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1. 发明申请

WO2012051374A2 USE OF MONOAMINE OXIDASE INHIBITORS TO IMPROVE EPITHELIAL BIOLOGY 审中-公开
标题翻译：使用单胺氧化酶抑制剂改善上皮生物学
公开(公告)号：WO2012051374A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/056076
申请日：2011-10-13
申请人： THE PROCTER & GAMBLE COMPANY , DICOLANDREA, Teresa , YOUNGQUIST, Robert, Scott , XIE, Sancai , BINDER, Robert, Lloyd , FUENTES, Gary, Richard , LADE, Deborah
发明人： DICOLANDREA, Teresa , YOUNGQUIST, Robert, Scott , XIE, Sancai , BINDER, Robert, Lloyd , FUENTES, Gary, Richard , LADE, Deborah
IPC分类号： A61K8/41 , A61P17/14
CPC分类号： A61K31/435 , A61K8/40 , A61K8/4926 , A61K8/4953 , A61K9/0014 , A61K31/137 , A61K31/138 , A61K31/495 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61Q19/08 , A61K2300/00
摘要： The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
摘要翻译：本发明提供了一种改善毛发生物学的方法，例如毛发生长。该方法包括向受试者施用单胺氧化酶抑制剂和血管扩张剂，羧酸锌盐，黄嘌呤化合物，吡啶硫酮或其盐，皂角苷，三萜烯，山梨醇酸，celastrol，积雪草酸，5- α-还原酶，1,4-甲基-4-氮灰石，雄激素受体拮抗剂，壬二酸或其衍生物，环孢菌素，三碘甲状腺原氨酸，二氮嗪，视黄酸，前列腺素类似物，胺氧化物，酒石酸肉碱，芹菜素，前肽或腺苷，有效地达到期望效果的量。本发明还提供减少或延迟与年龄相关的皮肤缺陷的外观的方法。该方法包括向受试者施用包含MAO抑制剂的组合物。还提供了一种用于改善毛发生长的试剂盒。

2. 发明申请

WO2008027541A2 HAIR CARE COMPOSITIONS, METHODS, AND ARTICLES OF COMMERCE THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR 审中-公开
标题翻译：头发护理组合物，方法和商品文章，可以增加厚度和充分发胶的外观
公开(公告)号：WO2008027541A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/019180
申请日：2007-08-30
申请人： THE PROCTER & GAMBLE COMPANY , DAWSON, Thomas, Larry, Jr. , OBLONG, John, Erich , YOUNGQUIST, Robert, Scott , XIE, Sancai
发明人： DAWSON, Thomas, Larry, Jr. , OBLONG, John, Erich , YOUNGQUIST, Robert, Scott , XIE, Sancai
IPC分类号： A61K8/49 , A61K8/67 , A61K8/42 , A61Q7/00
CPC分类号： A61Q5/12 , A61K8/42 , A61K8/4953 , A61K8/675 , A61Q5/002 , A61Q7/00 , A61Q7/02 , G06Q30/0225
摘要： Hair care compositions, methods, and articles of commerce that can increase the appearance of thicker and fuller hair. Such compositions can be applied to any areas where a thicker and fuller hair appearance is desired, such as the scalp or face. The present invention also relates to methods of marketing such compositions.
摘要翻译：头发护理组合物，方法和商品，可以增加更厚和更丰满的头发的外观。这样的组合物可以应用于需要更厚和更丰满的头发外观的任何区域，例如头皮或面部。本发明还涉及营销这种组合物的方法。

3. 发明申请

WO2007007255A3 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR 审中-公开
标题翻译：个人护理组合物和妈妈皮肤和头发的美容方法
公开(公告)号：WO2007007255A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006052293
申请日：2006-07-06
申请人： PROCTER & GAMBLE , XIE SANCAI , SREEKRISHNA KOTIKANYADANAM , NEWLAND ABBY BALLARD , BASCOM CHARLES CARSON , KACZVINSKY JOSEPH ROBERT JR , LAMMERS KAREN MARIE , VANOOSTHUYZE KRISTINA EMMA ING
发明人： XIE SANCAI , SREEKRISHNA KOTIKANYADANAM , NEWLAND ABBY BALLARD , BASCOM CHARLES CARSON , KACZVINSKY JOSEPH ROBERT JR , LAMMERS KAREN MARIE , VANOOSTHUYZE KRISTINA EMMA ING
IPC分类号： A61Q19/00 , A61K8/34 , A61K8/49 , A61K8/67 , A61K8/97
CPC分类号： A61K8/63 , A61K8/345 , A61K8/42 , A61K8/4926 , A61K8/494 , A61K8/675 , A61K8/97 , A61K31/522 , A61Q19/00 , A61Q19/08
摘要： Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4- dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9- (2-tetrahydropyranyl)adenine; 1,3-diphenylurea; l-phenyl-3-(l,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2- furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside- RB l; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside- RGl ; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.
摘要翻译：个人护理组合物，其包含约0.05％至约5％的至少一种选自黄嘌呤，咖啡因的水通道蛋白刺激性化合物; 2-氨基-6-甲基 - 巯基嘌呤; 1-甲基黄嘌呤; 2-氨基嘌呤; 茶碱; 可可碱; 腺嘌呤; 腺苷; 激动; 对氯苯氧乙酸; 2,4-二氯苯氧乙酸吲哚-3-丁酸; 吲哚-3-乙酸甲酯; β-萘氧乙酸; 2,3,5-三碘苯甲酸; 腺嘌呤半硫酸盐; 正 - 苄基-9-（2-四氢吡喃基）腺嘌呤; 1,3-二苯基脲; 1-苯基-3-（1,2,3-噻二唑-5-基）脲; 玉米素; 吲哚-3-乙酸; 6-苄氨基嘌呤; α-萘乙酸; 6-2-呋喃氨基嘌呤; 绿茶提取物; 白茶提取物; 薄荷; 茶树油; 人参皂甙人参皂苷RB3; 人参皂苷RC; 人参皂甙-Rd; 人参皂甙-RE; 人参皂苷-RG1; 人参根提取物; 人参花提取物; 石榴提取物，土豆提取物; 三色提取物及其组合; 选自烟酰胺，甘油及其混合物的另外的成分，以及皮肤病学上可接受的载体。

4. 发明申请

WO2012087779A2 HAIR CARE COMPOSITIONS AND METHODS TO IMPROVE HAIR APPEARANCE 审中-公开
标题翻译：毛发护理组合物和改善毛发外观的方法
公开(公告)号：WO2012087779A2
公开(公告)日：2012-06-28
申请号：PCT/US2011065345
申请日：2011-12-16
申请人： PROCTER & GAMBLE , DAWSON THOMAS LARRY JR , YOUNGQUIST ROBERT SCOTT , RICHARDS JEANETTE ANTHEA , XIE SANCAI , COMBS MARY JANE
发明人： DAWSON THOMAS LARRY JR , YOUNGQUIST ROBERT SCOTT , RICHARDS JEANETTE ANTHEA , XIE SANCAI , COMBS MARY JANE
IPC分类号： A61N1/37
CPC分类号： A61Q7/00 , A61K8/42 , A61K8/4953 , A61K8/498 , A61K8/675 , A61Q5/002
摘要： Hair care compositions and methods that can increase the appearance of healthier hair by increasing the appearance of thicker and fuller hair, longer hair, and/or delayed emergence of gray hair. Such compositions can be applied to any areas where healthier hair appearance is desired, such as the scalp or face.
摘要翻译：头发护理组合物和方法，其通过增加更浓密和更饱满的头发，更长的头发和/或灰发延迟出现的外观来增加更健康的头发的外观。这种组合物可以应用于需要更健康的头发外观的任何区域，例如头皮或面部。

5. 发明申请

WO2008027541A3 HAIR CARE COMPOSITIONS THAT CAN INCREASE THE APPEARANCE OF THICKER AND FULLER HAIR 审中-公开
标题翻译：头发护理组合物可以增加厚度和充分发胶的外观
公开(公告)号：WO2008027541A3
公开(公告)日：2008-10-09
申请号：PCT/US2007019180
申请日：2007-08-30
申请人： PROCTER & GAMBLE , DAWSON THOMAS LARRY JR , OBLONG JOHN ERICH , YOUNGQUIST ROBERT SCOTT , XIE SANCAI
发明人： DAWSON THOMAS LARRY JR , OBLONG JOHN ERICH , YOUNGQUIST ROBERT SCOTT , XIE SANCAI
IPC分类号： A61K8/49 , A61K8/42 , A61K8/67 , A61Q7/00
CPC分类号： A61Q5/12 , A61K8/42 , A61K8/4953 , A61K8/675 , A61Q5/002 , A61Q7/00 , A61Q7/02 , G06Q30/0225
摘要： Hair care compositions, methods, and articles of commerce that can increase the appearance of thicker and fuller hair. Such compositions can be applied to any areas where a thicker and fuller hair appearance is desired, such as the scalp or face. The present invention also relates to methods of marketing such compositions.
摘要翻译：头发护理组合物，方法和商品，可以增加更厚和更丰满的头发的外观。这样的组合物可以应用于需要更厚和更丰满的头发外观的任何区域，例如头皮或面部。本发明还涉及营销这种组合物的方法。

6. 发明申请

WO9947934A3 EARLY PREGNANCY DIAGNOSIS USING PAGS (PREGNANCY-ASSOCIATED GLYCOPROTEINS) 审中-公开
标题翻译：使用PAGS（PREGNANCY-Associated GLYCOPROTEINS）的早期诊断诊断
公开(公告)号：WO9947934A3
公开(公告)日：2001-07-19
申请号：PCT/US9906038
申请日：1999-03-19
申请人： UNIV MISSOURI , ROBERTS ROBERT MICHAEL , GREEN JONATHAN ANDREW , XIE SANCAI
发明人： ROBERTS ROBERT MICHAEL , GREEN JONATHAN ANDREW , XIE SANCAI
IPC分类号： C07K14/47 , G01N33/53 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/689 , C07K14/47 , G01N2333/471 , G01N2800/368 , Y10S435/973
摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.
摘要翻译：妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。选择的PAG是侵入性双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中很有用。在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

7. 发明申请

WO2012051374A3 USE OF MONOAMINE OXIDASE INHIBITORS TO IMPROVE EPITHELIAL BIOLOGY 审中-公开
标题翻译：单胺氧化酶抑制剂在改善上皮生物学中的应用
公开(公告)号：WO2012051374A3
公开(公告)日：2012-08-09
申请号：PCT/US2011056076
申请日：2011-10-13
申请人： PROCTER & GAMBLE , DICOLANDREA TERESA , YOUNGQUIST ROBERT SCOTT , XIE SANCAI , BINDER ROBERT LLOYD , FUENTES GARY RICHARD , LADE DEBORAH
发明人： DICOLANDREA TERESA , YOUNGQUIST ROBERT SCOTT , XIE SANCAI , BINDER ROBERT LLOYD , FUENTES GARY RICHARD , LADE DEBORAH
IPC分类号： A61K8/41 , A61K8/49 , A61K9/06 , A61K9/08 , A61K9/10 , A61K31/137 , A61K31/138 , A61K31/435 , A61K31/495 , A61Q7/00 , A61Q19/00 , A61Q19/08
CPC分类号： A61K31/435 , A61K8/40 , A61K8/4926 , A61K8/4953 , A61K9/0014 , A61K31/137 , A61K31/138 , A61K31/495 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61Q19/08 , A61K2300/00
摘要： The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analogue, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.
摘要翻译：本发明提供了用于改善毛发生物学，例如毛发生长的方法。该方法包括向受试者施用单胺氧化酶抑制剂和血管舒张剂，羧酸的锌盐，黄嘌呤化合物，羟基吡啶硫酮或其盐，皂苷，三萜烯，山楂酸，雷公藤红素，积雪草酸，5- 还原酶，1,4-甲基-4-氮杂甾体，雄激素受体拮抗剂，壬二酸或其衍生物，环孢菌素，三碘甲状腺氨酸，二氮嗪，视黄酸，前列腺素类似物，胺肟，酒石酸肉碱，芹菜素，前cap或腺苷以有效达到所需效果的量。本发明还提供了减少或延缓年龄相关的皮肤瑕疵外观的方法。该方法包括向受试者施用包含MAO抑制剂的组合物。还提供了用于改善头发生长的套件。

8. 发明申请

WO2012087779A3 HAIR CARE COMPOSITIONS AND METHODS TO IMPROVE HAIR APPEARANCE 审中-公开
公开(公告)号：WO2012087779A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/065345
申请日：2011-12-16
申请人： THE PROCTER & GAMBLE COMPANY , DAWSON, Thomas, Larry, Jr. , YOUNGQUIST, Robert, Scott , RICHARDS, Jeanette, Anthea , XIE, Sancai , COMBS, Mary, Jane
发明人： DAWSON, Thomas, Larry, Jr. , YOUNGQUIST, Robert, Scott , RICHARDS, Jeanette, Anthea , XIE, Sancai , COMBS, Mary, Jane
IPC分类号： A61K8/42 , A61K8/49 , A61K8/67 , A61Q5/00 , A61Q7/00 , A61Q5/06 , A61Q5/12
摘要： Hair care compositions and methods that can increase the appearance of healthier hair by increasing the appearance of thicker and fuller hair, longer hair, and/or delayed emergence of gray hair. Such compositions can be applied to any areas where healthier hair appearance is desired, such as the scalp or face.

9. 发明申请

WO2007007255A2 PERSONAL CARE COMPOSITIONS AND METHODS FOR THE BEAUTIFICATION OF MAMMALIAN SKIN AND HAIR 审中-公开
标题翻译：用于美容哺乳动物皮肤和头发的个人护理组合物和方法
公开(公告)号：WO2007007255A2
公开(公告)日：2007-01-18
申请号：PCT/IB2006/052293
申请日：2006-07-06
申请人： THE PROCTER & GAMBLE COMPANY , XIE, Sancai , SREEKRISHNA, Kotikanyadanam , NEWLAND, Abby, Ballard , BASCOM, Charles, Carson , KACZVINSKY, Joseph, Robert, Jr. , LAMMERS, Karen, Marie , VANOOSTHUYZE, Kristina, Emma Inge
发明人： XIE, Sancai , SREEKRISHNA, Kotikanyadanam , NEWLAND, Abby, Ballard , BASCOM, Charles, Carson , KACZVINSKY, Joseph, Robert, Jr. , LAMMERS, Karen, Marie , VANOOSTHUYZE, Kristina, Emma Inge
IPC分类号： A61Q19/00 , A61K8/97 , A61K8/49 , A61K8/34 , A61K8/67
CPC分类号： A61K8/63 , A61K8/345 , A61K8/42 , A61K8/4926 , A61K8/494 , A61K8/675 , A61K8/97 , A61K31/522 , A61Q19/00 , A61Q19/08
摘要： Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4- dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9- (2-tetrahydropyranyl)adenine; 1,3-diphenylurea; l-phenyl-3-(l,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2- furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside- RB l; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside- RGl ; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.
摘要翻译：个人护理组合物，其包含约0.05％至约5％的至少一种选自由黄嘌呤，咖啡因组成的组的刺激水孔蛋白的化合物; 2-氨基-6-甲基 - 巯基嘌呤; 1-甲基黄嘌呤; 2-氨基嘌呤; 茶碱; 可可碱; 腺嘌呤; 腺苷; 激动; 对氯苯氧乙酸; 2,4-二氯苯氧乙酸; 吲哚-3-丁酸; 吲哚-3-乙酸甲酯; β-萘氧基乙酸; 2,3,5-三碘苯甲酸; 腺嘌呤半硫酸盐; N-苄基-9-（2-四氢吡喃基）腺嘌呤; 1,3-二苯基脲; 1-苯基-3-（1,2,3-噻二唑-5-基）脲; 玉米素; 吲哚-3-乙酸; 6-苄氨基嘌呤; α-萘乙酸; 6-2-呋喃甲酰氨基嘌呤; 绿茶提取物; 白茶提取物; 薄荷; 茶树油; 人参皂甙-RB1; 人参皂苷RB3; 人参皂苷RC; 人参皂甙-Rd; 人参皂甙-RE; 人参皂甙-RG1; 人参根提取物; 人参花提取物; 石榴提取物，来自Ajuga turkestanica的提取物; 中提取物提取物及其组合; 选自烟酰胺，甘油及其混合物的额外成分和皮肤病学可接受的载体。

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