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1. 发明申请

WO2009098450A3 METHODS AND COMPOSITIONS 审中-公开
标题翻译：方法和组合物
公开(公告)号：WO2009098450A3
公开(公告)日：2009-10-29
申请号：PCT/GB2009000301
申请日：2009-02-04
申请人： MEDICAL RES COUNCIL , WINTER GREGORY , HEINIS CHRISTIAN
发明人： WINTER GREGORY , HEINIS CHRISTIAN
IPC分类号： C12N15/10 , A61K47/48 , C40B30/04 , C40B40/02 , G01N33/68
CPC分类号： C12N15/1062 , A61K47/54 , A61K47/55 , A61K47/64 , C07K1/1075 , C07K1/1077 , C07K14/005 , C12N15/1037 , C12N15/1041 , C12N15/1068 , C40B40/08 , C40B40/10 , C40B50/06 , G01N33/56983
摘要： The invention relates to a complex comprising a phage particle, said phage particle comprising (i) a polypeptide; (ii) a nucleic acid encoding the polypeptide of (i); (iii) a connector compound attached to said polypeptide wherein said connector compound is attached to the polypeptide by at least three discrete covalent bonds. The invention also relates to libraries, and to methods for making complexes and to methods of screening using same.
摘要翻译：本发明涉及包含噬菌体颗粒的复合物，所述噬菌体颗粒包含（i）多肽; （ii）编码（i）的多肽的核酸; （iii）连接到所述多肽上的连接化合物，其中所述连接化合物通过至少三个离散的共价键与多肽连接。本发明还涉及文库，以及制备复合物的方法和使用它们的筛选方法。

2. 发明申请

WO2007011839A3 MOBILE RESOURCE LOCATION-BASED CUSTOMER CONTACT SYSTEMS AND METHODS 审中-公开
标题翻译：基于移动资源定位的客户联系系统和方法
公开(公告)号：WO2007011839A3
公开(公告)日：2009-04-16
申请号：PCT/US2006027609
申请日：2006-07-14
申请人： AGILIS SYSTEMS INC , WINTER GREGORY J , HUBER DANIEL D , BARI NAEEM
发明人： WINTER GREGORY J , HUBER DANIEL D , BARI NAEEM
IPC分类号： H04W8/00 , H04W64/00 , H04W68/00
CPC分类号： H04W64/00 , G08G1/205 , H04L67/18 , H04W8/005 , H04W68/00
摘要： Mobile resource management systems and methods configured for managing mobile resources for contacting a customer based on a planned route or a location of a mobile agent.
摘要翻译：移动资源管理系统和方法被配置用于基于移动代理的规划路由或位置来管理用于联系客户的移动资源。

3. 发明申请

WO2007049017A3 AGENTS THAT BIND A TARGET IN PULMONARY TISSUE FOR TREATING RESPIRATORY DISEASES 审中-公开
公开(公告)号：WO2007049017A3
公开(公告)日：2007-05-03
申请号：PCT/GB2006/003935
申请日：2006-10-23
申请人： DOMANTIS LIMITED , ARGENTA DISCOVERY LIMITED , DE WILDT, Rudolf, M., T. , HOLMES, Steve , TOMLINSON, Ian, M. , WINTER, Gregory, P. , FITZGERALD, Mary, F. , FOX, Justian, Craig , SEPP, Armin , LEE, Jennifer , WOOLVEN, Benjamin, P.
发明人： DE WILDT, Rudolf, M., T. , HOLMES, Steve , TOMLINSON, Ian, M. , WINTER, Gregory, P. , FITZGERALD, Mary, F. , FOX, Justian, Craig , SEPP, Armin , LEE, Jennifer , WOOLVEN, Benjamin, P.
IPC分类号： C07K16/46 , C07K16/44 , A61K47/48
摘要： Disclosed is the use of an agent ( e.g. , antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFRl for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device ( e.g. , inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.

4. 发明申请

WO2007011839A2 MOBILE RESOURCE LOCATION-BASED CUSTOMER CONTACT SYSTEMS AND METHODS 审中-公开
标题翻译：基于移动资源定位的客户联系系统和方法
公开(公告)号：WO2007011839A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027609
申请日：2006-07-14
申请人： AGILIS SYSTEMS, INC. , WINTER, Gregory, J. , HUBER, Daniel, D. , BARI, Naeem
发明人： WINTER, Gregory, J. , HUBER, Daniel, D. , BARI, Naeem
IPC分类号： H04Q7/20
CPC分类号： H04W64/00 , G08G1/205 , H04L67/18 , H04W8/005 , H04W68/00
摘要： Mobile resource management systems and methods configured for managing mobile resources for contacting a customer based on a planned route or a location of a mobile agent.
摘要翻译：移动资源管理系统和方法被配置用于基于移动代理的规划路由或位置来管理用于联系客户的移动资源。

5. 发明申请

WO1997040141A2 ISOLATION OF ENZYMES 审中-公开
标题翻译：酶的分离
公开(公告)号：WO1997040141A2
公开(公告)日：1997-10-30
申请号：PCT/GB1997001153
申请日：1997-04-25
申请人： MEDICAL RESEARCH COUNCIL , NERI, Dario , DEMARTIS, Salvatore , HUBER, Adrian , VITI, Francesca , TAWFIK, Dan, S. , WINTER, Gregory, Paul
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N09/00
CPC分类号： C12N15/1086 , C07K14/4728 , C07K14/72 , C07K2319/00 , C12N9/00 , C12N9/0002 , C12N9/1088 , C12N9/1205 , C12N15/1037 , C40B40/02
摘要： The present invention relates to a method of isolating an enzyme having a desired chemical or biological activity, the method comprising linking the enzyme to a substrate for the enzyme, reacting the enzyme and substrate such that a product is produced which remains linked to the enzyme and isolating the enzyme by selectively isolating the product linked to the enzyme.
摘要翻译：本发明涉及一种分离具有所需化学或生物活性的酶的方法，该方法包括将酶与酶的底物连接，使酶和底物反应，使得产生与酶连接的产物，通过选择性分离与酶连接的产物来分离酶。

6. 发明申请

WO1995012672A1 MANUFACTURE AND USE OF POLYPEPTIDES TAGGED USING BINDING MOLECULES 审中-公开
标题翻译：使用结合分子标记的多肽的制备和使用
公开(公告)号：WO1995012672A1
公开(公告)日：1995-05-11
申请号：PCT/GB1994002420
申请日：1994-11-04
申请人： MEDICAL RESEARCH COUNCIL , NERI, Dario , WINTER, Gregory, Paul , DE LALLA, Claudia
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/12
CPC分类号： C07K14/4728 , C07K14/43568 , C07K14/47 , C07K2319/00 , G01N33/68
摘要： Molecules comprise (i) a polypeptide (such as calmodulin) which has calcium-dependent binding affinity for ligand and (ii) another polypeptide, the polypeptides preferably being joined by a peptide bond and produced by recombinant expression from a gene fusion. The molecules are useful in detection, immobilisation, targeting and purification, cell-labelling, and band-shift assays for determining binding of a member of a specific binding pair (sbp) for complementary sbp member. For purposes of band-shift assays, polypeptide (i) need not have calcium-dependent binding affinity for a ligand, but should have a dissociation constant for a ligand of 10nM or less, measured at a pH of between 6 and 9 at 20 DEG C. In an alternative embodiment, a calmodulin-binding polypeptide which is, or is derived from, mastoparan is joined, as polypeptide (i) instead of a binding polypeptide, to the other polypeptide.
摘要翻译：分子包含（i）对配体具有钙依赖性结合亲和力的多肽（例如钙调素）和（ii）另一种多肽，所述多肽优选通过肽键连接并通过基因融合体的重组表达产生。这些分子可用于检测，固定，靶向和纯化，细胞标记和带状移位测定，以确定用于互补sbp成员的特异性结合对（sbp）的成员的结合。为了频移测定的目的，多肽（i）不需要对配体具有钙依赖性结合亲和力，但是对于配体的解离常数为10nM或更低，在pH为6至9的20℃下测量。 C.在替代实施方案中，将多肽（i）代替结合多肽连接到另一多肽中，所述钙调蛋白结合多肽或其衍生自mastoparan的钙调蛋白结合多肽与其他多肽相连接。

7. 发明申请

WO1994006920A1 RECOMBINANT VIRUSES DISPLAYING A NONVIRAL POLYPEPTIDE ON THEIR EXTERNAL SURFACE 审中-公开
标题翻译：在其外表面上显示非天然多肽的重组病毒
公开(公告)号：WO1994006920A1
公开(公告)日：1994-03-31
申请号：PCT/GB1993001992
申请日：1993-09-22
申请人： MEDICAL RESEARCH COUNCIL , RUSSELL, Stephen, James , HAWKINS, Robert, Edward , WINTER, Gregory, Paul
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/86
CPC分类号： C40B40/02 , A61K48/00 , C12N15/1037 , C12N15/86 , C12N15/87 , C12N2740/13043 , C12N2740/13045 , C12N2810/859
摘要： We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.
摘要翻译：我们已经制备出显示功能性抗体片段的逆转录病毒颗粒。我们将编码针对半抗原的抗体片段的基因与编码亲和性莫洛尼鼠白血病病毒的病毒包膜蛋白（Pr80env）的基因融合。融合基因在携带新霉素磷酸转移酶基因（neo）的逆转录病毒质粒的亲和逆转录病毒包装细胞中共表达，并回收具有特异性半抗原活性的逆转录病毒颗粒。此外，半抗原结合颗粒能够将neo基因和抗体 - 包膜融合基因转移至小鼠成纤维细胞。原则上，重组逆转录病毒颗粒表面上的抗体片段的显示可用于将病毒靶向到细胞进行基因递送，或将病毒保留在靶组织中，或用于构建病毒显示包的文库。

8. 发明申请

WO1993011236A1 PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE 审中-公开
标题翻译：从抗体部分代码产生抗自身抗体并在噬菌体上显示
公开(公告)号：WO1993011236A1
公开(公告)日：1993-06-10
申请号：PCT/GB1992002240
申请日：1992-12-02
申请人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED , GRIFFITHS, Andrew, David , HOOGENBOOM, Hendricus, Renerus, Jacobus, Mattheus , MARKS, James, David , McCAFFERTY, John , WINTER, Gregory, Paul , GRIGG, Geoffrey, Walter
发明人： MEDICAL RESEARCH COUNCIL , CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED
IPC分类号： C12N15/13
CPC分类号： C40B40/02 , B01J2219/00718 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/26 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/2866 , C07K16/3007 , C07K16/3092 , C07K16/34 , C07K16/40 , C07K16/4208 , C07K16/4241 , C07K16/44 , C07K16/462 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , Y10S530/867
摘要： Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self-antigens of that species. Methods comprise providing a library of replicable genetic display packages (rgdps), such as filamentous phage, each rgdp displaying at its surface a member of a specific binding pair which is an antibody or antibody fragment, and each rgdp containing nucleic acid sequence derived from a species of mammal. The nucleic acid sequence in each rgdp encodes a polypeptide chain which is a component part of the sbp member displayed at the surface of that rgdp. Anti-self antibody fragments are selected by binding with a self antigen from the said species of mammal. The displayed antibody fragments may be scFv, Fd, Fab or any other fragment which has the capability of binding antigen. Nucleic acid libraries used may be derived from a rearranged V-gene sequences of unimmunised mammal. Synthetic or artificial libraries are described and shown to be useful.
摘要翻译：公开了用于产生抗自身抗体和抗体片段的方法，其是结合该物种的自身抗原的哺乳动物特定种类的抗体或片段。方法包括提供可复制的遗传显示包（rgdps）文库，例如丝状噬菌体，每个rgdp在其表面上显示作为抗体或抗体片段的特异性结合对的成员，以及每个含rgdp的核酸序列衍生自哺乳动物的种类每个rgdp中的核酸序列编码多肽链，其是在该rgdp的表面显示的sbp成员的组成部分。通过与来自所述哺乳动物种的自身抗原结合来选择抗自身抗体片段。显示的抗体片段可以是scFv，Fd，Fab或具有结合抗原能力的任何其它片段。所使用的核酸文库可以来源于未免疫的哺乳动物的重新排列的V基因序列。描述和显示合成或人造文库是有用的。

9. 发明申请

WO1989007452A1 IMPROVEMENTS IN OR RELATING TO ANTIBODIES 审中-公开
标题翻译：改善或相关于抗体
公开(公告)号：WO1989007452A1
公开(公告)日：1989-08-24
申请号：PCT/GB1989000113
申请日：1989-02-10
申请人： MEDICAL RESEARCH COUNCIL , WALDMANN, Herman , CLARK, Michael, Ronald , WINTER, Gregory, Paul , RIECHMANN, Lutz
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： A61K39/395
CPC分类号： C07K16/465 , A61K38/00 , C07K16/2893 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/02
摘要： An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in Figure 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.

10. 发明申请

WO2008051097A3 DIVERSION SYSTEM 审中-公开
公开(公告)号：WO2008051097A3
公开(公告)日：2008-05-02
申请号：PCT/NZ2007/000322
申请日：2007-10-24
申请人： TRIDENT MONITORING SERVICES LIMITED , WINTER, Gregory John , YOUNG, Geoffrey Paul
发明人： WINTER, Gregory John , YOUNG, Geoffrey Paul
IPC分类号： E03B3/02 , E03F1/00 , E03F5/14
摘要： The present invention relates to a method of diverting fluid from a runoff event on a catchment area, characterised by the steps of: (a) collecting fluid from the catchment area into a collection chamber; and (b) allowing the fluid to flow to a diversion system; and (c) the diversion system diverting an initial volume of the fluid into a first outlet system; and (d) continuing to divert fluid into the first outlet system if the flow rate of the fluid is below a pre-set rate; and (f) subsequently diverting the fluid into a second system if the flow rate exceeds the pre-set rate.

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