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1. 发明申请

WO2005060725A2 NUCIEIC ACID AMPLIFICATION METHODS 审中-公开
标题翻译：核酸扩增方法
公开(公告)号：WO2005060725A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/007237
申请日：2004-03-10
申请人： MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY , ZHANG, David, Y. , ZHANG, Wandi , YI, Jizu
发明人： ZHANG, David, Y. , ZHANG, Wandi , YI, Jizu
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/682 , C12Q1/6827 , C12Q1/6834 , C12Q1/6858 , C12Q2600/158 , C12Q2561/125 , C12Q2531/125 , C12Q2525/307 , C12Q2565/101 , C12Q2525/197 , C12Q2525/161 , C12Q2537/143 , C12Q2565/519 , C12Q2563/143 , C12Q2531/119 , C12Q2531/113
摘要： The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.
摘要翻译：本发明涉及用于进行用于快速，自动检测感染性病原体和正常和异常基因的所述测定的测定和试剂盒。本发明还涉及基因组DNA和总mRNA的一般扩增方法以及使用本文公开的扩增方法分析差异mRNA表达的方法。

2. 发明申请

WO2008013684A2 MEMBRANE-BASED DOUBLE-LAYER TUBE FOR SAMPLE COLLECTIONS 审中-公开
标题翻译：基于膜的双层管用于样品收集
公开(公告)号：WO2008013684A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016005
申请日：2007-07-13
申请人： BECTON, DICKINSON AND COMPANY , YI, Jizu , LIN, Fu Chung , MANOUSSAKIS, Dimitrios , GELFAND, Craig
发明人： YI, Jizu , LIN, Fu Chung , MANOUSSAKIS, Dimitrios , GELFAND, Craig
IPC分类号： B01L3/00 , B01L3/14
CPC分类号： B01L3/50825 , B01L3/502 , B01L3/5021 , B01L2300/047 , B01L2300/0672 , B01L2300/0681 , B01L2400/049
摘要： The fluid sample collection device is adapted to collect and separate a fluid sample into constituent parts such as separating plasma or serum from a blood sample. The device includes an evacuated outer container and an inner container. The outer container has a first open end and a second closed end. A pierceable closure closes the first open end thereby defining a first interior chamber. The inner container is contained within the outer container and separates the first interior chamber into an upper chamber portion and lower chamber portion in fluid communication. The inner container defines a second interior chamber separated from the lower chamber portion through a porous membrane. A port is provided for placing the second interior chamber in fluid communication with the first interior chamber. Another aspect of the device relates to a method of using the device to separate plasma or serum from a blood sample.
摘要翻译：流体样品收集装置适于将流体样品收集并分离成组成部分，例如从血液样品分离血浆或血清。该装置包括抽真空的外部容器和内部容器。外容器具有第一开口端和第二封闭端。可刺破的封闭件封闭第一开口端，由此限定第一内部室。内部容器容纳在外部容器内并且将第一内部室分离成上部室部分和下部室流体连通。内容器限定了通过多孔膜与下室部分隔开的第二内室。提供了一个用于将第二内室与第一内室流体连通的端口。该装置的另一方面涉及使用该装置将血浆或血清与血液样品分离的方法。

3. 发明申请

WO2005061722A1 NUCLEIC ACID AMPLIFICATION METHODS 审中-公开
标题翻译：核酸扩增方法
公开(公告)号：WO2005061722A1
公开(公告)日：2005-07-07
申请号：PCT/US2003/037199
申请日：2003-11-21
申请人： MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY , ZHANG, David, Y. , ZHANG, Wandi , YI, Jizu
发明人： ZHANG, David, Y. , ZHANG, Wandi , YI, Jizu
IPC分类号： C12P19/34
CPC分类号： C07H21/04
摘要： The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.
摘要翻译：本发明涉及用于进行用于快速，自动检测感染性病原体和正常和异常基因的所述测定的测定和试剂盒。本发明还涉及基因组DNA和总mRNA的一般扩增方法以及使用本文公开的扩增方法分析差异mRNA表达的方法。

4. 发明申请

WO2005060725A3 NUCLEIC ACID AMPLIFICATION METHODS 审中-公开
标题翻译：核酸扩增方法
公开(公告)号：WO2005060725A3
公开(公告)日：2009-03-26
申请号：PCT/US2004007237
申请日：2004-03-10
申请人： SINAI SCHOOL MEDICINE , ZHANG DAVID Y , ZHANG WANDI , YI JIZU
发明人： ZHANG DAVID Y , ZHANG WANDI , YI JIZU
IPC分类号： C12P19/34 , G01N33/53 , C07H21/02 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/682 , C12Q1/6827 , C12Q1/6834 , C12Q1/6858 , C12Q2600/158 , C12Q2561/125 , C12Q2531/125 , C12Q2525/307 , C12Q2565/101 , C12Q2525/197 , C12Q2525/161 , C12Q2537/143 , C12Q2565/519 , C12Q2563/143 , C12Q2531/119 , C12Q2531/113
摘要： The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.
摘要翻译：本发明涉及用于进行用于快速，自动检测感染性病原体和正常和异常基因的所述测定的测定和试剂盒。本发明还涉及基因组DNA和总mRNA的一般扩增方法以及使用本文公开的扩增方法分析差异mRNA表达的方法。

5. 发明申请

WO2008013684A3 MEMBRANE-BASED DOUBLE-LAYER TUBE FOR SAMPLE COLLECTIONS 审中-公开
标题翻译：用于样品收集的基于膜的双层管
公开(公告)号：WO2008013684A3
公开(公告)日：2008-06-05
申请号：PCT/US2007016005
申请日：2007-07-13
申请人： BECTON DICKINSON CO , YI JIZU , LIN FU CHUNG , MANOUSSAKIS DIMITRIOS , GELFAND CRAIG
发明人： YI JIZU , LIN FU CHUNG , MANOUSSAKIS DIMITRIOS , GELFAND CRAIG
IPC分类号： B01L3/00 , B01L3/14
CPC分类号： B01L3/50825 , B01L3/502 , B01L3/5021 , B01L2300/047 , B01L2300/0672 , B01L2300/0681 , B01L2400/049
摘要： The fluid sample collection device is adapted to collect and separate a fluid sample into constituent parts such as separating plasma or serum from a blood sample. The device includes an evacuated outer container and an inner container. The outer container has a first open end and a second closed end. A pierceable closure closes the first open end thereby defining a first interior chamber. The inner container is contained within the outer container and separates the first interior chamber into an upper chamber portion and lower chamber portion in fluid communication. The inner container defines a second interior chamber separated from the lower chamber portion through a porous membrane. A port is provided for placing the second interior chamber in fluid communication with the first interior chamber. Another aspect of the device relates to a method of using the device to separate plasma or serum from a blood sample.
摘要翻译：流体样本收集装置适于收集流体样本并将其分离成组成部分，例如从血液样本中分离血浆或血清。该装置包括抽空的外部容器和内部容器。外容器具有第一开口端和第二封闭端。可刺穿的闭合件关闭第一开口端，从而限定第一内部腔室。内部容器容纳在外部容器内并将第一内部腔室分隔成流体连通的上部腔室部分和下部腔室部分。内部容器限定通过多孔膜与下部腔室部分隔开的第二内部腔室。提供端口用于将第二内部腔室与第一内部腔室流体连通。该装置的另一方面涉及使用该装置从血液样品中分离血浆或血清的方法。

6. 发明申请

WO2009045552A1 SYSTEM AND METHOD FOR DIAGNOSING DISEASES 审中-公开
标题翻译：用于诊断疾病的系统和方法
公开(公告)号：WO2009045552A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011558
申请日：2008-10-03
申请人： BECTON, DICKINSON AND COMPANY , GELFAND, Craig, A. , YI, Jizu , JU, Gang
发明人： GELFAND, Craig, A. , YI, Jizu , JU, Gang
IPC分类号： G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/86 , G01N2333/75
摘要： One aspect of the invention provides a method of diagnosing a disease condition, comprising measuring presence or amount of a targeted protein or a degradation product of said protein in a collected biological sample as a marker for the disease condition. The targeted protein or degradation product is selected for measurement based on a prior identification of a measurable half-life at a predetermined time period, including the time at which said method is conducted, and correlating said measuring with the presence or absence of the disease condition. The targeted protein or degradation product may be identified by selecting a protein known or suspected to be a diagnostic marker for the disease condition, analyzing degradation of the protein in the collected biological sample, and selecting a protein or degradation product that exhibits a measurable half-life at a predetermined period of time. The analyzing may include identifying degradation product (s) of the protein as a function of time, and half-life of the protein and the degradation product (s).
摘要翻译：本发明的一个方面提供了一种诊断疾病状况的方法，包括测定收集的生物样品中所述蛋白质的靶向蛋白质或降解产物的存在或量作为疾病状况的标志物。基于在预定时间段（包括进行所述方法的时间）的可测量的半衰期的先前识别，并将所述测量与存在或不存在疾病状态相关联，选择靶向蛋白质或降解产物进行测量。可以通过选择已知或怀疑是疾病状况的诊断标记物的蛋白质或分解产物来分析靶向蛋白质或降解产物，分析所收集的生物样品中蛋白质的降解，以及选择显示可测量的半衰期的蛋白质或降解产物，寿命在预定的时间。分析可以包括鉴定蛋白质的降解产物作为时间的函数，以及蛋白质和降解产物的半衰期。

7. 发明申请

WO2005060725A8 NUCLEIC ACID AMPLIFICATION METHODS 审中-公开
标题翻译：核酸扩增方法
公开(公告)号：WO2005060725A8
公开(公告)日：2006-07-27
申请号：PCT/US2004007237
申请日：2004-03-10
申请人： ITY MOUNT SINAI SCHOOL OF MEDI , ZHANG DAVID Y , ZHANG WANDI , YI JIZU
发明人： ZHANG DAVID Y , ZHANG WANDI , YI JIZU
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N21/78 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/682 , C12Q1/6827 , C12Q1/6834 , C12Q1/6858 , C12Q2600/158 , C12Q2561/125 , C12Q2531/125 , C12Q2525/307 , C12Q2565/101 , C12Q2525/197 , C12Q2525/161 , C12Q2537/143 , C12Q2565/519 , C12Q2563/143 , C12Q2531/119 , C12Q2531/113
摘要： The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.
摘要翻译：本发明涉及用于进行用于快速，自动检测感染性病原体和正常和异常基因的所述测定的测定和试剂盒。本发明还涉及基因组DNA和总mRNA的一般扩增方法以及使用本文公开的扩增方法分析差异mRNA表达的方法。

8. 发明申请

WO2003034031A3 HIGHLY SENSITIVE METHODS FOR PROTEIN DETECTION IN PROTEOMICS 审中-公开
公开(公告)号：WO2003034031A3
公开(公告)日：2003-04-24
申请号：PCT/US2002/033171
申请日：2002-10-15
申请人： MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY , ZHANG, David, Y. , YI, Jizu
发明人： ZHANG, David, Y. , YI, Jizu
IPC分类号： C12Q1/00
摘要： The present invention relates to methods for identification and quantification of proteins expressed within a cell. The methods of the invention involve the separation of proteins based on their physical properties such as, for example, net charge, molecular weight, or immunoreactivity, followed by detection of said proteins using a number of different techniques including (i) ramification-extension amplification method (RAM); (ii) hybridization signal amplification method (HSAM); and (iii) detection with nanodots. The methods of the invention will have a variety of different uses including, but mot limited to, uses for screening, for diagnosis and prognosis of disease. The method of the invention are especially useful for identification of proteins that are identified due to the size of the protein, low concentration of the protein, or failure to separate proteins due to similar physical properties.

9. 发明申请

WO03034031A2 HIGHLY SENSITIVE METHODS FOR PROTEIN DETECTION IN PROTEOMICS 审中-公开
标题翻译：用于蛋白质检测的高灵敏度方法
公开(公告)号：WO03034031A2
公开(公告)日：2003-04-24
申请号：PCT/US0233171
申请日：2002-10-15
申请人： SINAI SCHOOL MEDICINE , ZHANG DAVID Y , YI JIZU
发明人： ZHANG DAVID Y , YI JIZU
IPC分类号： C12Q1/68 , G01N33/58 , G01N
CPC分类号： B82Y15/00 , C12Q1/68 , C12Q1/6844 , G01N33/58 , G01N33/588 , C12Q2563/179 , C12Q2525/307
摘要： The present invention relates to methods for identification and quantification of proteins expressed within a cell. The methods of the invention involve the separation of proteins based on their physical properties such as, for example, net charge, molecular weight, or immunoreactivity, followed by detection of said proteins using a number of different techniques including i ramification-extension amplification method RAM ii hybridization signal amplification method HSAM and iii detection with nanodots. The methods of the invention will have a variety of different uses including, but mot limited to, uses for screening, for diagnosis and prognosis of disease. The method of the invention are especially useful for identification of proteins that are identified due to the size of the protein, low concentration of the protein, or failure to separate proteins due to similar physical properties.
摘要翻译：本发明涉及鉴定和定量细胞内表达的蛋白质的方法。本发明的方法包括基于它们的物理特性（例如净电荷，分子量或免疫反应性）分离蛋白质，随后使用许多不同的技术检测所述蛋白质，包括i分枝扩增扩增方法RAM ii杂交信号放大法HSAM和iii用纳米点检测。本发明的方法将具有各种不同的用途，包括但不限于筛选用途，疾病的诊断和预后。本发明的方法特别可用于鉴定由于蛋白质的大小，蛋白质的低浓度或由于相似的物理性质而不能分离蛋白质而鉴定的蛋白质。

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