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1. 发明申请

WO2013025638A3 HEEL PROTECTOR 审中-公开
标题翻译：鞋保护
公开(公告)号：WO2013025638A3
公开(公告)日：2013-05-10
申请号：PCT/US2012050644
申请日：2012-08-13
申请人： GOGO HEEL LLC , HWANG GRACE , ZADNO NICOLAS
发明人： HWANG GRACE , ZADNO NICOLAS
IPC分类号： A43D25/20 , A43D86/00
CPC分类号： A43C13/00 , A43B21/265 , A43B21/437 , A43B21/52 , A43C15/04
摘要： A shielding cup is provided for use with a self-fusing member, collapsible heat- concentrating accessory, or on its own. The shielding cup is attached to a shoe heel as a temporary fix for a worn heel tip. The cup can be attached to the heel by a self-fusing member that binds to itself. The cup can also be attached by using a heat source and collapsible heat-concentrating accessory to concentrate heat on the heat-shrink version of the shielding cup. The heat-shrink cup can also be attached without the need for a separate accessory.
摘要翻译：提供屏蔽杯以与自熔部件，可折叠热集中配件或单独使用。屏蔽杯连接到鞋跟上，作为磨损的脚跟尖端的临时固定。杯子可以通过自身固定件与脚跟连接。杯子也可以通过使用热源和可折叠的热集中附件将热量集中在屏蔽杯的热缩型上。热缩杯也可以安装而不需要单独的附件。

2. 发明申请

WO2008061150A3 METHODS AND APPARATUS FOR INTRAVASCULARLY-INDUCED NEUROMODULATION OR DENERVATION 审中-公开
公开(公告)号：WO2008061150A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/084701
申请日：2007-11-14
申请人： ARDIAN, INC. , DEMARAIS, Denise , GIFFORD, Hanson, III , DEEM, Mark , SUTTON, Douglas , THAI, Erik , CLARK, Benjamin, J. , ZADNO, Nicolas
发明人： DEMARAIS, Denise , GIFFORD, Hanson, III , DEEM, Mark , SUTTON, Douglas , THAI, Erik , CLARK, Benjamin, J. , ZADNO, Nicolas
IPC分类号： A61N1/36
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation or denervation. Neuromodulation may be achieved via direct and/or via indirect application of energy or neuromodulatory agents to target neural matter, or to vascular structures that support the target neural matter. In some embodiments, parameters of the target neural matter, of non-target tissue, or of the apparatus may be monitored via one or more sensors for controlling the neuromodulation or denervation. Such monitoring data optionally may be utilized for feedback control of the neuromodulation or denervation.

3. 发明申请

WO2007121309A2 METHODS AND APPARATUS FOR MONOPOLAR RENAL NEUROMODULATION 审中-公开
标题翻译： MON AR NAL。。。。。。。。。。。。。。。。。。
公开(公告)号：WO2007121309A2
公开(公告)日：2007-10-25
申请号：PCT/US2007066539
申请日：2007-04-12
申请人： ARDIAN INC , DEMARAIS DENISE , GIFFORD HANSON , DEEM MARK , LEVIN HOWARD R , GELFAND MARK , ZADNO NICOLAS
发明人： DEMARAIS DENISE , GIFFORD HANSON , DEEM MARK , LEVIN HOWARD R , GELFAND MARK , ZADNO NICOLAS
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/32 , A61N1/327
摘要： Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
摘要翻译：提供了用于单极神经调节的方法和装置，例如通过脉冲电场。这种单极神经调节可能会导致不可逆的电穿孔或电融合，细胞凋亡的坏死和/或诱导，基因表达的改变，动作电位减弱或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，单极神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种单极神经调节是双侧进行的。

4. 发明申请

WO2007086965A2 METHODS AND APPARATUS FOR INTRAVASCULARLY-INDUCED NEUROMODULATION 审中-公开
标题翻译：用于血管内诱导神经调节的方法和装置
公开(公告)号：WO2007086965A2
公开(公告)日：2007-08-02
申请号：PCT/US2006/041889
申请日：2006-10-26
申请人： ARDIAN, INC. , DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik
发明人： DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik
IPC分类号： A61N1/00
CPC分类号： A61B18/1492 , A61B17/12136 , A61B2018/00083 , A61B2018/00285 , A61B2018/00434 , A61B2018/00613 , A61M25/0108 , A61M25/10 , A61N1/327 , A61N1/36007 , A61N1/36121 , A61N1/36182 , A61N1/37205 , A61N1/40
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.
摘要翻译：提供了使用脉冲电场进行血管内诱导的神经调节的方法和装置，例如，在靶神经纤维中实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化等。在一些实施例中，血管内PEF系统包括导管，其具有用于传送PEF的一对双极电极，第一电极位于阻抗改变元件的第一侧上，第二电极位于阻抗变换元件的相对侧上，改变元素可以规定电极的长度以及第一和第二电极之间的间隔距离，使得以阻抗变化元件部署的方式，其局部地增加患者血管内的阻抗，例如阻抗 - 改变元件被部署成与病人血管系统中的治疗部位处的血管壁接触，相对于具有类似间隔开的电极而没有（或一个或多个）的血管内PEF系统，减少了实现所需神经调节所需双极电极的施加电压的大小未部署）阻抗变化元件。在优选实施例中，阻抗改变元件包括构造成在患者的脉管系统内局部增加阻抗的可充气球囊。本发明的方法和装置可用于调节有助于肾功能的神经纤维。

5. 发明申请

WO2007035537A2 METHODS AND APPARATUS FOR INDUCING CONTROLLED RENAL NEUROMODULATION 审中-公开
标题翻译：诱导控制性肾脏神经调节的方法和装置
公开(公告)号：WO2007035537A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036120
申请日：2006-09-14
申请人： ARDIAN INC , DEMARAIS DENISE , ZADNO NICOLAS
发明人： DEMARAIS DENISE , ZADNO NICOLAS
IPC分类号： A61N1/00
CPC分类号： A61N1/327 , A61N1/0514 , A61N1/08 , A61N1/36007
摘要： Methods and apparatus are provided for inducing, monitoring and controlling renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. In some embodiments, tissue impedance, conductance or conductivity may be monitored to determine the effects of pulsed electric field therapy, e.g., to determine an extent of electroporation and its degree of irreversibility. Pulsed electric field electroporation of tissue causes a decrease in tissue impedance and an increase in tissue conductivity. If induced electroporation is reversible, upon cessation of the pulsed electric field, tissue impedance and conductivity should approximate baseline levels; however, if electroporation is irreversible, impedance and conductivity changes should persist. Thus, monitoring of impedance or conductivity may be utilized to determine the onset of electroporation and to determine the type or extent of electroporation. Furthermore, monitoring data may be used in one or more manual or automatic feedback loops to control the electroporation.
摘要翻译：提供了使用脉冲电场诱导，监测和控制肾神经调节以实现电穿孔或电融合的方法和装置。在一些实施例中，可以监测组织阻抗，电导或电导率以确定脉冲电场治疗的效果，例如确定电穿孔的程度及其不可逆程度。组织的脉冲电场电穿孔导致组织阻抗的减少和组织传导性的增加。如果诱导电穿孔是可逆的，则在停止脉冲电场后，组织阻抗和电导率应接近基线水平; 然而，如果电穿孔是不可逆的，阻抗和电导率的变化应该持续存在。因此，可以使用阻抗或电导率的监测来确定电穿孔的发生并确定电穿孔的类型或程度。此外，可以在一个或多个手动或自动反馈回路中使用监测数据来控制电穿孔。

6. 发明申请

WO2013025638A2 HEEL PROTECTOR 审中-公开
标题翻译：护理人员
公开(公告)号：WO2013025638A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/050644
申请日：2012-08-13
申请人： GOGO HEEL, LLC , HWANG, Grace , ZADNO, Nicolas
发明人： HWANG, Grace , ZADNO, Nicolas
IPC分类号： A43D25/20 , A43D86/00
CPC分类号： A43C13/00 , A43B21/265 , A43B21/437 , A43B21/52 , A43C15/04
摘要： A shielding cup is provided for use with a self-fusing member, collapsible heat- concentrating accessory, or on its own. The shielding cup is attached to a shoe heel as a temporary fix for a worn heel tip. The cup can be attached to the heel by a self-fusing member that binds to itself. The cup can also be attached by using a heat source and collapsible heat-concentrating accessory to concentrate heat on the heat-shrink version of the shielding cup. The heat-shrink cup can also be attached without the need for a separate accessory.
摘要翻译：提供了一个屏蔽杯，用于自熔合部件，可折叠热集中附件，或独立使用。屏蔽杯被连接到鞋跟上，作为磨损的脚跟尖端的临时固定。杯子可以通过与自身结合的自熔合构件附着到脚跟上。也可以通过使用热源和可折叠的热集中附件来连接杯子，以将热量集中在屏蔽杯的热收缩型上。热收缩杯也可以连接，而不需要单独的附件。

7. 发明申请

WO2008061150A2 METHODS AND APPARATUS FOR INTRAVASCULARLY-INDUCED NEUROMODULATION OR DENERVATION 审中-公开
标题翻译：用于血管内诱导的神经调节或降血脂的方法和装置
公开(公告)号：WO2008061150A2
公开(公告)日：2008-05-22
申请号：PCT/US2007084701
申请日：2007-11-14
申请人： ARDIAN INC , DEMARAIS DENISE , GIFFORD HANSON III , DEEM MARK , SUTTON DOUGLAS , THAI ERIK , CLARK BENJAMIN J , ZADNO NICOLAS
发明人： DEMARAIS DENISE , GIFFORD HANSON III , DEEM MARK , SUTTON DOUGLAS , THAI ERIK , CLARK BENJAMIN J , ZADNO NICOLAS
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B18/1492 , A61B2018/00214 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00613 , A61B2018/143 , A61B2018/1432 , A61N1/0529 , A61N1/0539 , A61N1/0551 , A61N1/36007 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/36114 , A61N7/022 , A61N2007/003
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation or denervation. Neuromodulation may be achieved via direct and/or via indirect application of energy or neuromodulatory agents to target neural matter, or to vascular structures that support the target neural matter. In some embodiments, parameters of the target neural matter, of non-target tissue, or of the apparatus may be monitored via one or more sensors for controlling the neuromodulation or denervation. Such monitoring data optionally may be utilized for feedback control of the neuromodulation or denervation.
摘要翻译：提供了用于血管内诱导的神经调节或去神经支配的方法和设备。神经调节可通过直接和/或通过间接应用能量或神经调节剂来靶向神经物质或支持目标神经物质的血管结构来实现。在一些实施例中，可通过用于控制神经调节或去神经支配的一个或多个传感器来监测目标神经元，非目标组织或装置的参数。这种监测数据可选地可用于神经调节或去神经支配的反馈控制。

8. 发明申请

WO2008003058A3 METHODS AND SYSTEMS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 审中-公开
公开(公告)号：WO2008003058A3
公开(公告)日：2008-01-03
申请号：PCT/US2007/072396
申请日：2007-06-28
申请人： ARDIAN, INC. , DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik , LEVIN, Howard, R. , GELFAND, Mark , WU, Andrew , GIFFORD, Hanson , DEEM, Mark
发明人： DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik , LEVIN, Howard, R. , GELFAND, Mark , WU, Andrew , GIFFORD, Hanson , DEEM, Mark
IPC分类号： A61F2/00
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

9. 发明申请

WO2007078997A3 METHODS AND APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH 审中-公开
标题翻译：脉冲电场神经网络的方法和装置，通过内向外方法
公开(公告)号：WO2007078997A3
公开(公告)日：2008-10-23
申请号：PCT/US2006048822
申请日：2006-12-21
申请人： ARDIAN INC , DEMARAIS DENISE , CLARK BENJAMIN J , ZADNO NICOLAS , THAI ERIK , GIFFORD HANSON III
发明人： DEMARAIS DENISE , CLARK BENJAMIN J , ZADNO NICOLAS , THAI ERIK , GIFFORD HANSON III
IPC分类号： A61N1/32
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00613 , A61B2018/126 , A61M5/14 , A61M37/00 , A61N1/05 , A61N1/0514 , A61N1/0551 , A61N1/321 , A61N1/327 , A61N1/36007
摘要： Methods and apparatus are provided for pulsed electric field neuromodulation . via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.
摘要翻译：为脉冲电场神经调制提供了方法和装置。通过血管外途径进行，例如，以实现不可逆的电穿孔或电融合，细胞凋亡的坏死和/或诱导，基因表达的改变，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，ITEV PEF系统包括具有一个或多个电极的血管内导管，其配置用于穿过患者血管的壁进行血管外放置以接近目标神经纤维。随着电极在PEF递送之前从血管内位置传递到血管外位置，可以相对于血管内PEF减少施加的电压或通过电极传递并且达到所需神经调节所必需的能量的大小系统具有一个或多个位于血管内的电极。本发明的方法和装置可以例如用于调节一种或多种有助于肾功能的靶神经纤维。

10. 发明申请

WO2008003058A8 METHODS AND SYSTEMS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 审中-公开
公开(公告)号：WO2008003058A8
公开(公告)日：2008-01-03
申请号：PCT/US2007/072396
申请日：2007-06-28
申请人： ARDIAN, INC. , DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik , LEVIN, Howard, R. , GELFAND, Mark , WU, Andrew , GIFFORD, Hanson , DEEM, Mark
发明人： DEMARAIS, Denise , ZADNO, Nicolas , CLARK, Benjamin, J. , THAI, Erik , LEVIN, Howard, R. , GELFAND, Mark , WU, Andrew , GIFFORD, Hanson , DEEM, Mark
IPC分类号： A61F2/00
摘要： Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

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