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1. 发明申请

WO2009045609A1 ORGANOSILICON AMINE-BASED ELECTROLYTES FOR USE IN ELECTROCHEMICAL DOUBLE-LAYER CAPACITORS 审中-公开
标题翻译：用于电化学双层电容器的基于有机硅胺的电解质
公开(公告)号：WO2009045609A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/071101
申请日：2008-07-25
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , WEST, Robert, C. , ZHANG, Lingzhi
发明人： WEST, Robert, C. , ZHANG, Lingzhi
IPC分类号： B01F17/00 , C07F7/08 , H01G9/038
CPC分类号： C07F7/0818 , C07F7/0852 , H01G9/038 , H01G11/62 , Y02E60/13 , Y02T10/7022
摘要： Disclosed are electrolytes that are organosilicon amine-based, and supercapacitors which incorporate them. These electrolytes are quaternary ammonium salts with an organosilicon moiety. They appear particularly suitable for use at high voltages in applications such as electric and hybrid electric vehicles.
摘要翻译：公开了基于有机硅胺的电解质和包含它们的超级电容器。这些电解质是具有有机硅部分的季铵盐。它们特别适用于诸如电动和混合电动车辆的应用中的高电压。

2. 发明申请

WO2008140950A2 SYSTEM AND METHOD FOR PROVIDING ELECTRONIC PRICE FEEDS FOR TRADEABLE OBJECTS 审中-公开
标题翻译：为贸易对象提供电子价格饲料的系统和方法
公开(公告)号：WO2008140950A2
公开(公告)日：2008-11-20
申请号：PCT/US2008/062172
申请日：2008-05-01
申请人： TRADING TECHNOLOGIES INTERNATIONAL, INC. , PRATT, Jeffrey , KAHLEY, Kevin, D. , WEST, Robert, A.
发明人： PRATT, Jeffrey , KAHLEY, Kevin, D. , WEST, Robert, A.
IPC分类号： G06Q10/00 , G06Q30/00
CPC分类号： G06Q40/04 , G06Q30/02 , G06Q30/0206
摘要： System and methods for a price feed generation are described. According to an example method described herein, upon receiving market information including a plurality of linear prices and order quantities, a reference price level is selected and a price feed message is generated to include the reference price level and the plurality of order quantities. The price feed message is then provided to client terminals.
摘要翻译：描述了价格馈送生成的系统和方法。根据本文所述的示例性方法，在接收到包括多个线性价格和订单数量的市场信息时，选择参考价格水平，并且生成价格馈送消息以包括参考价格水平和多个订单数量。然后将价格提要消息提供给客户终端。

3. 发明申请

WO2007073560A3 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS 审中-公开
标题翻译：药物组合物及使用高亲液性硫酸化合物的方法
公开(公告)号：WO2007073560A3
公开(公告)日：2008-02-07
申请号：PCT/US2006062418
申请日：2006-12-20
申请人： RND PHARMACEUTICALS INC , GATELY STEPHEN , WEST ROBERT
发明人： GATELY STEPHEN , WEST ROBERT
IPC分类号： A61K31/695
CPC分类号： C07F7/0818 , C07D213/60 , C07D213/75 , C07F7/0814
摘要： Novel compositions of silicon-containing sulfhydryl compounds, their preparation and use in methods for treating disease are described. Silicon confers lipophilicity that can enhance the penetration of the silicon derivative sulfhydryl compounds across the gut wall, cell membranes and blood brain barrier, thus improving therapeutic properties including bioavailability, metabolism, and/or pharmacokinetics. The organosilyl group provides compounds having improved pharmacokinetics. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：描述了含硅巯基化合物的新型组合物，其制备方法和用于治疗疾病的方法中的用途。硅赋予亲脂性，其可以增强硅衍生物巯基化合物穿过肠壁，细胞膜和血脑屏障的渗透，从而改善治疗特性，包括生物利用度，代谢和/或药代动力学。有机甲硅烷基提供具有改善的药代动力学的化合物。本发明包括新型化合物，类似物，前药和药学上可接受的盐，用于治疗疾病和其它疾病或病症等的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

4. 发明申请

WO2008014410A2 ZIMLIG2 POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE 审中-公开
标题翻译： ZIMLIG2多核苷酸和多肽及其使用方法
公开(公告)号：WO2008014410A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074509
申请日：2007-07-26
申请人： ZYMOGENETICS, INC. , SHEPPARD, Paul, O. , WEST, Robert, R. , STAMM, Michael, R. , APPLEBY, Mark, W. , BILSBOROUGH, Janine , THOMPSON, Penny, J. , WALKER, Kathleen, M.
发明人： SHEPPARD, Paul, O. , WEST, Robert, R. , STAMM, Michael, R. , APPLEBY, Mark, W. , BILSBOROUGH, Janine , THOMPSON, Penny, J. , WALKER, Kathleen, M.
IPC分类号： C07K14/435
CPC分类号： C07K14/47 , A61K38/00
摘要： Novel Zimlig2 polypeptides, polynucleotides and antibodies have inflammation modulating activity and tumor rejection and killing abilities, and are useful within related research and therapeutic applications.
摘要翻译：新型Zimlig2多肽，多核苷酸和抗体具有炎症调节活性和肿瘤排斥和杀伤能力，并且在相关研究和治疗应用中是有用的。

5. 发明申请

WO2007002643A3 SYSTEM AND METHOD FOR CALCULATING AND DISPLAYING VOLUME TO IDENTIFY BUYING AND SELLING 审中-公开
标题翻译：用于计算和显示批量以识别购买和出售的系统和方法
公开(公告)号：WO2007002643A3
公开(公告)日：2007-10-18
申请号：PCT/US2006024926
申请日：2006-06-26
申请人： TRADING TECHNOLOGIES INT INC , TANPOCO ALVIN , WEST ROBERT A
发明人： TANPOCO ALVIN , WEST ROBERT A
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： A system and method are provided for calculating and displaying volume to identify aggressive buying or selling activity. In a preferred embodiment, market information such as the inside market, last traded price, and last traded quantity is received from the electronic exchange and is used to assist a trader in determining the initiative side of a trade, either bid side or ask side. Once a determination is made, the result may be used to assist a trader analyzing the market volume. Other features and advantages are described herein.
摘要翻译：提供了一种用于计算和显示音量以识别积极的购买或销售活动的系统和方法。在优选实施例中，从电子交易所接收市场信息，如内部市场，最后交易价格和最后交易数量，并用于协助交易者确定交易的投标方或投标方。一旦作出了确定，结果可以用于协助交易者分析市场的数量。本文描述了其它特征和优点。

6. 发明申请

WO2007040779A3 ELECTROCHEMICAL DOUBLE-LAYER CAPACITOR USING ORGANOSILICON ELECTROLYTES 审中-公开
标题翻译：使用有机硅电解质的电化学双层电容器
公开(公告)号：WO2007040779A3
公开(公告)日：2007-09-20
申请号：PCT/US2006029917
申请日：2006-07-31
申请人： WISCONSIN ALUMNI RES FOUND , DEMENTIEV VIACHESLAV V , WEST ROBERT C , HAMERS ROBERT J , TSE KIU-YUEN
发明人： DEMENTIEV VIACHESLAV V , WEST ROBERT C , HAMERS ROBERT J , TSE KIU-YUEN
IPC分类号： H01G9/058 , H01G9/038
CPC分类号： H01G9/058 , H01G9/038 , H01G11/24 , H01G11/26 , H01G11/62 , Y02B10/30 , Y02E60/13 , Y02T10/7022
摘要： Disclosed are supercapacitors having organosilicon electrolytes, high surface area/porous electrodes, and optionally organosilicon separators. Electrodes are formed from high surface area material (such as porous carbon nanotubes or carbon nanof ibers) , which has been impregnated with the electrolyte. These type devices appear particularly suitable for use in electric and hybrid electric vehicles .
摘要翻译：公开了具有有机硅电解质，高表面积/多孔电极和任选的有机硅分离器的超级电容器。电极由已经浸渍有电解质的高表面积材料（例如多孔碳纳米管或碳纳米管）形成。这些类型的装置特别适用于电动和混合电动车辆。

7. 发明申请

WO2007027204A3 INJECTOR DEVICE WITH FORCE LOCK-OUT AND INJECTION RATE LIMITING MECHANISMS 审中-公开
标题翻译：具有强制锁定和注射速率限制机构的注射器装置
公开(公告)号：WO2007027204A3
公开(公告)日：2007-05-31
申请号：PCT/US2006013924
申请日：2006-04-11
申请人： BECTON DICKINSON CO , LOVELL JOHN , WEST ROBERT E , CHELAK TODD M , EASTERBROOK WILLIAM , FOLLMAN MARK , BROWKA EDWARD P
发明人： LOVELL JOHN , WEST ROBERT E , CHELAK TODD M , EASTERBROOK WILLIAM , FOLLMAN MARK , BROWKA EDWARD P
IPC分类号： A61M5/315 , A61M5/20
CPC分类号： A61M5/20 , A61M5/28 , A61M5/315 , A61M5/31551 , A61M5/31561 , A61M5/31571 , A61M5/3158 , A61M5/31593 , A61M5/3202 , A61M5/46 , A61M2005/2013
摘要： An injectable substance delivery device (100) comprising a pen device body (20), a cartridge (26), a plunger (10), a drive mechanism, and at least one of a lock-out mechanism and a rate-limiting mechanism. The lock-out mechanism is provided through a ratchet engagement between the body (20) and the plunger (10) to restrict plunger movement and to ensure that the required needle (72) puncture depth is realized prior to injection by locking out the injection mechanism from advancing until a specified force is applied to the skin (90). A rate-limiting mechanism is also provided through a user compressed plunger drive spring (50) to ensure that a specific rate of injection is realized during the injection of a medicament.
摘要翻译：一种包括笔装置本体（20），盒（26），柱塞（10），驱动机构以及锁定机构和速率限制机构中的至少一个的可注射物质输送装置（100）。锁定机构通过本体（20）和柱塞（10）之间的棘轮接合来提供，以限制柱塞运动，并且确保在注射之前通过锁定注射机构来实现所需针（72）穿刺深度从而推进直至对皮肤（90）施加规定的力。还通过用户压缩的柱塞驱动弹簧（50）提供速率限制机构，以确保在注射药物期间实现特定的注射速率。

8. 发明申请

WO2006102705A1 METHOD OF ENCAPSULATING A POST 审中-公开
标题翻译：封装邮政的方法
公开(公告)号：WO2006102705A1
公开(公告)日：2006-10-05
申请号：PCT/AU2006/000413
申请日：2006-03-29
申请人： PLASTIC POLE VAULT PTY LTD , WEST, Robert, Andrew , MCDONALD, David, Scott
发明人： WEST, Robert, Andrew , MCDONALD, David, Scott
IPC分类号： B29C47/02 , E04C3/36
CPC分类号： B29C47/025 , B29C47/0023 , B29C47/0033 , B29C47/028 , B29C47/8815 , B29C47/8895 , B29C2793/009 , B29K2023/06 , B29K2023/12 , B29K2027/06 , B29K2105/005 , B29K2711/14 , B29L2031/766 , E01B3/10 , E04C3/36 , Y10T428/239
摘要： A method and apparatus is disclosed enabling a length of wood (20) such as a post (40) to be encapsulated in a coat such as plastic (110). The method involves placing and caps (31, 33) at the ends of the post (40) and coating the resulting assembly. The method also provides for encapsulating a plurality of posts in a production line.
摘要翻译：公开了一种方法和装置，其使一长度的木材（20）例如柱（40）被包封在诸如塑料（110）的涂层中。该方法包括在柱（40）的端部放置和盖（31,33）并涂覆所得的组件。该方法还提供在生产线中封装多个柱。

9. 发明申请

WO2004066960A3 COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS 审中-公开
公开(公告)号：WO2004066960A3
公开(公告)日：2004-08-12
申请号：PCT/US2004/003565
申请日：2004-01-26
申请人： SCHERING CORPORATION , ANTHES, John, C. , WEST, Robert, E. , HEY, John, A. , ASLANIAN, Robert, G.
发明人： ANTHES, John, C. , WEST, Robert, E. , HEY, John, A. , ASLANIAN, Robert, G.
IPC分类号： A61K31/4525
摘要： The present invention includes methods for treating allergic conditions involving the airway by administering one or more histamine H3 receptor antagonists, one or more histamine H4 antagonist and optionally one or more histamine H1 antagonist.

10. 发明申请

WO2004052851A1 PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA 审中-公开
标题翻译：作为硫蛋白和因子XA的抑制剂的吡咯烷-2-酮衍生物
公开(公告)号：WO2004052851A1
公开(公告)日：2004-06-24
申请号：PCT/EP2003/013799
申请日：2003-12-04
申请人： GLAXO GROUP LIMITED , BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , PEACE, Simon , SENGER, Stefan , SHAH, Gita, Punjabhai , SMITH, Stephen, Allan , SMITH, Steven , WATSON, Nigel, Stephen , WEST, Robert, Ian , YOUNG, Robert, John
发明人： BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , PEACE, Simon , SENGER, Stefan , SHAH, Gita, Punjabhai , SMITH, Stephen, Allan , SMITH, Steven , WATSON, Nigel, Stephen , WEST, Robert, Ian , YOUNG, Robert, John
IPC分类号： C07D207/26
CPC分类号： C07D207/273 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of formula (I), wherein : R 1 represents hydrogen, C 1-4 alkyl, -CH 2 CO 2 H, -CH 2 CO 2 C 1 - 2 alkyl, or -CH 2 CONR7R 8 ; R 2 and R 3 independently represent hydrogen, -C 1-6 alkyl, -C 1-3 alkylCN, -C 1-3 alkylCO 2 H, -C 1-4 alkylOC 1-4 alkyl, -C 1-4 alkylS(O) n C 1-4 alkyl, -C 1-4 alkylNR 10 R 11 , -C 1-3 alkylNCO 2 C 1-4 alkyl, -C 1-3 alkylCONR 7 R 8 , -C 1-3 alkylCO 2 C 0-2 alkylR 9 , -C 1-3 alkylCOC 0-2 alkylR 9 , -C 1-3 alkylCON(R 8 ) C 0-2 alkylR 9 , -C 1-3 alkylNCO 2 C 0-2 alkylR 9 , -C 1-3 alkylNCOC 0-2 alkylR 9 or -C 0-2 alkylR 9 , with the proviso that one of R 2 and R 3 is hydrogen and the other is a substituent other than hydrogen; n is an integer between 0 and 2; R 4 and R 5 together with the nitrogen atom to which they are attached form a morpholino ring; R 6 represents a group selected from formula (II) wherein T 1 and T 2 independently represent CH 2 , NH, S or O with the proviso that when one of T 1 or T 2 represents NH, S or O the other represents CH 2 ; M represents CH 3 , -OH or PO; V represents CH or N; W represents H, CH 3 , Cl or F; X represents C1, Br, F or -CH 3 ; Y represents CH 3 or CF 3 ; Z represents -CH 3 or F; R 7 and R 8 are independently hydrogen, C 1-4 alkyl or together with the N atom to which they are bonded form a 5- or 6- membered non-aromatic heterocyclic ring, optionally containing an additional heteroatom selected from O, N or S; R 10 and R 11 independently represent C 1-4 alkyl or together with the N atom towhich they are bonded form a 5- or 6- membered non-aromatic heterocyclic ring, optionally containing an additionalheteroatom selected from O, N or S; R 9 represents phenyl or a 5- or 6- membered aromatic or non-aromatic heterocyclic group, containing at least one heteroatom selected from O, N or S, each of which is optionally substituted by 0-2 groups selected from: C 1-3 alkyl or halogen; and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a thrombin inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物，其中：R 1表示氢，C 1-4烷基，-CH 2 CO 2 H，-CH 2 CO 2 C 1-2烷基或-CH 2 CONR 7 R 8; R 2和R 3独立地表示氢，-C 1-6烷基，-C 1-3烷基，C 1-3烷基CO 2 H，-C 1-4烷基，C 1-4烷基，-C 1-4烷基，（O）n C 1-4烷基，-C 1-4烷基NR R 11，-C 1-3烷基，CO 2 C 1-4烷基，-C 1-3烷基CONR 7 R 8，-C 1-3烷基CO 2 C 0-2烷基R 9，-C 1-3烷基C 0 -C 20 - 烷基R 9，-C 1- 3烷基CON（R 8）C 0-2烷基R 9，-C 1-3烷基，CO 2 C 0-2烷基R 9，-C 1-3烷基，C 1-10烷基，R 9或-C 0-2烷基R 9，条件是R 2和R 3是氢，另一个是氢以外的取代基; n是0和2之间的整数; R 4和R 5与它们所连接的氮原子一起形成吗啉代环; R 6表示选自式（II）的基团，其中T 1和T 2独立地表示CH 2，NH，S或O，条件是当T 1或T 2中的一个表示NH，S或O时，另一个表示CH 2; M代表CH3，-OH或PO; V表示CH或N; W表示H，CH 3，Cl或F; X表示C1，Br，F或-CH3; Y表示CH3或CF3; Z表示-CH 3或F; R 7和R 8独立地是氢，C 1-4烷基或与它们所键合的N原子一起形成5-或6-元非芳族杂环，任选地含有另外的选自O， N或S; R 10和R 11独立地表示C 1-4烷基或与其键合的N原子一起形成5-或6-元非芳族杂环，任选地含有选自O，N或S的另外的杂原子; R 9表示苯基或含有至少一个选自O，N或S的杂原子的5-或6-元芳族或非芳族杂环基，其中每一个可任选地被选自以下的0-2个基团取代：C1 烷基或卤素; 及其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途，特别用于改善指示凝血酶抑制剂的临床病症。

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