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1. 发明申请

WO2007059952A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2007059952A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006/011218
申请日：2006-11-22
申请人： GLAXO GROUP LIMITED , CAMUS, Laure , CHUDASAMA, Reshma , DAY, Caroline, Jane , DESHMUKH, Deepali , GLEASON, John, Gerald , HARLING, John, David , LEE, Chao-Pin , SAKLATVALA, Paula , SENGER, Stefan , VALLANCE, Sarah , WATSON, John , WATSON, Nigel, Stephen , YOUNG, Robert, John , YUAN, Barbara
发明人： CAMUS, Laure , CHUDASAMA, Reshma , DAY, Caroline, Jane , DESHMUKH, Deepali , GLEASON, John, Gerald , HARLING, John, David , LEE, Chao-Pin , SAKLATVALA, Paula , SENGER, Stefan , VALLANCE, Sarah , WATSON, John , WATSON, Nigel, Stephen , YOUNG, Robert, John , YUAN, Barbara
CPC分类号： C07D409/14 , C07D403/04 , C07D403/14
摘要： The invention relates to chemical entities of formula (I): and/or pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）的化学实体：和/或其药学上可接受的衍生物。本发明还涉及制备式（I）化合物的方法，包含式（I）化合物的药物组合物和式（I）化合物在医药中的用途，特别是在改善临床病症方面指示因子Xa抑制剂。

2. 发明申请

WO02100886A8 PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF FACTOR XA 审中-公开
标题翻译：吡咯烷-2-酮衍生物作为因子XA的抑制剂
公开(公告)号：WO02100886A8
公开(公告)日：2004-02-05
申请号：PCT/GB0202586
申请日：2002-06-06
申请人： GLAXO GROUP LTD , CHAN CHUEN , HAMBLIN JULIE NICOLE , KELLY HENRY ANDERSON , KING , MASON ANDREW MCMURTRIE , PATEL VIPULKUMAR KANTIBHAI , SENGER STEFAN , SHAH GITA PUNJABHAI , WATSON NIGEL STEPHEN , WESTON HELEN ELISABETH , WHITWORTH CAROLINE , YOUNG ROBERT JOHN
发明人： CHAN CHUEN , HAMBLIN JULIE NICOLE , KELLY HENRY ANDERSON , KING , MASON ANDREW MCMURTRIE , PATEL VIPULKUMAR KANTIBHAI , SENGER STEFAN , SHAH GITA PUNJABHAI , WATSON NIGEL STEPHEN , WESTON HELEN ELISABETH , WHITWORTH CAROLINE , YOUNG ROBERT JOHN
IPC分类号： C07D487/08 , A61K31/4025 , A61K31/407 , A61K31/4365 , A61K31/437 , A61K31/439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07D207/273 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/14 , C07D471/04 , C07D471/08 , C07D491/08 , C07D495/04 , C07D498/08 , C07K5/06 , C07K5/078
CPC分类号： A61K9/0031 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/12 , A61K31/4025 , A61K31/454 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

3. 发明申请

WO2003053925A1 PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS 审中-公开
标题翻译：吡咯烷-2-酮作为因子XA抑制剂
公开(公告)号：WO2003053925A1
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014826
申请日：2002-12-20
申请人： GLAXO GROUP LIMITED , BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , KING, Nigel, Paul , KLEANTHOUS, Savvas , MASON, Andrew, McMurtrie , PINTO, Ivan, Leo , POLLARD, Derek, Roland , SENGER, Stefan , SHAH, Gita, Punjabhai , WATSON, Nigel, Stephen , YOUNG, Robert, John
发明人： BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , KING, Nigel, Paul , KLEANTHOUS, Savvas , MASON, Andrew, McMurtrie , PINTO, Ivan, Leo , POLLARD, Derek, Roland , SENGER, Stefan , SHAH, Gita, Punjabhai , WATSON, Nigel, Stephen , YOUNG, Robert, John
IPC分类号： C07D207/273
CPC分类号： C07D207/273 , C07D401/12 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/04
摘要： The invention relates to compounds of formula (I): , and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物：及其药学上可接受的衍生物。本发明还涉及制备式（I）化合物的方法，包含式（I）化合物的药物组合物和式（I）化合物在医药中的用途，特别是在改善临床病症方面指示因子Xa抑制剂。

4. 发明申请

WO2003043981A1 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS 审中-公开
标题翻译： 2-（3-磺酰氨基-2-氧代吡咯烷-1-基）丙酰胺作为因子XA抑制剂
公开(公告)号：WO2003043981A1
公开(公告)日：2003-05-30
申请号：PCT/GB2002/005134
申请日：2002-11-13
申请人： GLAXO GROUP LIMITED , BORTHWICK, Alan, David , CAMPBELL, Matthew , CHAN, Chuen , KELLY, Henry, Anderson , KING, Nigel, Paul , KLEANTHOUS, Savvas , MASON, Andrew, McMurtrie , SENGER, Stefan , SMITH, Paul, William , WATSON, Nigel, Stephen , YOUNG, Robert, John
发明人： BORTHWICK, Alan, David , CAMPBELL, Matthew , CHAN, Chuen , KELLY, Henry, Anderson , KING, Nigel, Paul , KLEANTHOUS, Savvas , MASON, Andrew, McMurtrie , SENGER, Stefan , SMITH, Paul, William , WATSON, Nigel, Stephen , YOUNG, Robert, John
IPC分类号： C07D207/26
CPC分类号： C07D207/273 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I), wherein: R 1 represents hydrogen or -C 1-3 alkylCONR a R b ; One of R 2 and R 3 represents -C 1-3 alkyl and the other represents hydrogen; R 4 represents hydrogen, -C 1-4 alkyl, -C 3-4 alkenyl, -C 2-4 alkylOH, -C 2-4 alkylOC 1-4 alkyl, -C 1-4 alkylCN or -C 0-4 alkylC 3-6 cycloalkyl; R 5 represents -C 2-4 alkylOH, -C 1-4 alkyl, -C 2-4 alkylOC 1-4 alkyl, -C 1-4 alkylCN, -C 1-4 alkylCONR c R d , -C 2-4 alkylNR a R b , -C 2-4 alkylNHCOC 1-3 alkyl, -C 2-4 alkylNHCONR a R b , -C2-4alkylNHSO 2 R e , -C 2-4 alkylSO 2 NR a R b , -C 2-4 alkylNHCO 2 C 1-4 alkyl, -C 2-4 alkylNHC(NH 2 )=NR f , or a group X-Y; X represents -C 1-4 alkylene- optionally substitued by -OH, or a direct link, with the proviso that when X is substituted by -OH, X represents C 2-4 alkylene and the -OH group is not alpha with respect to the amide N atom to which the group X is attached; Y represents -C 3-6 cycloalkyl, phenyl, or an aromatic or non-aromatic 5-, 6- or 7-membered heterocyclic group containing at least one heteroatom selected from O, N or S and optionally substituted at C and/or N atoms by -C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylOH, halogen, -CN, -CF 3 , -NH 2 , -CO 2 H and -OH; R a and R b independently represent hydrogen or -C 1-4 alkyl; R c and R d independently represent hydrogen or -C 1-4 alkyl or together with the N atom to which they are attached form a non-aromatic 5-, 6- or 7- membered heterocyclic group optionally substituted by a heteroatom selected from O, N or S; R e represents -C 1-4 alkyl or -CF 3 ; R f represents NO 2 or CN; R 6 represents a group selected from: (i), (ii), (iii), (iv), (v), Z represents an optional substituent halogen, alk represents alkylene or alkenylene, T represents a heteroatom selected from S or N; and pharmaceutically acceptable derivatives thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物，其中：R 1表示氢或-C 1-3烷基CONR a R b; R 2和R 3中的一个表示-C 1-3烷基，另一个表示氢; R 4表示氢，-C 1-4烷基，-C 3-4链烯基，-C 2-4烷基，C 2-4烷基，C 1-4烷基，-C 1-4烷基，或C 0-4烷基。 R 5表示-C 2-4芳烷基，C 1-4烷基，-C 2-4烷基，C 1-4烷基，-C 1-4烷基，C 1-4烷基，C R 6，-C 2-4烷基，NR a R b，，-C2-4烷基NHCOC1-3烷基，-C2-4烷基NHCORRαR2，-C2-4烷基NHSO2R5，-C2-4烷基，SO2NR，R2，-C2-4烷基，NHCO2C1-4烷基， 4烷基NH（NH 2）= NR或基团XY; X代表-C 1-4亚烷基 - 任选被-OH取代或直接连接，条件是当X被-OH取代时，X代表C2-4亚烷基，-OH基团相对于酰胺N原子不是α 组X连接到其上; Y代表-C3-6环烷基，苯基或含有至少一个选自O，N或S的杂原子的芳族或非芳族的5元，6元或7元杂环基，并且任选地在C和/或N原子被C -C 1-3烷基，C 1-3烷氧基，C 1-3烷基OH，卤素，-CN，-CF 3，-NH 2，-CO 2 H和-OH; R a和R b独立地表示氢或-C 1-4烷基; R c和R d独立地表示氢或-C 1-4烷基或与它们所连接的N原子一起形成任选被被选定的杂原子取代的非芳香族5-，6-或7-元杂环基来自O，N或S; R e表示-C 1-4烷基或-CF 3; R表示NO2或CN; R 6表示选自以下的基团：（i），（ii），（iii），（iv），（v），Z表示任选的取代基卤素，alk表示亚烷基或亚烯基，T表示选自S 或N; 及其药学上可接受的衍生物。本发明还涉及制备式（I）化合物的方法，包含式（I）化合物的药物组合物和式（I）化合物在医药中的用途，特别是在改善临床病症方面指示因子Xa抑制剂。

5. 发明申请

WO2010122088A1 PYRAZOLE AND TRIAZOLE CARBOXAMIDES AS CRAC CHANNEL INHIBITORS 审中-公开
标题翻译：作为CRAC通道抑制剂的吡唑和三唑类羧酰胺
公开(公告)号：WO2010122088A1
公开(公告)日：2010-10-28
申请号：PCT/EP2010/055318
申请日：2010-04-22
申请人： GLAXO GROUP LIMITED , COE, Diane, Mary , COOPER, Anthony, William, James , GORE, Paul, Martin , HOUSE, David , SENGER, Stefan , VILE, Sadie
发明人： COE, Diane, Mary , COOPER, Anthony, William, James , GORE, Paul, Martin , HOUSE, David , SENGER, Stefan , VILE, Sadie
IPC分类号： C07D231/14 , C07D249/04 , A61K31/415 , A61K31/4192 , A61P11/06
CPC分类号： C07D231/14 , C07D249/04
摘要： The present invention relates to amide compounds of formula (I) processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing these compounds and to their use in therapy.
摘要翻译：本发明涉及式（I）的酰胺化合物及其制备方法，可用于这些方法的中间体，含有这些化合物的药物组合物及其在治疗中的用途。

6. 发明申请

WO2008003697A1 SUBSTITUTED N-PHENYLMETHYL -5-OXO-PROLINE-2-AMIDES AS P2X7-RECEPTOR ANTAGONISTS AND THEIR METHODS OF USE 审中-公开
标题翻译：作为P2X7受体拮抗剂的取代的N-苯基甲基-5-氧代-2-丙氨酰胺及其使用方法
公开(公告)号：WO2008003697A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056675
申请日：2007-07-03
申请人： GLAXO GROUP LIMITED , CHAMBERS, Laura, J , GLEAVE, Robert , SENGER, Stefan , WALTER, Daryl, Simon
发明人： CHAMBERS, Laura, J , GLEAVE, Robert , SENGER, Stefan , WALTER, Daryl, Simon
IPC分类号： C07D207/28 , C07D401/06 , A61K31/4015 , A61K31/402 , A61P25/28 , A61P29/00
CPC分类号： C07D401/06 , C07D207/277
摘要： The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.
摘要翻译：本发明涉及调节P2X7受体功能并能够拮抗ATP在P2X7受体上的作用的式（I）的新型氧代 - 脯氨酰胺衍生物，以及这些化合物或其药物组合物在治疗由 P2X7受体，例如疼痛，炎症和神经变性。

7. 发明申请

WO2004052851A1 PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA 审中-公开
标题翻译：作为硫蛋白和因子XA的抑制剂的吡咯烷-2-酮衍生物
公开(公告)号：WO2004052851A1
公开(公告)日：2004-06-24
申请号：PCT/EP2003/013799
申请日：2003-12-04
申请人： GLAXO GROUP LIMITED , BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , PEACE, Simon , SENGER, Stefan , SHAH, Gita, Punjabhai , SMITH, Stephen, Allan , SMITH, Steven , WATSON, Nigel, Stephen , WEST, Robert, Ian , YOUNG, Robert, John
发明人： BORTHWICK, Alan, David , CHAN, Chuen , KELLY, Henry, Anderson , PEACE, Simon , SENGER, Stefan , SHAH, Gita, Punjabhai , SMITH, Stephen, Allan , SMITH, Steven , WATSON, Nigel, Stephen , WEST, Robert, Ian , YOUNG, Robert, John
IPC分类号： C07D207/26
CPC分类号： C07D207/273 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds of formula (I), wherein : R 1 represents hydrogen, C 1-4 alkyl, -CH 2 CO 2 H, -CH 2 CO 2 C 1 - 2 alkyl, or -CH 2 CONR7R 8 ; R 2 and R 3 independently represent hydrogen, -C 1-6 alkyl, -C 1-3 alkylCN, -C 1-3 alkylCO 2 H, -C 1-4 alkylOC 1-4 alkyl, -C 1-4 alkylS(O) n C 1-4 alkyl, -C 1-4 alkylNR 10 R 11 , -C 1-3 alkylNCO 2 C 1-4 alkyl, -C 1-3 alkylCONR 7 R 8 , -C 1-3 alkylCO 2 C 0-2 alkylR 9 , -C 1-3 alkylCOC 0-2 alkylR 9 , -C 1-3 alkylCON(R 8 ) C 0-2 alkylR 9 , -C 1-3 alkylNCO 2 C 0-2 alkylR 9 , -C 1-3 alkylNCOC 0-2 alkylR 9 or -C 0-2 alkylR 9 , with the proviso that one of R 2 and R 3 is hydrogen and the other is a substituent other than hydrogen; n is an integer between 0 and 2; R 4 and R 5 together with the nitrogen atom to which they are attached form a morpholino ring; R 6 represents a group selected from formula (II) wherein T 1 and T 2 independently represent CH 2 , NH, S or O with the proviso that when one of T 1 or T 2 represents NH, S or O the other represents CH 2 ; M represents CH 3 , -OH or PO; V represents CH or N; W represents H, CH 3 , Cl or F; X represents C1, Br, F or -CH 3 ; Y represents CH 3 or CF 3 ; Z represents -CH 3 or F; R 7 and R 8 are independently hydrogen, C 1-4 alkyl or together with the N atom to which they are bonded form a 5- or 6- membered non-aromatic heterocyclic ring, optionally containing an additional heteroatom selected from O, N or S; R 10 and R 11 independently represent C 1-4 alkyl or together with the N atom towhich they are bonded form a 5- or 6- membered non-aromatic heterocyclic ring, optionally containing an additionalheteroatom selected from O, N or S; R 9 represents phenyl or a 5- or 6- membered aromatic or non-aromatic heterocyclic group, containing at least one heteroatom selected from O, N or S, each of which is optionally substituted by 0-2 groups selected from: C 1-3 alkyl or halogen; and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a thrombin inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物，其中：R 1表示氢，C 1-4烷基，-CH 2 CO 2 H，-CH 2 CO 2 C 1-2烷基或-CH 2 CONR 7 R 8; R 2和R 3独立地表示氢，-C 1-6烷基，-C 1-3烷基，C 1-3烷基CO 2 H，-C 1-4烷基，C 1-4烷基，-C 1-4烷基，（O）n C 1-4烷基，-C 1-4烷基NR R 11，-C 1-3烷基，CO 2 C 1-4烷基，-C 1-3烷基CONR 7 R 8，-C 1-3烷基CO 2 C 0-2烷基R 9，-C 1-3烷基C 0 -C 20 - 烷基R 9，-C 1- 3烷基CON（R 8）C 0-2烷基R 9，-C 1-3烷基，CO 2 C 0-2烷基R 9，-C 1-3烷基，C 1-10烷基，R 9或-C 0-2烷基R 9，条件是R 2和R 3是氢，另一个是氢以外的取代基; n是0和2之间的整数; R 4和R 5与它们所连接的氮原子一起形成吗啉代环; R 6表示选自式（II）的基团，其中T 1和T 2独立地表示CH 2，NH，S或O，条件是当T 1或T 2中的一个表示NH，S或O时，另一个表示CH 2; M代表CH3，-OH或PO; V表示CH或N; W表示H，CH 3，Cl或F; X表示C1，Br，F或-CH3; Y表示CH3或CF3; Z表示-CH 3或F; R 7和R 8独立地是氢，C 1-4烷基或与它们所键合的N原子一起形成5-或6-元非芳族杂环，任选地含有另外的选自O， N或S; R 10和R 11独立地表示C 1-4烷基或与其键合的N原子一起形成5-或6-元非芳族杂环，任选地含有选自O，N或S的另外的杂原子; R 9表示苯基或含有至少一个选自O，N或S的杂原子的5-或6-元芳族或非芳族杂环基，其中每一个可任选地被选自以下的0-2个基团取代：C1 烷基或卤素; 及其药学上可接受的衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途，特别用于改善指示凝血酶抑制剂的临床病症。

8. 发明申请

WO2004110434A1 2-PYRROLIDONE DERIVATIVES AND USE THEREOF AS FACTOR XA INHIBITORS 审中-公开
标题翻译： 2-吡咯烷酮衍生物及其作为因子XA抑制剂的用途
公开(公告)号：WO2004110434A1
公开(公告)日：2004-12-23
申请号：PCT/EP2004/006591
申请日：2004-06-17
申请人： GLAXO GROUP LIMITED , BORTHWICK, Alan, David , KLEANTHOUS, Savvas , SENGER, Stefan , SMITH, Ian, Edward, David
发明人： BORTHWICK, Alan, David , KLEANTHOUS, Savvas , SENGER, Stefan , SMITH, Ian, Edward, David
IPC分类号： A61K31/4025
CPC分类号： C07D409/12 , C07D409/14
摘要： The invention relates to compounds of formula (I), and/or pharmaceutically acceptable derivative thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（I）化合物和/或其药学上可接受的衍生物。本发明还涉及制备式（I）化合物的方法，包含式（I）化合物的药物组合物和式（I）化合物在医药中的用途，特别是在改善临床病症方面指示因子Xa抑制剂。

9. 发明申请

WO2002100886A1 PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF FACTOR XA 审中-公开
标题翻译：吡咯烷-2-酮衍生物作为因子XA的抑制剂
公开(公告)号：WO2002100886A1
公开(公告)日：2002-12-19
申请号：PCT/GB2002/002586
申请日：2002-06-06
申请人： GLAXO GROUP LIMITED , CHAN, Chuen , HAMBLIN, Julie, Nicole , KELLY, Henry, Andreson , KING; Nigel, Paul , MASON, Andrew, McMurtrie , PATEL, Vipulkumar, Kantibhai , SENGER, Stefan , SHAH, Gita, Punjabhai , WATSON, Nigel, Stephen , WESTON, Helen, Elisabeth , WHITWORTH, Caroline , YOUNG, Robert, John
发明人： CHAN, Chuen , HAMBLIN, Julie, Nicole , KELLY, Henry, Andreson , KING; Nigel, Paul , MASON, Andrew, McMurtrie , PATEL, Vipulkumar, Kantibhai , SENGER, Stefan , SHAH, Gita, Punjabhai , WATSON, Nigel, Stephen , WESTON, Helen, Elisabeth , WHITWORTH, Caroline , YOUNG, Robert, John
IPC分类号： C07K5/06
CPC分类号： A61K9/0031 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/12 , A61K31/4025 , A61K31/454 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
摘要翻译：本发明涉及式（Ic）化合物的制备方法，含有它们的药物组合物及其在药物中的用途，特别是用于改善指定因子Xa抑制剂的临床病症。

10. 发明申请

WO2010122089A1 N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS 审中-公开
标题翻译： N-吡唑啉羧酸酯作为CRAC通道抑制剂
公开(公告)号：WO2010122089A1
公开(公告)日：2010-10-28
申请号：PCT/EP2010/055319
申请日：2010-04-22
申请人： GLAXO GROUP LIMITED , ALLEN, David, George , COE, Diane, Mary , COOPER, Anthony, William, James , GORE, Paul, Martin , HOUSE, David , SENGER, Stefan , SOLLIS, Steven, Leslie , VILE, Sadie , WILSON, Caroline
发明人： ALLEN, David, George , COE, Diane, Mary , COOPER, Anthony, William, James , GORE, Paul, Martin , HOUSE, David , SENGER, Stefan , SOLLIS, Steven, Leslie , VILE, Sadie , WILSON, Caroline
IPC分类号： C07D231/40 , A61K31/415 , A61P11/06
CPC分类号： C07D231/40
摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.
摘要翻译：本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其在治疗疾病，病症或病症例如过敏性疾病，炎症性疾病和免疫系统疾病中的用途。

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