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1. 发明申请

WO2004032881A3 IMPLANTATION OF ENCAPSULATED BIOLOGICAL MATERIALS FOR TREATING DISEASES 审中-公开
公开(公告)号：WO2004032881A3
公开(公告)日：2004-04-22
申请号：PCT/US2003/032842
申请日：2003-10-14
申请人： NOVOCELL, INC. , SCHARP, David , LATTA, Paul , YU, Xiaojie , YUE, Chengyun , HUBBELL, Jeffery
发明人： SCHARP, David , LATTA, Paul , YU, Xiaojie , YUE, Chengyun , HUBBELL, Jeffery
IPC分类号： A61F2/02
摘要： The present invention relates to compositions for treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. Several methods are presented for coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. These encapsulated biological materials are used to treat a variety of different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

2. 发明申请

WO2013040242A2 DERMAL FILLER COMPOSITIONS FOR FINE LINE TREATMENT 审中-公开
标题翻译：用于细线处理的DALAL FILLER组合物
公开(公告)号：WO2013040242A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055211
申请日：2012-09-13
申请人： ALLERGAN, INC. , NJIKANG, Gabriel N. , YU, Xiaojie , LIU, Futian , PALIWAL, Sumit , MANESIS, Nicholas J.
发明人： NJIKANG, Gabriel N. , YU, Xiaojie , LIU, Futian , PALIWAL, Sumit , MANESIS, Nicholas J.
IPC分类号： A61L27/20 , C08B37/08
CPC分类号： A61L27/20 , A61K8/676 , A61K8/735 , A61K2800/91 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/24 , C08J2305/08 , C08L5/08
摘要： The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.
摘要翻译：本发明提供高度注射，持久的透明质酸基水凝胶皮肤填充剂组合物，其特别有利于校正面部细纹。

3. 发明申请

WO2013036568A1 HYALURONIC ACID/COLLAGEN- BASED DERMAL FILLER COMPOSITIONS AND METHODS FOR MAKING SAME 审中-公开
标题翻译：基于丙氨酸/胶原的含氟组合物及其制备方法
公开(公告)号：WO2013036568A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/053853
申请日：2012-09-06
申请人： ALLERGAN, INC. , POLLOCK, Jacob, F. , YU, Xiaojie , MANESIS, Nicholas, J.
发明人： POLLOCK, Jacob, F. , YU, Xiaojie , MANESIS, Nicholas, J.
IPC分类号： C08B37/00 , C08H1/00 , C08L5/08 , C08L89/00 , A61K8/65 , A61K8/73 , A61L27/52 , A61K9/00
CPC分类号： A61L27/24 , A61K8/042 , A61K8/65 , A61K8/735 , A61K2800/91 , A61L27/26 , A61L27/52 , A61L2400/06 , A61L2430/34 , A61Q19/08 , C08B37/0072 , C08H1/00 , C08L5/08 , C08L89/00 , H04R1/1066 , H04R1/1075 , C08L5/00 , C08L89/06
摘要： Hyaluronic acid and collagen may be crosslinked in aqueous solution as described herein. The crosslinked macromolecular matrices obtained in this process may be used as a hydrogel for implants and fillers for human aesthetic and therapeutic products.
摘要翻译：透明质酸和胶原可以如本文所述在水溶液中交联。在该方法中获得的交联的大分子基团可以用作人类美容和治疗产品的植入物和填料的水凝胶。

4. 发明申请

WO2004032881A2 IMPLANTATION OF ENCAPSULATED BIOLOGICAL MATERIALS FOR TREATING DISEASES 审中-公开
标题翻译：用于治疗疾病的包埋生物材料的植入
公开(公告)号：WO2004032881A2
公开(公告)日：2004-04-22
申请号：PCT/US0332842
申请日：2003-10-14
申请人： NOVOCELL INC , SCHARP DAVID , LATTA PAUL , YU XIAOJIE , YUE CHENGYUN , HUBBELL JEFFERY
发明人： SCHARP DAVID , LATTA PAUL , YU XIAOJIE , YUE CHENGYUN , HUBBELL JEFFERY
IPC分类号： A61F2/02 , A61K9/00 , A61K9/50 , A61K35/12 , A61K45/00 , C12N5/00 , C12N5/071 , C12N11/08 , A61K
CPC分类号： C12N11/08 , A61K9/0024 , A61K9/5031 , A61K9/5036 , A61K2035/126 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/74
摘要： The present invention relates to compositions for treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. Several methods are presented for coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. These encapsulated biological materials are used to treat a variety of different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.
摘要翻译：本发明涉及通过将包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物。介绍了几种不同类型的生物材料的方法。涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。这些包封的生物材料用于通过将它们植入人体的包括皮下部位的几个区域来治疗各种不同的人和动物疾病或病症。可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护包封的生物材料免受宿主炎症和免疫的破坏不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。

5. 发明申请

WO2013040242A3 DERMAL FILLER COMPOSITIONS FOR FINE LINE TREATMENT 审中-公开
标题翻译：用于细线处理的DERMAL FILLER组合物
公开(公告)号：WO2013040242A3
公开(公告)日：2014-03-13
申请号：PCT/US2012055211
申请日：2012-09-13
申请人： ALLERGAN INC , NJIKANG GABRIEL N , YU XIAOJIE , LIU FUTIAN , PALIWAL SUMIT , MANESIS NICHOLAS J
发明人： NJIKANG GABRIEL N , YU XIAOJIE , LIU FUTIAN , PALIWAL SUMIT , MANESIS NICHOLAS J
IPC分类号： A61K8/73 , A61K8/67 , A61K47/48 , A61L27/20 , A61L27/50 , A61Q19/08 , C08B37/08
CPC分类号： A61L27/20 , A61K8/676 , A61K8/735 , A61K2800/91 , A61L2400/06 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/24 , C08J2305/08 , C08L5/08
摘要： The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.
摘要翻译：本发明提供高度注射，持久的透明质酸基水凝胶皮肤填充剂组合物，其特别有利于校正面部细纹。

6. 发明申请

WO2011143213A1 POROGEN COMPOSITIONS, METHODS OF MAKING AND USES 审中-公开
标题翻译：多孔组合物，制备方法和用途
公开(公告)号：WO2011143213A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035917
申请日：2011-05-10
申请人： ALLERGAN, INC. , LIU, Futian , MANESIS, Nicholas J. , YU, Xiaojie , CHAN, Athene W.
发明人： LIU, Futian , MANESIS, Nicholas J. , YU, Xiaojie , CHAN, Athene W.
IPC分类号： A61L24/00 , A61L28/00 , A61L31/14
CPC分类号： A61L31/10 , A61F2/12 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2430/04 , Y10T428/2989 , C08L83/04 , C08L23/22 , C08L53/02
摘要： The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices
摘要翻译：本说明书公开了包含核心材料和壳材料的致孔剂组合物，制备这种致孔剂组合物的方法，使用这种致孔剂组合物形成这种多孔材料的方法，包含这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法

7. 发明申请

WO2010053472A1 STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS FOR DIFFERENTIATION THEREOF 审中-公开
标题翻译：干细胞聚集悬浮组合物及其分化方法
公开(公告)号：WO2010053472A1
公开(公告)日：2010-05-14
申请号：PCT/US2008/082356
申请日：2008-11-04
申请人： NOVOCELL, INC. , GREEN, Chad , YU, Xiaojie , BANG, Anne , BRANDON, Eugene, P. , KELLY, Olivia , AGULNICK, Alan , BAETGE, Ed , D'AMOUR, Kevin , SCHULZ, Thomas, C. , ROBINS, Allan, J.
发明人： GREEN, Chad , YU, Xiaojie , BANG, Anne , BRANDON, Eugene, P. , KELLY, Olivia , AGULNICK, Alan , BAETGE, Ed , D'AMOUR, Kevin , SCHULZ, Thomas, C. , ROBINS, Allan, J.
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0606 , C12N2501/11 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/195 , C12N2501/48
摘要： The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single eel! suspensions and methods of differentiation thereof.
摘要翻译：本发明涉及从未分化或分化的胚胎干细胞单鳗生产未分化或分化的胚胎干细胞聚集悬浮培养物的方法！悬浮液及其分化方法。

8. 发明申请

WO2013028904A3 DERMAL FILLER COMPOSITIONS INCLUDING ANTIOXIDANTS 审中-公开
标题翻译：皮肤填充剂组合物，包括抗氧化剂
公开(公告)号：WO2013028904A3
公开(公告)日：2013-11-07
申请号：PCT/US2012052125
申请日：2012-08-23
申请人： ALLERGAN INC , LIU FUTIAN , YU XIAOJIE , WINER JESSAMINE P , MANESIS NICHOLAS J , LIU HENGLI , NJIKANG GABRIEL
发明人： LIU FUTIAN , YU XIAOJIE , WINER JESSAMINE P , MANESIS NICHOLAS J , LIU HENGLI , NJIKANG GABRIEL
IPC分类号： A61K8/73 , A61K8/67 , A61K47/48 , A61L27/20 , A61L27/50 , A61Q19/08 , C08B37/08
CPC分类号： A61L27/20 , A61K8/676 , A61K8/735 , A61K47/545 , A61K2800/91 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08L5/08
摘要： Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.
摘要翻译：提供可注射的包含共轭维生素C衍生物的基于透明质酸的皮肤填充剂组合物。该组合物提供活性维生素C到组织中的延长释放，促进胶原合成和对皮肤的其他益处。

9. 发明申请

WO2012167079A3 DERMAL FILLER COMPOSITIONS INCLUDING ANTIOXIDANTS 审中-公开
标题翻译：包含抗氧化剂的真空填充剂组合物
公开(公告)号：WO2012167079A3
公开(公告)日：2013-10-24
申请号：PCT/US2012040459
申请日：2012-06-01
申请人： ALLERGAN INC , LIU FUTIAN , MANESIS NICHOLAS J , YU XIAOJIE , CHAN ATHENE WAN CHIE
发明人： LIU FUTIAN , MANESIS NICHOLAS J , YU XIAOJIE , CHAN ATHENE WAN CHIE
IPC分类号： A61K8/73 , A61K8/04 , A61K8/67 , A61K47/48 , A61L27/20 , A61Q19/08 , C08B37/08
CPC分类号： A61L27/20 , A61K8/042 , A61K8/676 , A61K8/735 , A61K47/60 , A61K47/61 , A61K2800/91 , A61L27/00 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/204 , A61L2300/402 , A61L2400/06 , A61Q19/08 , C08B37/0072
摘要： Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.
摘要翻译：提供可注射的透明质酸基水凝胶组合物，包括缀合的维生素。

10. 发明申请

WO2005072764A3 FIBRIN-BOUND ANGIOGENIC FACTORS TO STIMULATE VASCULARIZATION OF TRANSPLANT SITE OF ENCAPSULATED CELLS 审中-公开
标题翻译： FIBRIN-BOUND ANGIOGENIC因子刺激移植细胞移植位点的血管化
公开(公告)号：WO2005072764A3
公开(公告)日：2005-12-15
申请号：PCT/US2005001445
申请日：2005-01-18
申请人： NOVOCELL INC , SCHARP DAVID WILLIAM , LATTA PAUL PRESLEY , YU XIAOJIE , HUBBELL JEFFREY , ZISCH ANDREAS H
发明人： SCHARP DAVID WILLIAM , LATTA PAUL PRESLEY , YU XIAOJIE , HUBBELL JEFFREY , ZISCH ANDREAS H
IPC分类号： A61K33/06 , A61K35/12 , A61K38/18 , A61K38/19 , A61K38/36 , A61K38/48 , A61K45/00 , A61L24/10 , A61L27/38 , A61L27/50 , C12N5/071 , C12N5/06
CPC分类号： A61L27/3804 , A61K35/12 , A61K35/39 , A61K38/1866 , A61K38/363 , A61K38/37 , A61K38/4833 , A61L24/10 , A61L27/507 , C12N5/0677 , A61K2300/00
摘要： The present invention relates to compositions and methods of treating a disease, such as diabetes, by implementing encapsulated biological material with a growth factor and fibrin glue into a patient in need of treatment. Several methods are presented to accomplish transplanting several different types of biological materials. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site.
摘要翻译：本发明涉及通过将具有生长因子和纤维蛋白胶的包封的生物材料施用到需要治疗的患者中来治疗疾病如糖尿病的组合物和方法。提出了几种方法来实现移植几种不同类型的生物材料。本发明还提供了利用这些封装的生物材料通过将它们植入包括皮下部位在内的身体的若干区域来治疗不同的人和动物疾病或病症的方法。

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