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1. 发明申请

WO2008052441A1 INHIBITORS FOR DISRUPTING THE INTERACTION OF UBIQUITINATION RELATED ENZYMES AND USES THEREOF 审中-公开
标题翻译：抑制UBIQUITINATION相关酶的相互作用的抑制剂及其用途
公开(公告)号：WO2008052441A1
公开(公告)日：2008-05-08
申请号：PCT/CN2007/003105
申请日：2007-11-01
申请人： HUANG, Lan , XING, Li
发明人： HUANG, Lan , XING, Li
IPC分类号： C07K14/47 , C07D519/00 , C07D231/18 , C07D237/26 , C07D209/14 , A61K31/437 , A61K31/415 , A61K31/517 , A61K31/403 , A61P35/00 , G01N33/68 , C07D471/04 , C07D333/70
CPC分类号： A61K31/403 , A61K31/415 , A61K31/437 , A61K31/517 , C07D209/14 , C07D231/18 , C07D239/93 , C07D471/04
摘要： A hydrophobic binding pocket on ubiquitin-protein ligase E3 is described, and used in designing the inhibitors disrupting ubiquitin conjugating enzyme E2 and E3 interaction. Four types of inhibitors designed by using the binding pocket are provided, which can be used for cancer treatment.
摘要翻译：描述了泛素 - 蛋白质连接酶E3上的疏水结合口袋，并用于设计破坏泛素缀合酶E2和E3相互作用的抑制剂。提供通过使用结合口袋设计的四种类型的抑制剂，其可用于癌症治疗。

2. 发明申请

WO2006018735A3 Triazolopyridine compounds 审中-公开
标题翻译：三唑并吡啶化合物
公开(公告)号：WO2006018735A3
公开(公告)日：2006-06-22
申请号：PCT/IB2005002868
申请日：2005-08-08
申请人： PHARMACIA & UPJOHN CO LLC , RUCKER PAUL V , JEROME KEVIN DE WAYNE , SELNESS SHAUN RAJ , BALDUS JOHN EDWARD , XING LI
发明人： RUCKER PAUL V , JEROME KEVIN DE WAYNE , SELNESS SHAUN RAJ , BALDUS JOHN EDWARD , XING LI
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): wherein R 1 , R 2 and R 3 , are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.
摘要翻译：本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。这样的三唑并吡啶包括通常在结构上对应于下式（I）的化合物：其中R 1，R 2和R 3定义同上在本说明书中。本发明还涉及这种三唑并吡啶（特别是药物组合物）的组合物，用于合成这种三唑并吡啶的中间体，制备这种三唑并吡啶的方法，以及用于治疗（包括预防）与p38激酶活性相关的病症（通常是病理状态）的方法， TNF活性和/或环氧合酶-2活性。

3. 发明申请

WO2006018735A2 NOVEL TRIAZOLOPYRIDINE COMPOUNDS 审中-公开
标题翻译：新型三唑并吡啶化合物
公开(公告)号：WO2006018735A2
公开(公告)日：2006-02-23
申请号：PCT/IB2005/002868
申请日：2005-08-08
申请人： FARMACIA & UPJOHN COMPANY LLC , RUCKER, Paul, V. , JEROME, Kevin, De Wayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
发明人： RUCKER, Paul, V. , JEROME, Kevin, De Wayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
CPC分类号： C07D471/04
摘要： This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): wherein R 1 , R 2 and R 3 , are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.
摘要翻译：本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。这样的三唑并吡啶包括通式与下式（I）相应的化合物：其中R

4. 发明申请

WO2004108939A2 BAV PACKAGING REGIONS AND E1 TRANSCRIPTIONAL CONTROL REGIONS 审中-公开
标题翻译： BAV包装区和E1转录控制区
公开(公告)号：WO2004108939A2
公开(公告)日：2004-12-16
申请号：PCT/IB2004002409
申请日：2004-06-10
申请人： UNIV SASKATCHEWAN , TIKOO SURESH K , XING LI
发明人： TIKOO SURESH K , XING LI
IPC分类号： A61K39/23 , A61K39/235 , A61K48/00 , C07K14/075 , C12N7/00 , C12N7/04 , C12N15/861 , C12Q1/70
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10323 , C12N2710/10343
摘要： The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and El transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising uBAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications BAV EI transcriptional control regions. The present inventionalso provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications BAV El transcriptional control regions.
摘要翻译：本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。本发明还提供了辅助载体，其包含在辅助病毒中用于繁殖重组腺病毒的用于壳化的uBAV序列。本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含修饰BAV EI转录控制区。本发明还提供了制备包含对于壳化所必需的BAV序列以及修饰BAV E1转录控制区的腺病毒载体的方法。

5. 发明申请

WO2009064084A2 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS 审中-公开
标题翻译： 2-羟基-5-苯甲酰氨基苯甲酸衍生物及其盐的制备方法
公开(公告)号：WO2009064084A2
公开(公告)日：2009-05-22
申请号：PCT/KR2008/006432
申请日：2008-10-30
申请人： NEUROTECH CO., LTD. , GWAG, Byoung-Joo , CHO, Jae-Young , LEE, Young-Ae , QILING, Cheng , WU, Yuliang , XING, Li
发明人： GWAG, Byoung-Joo , CHO, Jae-Young , LEE, Young-Ae , QILING, Cheng , WU, Yuliang , XING, Li
IPC分类号： C07C229/64
CPC分类号： C07C227/18 , C07C229/64
摘要： The present invention provides an efficient method for mass-producing 2-hydroxy-5- ( substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[ 2-( 4- trif luoromethylphenyl)ethylamino] benzoic acid or its salt.
摘要翻译：本发明提供了用于大规模生产由特定化学式表示的2-羟基-5-（取代的）苯基烷基氨基苯甲酸衍生物或其盐，特别是2-羟基-5- [2-（4-三氟甲基苯基）乙基氨基 ]苯甲酸或其盐。

6. 发明申请

WO2006018727A2 NOVEL TRIAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的新型三唑吡啶化合物
公开(公告)号：WO2006018727A2
公开(公告)日：2006-02-23
申请号：PCT/IB2005/002714
申请日：2005-08-08
申请人： PHARMACIA & UPJOHN COMPANY LLC , RUCKER, Paul, V. , JEROME, Kevin, DeWayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
发明人： RUCKER, Paul, V. , JEROME, Kevin, DeWayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , A61P29/00
CPC分类号： C07D471/04
摘要： This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.
摘要翻译：本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。这样的三唑并吡啶包括通常在结构上与下式（I）相应的化合物：其中R

7. 发明申请

WO2005018557A3 SUBSTITUTED PYRIDINONES 审中-公开
标题翻译：取代的吡啶酮
公开(公告)号：WO2005018557A3
公开(公告)日：2005-08-04
申请号：PCT/US2004026193
申请日：2004-08-13
申请人： PHARMACIA CORP , DEVADAS BALEKUDRU , WALKER JOHN , SELNESS SHAUN R , BOEHM TERRI L , DURLEY RICHARD C , DEVRAJ RAJESH , HICKORY BRIAN S , RUCKER PAUL V , JEROME KEVIN D , MADSEN HEATHER M , ALVIRA EDGARDO , PROMO MICHELE A , BLEVIS-BAL RADHIKA M , MARRUFO LAURA D , HITCHCOCK JEFF , OWEN THOMAS , NAING WIN , XING LI , SHIEH HUEY S , SAMBANDAM ARUNA , LIU SHUANG , SCOTT IAN L , MCGEE KEVIN F
发明人： DEVADAS BALEKUDRU , WALKER JOHN , SELNESS SHAUN R , BOEHM TERRI L , DURLEY RICHARD C , DEVRAJ RAJESH , HICKORY BRIAN S , RUCKER PAUL V , JEROME KEVIN D , MADSEN HEATHER M , ALVIRA EDGARDO , PROMO MICHELE A , BLEVIS-BAL RADHIKA M , MARRUFO LAURA D , HITCHCOCK JEFF , OWEN THOMAS , NAING WIN , XING LI , SHIEH HUEY S , SAMBANDAM ARUNA , LIU SHUANG , SCOTT IAN L , MCGEE KEVIN F
IPC分类号： A61K20060101 , A61K31/4412 , A61K31/4415 , A61K31/4439 , A61P29/00 , C07D211/86 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/84 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
CPC分类号： C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

8. 发明申请

WO2004087686A2 BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：苯并噻唑化合物可用于治疗炎症症状
公开(公告)号：WO2004087686A2
公开(公告)日：2004-10-14
申请号：PCT/IB2004/001113
申请日：2004-03-26
申请人： PHARMACIA CORPORATION , CARTER, Jeffery, Steven , ASTON, Karl, William , BROWN, David, Louis , DEPROW, Angela , FLETCHER, Theresa , HALLINAN, E., Ann , HAMPER, Bruce, Cameron , HUFF, Renee , KIEFER, James, Richard, Jr. , KOSZYK, Francis , KRAMER, Steven , LIAO, Subo , LIMBURG, David, Christopher , LUDWIG, Cindy , MCCALL, John, Michael , SPRINGER, John, Robert , TALLEY, John, J. , WANG, Lijuan, Jane , XING, Li , YU, Yi
发明人： CARTER, Jeffery, Steven , ASTON, Karl, William , BROWN, David, Louis , DEPROW, Angela , FLETCHER, Theresa , HALLINAN, E., Ann , HAMPER, Bruce, Cameron , HUFF, Renee , KIEFER, James, Richard, Jr. , KOSZYK, Francis , KRAMER, Steven , LIAO, Subo , LIMBURG, David, Christopher , LUDWIG, Cindy , MCCALL, John, Michael , SPRINGER, John, Robert , TALLEY, John, J. , WANG, Lijuan, Jane , XING, Li , YU, Yi
IPC分类号： C07D311/58
CPC分类号： C07D311/58 , C07D311/64 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04 , C07D417/06 , C07D493/04
摘要： The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R 1 , R 2 , R 3 , and R 4 are as described in specification.
摘要翻译：本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。特别感兴趣的化合物是苯并吡喃及其由式（1）定义的类似物。其中Z，X，R 1，R 2，R 3和R 4如说明书中所述。

9. 发明申请

WO1999009116A1 PROCESS AND APPARATUS FOR PRODUCING HYDROCARBON OIL FROM ORGANIC OR HIGH MOLECULAR WASTE MATERIAL 审中-公开
标题翻译：从有机或高分子废物生产石油的工艺和装置
公开(公告)号：WO1999009116A1
公开(公告)日：1999-02-25
申请号：PCT/CN1997000124
申请日：1997-11-13
申请人： XING, Li
IPC分类号： C10G01/10
CPC分类号： C10G1/10
摘要： The present invention discloses a process for producing hydrocarbon oil from organic or high molecular waste material, and an apparatus used for carrying out the process.
摘要翻译：本发明公开了一种从有机或高分子废料生产烃油的方法和用于实施该方法的装置。

10. 发明申请

WO2009064084A3 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS 审中-公开
标题翻译： 2-羟基-5-苯基烷基氨基苯甲酸衍生物及其盐的制造方法
公开(公告)号：WO2009064084A3
公开(公告)日：2009-07-16
申请号：PCT/KR2008006432
申请日：2008-10-30
申请人： NEUROTECH CO LTD , GWAG BYOUNG-JOO , CHO JAE-YOUNG , LEE YOUNG-AE , QILING CHENG , WU YULIANG , XING LI
发明人： GWAG BYOUNG-JOO , CHO JAE-YOUNG , LEE YOUNG-AE , QILING CHENG , WU YULIANG , XING LI
IPC分类号： C07C229/64
CPC分类号： C07C227/18 , C07C229/64
摘要： The present invention provides an efficient method for mass-producing 2-hydroxy-5- ( substituted)phenylalkylaminobenzoic acid derivative represented by the specific Chemical formula or its salt, particularly 2-hydroxy-5-[ 2-( 4- trif luoromethylphenyl)ethylamino] benzoic acid or its salt.
摘要翻译：本发明提供了一种有效的批量生产特定化学式或其盐的2-羟基-5-（取代）苯基烷基氨基苯甲酸衍生物，特别是2-羟基-5- [2-（4-三氟甲基苯基）乙基氨基 ]苯甲酸或其盐。

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