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1. 发明申请

WO2009079028A1 PURIFICATION AND CONCENTRATION OF PROTEINS AND DNA FROM A COMPLEX SAMPLE USING ISOTACHOPHORESIS AND A DEVICE TO PERFORM THE PURIFICATION 审中-公开
标题翻译：使用异位异构体和复合样品的蛋白质和DNA的纯化和浓度进行纯化
公开(公告)号：WO2009079028A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/065260
申请日：2008-07-18
申请人： JOHNS HOPKINS UNIVERSITY , YOUNG, Charles, C.
发明人： YOUNG, Charles, C.
IPC分类号： G01N37/00
CPC分类号： C07K1/26
摘要： A method of simultaneously co-purifying and concentrating nucleic acid and protein targets into a single volume is described. The method includes automation of the entire sample preparation process, performed by having an analyst add a sample into a device that performs all of the steps necessary to prepare a sample for analysis. The method provides for samples are not split during the sample preparation process and where common purification methods can be used for purifying multiple analytes.
摘要翻译：描述了将核酸和蛋白质靶标同时共同纯化并浓缩成单个体积的方法。该方法包括自动化整个样品制备过程，通过使分析人员将样品添加到执行准备样品进行分析所需的所有步骤的设备中进行。该方法提供样品在样品制备过程中不分裂，并且常用纯化方法可用于纯化多种分析物。

2. 发明申请

WO2008052079A2 METHOD FOR CREATING AND ANALYZING ADVERTISEMENTS 审中-公开
标题翻译：创建和分析广告的方法
公开(公告)号：WO2008052079A2
公开(公告)日：2008-05-02
申请号：PCT/US2007082427
申请日：2007-10-24
申请人： HELLO HELLO INC , YOUNG CHARLES
发明人： YOUNG CHARLES
IPC分类号： G06Q30/00 , G06Q90/00
CPC分类号： G06Q30/02 , G06Q30/0242 , G06Q30/0244 , H04N21/47815 , H04N21/812
摘要： A method for analyzing advertisements and advertising campaigns. Important images are selected from one or more advertisements and then ranked. The most important images are then assigned to a category which preferably corresponds to a memory type, such as knowledge, emotion, or action. The relative numbers of images in each type determine the focus of the advertisement(s), and may be used to tailor the memory type(s) of subsequent advertisements.
摘要翻译：分析广告和广告活动的方法。重要的图像从一个或多个广告中选择，然后排名。然后将最重要的图像分配给优选对应于记忆类型的类别，例如知识，情绪或行为。每种类型的图像的相对数量决定广告的焦点，并且可以用来裁剪后续广告的存储器类型。

3. 发明申请

WO2006116005A2 STABILIZATION OF CARDIAC TROPONIN 审中-公开
标题翻译： CARDIAC TROPONIN的稳定
公开(公告)号：WO2006116005A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/014958
申请日：2006-04-20
申请人： ABBOTT LABORATORIES , LAIRD, Don, M. , YOUNG, Charles, E.
发明人： LAIRD, Don, M. , YOUNG, Charles, E.
IPC分类号： G01N33/50
CPC分类号： G01N33/6887 , C07K14/4716 , G01N2800/324
摘要： The present invention relates to a troponin protein or complex of two troponin proteins stabilized in a matrix containing at least one anionic surfactant. The stabilized troponin or complex of troponin proteins is used as a control or calibration standard in assays for the determination of blood levels of troponin in patient samples that are expect to exhibit elevated levels of cardiac proteins. The troponin protein or complex of troponin proteins remains stabilized at room temperatures for at least six (6) months.
摘要翻译：本发明涉及稳定在含有至少一种阴离子表面活性剂的基质中的肌钙蛋白或两种肌钙蛋白的复合物。稳定的肌钙蛋白或肌钙蛋白复合物用作测定患者样本中肌钙蛋白的血液水平的测定中的对照或校准标准，预期其表现出升高的心脏蛋白水平。肌钙蛋白或肌钙蛋白复合物在室温下保持稳定至少六（6）个月。

4. 发明申请

WO2005007830A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS, STAGING AND PROGNOSIS OF PROSTATE CANCER 审中-公开
公开(公告)号：WO2005007830A3
公开(公告)日：2005-01-27
申请号：PCT/US2004/022850
申请日：2004-07-14
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , VANAJA, Donkena, K. , YOUNG, Charles, Y.F.
发明人： VANAJA, Donkena, K. , YOUNG, Charles, Y.F.
IPC分类号： C12Q1/68
摘要： The present invention provides, inter alia, novel methods and compositions for the diagnosis, staging and prognosis of prostate cancer, based on DNA methylation and/or modulation of gene expression, including transcriptional silencing. Preferred diagnostic and/or prognostic nucleic acid and protein markers include at least one of: the differentially (relative to benign tissue) down-regulated sequences corresponding to zinc finger protein 185 (ZNF 185), prostate secretory protein (PSP94), bullous pemphigoid antigen (BPAG), supervillin (SVIL), proline rich membrane anchor 1 (PRIMA1), TU3A, FLJ14084, KIAA1210, Sorbin and SH3 domain containing 1 (SORBS1), and C21orf63; and the differentially up-regulated sequences MARCKS-like protein (MLP) SRY (sex determining region Y)-box 4 (SOX4), fatty acid binding protein 5 (FABP5), MAL2, and Erg-2.

5. 发明申请

WO1998005524A1 ADVANCED ROLLBACK WHEEL-LIFT 审中-公开
标题翻译：高级滚动轮提升
公开(公告)号：WO1998005524A1
公开(公告)日：1998-02-12
申请号：PCT/US1997013765
申请日：1997-08-07
申请人： JERR-DAN CORPORATION , YOUNG, Charles, E. , HEDSTROM, David, D.
发明人： JERR-DAN CORPORATION
IPC分类号： B60J09/00
CPC分类号： B60P3/125
摘要： An improved wheel-lift apparatus (63) attachable to various types of transport trucks (22), including rollback trucks for loading and carrying disabled vehicles (51). The improved wheel-lift apparatus provides a horizontal extendable boom mechanism (55) long enough for receiving disabled vehicles. As a result of the wheel-lift's "low angle" or horizontal approach, the risk of damage occurring to the chassis or body of the disabled vehicle while in the loading and carrying modes is greatly diminished.
摘要翻译：一种可附接到各种类型的运输卡车（22）的改进的轮升降装置（63），包括用于装载和运载残疾车辆的回卷车（51）。改进的车轮提升装置提供了一个足够长的用于接收残疾车辆的水平伸缩臂机构（55）。由于轮式“低角度”或水平方式，在装载和搬运方式下，残疾车辆底盘或车身的损坏风险大大降低。

6. 发明申请

WO1997017248A1 CAR CARRIER HAVING ROLLBACK DECK FORMED UTILIZING ADHESIVES 审中-公开
标题翻译：带有滚筒式卡车的CAR CARRIER已形成使用粘合剂
公开(公告)号：WO1997017248A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017830
申请日：1996-11-07
申请人： JERR-DAN CORPORATION , YOUNG, Charles, E.
发明人： JERR-DAN CORPORATION
IPC分类号： B62D25/20
CPC分类号： B60P1/4492 , B60P3/122 , B62D25/2054
摘要： A transport vehicle having a rollback deck (30), which includes a plurality of individual elements (32) interconnected with one another so as to form a vehicle support surface (48). Each individual element (32) is also secured to at least a single "I" beam support member (34). The individual elements (32) being permenently secured to one another, as well as to the "I" beam support member (34) by means of an adhesive.
摘要翻译：一种具有回卷甲板（30）的运输车辆，其包括彼此互连以形成车辆支撑表面（48）的多个单独元件（32）。每个单个元件（32）也固定到至少一个“I”梁支撑构件（34）。各个元件（32）通过粘合剂永久地固定到“I”梁支撑构件（34）上。

7. 发明申请

WO1997017226A1 OVER-CENTER TOWING LOCKING MECHANISM FOR A WHEEL LIFT 审中-公开
标题翻译：用于车轮提升的超中心锁定机构
公开(公告)号：WO1997017226A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017873
申请日：1996-11-07
申请人： JERR-DAN CORPORATION , YOUNG, Charles, E. , WATSON, Scott, A.
发明人： JERR-DAN CORPORATION
IPC分类号： B60P03/12
CPC分类号： B60P3/125
摘要： The present invention relates to a wheel grid assembly (25) and vehicle towing apparatus. The wheel grid assembly (25) includes a wheel boom (26) and a pair of lift arms (31A, 31B). Each lift arm (31A, 31B) consists of an extension arm segment (32) transversely fixed to the wheel boom (26), and an engaging arm segment (33) having a pivot point designed for pivotal mounting near the end of the extension arm segment (32), remote from the wheel boom (26). The engaging arm segment (33) is made up of an actuating arm segment (35) and a gripping arm segment (34) extending in different directions from the pivot point. A pair of linear actuators (41) are pivotally attached to the wheel boom (26), with each having a fixed arm segment (36) and movable arm segment (37). The fixed arm segment (36) of each linear actuator is relatively transversely attached to the wheel boom (26) and the movable arm segment (37) of each is pivotally attached to an over-center locking mechanism (40).
摘要翻译：本发明涉及一种车轮网格组件（25）和车辆牵引装置。车轮网格组件（25）包括轮臂（26）和一对提升臂（31A，31B）。每个提升臂（31A，31B）由横向固定到轮臂（26）的延伸臂段（32）和一个具有枢转点的接合臂段（33）组成，该枢轴点设计用于在延伸臂的端部附近枢转安装（32），远离车轮吊杆（26）。接合臂段（33）由致动臂段（35）和从枢轴点沿不同方向延伸的夹臂段（34）构成。一对线性致动器（41）可枢转地附接到轮辋（26），每个具有固定臂段（36）和可动臂段（37）。每个线性致动器的固定臂部分（36）相对横向地附接到轮臂（26），并且每个线性致动器的可动臂段（37）可枢转地附接到过中心的锁定机构（40）。

8. 发明申请

WO1997017224A1 LIGHT WEIGHT/RUST RESISTANT TOW TRUCK BODY 审中-公开
标题翻译：轻重量/抗重载拖车车身
公开(公告)号：WO1997017224A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017257
申请日：1996-11-08
申请人： JERR-DAN CORPORATION , YOUNG, Charles, E. , BARTEL, James, J.
发明人： JERR-DAN CORPORATION
IPC分类号： B60P03/12
CPC分类号： B60P3/125
摘要： A tow truck (20, 22) having a body assembly including a left body structural unit (24) [a left body structural unit (24)] and a right body structural unit (26), each unit having a plurality of exterior panels (30) attached thereto. The structural unit is preferably formed from flanged (44) aluminum panels that are attached by adhesive (46). The improved underlift assembly (23) comprises a support arm (220) coupled to the vehicle, a base (222) coupled to an end of the support arm, a boom base (226) pivotally attached to the base at a first pivot pint (228) and a boom (236) pivotally attached to the boom base at a second pivot point (238). A first actuator (240) is coupled to the support arm and to the pivoting boom base. A second actuator is coupled to the boom base and the pivoting boom. The improved lifting boom (284) includes two lifting hydraulic actuators (290, 292) that are coupled to the lifting boom on each side and angled inward to provide improved stability.
摘要翻译：具有主体组件的牵引车（20,22），其包括左身体结构单元（24）[左身体结构单元（24）]和右身体结构单元（26），每个单元具有多个外部面板 30）。结构单元优选地由通过粘合剂（46）附接的带凸缘（44）铝板形成。改进的隆起组件（23）包括联接到车辆的支撑臂（220），联接到支撑臂的端部的基座（222），以第一枢轴点（...）枢转地附接到基座的动臂基座（226） 228）和悬臂（236），其在第二枢转点（238）处枢转地附接到所述起重臂基座。第一致动器（240）联接到支撑臂和枢转起重臂基座。第二致动器联接到动臂基座和枢转起重臂。改进的起重臂（284）包括两个提升液压致动器（290,292），每个提升液压致动器联接到每侧的提升吊臂并向内倾斜以提供改进的稳定性。

9. 发明申请

WO1995030758A1 RECOMBINANT HK2 POLYPEPTIDE 审中-公开
标题翻译：重组HK2 POLYPEPTIDE
公开(公告)号：WO1995030758A1
公开(公告)日：1995-11-16
申请号：PCT/US1995006157
申请日：1995-05-09
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , HYBRITECH INCORPORATED , TINDALL, Donald, J. , YOUNG, Charles, Yu, Fu , SAEDI, Mohammad, S.
发明人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , HYBRITECH INCORPORATED
IPC分类号： C12N15/57
CPC分类号： C12N9/6445 , A61K38/00 , C07K16/40 , C12N2799/026
摘要： An isolated, substantially homogenous hK2 polypeptide is provided as well as isolated nucleic acid molecules encoding hK2 polypeptide, including (a) a cDNA molecule comprising the nucleotide sequence of the coding region of human hK2 gene; (b) a DNA molecule capable of hybridizing under stringent conditions to a molecule of (a); and (c) a genetic variant of any of the DNA molecules of (a) and (b) which encodes of polypeptide processing an antigenic function of naturally occurring polypeptide.
摘要翻译：提供分离的基本上均匀的hK2多肽，以及编码hK2多肽的分离的核酸分子，包括（a）包含人hK2基因编码区的核苷酸序列的cDNA分子; （b）能够在严格条件下与（a）分子杂交的DNA分子; 和（c）编码多肽的（a）和（b）的任何DNA分子的遗传变体，其处理天然存在的多肽的抗原功能。

10. 发明申请

WO2013052161A1 UNIFYING CONNECTED DOMINATING SET USING LOCALIZED TWO HOP INFORMATION WITH A FLEXIBLE DOMINATING FACTOR 审中-公开
标题翻译：使用本地化的双向信息与灵活的因果关系进行统一连接的定位
公开(公告)号：WO2013052161A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/037292
申请日：2012-05-10
申请人： ROCKWELL COLLINS, INC. , YOUNG, Charles, D. , AMIS, Alan, D.
发明人： YOUNG, Charles, D. , AMIS, Alan, D.
IPC分类号： H04L12/28 , H04L12/26
CPC分类号： H04L45/14 , H04W40/246
摘要： The present disclosure is directed to a method for forming a connected dominating set (CDS) for a graph. The method may include directing each node of the graph to broadcast a dominating factor and neighboring node information; identifying a dominating set based on the dominating factor of each node in comparison with dominating factors of neighboring nodes according to a dominating set rule definition; identifying a connecting set for connecting nodes according to a connecting set rule definition; and forming the CDS as a union of the dominating set and the connecting set.
摘要翻译：本公开涉及用于形成图的连接支配集（CDS）的方法。该方法可以包括指示图的每个节点广播支配因子和相邻节点信息; 根据主导设定规则定义，与相邻节点的主导因素相比，基于每个节点的主导因素识别主导集; 根据连接集规则定义识别连接节点的连接集; 并将CDS形成为主导集合和连接集合的联合。

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