH-TrxR催化依次硒硒酚与过氧化氢的周转，因此是哺乳动物抗氧化剂。依布硒及其二硒化物是分别具有0.14μM和0.46μM的KI大肠杆菌TrxR的强竞争性抑制剂。缺乏谷胱甘肽还原酶或谷胱甘肽的大肠杆菌突变体对依贝硒的抑制更敏感。由于谷氧还蛋白或硫氧还蛋白系统是核糖核苷酸还原酶的电子供体，依普硒靶主要是谷胱甘肽和谷氧还蛋白阴性细菌，一类包括主要病原体。因此，依布硒林和类似化合物可用作抗菌剂，即使对于多抗性菌株也是有用的。以前不知道对ebselen，结核分枝杆菌（结核分枝杆菌）和幽门螺杆菌（胃溃疡和癌症）敏感的两种主要致病菌被证明是优异的靶标。幽门螺杆菌

3. 发明申请

WO2006028344A1 A COMPOSITION COMPRISING THE PURIFIED ESSENTIAL OIL EXTRACT AND LOWER ALCOHOL SOLUBLE EXTRACT ISOLATED FROM ANGELICA GIGAS FOR THE PREVENTION AND TREATMENT OF NICOTINE ADDICTION AND WITHDRAWAL SYMPTOMS 审中-公开
标题翻译：包含纯化的基本油提取物和从ANGELICA GIGAS分离的低级醇溶性提取物的组合物，用于预防和治疗非小细胞肺癌的接受和戒断症状
公开(公告)号：WO2006028344A1
公开(公告)日：2006-03-16
申请号：PCT/KR2005/002942
申请日：2005-09-06
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION DAEGU HAANY UNIVERSITY , SEO, Jung Chul , YANG, Chae Ha , KOO, Byung Soo , KWON, Young Kyu , KIM, Kwang Joong , KIM, Mi Ryeo , KIM, Sang Chan , LEE, Jae Chul , LEE, Jong Rok , ZHAO, Rong Jie , HUH, Tae Lin
发明人： YANG, Chae Ha , KOO, Byung Soo , KWON, Young Kyu , KIM, Kwang Joong , KIM, Mi Ryeo , KIM, Sang Chan , LEE, Jae Chul , LEE, Jong Rok , ZHAO, Rong Jie , HUH, Tae Lin
IPC分类号： A61K35/78
CPC分类号： A61K36/232
摘要： The present invention is related to a composition comprising the purified essential oil extract and lower alcohol soluble extract isolated fromAngelica gigas Nakai for the prevention and treatment of nicotine addiction and withdrawal symptoms. The purified essential oil extract and lower alcohol soluble extract isolated fromAngelica gigas Nakaiof the present invention inhibits the sensitization effects on drug reinforcing property and decrease the behavior activity in nicotine drug addiction induced by chronic nicotine treatment by inhibiting the release of dopamine, DOPAC and HVC in a dose dependent manner. Therefore, it can be useful in treating or preventing nicotine addiction and withdrawal symptoms in the form of a medicine or health care food.
摘要翻译：本发明涉及包含纯化的精油提取物和从黑头小蠊Nakai分离的低级醇可溶性提取物的组合物，用于预防和治疗尼古丁成瘾和戒断症状。从本发明中分离出的纯化精油提取物和低级醇可溶性提取物抑制药物增强性能的敏化作用，并通过抑制多巴胺，DOPAC和HVC的释放来抑制慢性尼古丁治疗引起的尼古丁药物成瘾中的行为活性剂量依赖的方式。因此，它可用于以药物或保健食品的形式治疗或预防尼古丁成瘾和戒断症状。

4. 发明申请

WO2005081256A1 ELECTRICALLY WRITEABLE AND ERASABLE MEMORY MEDIUM 审中-公开
标题翻译：电可写和可擦除的存储介质
公开(公告)号：WO2005081256A1
公开(公告)日：2005-09-01
申请号：PCT/SG2005/000022
申请日：2005-01-27
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , CHONG, Tow Chong , SHI, Lu Ping , ZHAO, Rong , MIAO, Xiang Shui , TAN, Pik Kee , MENG, Hao , YI, Kai Jun , HU, Xiang , LI, Ke Bin , LUO, Ping
发明人： CHONG, Tow Chong , SHI, Lu Ping , ZHAO, Rong , MIAO, Xiang Shui , TAN, Pik Kee , MENG, Hao , YI, Kai Jun , HU, Xiang , LI, Ke Bin , LUO, Ping
IPC分类号： G11C11/04
CPC分类号： H01L45/144 , G11C11/161 , H01L45/06 , H01L45/1233 , H01L45/126
摘要： A memory cell for an electrically writeable and erasable memory medium as well as a memory medium thereof is provided. The memory cell comprises a data recording element, the data recording element has a plurality of multiple-layer structure disposed one on top of another; each the multiple-layer structure comprising a plurality of sequentially disposed individual layers. At least one of the plurality of individual layers is capable of changing phase between a crystalline state and an amorphous state in response to an electrical pulse, one of the plurality of individual layers having at least one atomic element which is absent from other one of the plurality of individual layers, and the plurality of multiple-layer structure is of a superlattice-like structure to lower a heat diffusion out of the data recording element to shorten a phase change time of the respective individual layers.
摘要翻译：提供了一种用于电可写和可擦除存储介质及其存储介质的存储单元。所述存储单元包括数据记录元件，所述数据记录元件具有多个多层结构，所述多层结构一个在另一个之上; 每个多层结构包括多个顺序设置的各层。多个单独层中的至少一个能够响应于电脉冲改变结晶状态和非晶状态之间的相位，所述多个单独层中的一个具有至少一个原子元素，其不存在于多个单独的层，并且多个多层结构是超晶格结构，以将数据记录元件的热扩散降低以缩短各个层的相变时间。

5. 发明申请

WO2006075999A2 METHOD FOR SCAVENGING MERCURY 审中-公开
标题翻译：切割汞的方法
公开(公告)号：WO2006075999A2
公开(公告)日：2006-07-20
申请号：PCT/US2005/012046
申请日：2005-04-08
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHANG, Shih-Ger , LIU, Shou-heng , LIU, Zhao-rong , YAN, Naiqiang
发明人： CHANG, Shih-Ger , LIU, Shou-heng , LIU, Zhao-rong , YAN, Naiqiang
IPC分类号： B01D53/64
CPC分类号： B01D53/64 , B01D2257/602
摘要： Disclosed herein is a method for removing mercury from a gas stream comprising contacting the gas stream with a getter composition comprising bromine, bromochloride, sulphur bromide, sulphur dichloride or sulphur monochloride and mixtures thereof. In one preferred embodiment the getter composition is adsorbed onto a sorbent. The sorbent may be selected from the group consisting of flyash, limestone, lime, calcium sulphate, calcium sulfite, activated carbon, charcoal, silicate, alumina and mixtures thereof. Preferred is flyash, activated carbon and silica.
摘要翻译：本文公开了一种从气流中除去汞的方法，包括使气流与包含溴，溴氯化物，溴化硫，二氯化硫或一氯化硫的吸气剂组合物及其混合物接触。在一个优选实施方案中，吸气剂组合物被吸附到吸附剂上。吸附剂可以选自飞灰，石灰石，石灰，硫酸钙，亚硫酸钙，活性炭，木炭，硅酸盐，氧化铝及其混合物。优选的是飞灰，活性炭和二氧化硅。

6. 发明申请

WO2006075999A3 METHOD FOR SCAVENGING MERCURY 审中-公开
标题翻译：切割汞的方法
公开(公告)号：WO2006075999A3
公开(公告)日：2007-02-08
申请号：PCT/US2005012046
申请日：2005-04-08
申请人： UNIV CALIFORNIA , CHANG SHIH-GER , LIU SHOU-HENG , LIU ZHAO-RONG , YAN NAIQIANG
发明人： CHANG SHIH-GER , LIU SHOU-HENG , LIU ZHAO-RONG , YAN NAIQIANG
IPC分类号： C22B3/10 , B01D50/00 , B01D53/00 , B01J19/08 , C01B9/02 , C22B43/00
CPC分类号： B01D53/64 , B01D2257/602
摘要： Disclosed herein is a method for removing mercury from a gas stream comprising contacting the gas stream with a getter composition comprising bromine, bromochloride, sulphur bromide, sulphur dichloride or sulphur monochloride and mixtures thereof. In one preferred embodiment the getter composition is adsorbed onto a sorbent. The sorbent may be selected from the group consisting of flyash, limestone, lime, calcium sulphate, calcium sulfite, activated carbon, charcoal, silicate, alumina and mixtures thereof. Preferred is flyash, activated carbon and silica.
摘要翻译：本文公开了一种从气流中除去汞的方法，包括使气流与包含溴，溴氯化物，溴化硫，二氯化硫或一氯化硫的吸气剂组合物及其混合物接触。在一个优选实施方案中，吸气剂组合物被吸附到吸附剂上。吸附剂可以选自飞灰，石灰石，石灰，硫酸钙，亚硫酸钙，活性炭，木炭，硅酸盐，氧化铝及其混合物。优选的是飞灰，活性炭和二氧化硅。

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