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1. 发明申请

WO2013039980A1 METHOD FOR SELECTION OF SURFACTANTS IN WELL STIMULATION 审中-公开
标题翻译：选择表面活性剂在良好刺激中的方法
公开(公告)号：WO2013039980A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054768
申请日：2012-09-12
申请人： MULTI-CHEM GROUP, LLC , XU, Liang , FU, Qiang
发明人： XU, Liang , FU, Qiang
IPC分类号： E21B43/00
CPC分类号： C09K8/602 , C09K8/584 , C09K8/68 , C09K8/86 , G01N13/02 , G01N2013/0275
摘要： A method of determining the suitability of a surfactant for use in a formation can include sampling water in the formation, providing at least two surfactants, and mixing each of the surfactants with the formation water to form surfactant/water samples. The method can further include determining the solubility of each surfactant with the formation water, comparing the solubility of each surfactant with the other surfactant, and assigning a solubility performance value for each surfactant based on its solubility in the formation water sample compared to the other surfactant.
摘要翻译：确定用于地层中的表面活性剂的适用性的方法可以包括在地层中取样水，提供至少两种表面活性剂，并将每种表面活性剂与地层水混合以形成表面活性剂/水样品。该方法可以进一步包括测定每种表面活性剂与地层水的溶解度，比较每种表面活性剂与其它表面活性剂的溶解度，并根据其在地层水样品中与其它表面活性剂的溶解性分配每种表面活性剂的溶解性能值。

2. 发明申请

WO2012166782A2 THEROMPLASTIC ELASTOMER COMPOUNDS EXHIBITING SHAPE MEMORY VIA THERMO-MECHANICAL ACTION 审中-公开
标题翻译：透明弹性体化合物通过机械作用展现形状记忆
公开(公告)号：WO2012166782A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/039966
申请日：2012-05-30
申请人： POLYONE CORPORATION , XU, Liang
发明人： XU, Liang
IPC分类号： C08L101/00 , C08L25/08 , C08L67/04 , C08L91/06 , C08J5/00
CPC分类号： C08L53/005 , C08L51/06 , C08L53/00 , C08L53/025 , C08L67/04 , C08L91/00 , C08L91/06 , C08L2205/03 , C08L2205/06 , C08L2207/04 , C08L53/02 , C08L23/12
摘要： A thermoplastic elastomer compound is disclosed having a high strain recovery rate and a high strain fixity rate to provide shape memory, preferably manageable shape memory. One type of thermoplastic elastomer compound is comprises a maleated styrenic block copolymer and polycaprolactone to achieve the shape memory. A second type of thermoplastic elastomer compound comprises styrene-ethylene/butylene-styrene and a paraffin wax having less than about 0.5% oil content. Shape modes of articles made from the thermoplastic elastomer compound can be altered by at least one thermo-mechanical event to cause deformation of the compound from a first shape to a second shape with retention of the compound in the second shape for any reasonable time interval.
摘要翻译：公开了具有高应变恢复率和高应变固定率的热塑性弹性体化合物，以提供形状记忆，优选可管理的形状记忆。一种类型的热塑性弹性体化合物包括马来酸化苯乙烯嵌段共聚物和聚己内酯以实现形状记忆。第二类热塑性弹性体化合物包括苯乙烯 - 乙烯/丁烯 - 苯乙烯和具有小于约0.5％油含量的石蜡。由热塑性弹性体化合物制成的制品的形状模式可以通过至少一个热机械事件而改变，以使化合物从第一形状变形成第二形状，同时在任何合理的时间间隔内使化合物保持在第二形状。

3. 发明申请

WO2010055487A3 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：大肠癌微RNA表达谱的组成和方法
公开(公告)号：WO2010055487A3
公开(公告)日：2010-09-30
申请号：PCT/IB2009055057
申请日：2009-11-13
申请人： KONINKL PHILIPS ELECTRONICS NV , WU YING , ZHU HONGGUANG , LI JIAN , XU LIANG , VERHAEGH WILHELMUS F J , REN YIPING , JANEVSKI ANGEL , VARADAN VINAY , LI ZHAOYONG , DIMITROVA NEVENKA
发明人： WU YING , ZHU HONGGUANG , LI JIAN , XU LIANG , VERHAEGH WILHELMUS F J , REN YIPING , JANEVSKI ANGEL , VARADAN VINAY , LI ZHAOYONG , DIMITROVA NEVENKA
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结直肠癌的微RNA（miRNA）表达谱分析的组合物和方法。具体而言，本发明涉及分子标记的诊断试剂盒，用于鉴定展现或具有发展结肠直肠癌倾向的一种或多种哺乳动物靶细胞，所述试剂盒包含多个核酸分子，每个核酸分子编码miRNA序列，其中所述多种核酸分子中的一种或多种在所述靶细胞和一种或多种对照细胞中差异表达，并且其中所述一种或多种差异表达的核酸分子一起表示核酸表达签名，或发展大肠癌的倾向。本发明进一步涉及使用此类核酸表达签名鉴定一种或多种哺乳动物靶细胞的相应方法，所述一种或多种哺乳动物靶细胞展现或具有发展结肠直肠癌的倾向以及用于预防或治疗这样的状况。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

4. 发明申请

WO2006010118A3 CONFORMATIONALLY CONSTRAINED SMAC MIMETICS AND THE USES THEREOF 审中-公开
标题翻译：构形约束的SMAC模拟及其用途
公开(公告)号：WO2006010118A3
公开(公告)日：2007-06-28
申请号：PCT/US2005024530
申请日：2005-07-11
申请人： UNIV MICHIGAN , WANG SHAOMENG , SUM HAIYING , NIKOLOVSKA-COLESKA ZANETA , YANG CHAO-YIE , XU LIANG , SAITO NAOYUKI G , CHEN JIANGYONG
发明人： WANG SHAOMENG , SUM HAIYING , NIKOLOVSKA-COLESKA ZANETA , YANG CHAO-YIE , XU LIANG , SAITO NAOYUKI G , CHEN JIANGYONG
IPC分类号： A61K31/41 , A01N37/18 , C07D207/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译：本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂起作用。本发明还涉及这些模拟物用于诱导凋亡细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。

5. 发明申请

WO2006135437A9 REAL-TIME PCR MICROARRAY BASED ON AN EVANESCENT WAVE BIOSENSOR 审中-公开
标题翻译：基于EVANESCENT WAV生物传感器的实时PCR微波
公开(公告)号：WO2006135437A9
公开(公告)日：2007-05-18
申请号：PCT/US2005037833
申请日：2005-10-21
申请人： HONEYWELL INT INC , XU LIANG
发明人： XU LIANG
IPC分类号： C12Q1/68
CPC分类号： G06N3/02 , H04L67/12 , H04L69/329
摘要： A system and method for simultaneous, quantitative measurement of nucleic acids in a sample. Fluorescently tagged amplicons of the target nucleic acids are localized on a substrate surface by hybridization to oligopobes that have been arrayed and tethered to the substrate surface in a pre-determined, two-dimensional pattern. The hybridized, amplicons are then detected by exciting their fluorescent tags using an evanescent wave flight of the appropriate wave-length. Because of the limited penetration of the evanescent wave (about 100-300 nm), the fluorescently tagged nucleotides in the remainder of the reaction cell do not fluoresce. By measuring the fluorescence at various locations on the substrate surface, the current abundance of hybridized amplicons of each of the target nucleic acids can be determined. The analytic techniques of real time PCR may then be used to obtain accurate, quantitative measurements for each of the nucleic acids in the sample.
摘要翻译：用于同时，定量测量样品中核酸的系统和方法。通过与已经以预定的二维图案排列和束缚到基底表面的寡核苷酸杂交，将目标核酸的荧光标记的扩增子定位在底物表面上。然后通过使用适当波长的ev逝波飞行激发其荧光标签来检测杂交的扩增子。由于ev逝波（约100-300nm）的穿透有限，反应池其余部分的荧光标记核苷酸不发荧光。通过测量底物表面上各个位置的荧光，可以确定每个目标核酸的杂交扩增子的当前丰度。然后可以使用实时PCR的分析技术来获得样品中每个核酸的准确，定量的测量。

6. 发明申请

WO2006023778A2 SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF 审中-公开
标题翻译：抗BCL-2家族成员的小分子抑制剂及其用途
公开(公告)号：WO2006023778A2
公开(公告)日：2006-03-02
申请号：PCT/US2005029634
申请日：2005-08-22
申请人： UNIV MICHIGAN , WANG SHAOMENG , WANG GUOPING , TANG GUOZHI , WANG RENXIAO , NIKOLOVSKA-COLESKA ZANETA , WANG DAJON , XU LIANG
发明人： WANG SHAOMENG , WANG GUOPING , TANG GUOZHI , WANG RENXIAO , NIKOLOVSKA-COLESKA ZANETA , WANG DAJON , XU LIANG
IPC分类号： A61K31/5377 , A61K31/165 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/506 , C07C317/32 , C07D401/02 , C07D413/02
CPC分类号： C07C205/38 , C07C39/10 , C07C39/15 , C07C39/17 , C07C39/367 , C07C43/23 , C07C43/295 , C07C49/747 , C07C49/82 , C07C49/83 , C07C49/84 , C07C65/105 , C07C235/60 , C07C235/64 , C07C311/29 , C07C311/46 , C07C317/22 , C07C317/40 , C07C317/44 , C07C2601/14 , C07C2603/74 , C07D211/16 , C07D213/70 , C07D215/227 , C07D215/233 , C07D217/06 , C07D263/56 , C07D277/64 , C07D307/84 , C07D321/12 , C07D333/60 , C07D333/76 , C07D401/12 , C07D405/12
摘要： The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
摘要翻译：本发明涉及作为抗凋亡Bcl-2家族成员蛋白（例如Bcl-2和Bcl-xL）的抑制剂的小分子。本发明还涉及这些化合物用于诱导凋亡细胞死亡和使细胞对诱导凋亡性细胞死亡致敏的用途。

7. 发明申请

WO0043043B1 LIGAND-PEG POST-COATING STABILIZED LIPOPLEX AND POLYPLEX FOR TARGETED GENE DELIVERY 审中-公开
标题翻译： LIGAND-PEG后涂层稳定的LIPOPLEX和POLYPLEX用于目标基因传递
公开(公告)号：WO0043043B1
公开(公告)日：2000-09-21
申请号：PCT/US0001346
申请日：2000-01-21
申请人： UNIV GEORGETOWN , XU LIANG , CHANG ESTHER H
发明人： XU LIANG , CHANG ESTHER H
IPC分类号： A61K47/48 , A61K48/00 , A61P35/00
CPC分类号： A61K47/6935 , A61K47/551 , A61K47/59 , A61K47/60 , A61K47/6911
摘要： This invention relates to the area of systemic, tissue-specific non-viral gene delivery. The present invention provides a novel method to prepare ligand-directed, PEG-stabilized complex as gene delivery systems for targeted gene therapy. Due to the presence of PEG these novel complexes have longer circulating times than conventional ligand-liposome complexes. In addition, due to the presence of the ligand in the complex with PEG, these complexes are tissue targeting. Their small size further makes them very desirable for in vivo use.
摘要翻译：本发明涉及全身，组织特异性非病毒基因递送的面积。本发明提供了一种制备配体导向的PEG稳定复合物作为靶向基因治疗的基因递送系统的新方法。由于PEG的存在，这些新型配合物比常规配体 - 脂质体复合物具有更长的循环时间。此外，由于配体与PEG的配合物的存在，这些复合物是组织靶向的。它们的小尺寸进一步使得它们非常适合于体内使用。

8. 发明申请

WO2011112929A3 MAGNETIC SENSOR BASED QUANTITATIVE BINDING KINETICS ANALYSIS 审中-公开
标题翻译：基于磁传感器的定量绑定动力学分析
公开(公告)号：WO2011112929A3
公开(公告)日：2012-03-29
申请号：PCT/US2011028090
申请日：2011-03-11
申请人： UNIV LELAND STANFORD JUNIOR , WANG SHAN X , GASTER RICHARD S , XU LIANG , HAN SHU-JEN , WILSON ROBERT
发明人： WANG SHAN X , GASTER RICHARD S , XU LIANG , HAN SHU-JEN , WILSON ROBERT
IPC分类号： G01N27/74 , C12Q1/68 , G01N33/483 , G01N33/53
CPC分类号： G01N27/745 , G01N33/557 , Y10T436/143333
摘要： Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.
摘要翻译：提供了定量测定分子结合相互作用的结合动力学参数的方法。所述方法的实施方案的方面包括：产生包括与包含磁性标记分子的测定混合物接触的磁传感器的磁传感器装置，以产生可检测的分子结合相互作用; 从磁传感器获得实时信号; 并从实时信号中定量测定分子结合相互作用的结合动力学参数。还提供了配置用于该方法的系统和套件。

9. 发明申请

WO2006135437A3 REAL-TIME PCR MICROARRAY BASED ON AN EVANESCENT WAVE BIOSENSOR 审中-公开
标题翻译：基于EVANESCENT WAVE BIOSENSOR的实时PCR微阵列
公开(公告)号：WO2006135437A3
公开(公告)日：2007-04-05
申请号：PCT/US2005037833
申请日：2005-10-21
申请人： HONEYWELL INT INC , XU LIANG
发明人： XU LIANG
IPC分类号： C12Q1/68
CPC分类号： G06N3/02 , H04L67/12 , H04L69/329
摘要： A system and method for simultaneous, quantitative measurement of nucleic acids in a sample. Fluorescently tagged amplicons of the target nucleic acids are localized on a substrate surface by hybridization to oligopobes that have been arrayed and tethered to the substrate surface in a pre-determined, two-dimensional pattern. The hybridized, amplicons are then detected by exciting their fluorescent tags using an evanescent wave flight of the appropriate wave-length. Because of the limited penetration of the evanescent wave (about 100-300 nm), the fluorescently tagged nucleotides in the remainder of the reaction cell do not fluoresce. By measuring the fluorescence at various locations on the substrate surface, the current abundance of hybridized amplicons of each of the target nucleic acids can be determined. The analytic techniques of real time PCR may then be used to obtain accurate, quantitative measurements for each of the nucleic acids in the sample.
摘要翻译：用于同时定量测量样品中核酸的系统和方法。靶核酸的荧光标记的扩增子通过与已经以预定的二维图案排列并连接到基底表面的寡聚体杂交而定位在基底表面上。然后通过使用适当波长的eva逝波飞行激发它们的荧光标签来检测杂交的扩增子。由于渐逝波（约100-300nm）的有限穿透，反应池剩余部分中荧光标记的核苷酸不发荧光。通过测量底物表面上不同位置处的荧光，可以确定每种靶核酸的杂交扩增子的电流丰度。然后可以使用实时PCR的分析技术来获得样品中每种核酸的精确的定量测量结果。

10. 发明申请

WO2005069894A3 CONFORMATIONALLY CONSTRAINED SMAC MIMETICS AND THE USES THEREOF 审中-公开
公开(公告)号：WO2005069894A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/001406
申请日：2005-01-18
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Shaomeng , SUN, Haiying , NIKOLOVSKA-COLESKA, Zaneta , YANG, Chao-Yie , XU, Liang
发明人： WANG, Shaomeng , SUN, Haiying , NIKOLOVSKA-COLESKA, Zaneta , YANG, Chao-Yie , XU, Liang
IPC分类号： A61K31/395 , A61K31/407 , A61K31/4353 , A61K31/437 , A61K31/4375 , A61K31/55 , A61P35/00 , C07D455/02 , C07D471/04 , C07D487/04
摘要： The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

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