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1. 发明申请

WO2019023275A1 DIMERIC PEPTIDE INHIBITORS OF APOPTOSIS PROTEINS 审中-公开
公开(公告)号：WO2019023275A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043550
申请日：2018-07-24
申请人： HEPAGENE THERAPEUTICS, INC. , XU, Xiaodong
发明人： XU, Xiaodong
IPC分类号： A61P31/20 , C07K5/06 , C07K5/08 , C07K7/06 , A61P35/00
摘要： The present technology is directed to compounds, compositions, and methods related to treatment of cancers and viral infections mediated by lAPs. In particular the present compounds and compositions may be used to treat lAP-mediated ovarian cancer and hepatitis B infection.

2. 发明申请

WO2010027996A9 NOVEL IMINO SUGAR DERIVATIVES DEMONSTRATE POTENT ANTIVIRAL ACTIVITY AND REDUCED TOXICITY 审中-公开
公开(公告)号：WO2010027996A9
公开(公告)日：2010-03-11
申请号：PCT/US2009/055658
申请日：2009-09-02
申请人： INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH , BLOCK, Timothy, M. , CHANG, Jinhong , XU, Xiaodong
发明人： BLOCK, Timothy, M. , CHANG, Jinhong , XU, Xiaodong
IPC分类号： A01N43/42 , A61K31/47
摘要： lmino sugars, such as deoxynojιrimycin(DNJ), are glucose analogues that selectively inhibit cellular a-glucosidase I and Il (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrwn antiviral activities against many enveloped 5 viruses. In order to develop' imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. Furthermore, these new compounds were shown to be active againstDengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potentantι-DV activity having submicromolar EC50 values and SI of greater than 900. Thesecompounds represent a new generation of iminio sugars and their analogues, having IS application in the clinical treatment of infection ofbv and other members of flavivirdae.

3. 发明申请

WO2010027996A1 NOVEL IMINO SUGAR DERIVATIVES DEMONSTRATE POTENT ANTIVIRAL ACTIVITY AND REDUCED TOXICITY 审中-公开
标题翻译：新型三嗪糖衍生物衍生物抗病毒活性和降低毒性
公开(公告)号：WO2010027996A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055658
申请日：2009-09-02
申请人： INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH , BLOCK, Timothy, M. , CHANG, Jinhong , XU, Xiaodong
发明人： BLOCK, Timothy, M. , CHANG, Jinhong , XU, Xiaodong
IPC分类号： A01N43/42 , A61K31/47
CPC分类号： A61K31/47 , A61K31/7056 , C07D211/46 , Y02A50/393 , A61K2300/00
摘要： lmino sugars, such as deoxynojιrimycin(DNJ), are glucose analogues that selectively inhibit cellular a-glucosidase I and Il (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrwn antiviral activities against many enveloped 5 viruses. In order to develop' imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. Furthermore, these new compounds were shown to be active againstDengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potentantι-DV activity having submicromolar EC50 values and SI of greater than 900. Thesecompounds represent a new generation of iminio sugars and their analogues, having IS application in the clinical treatment of infection ofbv and other members of flavivirdae.
摘要翻译：诸如脱氧核糖核苷酸（DNJ）的葡萄糖是选择性抑制细胞α-葡萄糖苷酶I和II（在糖蛋白中加工N-连接聚糖的酶）的葡萄糖类似物，并且对许多包膜的5种病毒表现出广泛的抗病毒活性。为了开发具有更强效抗病毒活性的亚氨基糖以及改进的毒性特征，OSL-95II通过使氮连接的烷基化侧链多样化而被修饰。此外，这些新化合物被证明对BHK细胞中的登革热病毒（DV）和西尼罗病毒（WNV）感染具有活性，其中具有亚微摩尔EC 50值和SI大于900的有效β-DV活性。该化合物代表新一代亚氨基糖类及其类似物，具有IS应用于临床治疗紫薇和其他成虫的感染。

4. 发明申请

WO2020206000A1 BIVALENT ANTAGONISTS OF INHIBITORS OF APOPTOSIS PROTEINS 审中-公开
公开(公告)号：WO2020206000A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026220
申请日：2020-04-01
申请人： HEPAGENE THERAPEUTICS (HK) LIMITED , XU, Xiaodong
发明人： XU, Xiaodong
IPC分类号： A61P31/00 , A61P35/00 , C07K5/083
摘要： The present technology is directed to compounds, compositions, and methods related to treatment of cancers and viral infections mediated by IAPs, e.g. , compounds of Formula I (including Formulas IA, IB, IC, ID, IE, IF, and IG), a stereoisomer thereof, or a pharmaceutically acceptable salt of the compound or the stereoisomer of the compound. In particular, the present compounds and compositions may be used to treat IAP-mediated ovarian cancer and hepatitis B infection.

5. 发明申请

WO2014198232A1 INTERFERENCE COORDINATION METHOD, INTERFERENCE COORDINATION DEVICE AND MEASUREMENT DEVICE 审中-公开
标题翻译：干扰协调方法，干扰协调装置和测量装置
公开(公告)号：WO2014198232A1
公开(公告)日：2014-12-18
申请号：PCT/CN2014/079830
申请日：2014-06-13
申请人： SONY CORPORATION , XU, Xiaodong , SUN, Yu , GAO, Rui , WU, Baoxue
发明人： XU, Xiaodong , SUN, Yu , GAO, Rui , WU, Baoxue
IPC分类号： H04W28/18
CPC分类号： H04W52/244 , H04W16/08 , H04W36/08 , H04W36/165 , H04W36/38 , H04W52/06 , H04W52/143 , H04W52/223 , H04W52/226 , H04W52/246 , H04W52/343
摘要： A system that determines to modify transmission power of a first small cell; determines an effect of modifying the transmission power of the first small cell on a user equipment that is served by the first small cell; and controls modifying the transmission power of the first small cell based on the determination to modify the transmission power and the determined effect of modifying the transmission power on the user equipment that is served by the first small cell.
摘要翻译：确定修改第一小区的传输功率的系统; 确定在由第一小区服务的用户设备上修改第一小区的发射功率的效果; 并且基于修改发送功率的确定以及确定对由第一小小区服务的用户设备修改发送功率的确定的效果来控制修改第一小小区的发送功率。

6. 发明申请

WO2007131168A3 INHIBITORS OF SECRETION OF HEPATITIS B VIRUS ANTIGENS FOR TREATMENT OF A CHRONIC HEPATITIS VIRUS 审中-公开
标题翻译：用于治疗慢性乙型肝炎病毒的乙型肝炎病毒抗原的分泌抑制剂
公开(公告)号：WO2007131168A3
公开(公告)日：2008-11-20
申请号：PCT/US2007068241
申请日：2007-05-04
申请人： INST HEPATITIS & VIRUS RES , UNIV DREXEL , CUCONATI ANDREA , BLOCK TIMOTHY M , XU XIAODONG
发明人： CUCONATI ANDREA , BLOCK TIMOTHY M , XU XIAODONG
IPC分类号： C07D487/04 , A61K31/519 , A61K31/662 , A61P31/22 , C07F9/32
CPC分类号： A61K31/519 , A61K31/7052 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an effective amount of a compound of formulas (I-III) and a pharmaceutically acceptable carrier. Methods for treating a hepatitis virus in a patient comprising administering an effective amount of the compound of formulas (I-III) are also presented.
摘要翻译：一种药物组合物，其包含有效量的式（I-III）化合物和药学上可接受的载体。还提供了治疗患者中的肝炎病毒的方法，包括给予有效量的式（I-III）化合物。

7. 发明申请

WO2005087007A1 HERBICIDAL COMPOSITIONS CONTAINING N-PHOSPHONOMETHYL GLYCINE AND AN AUXIN HERBICIDE 审中-公开
标题翻译：含有N-磷酰基甘氨酸和除草剂的除草剂组合物
公开(公告)号：WO2005087007A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/008029
申请日：2005-03-10
申请人： MONSANTO TECHNOLOGY LLC , BECHER, David, Z. , AGBAJE, Henry, E. , TRAVERS, Jeffrey, N. , BRINKER, Ronald, J. , XU, Xiaodong, C. , OTTENS, Timothy, S.
发明人： BECHER, David, Z. , AGBAJE, Henry, E. , TRAVERS, Jeffrey, N. , BRINKER, Ronald, J. , XU, Xiaodong, C. , OTTENS, Timothy, S.
IPC分类号： A01N57/20
CPC分类号： A01N57/20 , A01N25/30 , A01N37/38 , A01N37/40 , A01N2300/00 , A01N43/42 , A01N43/40 , A01N39/04 , A01N39/02
摘要： Herbicidal compositions are provided which cause rapid symptomology while delivering long term control of regrowth of plants. The herbicidal concentrate compositions comprise N-phosphonomethylglycine or a herbicidal derivative thereof, an auxin herbicide or a herbicidal derivative thereof, and at least one surfactant. Also provided is a method for killing or controlling the growth of certain plants by contacting the foliage of the plants with the diluted concentrate composition.
摘要翻译：提供除草剂组合物，其引起快速症状，同时长期控制植物的再生长。除草浓缩物组合物包含N-膦酰甲基甘氨酸或其除草衍生物，生长素除草剂或其除草衍生物和至少一种表面活性剂。还提供了通过使植物的叶子与稀释的浓缩物组合物接触来杀死或控制某些植物的生长的方法。

8. 发明申请

WO2005048846A1 COLLIMATOR, X-RAY IRRADIATOR, AND X-RAY APPARATUS 审中-公开
标题翻译： COLLIMATOR，X-RAY IRRADIATOR和X-RAY APPARATUS
公开(公告)号：WO2005048846A1
公开(公告)日：2005-06-02
申请号：PCT/CN2003/000986
申请日：2003-11-20
申请人： GE MEDICAL SYSTEMS GLOBAL TECHNOLOGY COMPANY, LLC. , XU, Xiaodong
发明人： XU, Xiaodong
IPC分类号： A61B6/06
CPC分类号： G21K1/04 , A61B6/06
摘要： A collimator is to be provided which permits the reduction of size without using any special material and without sacrificing an aperture. To this end, the collimator comprises: a pair of first plate members each having X-ray absorbability, movable in a direction parallel to a surface thereof, and defining an X-ray passing aperture by a spacing between respective mutually opposed end faces; and a pair of second plate members each having X-ray absorbability, the second block members, in order to block other X-rays than the X-ray passing through the aperture, being connected at respective one ends by hinges to end portions of the pair of first plate members opposite to the mutually opposed end faces of the first plate members and being supported at respective opposite ends so as to be movable obliquely with respect to the moving direction of the first plate members with movement of the first plate members.
摘要翻译：将提供准直器，其允许在不使用任何特殊材料的情况下减小尺寸并且不牺牲孔径。为此，准直器包括：一对第一板构件，每个第一板构件具有可在平行于其表面的方向上移动的X射线吸收性，并且通过各自相对的端面之间的间隔限定X射线通过孔; 以及一对具有X射线吸收性的第二板构件，所述第二块构件为了阻挡除穿过所述孔的X射线以外的其它X射线，在各自的一端通过铰链连接到所述第二板构件的端部一对第一板构件与第一板构件的相对的端面相对，并且被支撑在相应的相对端，以便随着第一板构件的运动而相对于第一板构件的移动方向倾斜移动。

9. 发明申请

WO2018075207A1 HETEROCYCLIC FXR MODULATORS 审中-公开
标题翻译：杂环FXR调制器
公开(公告)号：WO2018075207A1
公开(公告)日：2018-04-26
申请号：PCT/US2017/053773
申请日：2017-09-27
申请人： HEPAGENE THERAPEUTICS, INC. , XU, Xiaodong
发明人： XU, Xiaodong
IPC分类号： C07D413/12 , C07D417/12 , C07D261/08 , A61K31/4427 , A61K31/428 , A61K31/427 , A61K31/42 , A61K31/416 , A61K31/4155 , A61P3/00
摘要： The present technology is directed to compounds of formula (I), compositions, and methods related to modulation of FXR. In particular, the present compounds and compositions may be used to treat FXR-mediated disorders and conditions, including, e.g., liver disease, hyperlipidemia, hypercholesteremia, obesity, metabolic syndrome, cardiovascular disease, gastrointestinal disease, and atherosclerosis, and renal disease.
摘要翻译：本技术涉及与调节FXR有关的式（I）化合物，组合物和方法。特别地，本发明化合物和组合物可用于治疗FXR介导的病症和病症，包括例如肝病，高脂血症，高胆固醇血症，肥胖症，代谢综合征，心血管疾病，胃肠疾病和动脉粥样硬化以及肾病。 / p>

10. 发明申请

WO2014194796A1 DEVICE AND METHOD IN WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：无线通信系统中的设备和方法
公开(公告)号：WO2014194796A1
公开(公告)日：2014-12-11
申请号：PCT/CN2014/078950
申请日：2014-05-30
申请人： SONY CORPORATION , XU, Xiaodong , YU, Cuibo , HONG, Yateng , LIU, Ya , ZHENG, Cong , WEI, Liyao , SONG, Xiaojia , QIN, Zhongbin
发明人： XU, Xiaodong , YU, Cuibo , HONG, Yateng , LIU, Ya , ZHENG, Cong , WEI, Liyao , SONG, Xiaojia , QIN, Zhongbin
IPC分类号： H04W16/18
CPC分类号： H04W36/32 , H04W36/04 , H04W36/24 , H04W48/20 , H04W84/045
摘要： A system that determines a cell density and cell type in an area corresponding to a location of a user equipment; determines a mobility state of the user equipment based on the determined cell density and the determined cell type; and controls cell reselection for the user equipment based on the determined mobility state of the user equipment.
摘要翻译：确定与用户设备的位置对应的区域中的小区密度和小区类型的系统; 基于所确定的小区密度和确定的小区类型来确定用户设备的移动性状态; 并且基于所确定的用户设备的移动性状态来控制用户设备的小区重选。

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