基本信息:
- 专利标题： NOVEL TRIAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION
- 专利标题（中）：用于治疗炎症的新型三唑吡啶化合物
- 申请号：PCT/IB2005/002714 申请日：2005-08-08
- 公开(公告)号：WO2006018727A2 公开(公告)日：2006-02-23
- 发明人： RUCKER, Paul, V. , JEROME, Kevin, DeWayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
- 申请人： PHARMACIA & UPJOHN COMPANY LLC , RUCKER, Paul, V. , JEROME, Kevin, DeWayne , SELNESS, Shaun, Raj , BALDUS, John, Edward , XING, Li
- 申请人地址： 301 Henrietta Street, Kalamazoo, MI 49001 US
- 专利权人： PHARMACIA & UPJOHN COMPANY LLC,RUCKER, Paul, V.,JEROME, Kevin, DeWayne,SELNESS, Shaun, Raj,BALDUS, John, Edward,XING, Li
- 当前专利权人： PHARMACIA & UPJOHN COMPANY LLC,RUCKER, Paul, V.,JEROME, Kevin, DeWayne,SELNESS, Shaun, Raj,BALDUS, John, Edward,XING, Li
- 当前专利权人地址： 301 Henrietta Street, Kalamazoo, MI 49001 US
- 代理机构： FULLER, Grover, F., Jr. et al.
- 优先权： US60/602,453 20040818
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61K31/4745 ; A61P29/00
摘要：
This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.
摘要（中）：
本发明一般涉及通常抑制p38激酶，TNF和/或环氧合酶活性的三唑并吡啶化合物。 这样的三唑并吡啶包括通常在结构上与下式（I）相应的化合物：其中R
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D471/00 | 在稠环系中含有氮原子作为仅有的杂环原子、其中至少1个环是含有1个氮原子的六元环的杂环化合物，C07D451/00至C07D463/00不包括的 |
| --------C07D471/02 | .在稠环系中含两个杂环 |
| ----------C07D471/04 | ..邻位稠环系 |