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1. 发明申请

WO2003061841A1 ELECTROSTATIC APPLICATION OF POWDER MATERIAL TO SOLID DOSAGE FORMS 审中-公开
标题翻译：将粉末材料静电应用于固体剂型
公开(公告)号：WO2003061841A1
公开(公告)日：2003-07-31
申请号：PCT/GB2003/000224
申请日：2003-01-17
申请人： PHOQUS PHARMACEUTICALS LIMITED , WHITEMAN, Marshall , HALLETT, Martin, David , FEATHER, David, Hoover , NELSON, Douglas, Howard , GAZZA, Jack, Michael
发明人： WHITEMAN, Marshall , HALLETT, Martin, David , FEATHER, David, Hoover , NELSON, Douglas, Howard , GAZZA, Jack, Michael
IPC分类号： B05B5/08
CPC分类号： B05B5/087 , A61K9/2893 , B05B5/082
摘要： An apparatus for electrostatically applying a powder material to a solid dosage from includes a source (1) of charged powder material, a support assembly (2) for supporting the solid dosage form (3) with a front face in the vicinity of the source of powder material and facing the source of powder material, the support assembly (2) including an electrically conducting member (5) in the vicinity of the rear face of the solid dosage form and an electrically conducting shield (8) disposed closely around the solid dosage from (3) between the front face and the rear face of the solid dosage form, and means (4) for creating a potential difference between the source of powder material and the electrically conducting member and for maintaining the electrically conducting shield at a potential more similar to that of the source of powder material than to that of the electrically conducting member.
摘要翻译：用于将粉末材料静电施用于固体剂量的装置包括：带电粉末材料源（1），用于将固体剂型（3）支撑在所述固体剂型（3）附近的前表面的支撑组件（2）粉末材料并面向粉末材料源，支撑组件（2）包括在固体剂型背面附近的导电构件（5）和紧密围绕固体剂量设置的导电屏蔽（8）从固体剂型的前表面和后表面之间的（3）和用于在粉末材料源和导电构件之间产生电位差并且用于将导电屏蔽保持在更多电位的装置（4）类似于粉末材料源与导电构件的源相似。

2. 发明申请

WO1993001809A1 PHARMACEUTICAL FORMULATIONS COMPRISED OF MICRONISED HALOFANTRINE 审中-公开
标题翻译：包含微量HALOFANTRINE的药物制剂
公开(公告)号：WO1993001809A1
公开(公告)日：1993-02-04
申请号：PCT/GB1992001269
申请日：1992-07-13
申请人： SMITHKLINE BEECHAM PLC , WHITEMAN, Marshall , HEALEY, John, Norman, Charles
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： A61K31/135
CPC分类号： A61K9/14 , A61K31/135 , Y02A50/411
摘要： Novel formulations of the anti-malarial compound halofantrine and pharmaceutically acceptable salts thereof, having improved bioavailability.
摘要翻译：具有改善的生物利用度的抗疟疾化合物卤伏兰汀及其药学上可接受的盐的新型制剂。

3. 发明申请

WO2005014069A1 COATING OF SURGICAL DEVICES 审中-公开
标题翻译：手术器械涂层
公开(公告)号：WO2005014069A1
公开(公告)日：2005-02-17
申请号：PCT/GB2004/003405
申请日：2004-08-05
申请人： PHOQUS PHARMACEUTICALS LIMITED , HALLETT, Martin, David , WHITEMAN, Marshall , STRINGER, Ian, James , GREEN, Linda
发明人： HALLETT, Martin, David , WHITEMAN, Marshall , STRINGER, Ian, James , GREEN, Linda
IPC分类号： A61L27/00
CPC分类号： B05D1/06 , A61L27/34
摘要： The invention provides a method for the coating of a surgical device, wherein the coating is carried out by electrostatic Powder deposition. The device may be a device used in a surgical or diagnostic procedure, including interventional devices as well as implantable devices. Because the coating is applied electrostatically, it is attracted to all parts of the device, not just those parts that are in the 'line of sight' of the spray, as is the case with conventional liquid spray coating. The process allows uniform and reproducible amounts to be deposited and thus drug-eluting coatings can be accurately applied to stents and other surgical devices, resulting in good control over drug release. Furthermore, drug-eluting coats can be applied in a single step, although multiple layers can easily be applied if desired to create a specific drug release profile.
摘要翻译：本发明提供了一种外科手术装置的涂覆方法，其中涂层通过静电粉末沉积进行。该装置可以是用于手术或诊断程序的装置，包括介入装置以及可植入装置。因为涂层是静电的，所以它被吸引到设备的所有部件上，而不仅仅是那些在喷雾的“视线”部分，就像传统的液体喷涂一样。该方法允许沉积均匀且可重复的量，因此可以将药物洗脱的涂层精确地应用于支架和其它手术装置，从而很好地控制药物释放。此外，药物洗脱涂层可以在单一步骤中应用，尽管如果需要多层可以容易地应用以产生特定的药物释放曲线。

4. 发明申请

WO2002087550A1 TABLETS WITH COLOURED PATTERNS AND PREPARATION THEREOF 审中-公开
标题翻译：具有彩色图案的片剂及其制备
公开(公告)号：WO2002087550A1
公开(公告)日：2002-11-07
申请号：PCT/GB2002/002043
申请日：2002-05-02
申请人： PHOQUS LIMITED , HALLETT, Martin, D. , REEVES, Linda, A , WHITEMAN, Marshall
发明人： HALLETT, Martin, D. , REEVES, Linda, A , WHITEMAN, Marshall
IPC分类号： A61K9/44
CPC分类号： A61K9/2072 , A61K9/2893 , Y10T428/25 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： A tablet comprising a core which is at least partially coated with an outer layer obtained by electrostatic deposition of a powder and subsequent fusing of the deposited powder to form a film characterised in that a surface of the tablet coated with said outer layer is contoured to provide higher regions and lower regions, the outer layer having a different colour in said lower regions to the outer layer in said higher regions.
摘要翻译：一种片剂，其包含芯，其至少部分地涂覆有通过静电沉积粉末获得的外层，随后熔融沉积的粉末以形成膜，其特征在于，涂覆有所述外层的片剂的表面具有轮廓，以提供高级区域和下部区域，所述外部层在所述较高区域中在所述下部区域中与外层具有不同的颜色。

5. 发明申请

WO2005000264A1 PRODUCTION OF CAPSULE SHELLS AND CAPSULES 审中-公开
标题翻译：生产胶囊和胶囊
公开(公告)号：WO2005000264A1
公开(公告)日：2005-01-06
申请号：PCT/GB2004/002742
申请日：2004-06-25
申请人： PHOQUS PHARMACEUTICALS LIMITED , GREEN, Linda , HARRISON, Adrian, Mark , BLANEY, Terrance, William, Donald , WHITEMAN, Marshall , HALLETT, Martin, David
发明人： GREEN, Linda , HARRISON, Adrian, Mark , BLANEY, Terrance, William, Donald , WHITEMAN, Marshall , HALLETT, Martin, David
IPC分类号： A61K9/00
CPC分类号： B29C41/085 , B05B5/081 , B05B5/082 , B29C41/006 , B29K2001/00 , B29K2001/12 , B29K2039/06 , B29K2105/251
摘要： A method for the production of a capsule shell comprises preparing the capsule shell by electrostatic powder deposition. A plurality of capsule shells may be produced by a process comprising electrostatically applying a powder coating material to a plurality of shaped substrates, treating the powder to form a continuous coating layer on each of the shaped substrates, and removing the shaped coating layers from the substrate to provide hollow capsule shells. An apparatus for the production of a capsule shell includes a substrate, a source of charged powder material and a voltage source for applying a bias voltage between the source of powder material and the substrate to generate an electric field therebetween such that powder material is applied to the substrate.
摘要翻译：制造胶囊壳的方法包括通过静电粉末沉积制备胶囊壳。多个胶囊壳可以通过包括将粉末涂料静电施涂到多个成形基底上的方法来生产，处理粉末以在每个成形基底上形成连续的涂层，以及从基底上去除成形涂层提供中空胶囊壳。一种用于制造胶囊壳的装置，包括基板，带电粉末材料源和用于在粉末材料源和基板之间施加偏置电压的电压源，以在其间产生电场，使得将粉末材料施加到底物。

6. 发明申请

WO2003072086A1 PHARMACEUTICAL DOSAGE FORMS COMPRISING TABLET CORE HAVING A TENSILE STRENGTH BELOW 38 N/SQCM AND A COATING TO PROTECT THE SOFT CORE 审中-公开
标题翻译：含有下列拉伸强度的片状核心的药物剂型38 N / SQCM和用于保护软核的涂层
公开(公告)号：WO2003072086A1
公开(公告)日：2003-09-04
申请号：PCT/GB2003/000855
申请日：2003-02-28
申请人： PHOQUS LIMITED , TIAN, Wei , LANGRIDGE, John , WHITEMAN, Marshall
发明人： TIAN, Wei , LANGRIDGE, John , WHITEMAN, Marshall
IPC分类号： A61K9/28
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/2072 , A61K9/2077 , A61K9/284 , A61K9/2846
摘要： A pharmaceutical dosage form comprising: a) a tablet core comprising a pharmaceutically active ingredient and one or more pharmaceutically active ingredient and one or more pharmaceutically acceptable adjuvants, the tablet core having a tensile strength of less than 38 N/cm 2 before coating and fusion and b) a coating extending over at least 25% of the surface area of the tablet core, the coating resulting from deposition of a powder comprising fusible particles and fusing the particles to form a coating film, thereby providing the pharmaceutical dosage form with a greater hardness/crush strength than the tablet core. The tablet core may be formed by light compression with enables coated components and fragile components, such as capsules, to be used within the compression blend with little or no damage.
摘要翻译：一种药物剂型，其包含：包含药物活性成分和一种或多种药学活性成分和一种或多种药学上可接受的佐剂的片芯，所述片芯在包衣和融合和包衣之前具有小于38N / cm 2的拉伸强度延伸至片芯的至少25％的表面积，该涂层是由包含可熔颗粒的粉末沉积而得到的，并使颗粒熔合形成涂膜，从而为药物剂型提供了比/ 片芯。片芯可以通过轻压缩形成，使得能够在压缩共混物内使用涂覆组分和易碎组分（例如胶囊），几乎没有或没有损伤。

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